Drugs that smooth away wrinkles could boost longevity

''If you interfere with this expression, you interfere with the lifespan extension. And if you over-express some of these genes, the worm actually lives a little bit longer.''

Although the worm is a long way from a human being in evolutionary terms, it has been shown to mirror ageing processes in higher forms of life.

''That's a strong predictor that this mechanism is relevant to people as well,'' said Dr Blackwell.

Collagens are the main structural components in connective tissue and make up about a third of the proteins in the human body.

''Collagens are everywhere,'' Dr Blackwell added. ''They are like the scaffolding for our tissues, and they give us tissue elasticity and strength.''

ECM structures deteriorate with age and collagens have been implicated in conditions ranging from diabetes complications to heart and artery and kidney diseases.

Separate studies have shown that mice given a treatment that makes them genetically disposed to living longer develop stronger and more elastic muscle tendons.

But until now, no one has looked at the possibility that ECM remodelling might be a defence against ageing. Instead, work has focused on protecting and regenerating cells.

The discovery could lead to cosmetic products that also improve health, according to the team whose findings appear Nature journal's online edition.

''It says that beauty is definitely not skin deep,'' said Dr Blackwell. ''In fact, the richest beauty is inner beauty, because if you want to look young you don't start with the outside, you start with the inside.

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Drugs that smooth away wrinkles could boost longevity