Vanqua Bio Launches with $85 Million Series B Financing and – Health Bollyinside – BollyInside

Novel drug-development approach combines advanced insights into critical neuronal cell pathways with cutting-edge assays to enable next-generation therapies

Lead program targets Parkinsons disease and all forms of Gaucher disease

CHICAGO, Sept. 14, 2021 (News) Vanqua Bio, a Chicago-based biopharmaceutical company dedicated to discovering and developing next-generation medicines for neurodegenerative diseases, today announced that it closed an $85 million Series B financing round, led by Omega Funds. The syndicate includes Series A investor OrbiMed and new investors Omega Funds, Surveyor Capital (a Citadel company), Avoro Ventures, Casdin Capital, Pontifax, Eli Lilly and Company, Logos Capital, and Osage University Partners. Proceeds from the financing will be used to accelerate the development of the companys innovative therapeutic programs. The need for effective neurodegenerative therapies is urgent; every day, the lives of thousands of people are changed forever following a diagnosis of Parkinsons disease (PD), Gaucher disease (GD), Alzheimers disease (AD), or amyotrophic lateral sclerosis (ALS).

Vanqua Bio is helping usher in a new era of hope for people living with neurodegenerative disorders. Our mission to develop effective therapies that slow or stop the progression of PD, AD, ALS, and Gaucher disease is a very personal one, and we are excited to have the support of world-class investors, said Jim Sullivan, PhD, Co-founder and Chief Executive Officer of Vanqua Bio. We are a patient-founded company with a technology platform based on seminal research conducted by Dimitri Krainc, MD, PhD, Chair of the Department of Neurology at Northwestern Universitys Feinberg School of Medicine, that is allowing us to identify a new generation of therapeutics with transformative potential. (Click to Tweet.)

Vanqua Bios drug development approach overcomes longstanding challenges in the neuroscience field by capitalizing on the power of human genetics to identify genes that cause or increase the risk of neurodegenerative disease. The company leverages novel, proprietary research tools and in vitro modeling of disease based on patient-derived neuronal cells to translate these genetic insights into transformative therapies.

We are delighted to have successfully led this financing for Vanqua Bio, and to partner with Jim and his team and the companys strong syndicate of dedicated, long-term investors, said Bernard Davitian, Partner at Omega Funds. Omega believes Vanqua Bios accomplished management team is well positioned to deliver on the immense potential of the companys precision medicine approach to neurodegeneration.

Targeting GCase Activation

The companys lead program is focused on developing small-molecule activators of glucocerebrosidase (GCase), an enzyme that regulates lipid homeostasis in cells. Reductions in the activity of GCase disrupt the function of the lysosome, the recycling center of the cell, enabling toxic forms of proteins, including alpha synuclein, to accumulate and harm neurons. Alpha synuclein aggregation is a hallmark of multiple neurodegenerative diseases including PD. Mutations in the gene that encodes GCase (GBA1) can cause GD and are strongly associated with a form of Parkinsons disease called GBA-PD and a subset of Lewy body dementia (GBA-LBD) cases. Vanqua Bios Series B financing will advance the companys best-in-class GCase activators into human testing within the next two years, initially focusing on GD and GBA-PD.

Of the eight million Parkinsons patients around the world, up to 800,000 have GBA-PD. These individuals urgently need targeted therapies that can improve their outcomes, said Jonathan Silverstein, J.D., a member of Vanqua Bios Board of Directors, Executive Partner at OrbiMed, and founder of the Silverstein Foundation for Parkinsons with GBA. Vanqua Bios unique approach to discovering novel GCase activators holds great promise in enabling new targeted therapies for GBA-PD patients. I have confidence in the companys potential to impact patients lives, dramatically improve the discovery and development process for additional neurodegenerative disease therapies, and create value for investors.

In addition to its GCase activator programs, Vanqua Bio will also advance programs targeting the innate immune system, which, when overactivated, can accelerate the progression of several neurological diseases. The company is advancing small molecule and antisense oligonucleotide programs with an initial focus on ALS and AD.

Proven Leadership Team

Vanqua Bios leadership team brings a track record of discovering and developing cutting-edge, commercially successful therapeutics. Previously Vice President of Research at AbbVie, Dr. Sullivan helped discover multiple therapies, including RINVOQ, VENCLEXTAand MAVYRET, which have transformed the treatment of rheumatoid arthritis, certain blood cancers, and hepatitis C, respectively. Kevin Hunt, PhD, Vanqua Bios Chief Scientific Officer, previously served as Executive Director of Drug Discovery for Edgewise Therapeutics, overseeing both internal and external preclinical drug discovery and development. Dr. Hunt also discovered multiple clinical candidates for severe diseases and held prior roles at Array Biopharma, Calico Life Sciences, and the University of Texas Southwestern Medical Center. Co-Founder Dr. Dimitri Krainc, a leading expert on uncovering molecular pathways that contribute to neurodegenerative diseases, chairs Vanqua Bios Scientific Advisory Board.

Mr. Davitian and Sara Nayeem, MD (Avoro Ventures), are joining Vanqua Bios Board of Directors, which includes Dr. Sullivan, Mr. Silverstein (OrbiMed), Mona Ashiya, PhD (OrbiMed), and Stephen Squinto, PhD (OrbiMed).

Given the strong genetic validation for GCase as a target for GBA Parkinsons and Gaucherpatients, the high unmet need inthese populations, and the expertise of the Vanqua Bio team in developing small molecule drugs, we are very enthusiastic about Vanquas strategy, said Dr. Nayeem of Avoro Ventures. The company also benefits from an impressive and deeply knowledgeable board of directors, which Avoro Ventures is honored to join.

About Vanqua Bio

Founded in 2019 and headquartered in Chicago near Northwestern Universitys world-renowned Krainc Laboratory, Vanqua Bio is a biopharmaceutical company dedicated to discovering and developing next-generation medicines that have the potential to transform the lives of patients with neurodegenerative diseases. Our technology platform utilizes human genetics and patient-derived neuronal cells to identify, validate, and clinically translate novel disease pathways associated with lysosomal dysfunction or aberrant activation of the innate immune system. Our lead program targets glucocerebrosidase (GCase) as a potential treatment for Parkinsons disease (PD) and all forms of Gaucher disease. Additional programs address overactivation of the innate immune system in central and peripheral neurodegenerative disorders, including ALS and Alzheimers disease. For more information, go to http://www.vanquabio.com.

Media Contact

Erich SandovalLazar-FINN PartnersErich.sandoval@finnpartners.com(917) 497-2867

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Vanqua Bio Launches with $85 Million Series B Financing and - Health Bollyinside - BollyInside