Postdoctoral position with combined wet and dry lab work at the – Nature.com

The University Hospital Heidelberg is one of the major healthcare centers in Germany. Our objective is the development of innovative diagnostics and therapies as well as their quick implementation for the patient. With about 10,700 employees in more than 50 specialized clinical departments with almost 2,000 beds, about 80,000 patients in part-time and full-time inpatient treatment as well as 1,000,000 patients in ambulant treatment are medicated each year.

Postdoctoral position with combined wet and dry lab work at the Institute of Human Genetics (m/f/d)

JobID: P0025V441

at the earliest possible date searched for, AG Laugsch at the Institute of Human Genetics.

We are looking for an enthusiastic postdoc to join our research group at the Institute of Human Genetics of the University of Heidelberg. The position is limited to 3 years, with the option of further extension. The salary is based on TV-L salary groups.

Our laboratory explores the relationship between the head (craniofacial structures) and brain development in health and disease. We focus on developmental genes specifically and dynamically regulated, e.g., by enhancers. That regulation ensures the establishment of precise gene expression patterns during development, which might have pathological consequences when being disrupted.

Composed of international and multi-disciplinary scientists, our group creates a unique and inspiring environment and supports individual career development. For more information visit:

https://www.klinikum.uni-heidelberg.de/humangenetik/forschung/abt-humangenetik/ag-laugsch

(Magdalena Laugsch et al., Cell Stem Cell. 2019 May 2nd; Modelling the pathological longe-range regulatory effects of human structural variation with patient-specific hiPSC.;24(5):736-752)

Tasks and responsibilities

Creating and analyzing next-generation sequencing data, the successfull applicant will investigate the impact of cohesin on neural crest cells (hNCC) development and their contribution to Cornelia de Lange Syndrome (CdLS).

This rare but severe genetic disorder is caused by mutations in the cohesin complex or and its auxiliary factors and characterized by craniofacial and limbs malformations, heart defects, and cognitive deficits. Cohesin regulates the three-dimensional (3D) structure of chromatin and impacts the regulation of gene transcription. A large set of craniofacial abnormalities observed in CdLS patients most likely arises during the embryonic development of the hNCC. Hence, the postdoc will investigate the underlying molecular defects in hNCC derived from human induced pluripotent stem cells (hiPSC).

Combining genetic, epigenetic, and bioinformatic tools (hiPSC culture, CRISPR/Cas9 targeting, hNCC differentiation, RNA- and scRNA-seq, Hi-ChIP-seq, ATAC-seq, and analysis using advanced bioinformatics), the scientist will identify the 3D structure of chromatin and regulatory networks controlled by cohesin.

Your Profile

Ability to analyze your own data and significant proficiency as well as strong interest in Python, R, shell scripting and working with NGS data.

We offer

The application must include your motivation, a brief statement of your scientific interests, contact details from three references, curriculum vitae, separated publication list, and relevant certificates.

Please forward your complete application (in a single pdf document Filename: P0025V441_First Name_Second Name No other format will be accepted) by email.

Universittsklinikum Heidelberg

Institut fr Humangenetik

Dr. rer. nat. Magdalena Laugsch, Group Leader

Im Neuenheimer Feld 366

69120 Heidelberg

phone: +49 6221 56-39128

magdalena.laugsch@uni-heidelberg.de

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Postdoctoral position with combined wet and dry lab work at the - Nature.com