Butler, M. S. et al. Analysis of the clinical pipeline of treatments for drug-resistant bacterial infections: despite progress, more action is needed. Antimicrob. Agents Chemother. 66, e0199121 (2022).
Article PubMed Google Scholar
Martnez-Garca, L., Gonzlez-Alba, J. M., Baquero, F., Cantn, R. & Galn, J. C. Ceftazidime is the key diversification and selection driver of VIM-type carbapenemases. mBio 9, e02109e02117 (2018).
Article PubMed PubMed Central Google Scholar
Baquero, F. et al. Allogenous selection of mutational collateral resistance: old drugs select for new resistance within antibiotic families. Front. Microbiol. 12, 757833 (2021).
Article PubMed PubMed Central Google Scholar
Rajer, F., Allander, L., Karlsson, P. A. & Sandegren, L. Evolutionary trajectories toward high-level -lactam/-lactamase inhibitor resistance in the presence of multiple -lactamases. Antimicrob. Agents Chemother. 66, e0029022 (2022).
Article PubMed Google Scholar
Poirel, L., Sadek, M., Kusaksizoglu, A. & Nordmann, P. Co-resistance to ceftazidimeavibactam and cefiderocol in clinical isolates producing KPC variants. Eur. J. Clin. Microbiol. Infect. Dis. 41, 677680 (2022).
Article CAS PubMed Google Scholar
Silver, L. L. Challenges of antibacterial discovery. Clin. Microbiol. Rev. 24, 71109 (2011).
Article CAS PubMed PubMed Central Google Scholar
Baker, S. J., Payne, D. J., Rappuoli, R. & De Gregorio, E. Technologies to address antimicrobial resistance. Proc. Natl Acad. Sci. USA 115, 1288712895 (2018).
Article CAS PubMed PubMed Central Google Scholar
Payne, D. J., Gwynn, M. N., Holmes, D. J. & Pompliano, D. L. Drugs for bad bugs: confronting the challenges of antibacterial discovery. Nat. Rev. Drug Discov. 6, 2940 (2007).
Article CAS PubMed Google Scholar
Tommasi, R., Brown, D. G., Walkup, G. K., Manchester, J. I. & Miller, A. A. ESKAPEing the labyrinth of antibacterial discovery. Nat. Rev. Drug Discov. 14, 529542 (2015).
Article CAS PubMed Google Scholar
Brotz-Oesterhelt, H. & Sass, P. Postgenomic strategies in antibacterial drug discovery. Future Microbiol. 5, 15531579 (2010).
Article PubMed Google Scholar
Lewis, K. Platforms for antibiotic discovery. Nat. Rev. Drug Discov. 12, 371387 (2013).
Article CAS PubMed Google Scholar
Muoz, K. A. & Hergenrother, P. J. Facilitating compound entry as a means to discover antibiotics for Gram-negative bacteria. Acc. Chem. Res. 54, 13221333 (2021).
Article PubMed PubMed Central Google Scholar
Zhao, S. et al. Defining new chemical space for drug penetration into Gram-negative bacteria. Nat. Chem. Biol. 16, 12931302 (2020).
Article CAS PubMed PubMed Central Google Scholar
Sadybekov, A. V. & Katritch, V. Computational approaches streamlining drug discovery. Nature 616, 673685 (2023).
Article CAS PubMed Google Scholar
Lluka, T. & Stokes, J. M. Antibiotic discovery in the artificial intelligence era. Ann. NY Acad. Sci. 1519, 7493 (2023).
Article CAS PubMed Google Scholar
Lyu, J. et al. Ultra-large library docking for discovering new chemotypes. Nature 566, 224229 (2019).
Article CAS PubMed PubMed Central Google Scholar
Mobegi, F. M. et al. From microbial gene essentiality to novel antimicrobial drug targets. BMC Genomics 15, 958 (2014).
Article PubMed PubMed Central Google Scholar
Agarwal, P. & Searls, D. B. Can literature analysis identify innovation drivers in drug discovery? Nat. Rev. Drug Discov. 8, 865 (2009).
Article CAS PubMed PubMed Central Google Scholar
Lange, R. P., Locher, H. H., Wyss, P. C. & Then, R. L. The targets of currently used antibacterial agents: lessons for drug discovery. Curr. Pharm. Des. 13, 31403154 (2007).
Article CAS PubMed Google Scholar
Theuretzbacher, U. & Piddock, L. J. V. Non-traditional antibacterial therapeutic options and challenges. Cell Host Microbe 26, 6172 (2019).
Article CAS PubMed Google Scholar
Frearson, J. A., Wyatt, P. G., Gilbert, I. H. & Fairlamb, A. H. Target assessment for antiparasitic drug discovery. Trends Parasitol. 23, 589595 (2007).
Article CAS PubMed PubMed Central Google Scholar
Streker, K. et al. In vitro and in vivo validation of ligA and tarI as essential targets in Staphylococcus aureus. Antimicrob. Agents Chemother. 52, 44704474 (2008).
Article CAS PubMed PubMed Central Google Scholar
Rancati, G., Moffat, J., Typas, A. & Pavelka, N. Emerging and evolving concepts in gene essentiality. Nat. Rev. Genet. 19, 3449 (2018).
Article CAS PubMed Google Scholar
Bosch-Guiteras, N. & van Leeuwen, J. Exploring conditional gene essentiality through systems genetics approaches in yeast. Curr. Opin. Genet. Dev. 76, 101963 (2022).
Article CAS PubMed Google Scholar
Zhang, Z. & Ren, Q. Why are essential genes essential? the essentiality of Saccharomyces genes. Microb. Cell 2, 280287 (2015).
Article CAS PubMed PubMed Central Google Scholar
Chessher, A. Evaluating the suitability of essential genes as targets for antibiotic screening assays using proteomics. Protein Cell 3, 57 (2012).
Article PubMed PubMed Central Google Scholar
Editorial. Putting gene essentiality into context. Nat. Rev. Genet. 19, 1 (2017).
Google Scholar
Chaudhary, A. S., Chen, W., Jin, J., Tai, P. C. & Wang, B. SecA: a potential antimicrobial target. Future Med. Chem. 7, 9891007 (2015).
Article CAS PubMed Google Scholar
Emmerich, C. H. et al. Improving target assessment in biomedical research: the GOT-IT recommendations. Nat. Rev. Drug Discov. 20, 6481 (2021).
Article CAS PubMed Google Scholar
Murima, P., McKinney, J. D. & Pethe, K. Targeting bacterial central metabolism for drug development. Chem. Biol. 21, 14231432 (2014).
Article CAS PubMed Google Scholar
Hedstrom, L. The bare essentials of antibiotic target validation. ACS Infect. Dis. 3, 24 (2017).
Article CAS PubMed Google Scholar
Hogan, A. M. & Cardona, S. T. Gradients in gene essentiality reshape antibacterial research. FEMS Microbiol. Rev. 46, fuac005 (2022).
Article PubMed PubMed Central Google Scholar
Bergmiller, T., Ackermann, M. & Silander, O. K. Patterns of evolutionary conservation of essential genes correlate with their compensability. PLoS Genet. 8, e1002803 (2012).
Article CAS PubMed PubMed Central Google Scholar
Dunman, P. M. & Tomaras, A. P. Translational deficiencies in antibacterial discovery and new screening paradigms. Curr. Opin. Microbiol. 27, 108113 (2015).
Article CAS PubMed PubMed Central Google Scholar
Rosconi, F. et al. A bacterial pan-genome makes gene essentiality strain-dependent and evolvable. Nat. Microbiol. 7, 15801592 (2022).
Article CAS PubMed PubMed Central Google Scholar
Kaur, H., Kalia, M. & Taneja, N. Identification of novel non-homologous drug targets against Acinetobacter baumannii using subtractive genomics and comparative metabolic pathway analysis. Microb. Pathog. 152, 104608 (2021).
Article CAS PubMed Google Scholar
Uddin, R., Masood, F., Azam, S. S. & Wadood, A. Identification of putative non-host essential genes and novel drug targets against Acinetobacter baumannii by in silico comparative genome analysis. Microb. Pathog. 128, 2835 (2019).
Article CAS PubMed Google Scholar
Ramos, P. I. P. et al. An integrative, multi-omics approach towards the prioritization of Klebsiella pneumoniae drug targets. Sci. Rep. 8, 10755 (2018).
Article PubMed PubMed Central Google Scholar
Rafiq, H. et al. A computational subtractive genome analysis for the characterization of novel drug targets in Klebsiella pneumoniae strain PittNDM01. Microb. Pathog. 146, 104245 (2020).
Article CAS PubMed Google Scholar
Uddin, R. & Jamil, F. Prioritization of potential drug targets against P. aeruginosa by core proteomic analysis using computational subtractive genomics and proteinprotein interaction network. Comput. Biol. Chem. 74, 115122 (2018).
Article CAS PubMed Google Scholar
Nazarshodeh, E., Marashi, S. A. & Gharaghani, S. Structural systems pharmacology: a framework for integrating metabolic network and structure-based virtual screening for drug discovery against bacteria. PLoS ONE 16, e0261267 (2021).
Article CAS PubMed PubMed Central Google Scholar
Bakheet, T. M. & Doig, A. J. Properties and identification of antibiotic drug targets. BMC Bioinformatics 11, 195 (2010).
Article PubMed PubMed Central Google Scholar
Bosch, B. et al. Genome-wide gene expression tuning reveals diverse vulnerabilities of M. tuberculosis. Cell 184, 45794592.e24 (2021).
Article CAS PubMed PubMed Central Google Scholar
Hawkins, J. S. et al. Mismatch-CRISPRi reveals the co-varying expressionfitness relationships of essential genes in Escherichia coli and Bacillus subtilis. Cell Syst. 11, 523535.e9 (2020).
Article CAS PubMed PubMed Central Google Scholar
Luo, H., Gao, F. & Lin, Y. Evolutionary conservation analysis between the essential and nonessential genes in bacterial genomes. Sci. Rep. 5, 13210 (2015).
Article CAS PubMed PubMed Central Google Scholar
Arun, P. V. P. S. et al. Identification and functional analysis of essential, conserved, housekeeping and duplicated genes. FEBS Lett. 590, 14281437 (2016).
Article CAS PubMed Google Scholar
Du, W. et al. Two active forms of UDP-N-acetylglucosamine enolpyruvyl transferase in Gram-positive bacteria. J. Bacteriol. 182, 41464152 (2000).
Article CAS PubMed PubMed Central Google Scholar
Naz, S., Ngo, T., Farooq, U. & Abagyan, R. Analysis of drug binding pockets and repurposing opportunities for twelve essential enzymes of ESKAPE pathogens. PeerJ 5, e3765e3765 (2017).
Article PubMed PubMed Central Google Scholar
Klahn, P. & Bronstrup, M. New structural templates for clinically validated and novel targets in antimicrobial drug research and development. Curr. Top. Microbiol. Immunol. 398, 365417 (2016).
CAS PubMed Google Scholar
Miranda, R. R., Parthasarathy, A. & Hudson, A. O. Exploration of chemical biology approaches to facilitate the discovery and development of novel antibiotics. Front. Trop. Dis. 3, 845469 (2022).
Article Google Scholar
See the original post:
Unrealized targets in the discovery of antibiotics for Gram-negative ... - Nature.com
- SCARY GHOST ENCOUNTER! (The Hidden) - Video [Last Updated On: September 7th, 2012] [Originally Added On: September 7th, 2012]
- Human Genetics and Genomics: The Science for the 21st Century - Video [Last Updated On: September 7th, 2012] [Originally Added On: September 7th, 2012]
- DNA Research - 07-09-2012 - Video [Last Updated On: September 7th, 2012] [Originally Added On: September 7th, 2012]
- Replying to Equestions on Junk DNA - Video [Last Updated On: September 7th, 2012] [Originally Added On: September 7th, 2012]
- 2013 Rosalind Franklin Young Investigator Awards Announced [Last Updated On: September 8th, 2012] [Originally Added On: September 8th, 2012]
- Jackson Lab CEO Leads From Heart [Last Updated On: September 28th, 2012] [Originally Added On: September 28th, 2012]
- Love of science lifts Hobe Sound teen to genetics conference in Germany [Last Updated On: September 30th, 2012] [Originally Added On: September 30th, 2012]
- Nobel Laureates and Experts Gather to Discuss Genetics and Society [Last Updated On: September 30th, 2012] [Originally Added On: September 30th, 2012]
- Seattle Genetics and Millennium Complete Enrollment in Phase III AETHERA Trial of ADCETRIS® for Post-Transplant ... [Last Updated On: September 30th, 2012] [Originally Added On: September 30th, 2012]
- GENETICS Journal Highlights for October 2012 [Last Updated On: October 2nd, 2012] [Originally Added On: October 2nd, 2012]
- Myriad Genetics Sponsors Cancer Awareness Initiatives in Support of National Hereditary Breast and Ovarian Cancer Week [Last Updated On: October 3rd, 2012] [Originally Added On: October 3rd, 2012]
- Study Says Genetics Of Intelligence Remains A Riddle, For Now [Last Updated On: October 3rd, 2012] [Originally Added On: October 3rd, 2012]
- ORF Genetics to Offer endotoxin- and Animal-free FGFb and mLIF for Stem Cell Research [Last Updated On: October 4th, 2012] [Originally Added On: October 4th, 2012]
- Research and Markets: Human Genes and Genomes. Science, Health, Society Provides Students and Professionals Alike With ... [Last Updated On: October 5th, 2012] [Originally Added On: October 5th, 2012]
- Mosquito genetics may offer clues to control malaria, researchers say [Last Updated On: October 5th, 2012] [Originally Added On: October 5th, 2012]
- Delphi Genetics Grants Merck License for the Use of the StabyExpress™ System [Last Updated On: October 8th, 2012] [Originally Added On: October 8th, 2012]
- This Week in PNAS [Last Updated On: October 10th, 2012] [Originally Added On: October 10th, 2012]
- Outsmarting breast cancer [Last Updated On: October 10th, 2012] [Originally Added On: October 10th, 2012]
- Economics and genetics meet in uneasy union [Last Updated On: October 10th, 2012] [Originally Added On: October 10th, 2012]
- Nurture trumps nature in study of oral bacteria in human twins, study finds [Last Updated On: October 12th, 2012] [Originally Added On: October 12th, 2012]
- Nurture trumps nature in study of oral bacteria in human twins, says CU study [Last Updated On: October 12th, 2012] [Originally Added On: October 12th, 2012]
- Claim That Links Economic Success and Genetic Diversity Draws Criticism [Last Updated On: October 12th, 2012] [Originally Added On: October 12th, 2012]
- Master-builder of the Human Genetics Unit [Last Updated On: October 15th, 2012] [Originally Added On: October 15th, 2012]
- Genetics Society of America announces 2013 award recipients [Last Updated On: October 15th, 2012] [Originally Added On: October 15th, 2012]
- Myriad Genetics to Announce First Fiscal Quarter 2013 Results on Monday, November 5, 2012 [Last Updated On: October 15th, 2012] [Originally Added On: October 15th, 2012]
- Petes Wins Lifetime Achievement Award in Genetics [Last Updated On: October 16th, 2012] [Originally Added On: October 16th, 2012]
- 23andMe Names Christine Castro, Neil Rothstein and Jonathan Ward to Leadership Positions [Last Updated On: October 16th, 2012] [Originally Added On: October 16th, 2012]
- Privately owned genetic databases may hinder diagnosis and bar the way to the arrival of personalized medicine [Last Updated On: November 2nd, 2012] [Originally Added On: November 2nd, 2012]
- Neil Risch - Wiki Article - Video [Last Updated On: November 2nd, 2012] [Originally Added On: November 2nd, 2012]
- GHOST DANCE (The Hidden) - Video [Last Updated On: November 2nd, 2012] [Originally Added On: November 2nd, 2012]
- SCARY GAME - "The Hidden" With Mr.Mitch361, Charlie, and ChildDolphin - Video [Last Updated On: November 2nd, 2012] [Originally Added On: November 2nd, 2012]
- International Academy of Cardiology: Neil Bowles, Ph.D.: GENETIC CAUSES OF CONGENITAL HEART DEFECTS - Video [Last Updated On: November 2nd, 2012] [Originally Added On: November 2nd, 2012]
- The Best Of: "The Hidden" - Video [Last Updated On: November 2nd, 2012] [Originally Added On: November 2nd, 2012]
- MEAT SHIELD (The Hidden) - Video [Last Updated On: November 4th, 2012] [Originally Added On: November 4th, 2012]
- The 10000 Year Explosion: How Civilization Accelerated Human Evolution - , Henry Harpending - Video [Last Updated On: November 4th, 2012] [Originally Added On: November 4th, 2012]
- Humans, chimpanzees and monkeys share DNA but not gene regulatory mechanisms [Last Updated On: November 7th, 2012] [Originally Added On: November 7th, 2012]
- Surprising findings from NHLBI Exome Sequencing Project reported [Last Updated On: November 7th, 2012] [Originally Added On: November 7th, 2012]
- New method helps link genomic variation to protein production [Last Updated On: November 7th, 2012] [Originally Added On: November 7th, 2012]
- Ariosa Diagnostics to Present Clinical Data on the Harmony™ Prenatal Test at American Society of Human Genetics Annual ... [Last Updated On: November 7th, 2012] [Originally Added On: November 7th, 2012]
- ALEX JONES Talks To DAVID ICKE: Human Genetics, Election FRAUD [Last Updated On: November 7th, 2012] [Originally Added On: November 7th, 2012]
- David Icke Exposes ROYAL PAEDOPHILES - Video [Last Updated On: November 7th, 2012] [Originally Added On: November 7th, 2012]
- Alex Jones - David Icke: Human Genetics, The Religion Of Death - Video [Last Updated On: November 7th, 2012] [Originally Added On: November 7th, 2012]
- David Icke - Infowars Election Coverage 2012 - Video [Last Updated On: November 7th, 2012] [Originally Added On: November 7th, 2012]
- David Icke: Human Genetics, The Religion of Death - Video [Last Updated On: November 7th, 2012] [Originally Added On: November 7th, 2012]
- Evening with the UC Davis Genome Center - Oct 6, 2012 - David Segal - Video [Last Updated On: November 7th, 2012] [Originally Added On: November 7th, 2012]
- The Hidden - (Blood For The Blood God, I Must Feed) - Video [Last Updated On: November 7th, 2012] [Originally Added On: November 7th, 2012]
- GHOST ISSUES (The Hidden) - Video [Last Updated On: November 7th, 2012] [Originally Added On: November 7th, 2012]
- The Hidden - (Fart Grenades And Friendly Fire) - Video [Last Updated On: November 7th, 2012] [Originally Added On: November 7th, 2012]
- GHOST ISLAND (The Hidden) - Video [Last Updated On: November 7th, 2012] [Originally Added On: November 7th, 2012]
- Growth Hormone - Video [Last Updated On: November 7th, 2012] [Originally Added On: November 7th, 2012]
- Social Anthropology And Human Origins - Alan Barnard - Video [Last Updated On: November 7th, 2012] [Originally Added On: November 7th, 2012]
- Protein Structural Biology In Biomedical Research. Advances In Molecular And Cell Biology, Volume 22 - Video [Last Updated On: November 7th, 2012] [Originally Added On: November 7th, 2012]
- Exome sequencing: Potential diagnostic assay for unexplained intellectual disability [Last Updated On: November 9th, 2012] [Originally Added On: November 9th, 2012]
- Unexplained intellectual disability explained by state-of-the-art genetic analysis [Last Updated On: November 9th, 2012] [Originally Added On: November 9th, 2012]
- DNA variants explain over 10 percent of inherited genetic risk for heart disease [Last Updated On: November 9th, 2012] [Originally Added On: November 9th, 2012]
- Novel type 2 diabetes genetic study involves 5 major ancestry groups [Last Updated On: November 9th, 2012] [Originally Added On: November 9th, 2012]
- Significant relationship between mortality and telomere length discovered [Last Updated On: November 9th, 2012] [Originally Added On: November 9th, 2012]
- Alex Jones on David Icke 2001 - The Turd - Video [Last Updated On: November 9th, 2012] [Originally Added On: November 9th, 2012]
- David Icke Human Genetics [Last Updated On: November 9th, 2012] [Originally Added On: November 9th, 2012]
- BLINDNESS (The Hidden) - Video [Last Updated On: November 9th, 2012] [Originally Added On: November 9th, 2012]
- Human Genetics, The Religion of Death : David Icke - Video [Last Updated On: November 9th, 2012] [Originally Added On: November 9th, 2012]
- Alex Jones Show - David Icke: Human Genetics, Paedophile Gov., The Religion of Death - Video [Last Updated On: November 9th, 2012] [Originally Added On: November 9th, 2012]
- Human Genetics - Video [Last Updated On: November 9th, 2012] [Originally Added On: November 9th, 2012]
- DAVID ICKE: Human Genetics, The Religion of Death (11/6/2012) - Video [Last Updated On: November 9th, 2012] [Originally Added On: November 9th, 2012]
- Human Genetics: The Basics - Ricki Lewis - Video [Last Updated On: November 9th, 2012] [Originally Added On: November 9th, 2012]
- The Hidden - (Meat Shields Everywhere, Face Of Protection) - Video [Last Updated On: November 9th, 2012] [Originally Added On: November 9th, 2012]
- Leading Genomic Services Company and Its Partners Raise More Than $150,000 in Support of Pediatric Genetics Research [Last Updated On: November 11th, 2012] [Originally Added On: November 11th, 2012]
- Verinata Health Announces New Findings At The American Society Of Human Genetics [Last Updated On: November 11th, 2012] [Originally Added On: November 11th, 2012]
- DAVID ICKE: Human Genetics, The Religion of Death! ALEX JONES [INFOWARS Nightly News] - Video [Last Updated On: November 11th, 2012] [Originally Added On: November 11th, 2012]
- ALEX-JONES-Talks-To-DAVID-ICKE--Human-Genetics,-Election-FRAUD-n-The-Religion-Of-DEATH - Video [Last Updated On: November 11th, 2012] [Originally Added On: November 11th, 2012]
- Illumina Bioninformatics Overview at ASHG 2012 - Video [Last Updated On: November 11th, 2012] [Originally Added On: November 11th, 2012]
- The Hidden - Fun With No Silence [Last Updated On: November 11th, 2012] [Originally Added On: November 11th, 2012]
- David Icke - Human Genetics, The Religion of Death [11/06/2012] - Video [Last Updated On: November 11th, 2012] [Originally Added On: November 11th, 2012]
- Genetics Center takes part in global meet [Last Updated On: November 12th, 2012] [Originally Added On: November 12th, 2012]
- Half Life 2 Mods: The Hidden | Part 4 | TO WIN, OR NOT TO WIN! - Video [Last Updated On: November 12th, 2012] [Originally Added On: November 12th, 2012]
- US-X - Video [Last Updated On: November 12th, 2012] [Originally Added On: November 12th, 2012]
- Personalized Medicine From Genomics and Bioinformatics Highlighted at UCSF Genetics Symposium [Last Updated On: November 14th, 2012] [Originally Added On: November 14th, 2012]
- News in Brief: Highlights from the American Society of Human Genetics annual meeting [Last Updated On: November 14th, 2012] [Originally Added On: November 14th, 2012]
- Star Visitors - Dr. Richard Boylan - Coast to Coast AM Classic - Video [Last Updated On: November 14th, 2012] [Originally Added On: November 14th, 2012]
- Protein Structural Biology In Biomedical Research, Part A - C. Woodward - Video [Last Updated On: November 14th, 2012] [Originally Added On: November 14th, 2012]