Changing One Codon Of Telomerase Gives Greater Human Longevity.flv – Video

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Changing One Codon Of Telomerase Gives Greater Human Longevity.flv
Varying the ubiquination of proteins makes them persist 200 times longerModify telomerase to have greater duration of cytosolic availability to minimize aging Modifying one N-terminal codon of telomerase to give greater human longevity Voet, Biochemistry, 1999, says The structural features that direct ubiquination based recycling are the N-terminal amino acids on the protein if it is asp, leu, lys, phe then the protein has a half life of just 2 or 3 minutes if it has ala, gly, met, ser, val then it has a half life over ten hours. Thus if you want any protein to be rapidly recycled you just end it with a 2 or 3 minute amino acid, if you want 200 times greater protein durability just end it with a ten hour amino acid Making a version of TERT with ala, gly, met, ser, val at the N-terminal end thus creates telomerase that lasts up to 200 times longermore telomerase has been linked to longevity Yet I have not looked up the telomerase sequence, what if it is already superdurable at the cytosol?There are 4 genes with the description telomerase at genenames.org, there also appear to be several N-terminal codon variants at TERT (Bosoy, 2003), the most prominent telomerase gene.I predict a different N-terminal amino acid, or a brief codon sequence, than those yet studied will provide reduced ubiquination to give greater telomerase durability I urge research on how this one codon change to TERT could give humans much greater longevityFrom:beinganangeltreonViews:2188 3ratingsTime:01:31More inScience Technology

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Changing One Codon Of Telomerase Gives Greater Human Longevity.flv - Video