KING OF PRUSSIA, Pa. and SIOUX FALLS, S.D., April 8, 2020 /PRNewswire/ --Global biotherapeutics leader, CSL Behringand innovative human antibody development company SAB Biotherapeutics(SAB) announced today their partnership to combat the coronavirus pandemic with the rapid development of SAB-185, a COVID-19 therapeutic candidate on track for clinical evaluation by early summer. The partnership joins the forces of CSL Behring's leading protein science capabilities with SAB's novel immunotherapy platform capable of rapidly developing and producing natural, highly-targeted, high-potency, fully human polyclonal antibodies without the need for blood plasma donations from recovered patients.
The therapeutic candidate, SAB-185, is generated from SAB's proprietary DiversitAb platform producing large volumes of human polyclonal antibodies targeted specifically to SARS-CoV-2, the virus that causes COVID-19. Driven by advanced genetic engineering and antibody science, SAB's novel approach, leveraging genetically engineered cattle to produce fully human antibodies, enables a scalable and reliable production of targeted, higher potency neutralizing antibody product than has been previously possible. SAB's approach has expedited the rapid development of a novel immunotherapy for COVID-19 deploying the same natural immune response to fight the disease as recovered patients, but with a much higher concentration of targeted antibodies.
"COVID-19 is a nearly unprecedented public health crisis," said CSL Behring's Executive Vice President and Head of R&D Bill Mezzanotte, M.D. "That's why we're combining our leading capabilities in plasma product development and immunology with external collaborators to help find multiple, rapid solutions. In the near-term, SAB Biotherapeutics' novel immunotherapy platform provides a new and innovative solution to rapidly respond without the need for human plasma adding a different dimension to the industry-wide plasma-derived hyperimmune alliance effort we recently launched for the COVID-19 crisis. For future pandemics, SAB's platform may allow us to even more rapidly respond to patients' needs."
"Our targeted high-potency immunotherapies leverage the native immune response thereby providing a highly-specific match against the complexity, diversity and mutation of a disease," said Eddie J. Sullivan, PhD, SAB Biotherapeutics president, CEO and co-founder. "Our partnership with CSL Behring shifts our development trajectory to more rapidly scale-up and delivery of our highly targeted and potent COVID-19 therapeutic candidate, and deploy our unique capabilities to help combat this crisis. We have a successful preclinical track record for addressing infectious disease targets including Ebola, MERS, and SARS with our proprietary platform and appreciate that this collaboration with a global biopharmaceutical powerhouse will magnify the potential impact of a COVID-19 immunotherapy and provide an important framework for establishing sustainable solutions for the future."
CSL Behring has provided seed funding to offset some initial development costs that were funded by SAB in good faith, responding to the global pandemic as quickly as possible. SAB has already secured approximately $7.2 million in funding through an interagency agreement with the Joint Program Executive Office for Chemical, Biological, Radiological, and Nuclear Defense (JPEO - CBRND) and Biomedical Advanced Research and Development Authority (BARDA)to support SAB to complete manufacturing and preclinical studies. CSL Behring will then commit its clinical, regulatory, manufacturing and supply chain expertise and resources to deliver the therapeutic to the market as soon as possible, on terms to be agreed with SAB.
Earlier this year, the companies announceda collaboration to investigate SAB's platform technology as a new source for human immunoglobulin G (IgG) and the potential for new therapies to treat challenging autoimmune, infectious and idiopathic diseases by leveraging SAB's DiversitAb platform.
About CSL Behring CSL Behring is a global biotherapeutics leader driven by its promise to save lives. Focused on serving patients' needs by using the latest technologies, we develop and deliver innovative therapies that are used to treat coagulation disorders, primary immune deficiencies, hereditary angioedema, inherited respiratory disease, and neurological disorders. The company's products are also used in cardiac surgery, burn treatment and to prevent hemolytic disease of the newborn. CSL Behring operates one of the world's largest plasma collection networks, CSL Plasma. The parent company, CSL Limited (ASX:CSL;USOTC:CSLLY), headquartered in Melbourne, Australia, employs more than 26,000 people, and delivers its life-saving therapies to people in more than 70 countries. For more information, visit http://www.cslbehring.com and for inspiring stories about the promise of biotechnology, visit Vita http://www.cslbehring.com/Vita
About SAB Biotherapeutics, Inc.SAB Biotherapeutics, Inc. (SAB), headquartered in Sioux Falls, S.D. is a clinical-stage, biopharmaceutical development company advancing a new class of immunotherapies leveraging fully human polyclonal antibodies. Utilizing some of the most complex genetic engineering and antibody science in the world, SAB has developed the only platform that can rapidly produce natural, highly targeted, high-potency, immunotherapies at commercial scale. The company is advancing programs in autoimmunity, infectious diseases, inflammation and exploratory oncology. SAB is rapidly progressing on a new therapeutic for COVID-19, SAB-185, a fully human polyclonal antibodies targeted to SARS-CoV-2 without using human donors. SAB-185 is expected to be ready for evaluation as early as summer 2020. The company was also recently awarded a $27 million contract from the U.S. Department of Defense (DoD) to leverage its unique capabilities as part of a Rapid Response Antibody Program, valued at up to $27 million. For more information visit: http://www.sabbiotherapeutics.com.
View original content to download multimedia:http://www.prnewswire.com/news-releases/csl-behring-and-sab-biotherapeutics-join-forces-to-deliver-new-potential-covid-19-therapeutic-301037503.html
SOURCE CSL Behring
Read more here:
CSL Behring and SAB Biotherapeutics Join Forces to Deliver New Potential COVID-19 Therapeutic - P&T Community
- Main Show Only - Genetic Engineering - Coast to Coast AM - Video [Last Updated On: September 7th, 2012] [Originally Added On: September 7th, 2012]
- RTPB | Genetic Engineering [Last Updated On: September 7th, 2012] [Originally Added On: September 7th, 2012]
- Stop Monsanto From Poisoning Hawai'i: Genetic Engineering Chemical Warfare - Video [Last Updated On: September 7th, 2012] [Originally Added On: September 7th, 2012]
- Informatics 161 PSA: Human Genetic Engineering - Video [Last Updated On: September 7th, 2012] [Originally Added On: September 7th, 2012]
- Don't Trust Whole Foods or Other Health Food Stores For Non- GMO Foods | Genetic Engineering - Video [Last Updated On: September 7th, 2012] [Originally Added On: September 7th, 2012]
- Genetic Engineering - Video [Last Updated On: September 7th, 2012] [Originally Added On: September 7th, 2012]
- Easier Genetic Engineering! (Brainstorm Ep69) - Video [Last Updated On: September 7th, 2012] [Originally Added On: September 7th, 2012]
- TEDxUCIrvine - Francisco Ayala - Cloning, Genetic Engineering, [Last Updated On: September 7th, 2012] [Originally Added On: September 7th, 2012]
- Genetic Engineering in Agriculture - Video [Last Updated On: September 7th, 2012] [Originally Added On: September 7th, 2012]
- Infowars Special Report : Genetic Engineering - Video [Last Updated On: September 7th, 2012] [Originally Added On: September 7th, 2012]
- Glowing Rats and Extreme Genetic Engineering - Video [Last Updated On: September 7th, 2012] [Originally Added On: September 7th, 2012]
- Endangered Cat Born at Audubon - Video [Last Updated On: September 7th, 2012] [Originally Added On: September 7th, 2012]
- Danger of Genetic Engineering - Video [Last Updated On: September 7th, 2012] [Originally Added On: September 7th, 2012]
- AQA GCSE core science and B1 - Genetic Engineering - Video [Last Updated On: September 7th, 2012] [Originally Added On: September 7th, 2012]
- genetic engineering rDNA.wmv - Video [Last Updated On: September 7th, 2012] [Originally Added On: September 7th, 2012]
- Genetic Engineering for Human Enhancement.mp4 - Video [Last Updated On: September 7th, 2012] [Originally Added On: September 7th, 2012]
- Genetic Engineering - Seven Wonders of the Microbe World (6/7) - Video [Last Updated On: September 7th, 2012] [Originally Added On: September 7th, 2012]
- Promising new drug target for inflammatory lung diseases [Last Updated On: September 8th, 2012] [Originally Added On: September 8th, 2012]
- Mandatory GM Labeling Would Require Major Change [Last Updated On: September 10th, 2012] [Originally Added On: September 10th, 2012]
- GEN reports on ocular therapeutics targeting the retina [Last Updated On: September 11th, 2012] [Originally Added On: September 11th, 2012]
- Prop. 37: Another example of the perils of the initiative process [Last Updated On: September 15th, 2012] [Originally Added On: September 15th, 2012]
- Genetic test predicts risk for Autism [Last Updated On: September 19th, 2012] [Originally Added On: September 19th, 2012]
- Immediate withdrawal of unsafe GE corn vital - Greens [Last Updated On: September 20th, 2012] [Originally Added On: September 20th, 2012]
- Immediate withdrawal of unsafe GE corn vital [Last Updated On: September 20th, 2012] [Originally Added On: September 20th, 2012]
- NZ out of step on GE [Last Updated On: September 21st, 2012] [Originally Added On: September 21st, 2012]
- Ballot Watch: Labeling genetically engineered foods [Last Updated On: September 30th, 2012] [Originally Added On: September 30th, 2012]
- Just another GE mirage [Last Updated On: October 2nd, 2012] [Originally Added On: October 2nd, 2012]
- The GM Barnyard [Last Updated On: October 3rd, 2012] [Originally Added On: October 3rd, 2012]
- Free Engine [Last Updated On: October 3rd, 2012] [Originally Added On: October 3rd, 2012]
- Cellectis Publishes Results Paving the Way for New Therapeutic Approaches against Cancer and Genetic Diseases [Last Updated On: October 3rd, 2012] [Originally Added On: October 3rd, 2012]
- Does moral decision-making in video games mirror the real world? [Last Updated On: October 3rd, 2012] [Originally Added On: October 3rd, 2012]
- Animals engineered with pinpoint accuracy [Last Updated On: October 3rd, 2012] [Originally Added On: October 3rd, 2012]
- Valley farmers fear 'modified' wording in Prop. 37 [Last Updated On: October 4th, 2012] [Originally Added On: October 4th, 2012]
- No on Proposition 37 [Last Updated On: October 4th, 2012] [Originally Added On: October 4th, 2012]
- The Dangers of Genetic Engineering [Last Updated On: October 5th, 2012] [Originally Added On: October 5th, 2012]
- Are inhaled medications effective and safe in critically ill patients on mechanical ventilation? [Last Updated On: October 5th, 2012] [Originally Added On: October 5th, 2012]
- Calif. initiative will test appetite for GMO food [Last Updated On: October 7th, 2012] [Originally Added On: October 7th, 2012]
- Calif. initiative will test appetite for GMO food - Sat, 06 Oct 2012 PST [Last Updated On: October 7th, 2012] [Originally Added On: October 7th, 2012]
- California to vote on 'genetically modified' labels [Last Updated On: October 7th, 2012] [Originally Added On: October 7th, 2012]
- California initiative will test appetite for genetically modified foods [Last Updated On: October 7th, 2012] [Originally Added On: October 7th, 2012]
- Do we have an appetite for genetically modified food? [Last Updated On: October 7th, 2012] [Originally Added On: October 7th, 2012]
- Genetic labelling mooted in California [Last Updated On: October 7th, 2012] [Originally Added On: October 7th, 2012]
- California initiative to test appetite for 'genetically engineered' food [Last Updated On: October 7th, 2012] [Originally Added On: October 7th, 2012]
- New tool for making genetic engineering of microbial circuits reliably predictable [Last Updated On: October 10th, 2012] [Originally Added On: October 10th, 2012]
- Researchers develop new tool for making genetic engineering of microbial circuits reliably predictable [Last Updated On: October 10th, 2012] [Originally Added On: October 10th, 2012]
- A Welcome Predictability [Last Updated On: October 10th, 2012] [Originally Added On: October 10th, 2012]
- Engineered flies spill secret of seizures [Last Updated On: October 12th, 2012] [Originally Added On: October 12th, 2012]
- Genetic 'remix' key to evolution of bee behavior, researchers find [Last Updated On: October 15th, 2012] [Originally Added On: October 15th, 2012]
- Can vaccines be delivered via the lungs instead of by injection? [Last Updated On: October 15th, 2012] [Originally Added On: October 15th, 2012]
- Food labeling regulations [Last Updated On: October 16th, 2012] [Originally Added On: October 16th, 2012]
- Research and Markets: Therapeutic Antibody Engineering: Current and Future Advances Driving the Strongest Growth Area ... [Last Updated On: November 2nd, 2012] [Originally Added On: November 2nd, 2012]
- Is there a difference between GE & GMO? [Last Updated On: November 2nd, 2012] [Originally Added On: November 2nd, 2012]
- Port Townsend Food Coop: A Sad Story of GMO Crop Cross Pollination - Video [Last Updated On: November 2nd, 2012] [Originally Added On: November 2nd, 2012]
- PUT IT IN YOUR MOUTH! Yes to Prop 37 — it's your right to know what's in your food! - Video [Last Updated On: November 2nd, 2012] [Originally Added On: November 2nd, 2012]
- editta braun company: planet LUVOS (clip, 4:30) - Video [Last Updated On: November 2nd, 2012] [Originally Added On: November 2nd, 2012]
- Mimic: The Director's Cut (Blu-ray Trailer) - Video [Last Updated On: November 2nd, 2012] [Originally Added On: November 2nd, 2012]
- South Park Season 1 Episode 7 - An Elephant Makes Love to a Pig - Video [Last Updated On: November 2nd, 2012] [Originally Added On: November 2nd, 2012]
- Yes on Prop 37: Animated Video - Video [Last Updated On: November 2nd, 2012] [Originally Added On: November 2nd, 2012]
- The Day of the Triffids Part 1 Full Movie - Video [Last Updated On: November 2nd, 2012] [Originally Added On: November 2nd, 2012]
- YES on prop 37 "flashmob" march - Santa Cruz, CA Sept. 2012 - Video [Last Updated On: November 2nd, 2012] [Originally Added On: November 2nd, 2012]
- World's Weirdest Places Discussed - Video [Last Updated On: November 2nd, 2012] [Originally Added On: November 2nd, 2012]
- THE CLUB OF ROME - DEPOPULATION AGENDA 21 - THE UNHIVED MIND - Video [Last Updated On: November 2nd, 2012] [Originally Added On: November 2nd, 2012]
- 27-Medical BiotechnologySG Part II.Gene Therapy, Tissue Engineering and Nanotechnology.mov - Video [Last Updated On: November 2nd, 2012] [Originally Added On: November 2nd, 2012]
- 26-Medical BiotechnologySG Part Ic. Animal and Human Cloning and Genetic Engineering.mov - Video [Last Updated On: November 2nd, 2012] [Originally Added On: November 2nd, 2012]
- How to Clone Animals - Video [Last Updated On: November 2nd, 2012] [Originally Added On: November 2nd, 2012]
- Fringe Opening sequence (Season 3 - The Day We Died) - Video [Last Updated On: November 4th, 2012] [Originally Added On: November 4th, 2012]
- Fringe Opening sequence (Season 3 - Olivia) - Video [Last Updated On: November 4th, 2012] [Originally Added On: November 4th, 2012]
- Fringe Opening sequence (Season 3 - Entrada) - Video [Last Updated On: November 4th, 2012] [Originally Added On: November 4th, 2012]
- Fringe Opening sequence (Season 4) - Video [Last Updated On: November 4th, 2012] [Originally Added On: November 4th, 2012]
- Fringe Opening sequence (Season 3) - Video [Last Updated On: November 4th, 2012] [Originally Added On: November 4th, 2012]
- Fringe Opening sequence (Season 2) - Video [Last Updated On: November 4th, 2012] [Originally Added On: November 4th, 2012]
- Fringe Opening sequence (1985) - Video [Last Updated On: November 4th, 2012] [Originally Added On: November 4th, 2012]
- Dendritic Cells: Biology And Clinical Applications - Video [Last Updated On: November 4th, 2012] [Originally Added On: November 4th, 2012]
- Port Townsend Food Coop: "I want my food untainted by GMOs" - Video [Last Updated On: November 4th, 2012] [Originally Added On: November 4th, 2012]
- Catholic Priest vs. Biologist - Video [Last Updated On: November 4th, 2012] [Originally Added On: November 4th, 2012]
- Watch Real Life Superhero Muscles Like Marvel's The Avengers - Video [Last Updated On: November 4th, 2012] [Originally Added On: November 4th, 2012]
- Fringe Opening sequence (Season 1) - Video [Last Updated On: November 4th, 2012] [Originally Added On: November 4th, 2012]
- Fringe Opening sequence (The Final Season: "Fight For The Future") - Video [Last Updated On: November 4th, 2012] [Originally Added On: November 4th, 2012]
- Port Townsend Food Coop: I Want To Know If GMOs Are In My Food - Video [Last Updated On: November 4th, 2012] [Originally Added On: November 4th, 2012]
- ProCognia jumps on expanded biosimilar collaboration [Last Updated On: November 7th, 2012] [Originally Added On: November 7th, 2012]