NEW YORK, May 17, 2022 /PRNewswire/ -- SCRIPT BIOSCIENCES INC, a biotechnology company developing curative therapies using a novel gene editing platform (CasPlus), and NYU Grossman School of Medicine, presented a poster titled "Enhancement of Predictable and Template-free Gene Editing by the Association of CAS with DNA Polymerase" at the 25th annual American Society of Gene & Cell Therapy meeting in Washington DC (May 16-19, 2022). Highlights of the data include:
Dr. Chengzu Long, Principal Investigator and Assistant Professor, Division of Cardiology and The Helen and Martin Kimmel Center for Stem Cell Biology, NYU Grossman School of Medicine, said, "CRISPR/Cas9-mediated on-target DNA damage is an underappreciated risk factor for safe application of genome editing tools. While numerous approaches have already been developed to reduce well-known off-target effects of CRISPR-mediated editing, the CasPlus system prevents CRISPR-mediated collateral on-target large deletions and thus offers the promise of safer therapeutic gene editing in humans."
Anil Namboodiripad, Ph.D., CEO of Script Biosciences said, "We are encouraged by this data and it is a step forward in our mission to develop lasting cures for patients suffering from serious diseases. In vivo translational studies in humanized mouse models are ongoing. We plan to advance our lead program in DMD towards IND-enabling studies, while also expanding our pipeline to other gene targets".
About Script BiosciencesScript Biosciences (www.scriptbiosciences.com) is an early stage biotechnology company committed to developing safe, efficient, and durable cures for genetic diseases with few or no treatment options using our proprietary CasPlus genome editing platform (CasPlus). CasPlus corrects mutations by predictable and efficient insertion of base pairs. The superior precision of CasPlus paves the way towards safer genome editing in humans. The technology was developed at New York University with a worldwide license granted to Script.
SOURCE Script Biosciences Inc
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