Category Archives: DNA

Sep. 24, 2013 Chemists from Nijmegen have developed a catalyst that binds to DNA, slides over it and splits the molecule in particular places. The researchers were able to do this by synthetically modifying a natural catalyst. This finding is a first in the field of chemistry and will help in the selective modification of polymers such as DNA. The results were published online in Nature Chemistry on 22 September.

Roeland Nolte, Emeritus Professor of Organic Chemistry at Radboud University Nijmegen, is the leader of the research project. As he explains, 'Natural enzymes exist that are able to replicate -- that is make a copy of -- DNA. These enzymes consist of a ring to which another enzyme, the replicating catalyst, is clamped. We modified the natural ring and introduced porphyrines, with the result that the system is able to split DNA. We have therefore constructed our own, modifiable, biohybrid catalyst, inspired by nature.'

DNA signposting

The tiny molecular machine is actually not a ring, but a c-shape with a narrow opening. This means that it can easily bind to and slide over DNA. While it is sliding, the machine only splits at a specific sequence: the letters AAA in the DNA -- a repetitive sequence of three adenine molecules. Adenine is one of the four DNA building blocks. 'We can also influence the direction of the catalyst, by sliding it from the left or the right over the DNA', says Nolte. 'We do this by molecularly blocking one side of the DNA so that the catalyst can only move in the other direction.'

Visible splitting positions

The chemists have developed a new technique that shows exactly where the molecular machine has performed the splitting action. The splitting produces a functional group in the DNA that, following treatment with the streptavidin protein, can be visualised using Atomic Force Microscopy (AFM). AFM can be used to investigate the surface of a molecule in detail because the microscope scans the surface using a needle. Using this technique, the researchers were able to detect the splitting locations in the DNA and thereby determine whether or not the machine was indeed moving in the intended direction.

Molecular computer

Molecular machines like this catalyst are very useful in organic chemistry as they make it possible to split DNA in a controlled manner. Nolte explains, 'Our ultimate goal is a fully synthetic catalyst. We would be able to use this in various solvents, whereas the catalyst we currently use only works in a water solution. The synthetic catalyst I have in mind would be a kind of molecular computer that uses the information input to perform precise tasks. We could then use this to modify polymer chains as we please, for example to strengthen them or to store information in them.'

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Chemists slide a splitting catalyst over DNA for first time

Amazing Transformation by Speaking Life to My Cells Dna and Atoms
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DNA//Drawing EYE
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DNA//Drawing EYE - Video

The Star/Asia News Network

Tuesday, Sep 24, 2013

BUTTERWORTH - The Sessions Court here heard that five different sets of semen stains were found on the panties of an Indonesian woman who claimed to have been raped by three policemen.

Padillah Yahya, 39, a chemist with the state Chemistry Department told the court that the semen stains were those of Kons Syahiran Romli, 22, Kpl Nik Sin Mat Lazin, 33 and Kons Remy Anak Dara, 26, and two other unidentified males.

"We also found DNA samples of Syahiran, a third and fourth unidentified male and an unidentified female on a bedsheet taken from the police barracks in the Prai police station," she said.

She added that a DNA sample of the third male was also found on a towel taken from the same barracks.

Padillah told Sessions judge Meor Sulaiman Ahmad Tarmizi that the samples were among the 19 items that were passed to her to be tested on Nov 14 last year.

The items included a blouse belonging to the 26-year-old victim, semen, blood samples and hair.

The three policemen are alleged to have raped the woman in Room 4 of the Prai police station barracks between 6.40am and 7.30am on Nov 9 last year.

They were charged under Section 376 of the Penal Code, which carries a jail term of up to 20 years and whipping.

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DNA of five found on panties

23 September 2013 Last updated at 21:59 ET By Phil Mackie Reporter, BBC Radio 5 live

DNA samples taken from thousands of former prisoners could be destroyed if police lose a judicial review later.

An ex-prisoner, referred to in court as R, argues that a police force's request to collect his DNA threatens arrest and infringes his human rights.

Under Operation Nutmeg, DNA samples have been collected from prisoners who pre-date routine collection.

Judges will decide if the force's approach was unlawful and if DNA collected in such a way can be kept.

The police force at the centre of the case - which also cannot be named for legal reasons - was trying to collect the sample as part of Operation Nutmeg, a nationwide push to collect genetic material from people jailed for serious crimes before 1994.

After that date, people convicted of serious crimes had DNA swabs routinely taken to add to the national database.

The aim of the operation is to see if there is any match to unsolved crimes with DNA from the former prisoners.

By July of this year, 6,204 samples had been taken under the scheme, with 111 being matched to crime scenes.

R - who was jailed for manslaughter in the 1980s but after his release was only in trouble for a lesser, non-violent offence - argues that he has turned his life around since 2000.

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Police await DNA destruction ruling

Touché Amoré - DNA
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ENEM - Experimento com Alterações do DNA - Video

Open-Source Your DNA - Popular Science Rants!
Genetic privacy is a pipe dream. It #39;s time to let science run free with our DNA. Read Popular Science contributor Erin Biba #39;s essay here: http://www.popsci.c...

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When KABOOM Remix Goes Wrong w/ Charlie Clips and DNA
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DNA Test likely to undergo on Rajasthan Ex-Minister Babulal Nagar
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DNA Test likely to undergo on Rajasthan Ex-Minister Babulal Nagar - Video