Solving the mystery of aging: Longevity gene makes Hydra immortal and humans grow older

ScienceDaily (Nov. 13, 2012) Why do we get older? When do we die and why? Is there a life without aging? For centuries, science has been fascinated by these questions. Now researchers from Kiel (Germany) have examined why the polyp Hydra is immortal -- and unexpectedly discovered a link to aging in humans.

The study carried out by Kiel University together with the University Medical Center Schleswig-Holstein (UKSH) will be published this week in the Proceedings of the National Academy of Sciences (PNAS).

Hydra -- mysteriously immortal

The tiny freshwater polyp Hydra does not show any signs of aging and is potentially immortal. There is a rather simple biological explanation for this: these animals exclusively reproduce by budding rather than by mating. A prerequisite for such vegetative-only reproduction is that each polyp contains stem cells capable of continuous proliferation. Without these stem cells, the animals could not reproduce any more. Due to its immortality, Hydra has been the subject of many studies regarding aging processes for several years.

Aging in humans

When people get older, more and more of their stem cells lose the ability to proliferate and thus to form new cells. aging tissue cannot regenerate any more, which is why for example muscles decline. Elderly people tend to feel weaker because their heart muscles are affected by this aging process as well. If it were possible to influence these aging processes, humans could feel physically better for much longer. Studying animal tissue such as those of Hydra -- an animal full of active stem cells during all its life -- may deliver valuable insight into stem cell aging as such.

Human longevity gene discovered in Hydra

"Surprisingly, our search for the gene that causes Hydra to be immortal led us to the so-called FoxO gene," says Anna-Marei Bhm, PhD student and first author of the study. The FoxO gene exists in all animals and humans and has been known for years. However, until now it was not known why human stem cells become fewer and inactive with increasing age, which biochemical mechanisms are involved and if FoxO played a role in aging. In order to find the gene, the research group isolated Hydra's stem cells and then screened all of their genes.

Immortality mechanism of Hydra revealed

The Kiel research team examined FoxO in several genetically modified polyps: Hydra with normal FoxO, with inactive FoxO and with enhanced FoxO. The scientists were able to show that animals without FoxO possess significantly fewer stem cells. Interestingly, the immune system in animals with inactive FoxO also changes drastically. "Drastic changes of the immune system similar to those observed in Hydra are also known from elderly humans," explains Philip Rosenstiel of the Institute of Clinical Molecular Biology at UKSH, whose research group contributed to the study.

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Solving the mystery of aging: Longevity gene makes Hydra immortal and humans grow older