Sharma, A. et al. Global trends in pesticides: A looming threat and viable alternatives. Ecotoxicol. Environ. Safe 201, 110812. https://doi.org/10.1016/j.ecoenv.2020.110812 (2020).
CAS Article Google Scholar
Morillo, E. & Villaverde, J. Advanced technologies for the remediation of pesticide-contaminated soils. Sci. Total Environ. 586, 576597. https://doi.org/10.1016/j.scitotenv.2017.02.020 (2017).
ADS CAS Article PubMed Google Scholar
Bind, V. & Kumar, A. Pesticides toxicity may causes adverse effects to our health-a review. MOJ Toxicol. 5, 1718 (2019).
Google Scholar
Giordano, G. et al. Organophosphorus insecticides chlorpyrifos and diazinon and oxidative stress in neuronal cells in a genetic model of glutathione deficiency. Toxicol. Appl. Pharmacol. 219(23), 181189. https://doi.org/10.1016/j.taap.2006.09.016 (2007).
CAS Article PubMed Google Scholar
Wang, C. et al. Enantioselective interaction with acetylcholinesterase of an organophosphate insecticide fenamiphos. Chiral. Pharmacol. Biol. Chem. Conseq. Mole. Asym. 22(6), 612617. https://doi.org/10.1002/chir.20800 (2010).
CAS Article Google Scholar
European Commission implementing regulation (EU) 2020/18. Off J Eur U 13.1.2020: L7/14-L7/16. http://data.europa.eu/eli/reg_impl/2020/18/oj (2020).
Lee, W. et al. Pesticide use and colorectal cancer risk in the Agricultural Health Study. Int. J. Cancer. 121(2), 339346. https://doi.org/10.1002/ijc.22635 (2007).
CAS Article PubMed PubMed Central Google Scholar
Alavanja, M. C. et al. A Pesticides and lung cancer risk in the agricultural health study cohort. Am. J. Epidemiol. 160(9), 876885. https://doi.org/10.1093/aje/kwh290 (2004).
Article PubMed Google Scholar
Madrigal, J. M. et al. Residential exposure to carbamate, organophosphate, and pyrethroid insecticides in house dust and risk of childhood acute lymphoblastic leukemia. Environ. Res. https://doi.org/10.1016/j.envres.2021.111501 (2021).
Article PubMed Google Scholar
IARC Working Group on the Evaluation of Carcinogenic Risks to Humans. Some organophosphate insecticides and herbicides. PMID:31829533 (2017).
Guyton, K. Z. et al. International agency for research on cancer monograph working group ILF. Carcinogenicity of tetrachlorvinphos, parathion, malathion, diazinon, and glyphosate. Lancet Oncol. 16(5), 490491. https://doi.org/10.1016/S1470-2045(15)70134-8 (2015).
Article PubMed Google Scholar
Koureas, M., Tsakalof, A., Tsatsakis, A. & Hadjichristodoulou, C. Systematic review of biomonitoring studies to determine the association between exposure to organophosphorus and pyrethroid insecticides and human health outcomes. Toxicol. Lett. 210(2), 155168. https://doi.org/10.1016/j.toxlet.2011.10.007 (2012).
CAS Article PubMed Google Scholar
Chen, S. et al. Exposure to pyrethroid pesticides and the risk of childhood brain tumors in East China. Environ Pollut 218, 11281134. https://doi.org/10.1016/j.envpol.2016.08.066 (2016).
CAS Article PubMed Google Scholar
Kannarkat, G. T. et al. Common genetic variant association with altered HLA expression, synergy with pyrethroid exposure, and risk for Parkinsons disease: An observational and casecontrol study. NPJ. Parkinsons Disease 1, 19. https://doi.org/10.1038/npjparkd.2015.2 (2015).
CAS Article Google Scholar
Paul, K. C. et al. Organophosphate pesticides and PON1 L55M in Parkinsons disease progression. Environ. Int. 107, 7581. https://doi.org/10.1016/j.envint.2017.06.018 (2017).
CAS Article PubMed PubMed Central Google Scholar
Javeres, M. N. L. et al. Analysis of PON1 gene polymorphisms (rs662 and rs854560) and inflammatory markers in organophosphate pesticides exposed cohorts from two distinct populations. Environ. Res. 191, 110210. https://doi.org/10.1016/j.envres.2020.110210 (2020).
CAS Article Google Scholar
Li, H. L., Liu, D. P. & Liang, C. C. Paraoxonase gene polymorphisms, oxidative stress, and diseases. J. Mol. Med. 81(12), 766779. https://doi.org/10.1007/s00109-003-0481-4 (2003).
CAS Article PubMed Google Scholar
Czajka, M. et al. Organophosphorus pesticides can influence the development of obesity and type 2 diabetes with concomitant metabolic changes. Environ. Res. 178, 108685. https://doi.org/10.1016/j.envres.2019.108685 (2019).
CAS Article PubMed Google Scholar
Gutirrez-Jara, J. P., Crdova-Lepe, F. D., Muoz-Quezada, M. T. & Chowell, G. Susceptibility to organophosphates pesticides and the development of infectious-contagious respiratory diseases. J. Theor. Biol. 488, 110133. https://doi.org/10.1016/j.jtbi.2019.110133 (2020).
MathSciNet CAS Article PubMed MATH Google Scholar
Abreu-Villaca, Y. & Levin, E. D. Developmental neurotoxicity of succeeding generations of insecticides. Environ. Int. 99, 5577. https://doi.org/10.1016/j.envint.2016.11.019 (2017).
CAS Article PubMed Google Scholar
Demirel, T. et al. Association of paraoxonase (PON1) polymorphisms and activity with colorectal cancer predisposition. Biotechnol. Biotechnol. Equip. 35, 232238. https://doi.org/10.1080/13102818.2020.1867006 (2021).
CAS Article Google Scholar
Abolhassani, M. et al. Organochlorine and organophosphorous pesticides may induce colorectal cancer; A case-control study. Ecotoxicol. Environ. Saf. 178, 168177. https://doi.org/10.1016/j.ecoenv.2019.04.030 (2019).
CAS Article PubMed Google Scholar
Littlefield, J. W. NIH 3T3 cell line. Science 218(4569), 214216. https://doi.org/10.1126/science.218.4569.214.c (1982).
ADS CAS Article PubMed Google Scholar
Kahl, V. F. S. et al. Role of PON1, SOD2, OGG1, XRCC1, and XRCC4 polymorphisms on modulation of DNA damage in workers occupationally exposed to pesticides. Ecotox. Environ. Saf. 159, 164171. https://doi.org/10.1016/j.ecoenv.2018.04.052 (2018).
CAS Article Google Scholar
Medina-Daz, I. M. et al. Downregulation of human paraoxonase 1 (PON1) by organophosphate pesticides in HepG2 cells. Environ. Toxicol. 32(2), 490500. https://doi.org/10.1002/tox.22253 (2017).
ADS CAS Article PubMed Google Scholar
Dardiotis, E. et al. Paraoxonase-1 genetic polymorphisms in organophosphate metabolism. Toxicology 411, 2431. https://doi.org/10.1016/j.tox.2018.10.012 (2019).
CAS Article PubMed Google Scholar
Mackness, M. & Mackness, B. Human paraoxonase-1 (PON1): Gene structure and expression, promiscuous activities and multiple physiological roles. Gene 567, 1221. https://doi.org/10.1016/j.gene.2015.04.088 (2015).
CAS Article PubMed PubMed Central Google Scholar
Tsatsakis, A. M., Zafiropoulos, A., Tzatzarakis, M. N., Tzanakakis, G. N. & Kafatos, A. Relation of PON1 and CYP1A1 genetic polymorphisms to clinical findings in a cross-sectional study of a Greek rural population professionally exposed to pesticides. Toxicol. Lett. 186, 6672. https://doi.org/10.1016/j.toxlet.2008.10.018 (2009).
CAS Article PubMed Google Scholar
Costa, L. G., Cole, T. B., Vitalone, A. & Furlong, C. E. Measurement of paraoxonase (PON1) status as a potential biomarker of susceptibility to organophosphate toxicity. Clin. Chim. Acta 352(12), 3747. https://doi.org/10.1016/j.cccn.2004.09.019 (2005).
CAS Article PubMed Google Scholar
Kaur, G., Jain, A. K. & Kaur, S. CYP/PON genetic variations as determinant of organophosphate pesticides toxicity. J. Genet. 96, 187201. https://doi.org/10.1007/s12041-017-0741-7 (2017).
CAS Article PubMed Google Scholar
Szmen, B., Peker, , Kaya, ., Erkan, M. & Szmen, E. Y. Markers of long-term exposure to organophosphorus pesticides in farmers who work in viniculture and tobacco production in Turkey. Toxicol. Mech. Methods 17(7), 379384. https://doi.org/10.1080/15376510601094115 (2007).
CAS Article PubMed Google Scholar
Imran, I., Saleem, S., Azhar, A. & Zehra, S. Pyrethroid exposure: as determinant of CYP1A1 and GSTP1 genetic variations in occupationally exposed Sindh farmers. Biologia https://doi.org/10.1007/s11756-021-00698-w (2021).
Article Google Scholar
Wadani, Z. H., Azam, I., Irfan, M. & Fatmi, Z. Pesticides use and impaired lung function among male agricultural farmers in rural Sindh, Pakistan. Asia Pac J Public Health https://doi.org/10.1177/10105395211065647 (2021).
Article PubMed Google Scholar
Ahmed, H., Sharif, A., Bakht, S., Javed, F. & Hassan, W. Persistent organic pollutants and neurological disorders: from exposure to preventive interventions. In Environmental Contaminants and Neurological Disorders (pp. 231247). Springer, Cham. https://doi.org/10.1007/978-3-030-66376-6_11 (2021).
Ali, T. et al. Pesticide genotoxicity in cotton picking women in Pakistan evaluated using comet assay. Drug Chem. Toxicol. 41(2), 213220. https://doi.org/10.1080/01480545.2017.1343342 (2018).
CAS Article PubMed Google Scholar
Sandal, S. & Yilmaz, B. Genotoxic effects of chlorpyrifos, cypermethrin, endosulfan and 2,4-D on human peripheral lymphocytes cultured from smokers and nonsmokers. Environ. Toxicol. 26, 433442. https://doi.org/10.1002/tox.20569 (2011).
ADS CAS Article PubMed Google Scholar
Ambali, S. F. & Aliyu, M. B. Short-term sensorimotor and cognitive changes induced by acute chlorpyrifos exposure in Wistar rats: Ameliorative effect of vitamin E. Pharmacologia 3(2), 3138. https://doi.org/10.5567/pharmacologia2012.31.38 (2012).
CAS Article Google Scholar
Badr, A. M. Organophosphate toxicity: Updates of Malathion potential toxic effects in mammals and potential treatments. Environ. Sci. Pollut. Res. Int. 27, 2603626057. https://doi.org/10.1007/s11356-020-08937-4 (2020).
CAS Article PubMed Google Scholar
Ozkan, U. et al. Effects of intralipid and caffeic acid phenethyl ester on neurotoxicity, oxidative stress, and acetylcholinesterase activity in acute chlorpyriphos intoxication. Int. J. Clin. Exp. Med. 7(4), 837 (2014).
PubMed PubMed Central Google Scholar
Mehmood, Y., Arshad, M., Mahmood, N., Kchele, H. & Kong, R. Occupational hazards, health costs, and pesticide handling practices among vegetable growers in Pakistan. Environ. Res 200, 111340. https://doi.org/10.1016/j.envres.2021.111340 (2021).
CAS Article PubMed Google Scholar
Berridge, M. V., Herst, P. M. & Tan, A. S. Tetrazolium dyes as tools in cell biology: new insights into their cellular reduction. Biotech. Ann. Rev. 11, 127152. https://doi.org/10.1016/S1387-2656(05)11004-7 (2005).
CAS Article Google Scholar
Mathew, C. G. P. The isolation of high molecular weight eukaryotic DNA in nucleic acids methods in molecular Biology. Springer 9, 3134. https://doi.org/10.1385/0-89603-064-4:31 (1984).
ADS Article Google Scholar
Fong, C. S., Cheng, C. W. & Wu, R. M. Pesticides exposure and genetic polymorphism of Paraoxonase in the susceptibility of Parkinsons disease. Acta Neurol. Taiwan 14(2), 5560 (2005).
PubMed Google Scholar
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Insights of OPs and PYR cytotoxic potential Invitro and genotoxic impact on PON1 genetic variant among exposed workers in Pakistan | Scientific...
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