The association of APOE genotype with COVID-19 disease severity | Scientific Reports – Nature.com

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Wu, A. et al. Genome composition and divergence of the novel coronavirus (2019-nCoV) originating in China. Cell Host Microbe 27(3), 325328 (2020).

CAS Article Google Scholar

Yanes-Lane, M. et al. Proportion of asymptomatic infection among COVID-19 positive persons and their transmission potential: A systematic review and meta-analysis. PLoS ONE 15(11), e0241536 (2020).

CAS Article Google Scholar

Wu, Z. & McGoogan, J. M. Characteristics of and important lessons from the coronavirus disease 2019 (COVID-19) outbreak in China: Summary of a report of 72 314 cases from the Chinese Center for Disease Control and Prevention. JAMA 323(13), 12391242 (2020).

CAS Article Google Scholar

Schurr, T. G. Host genetic factors and susceptibility to SARS-CoV-2 infection. Am. J. Hum. Biol. 32(5), e23497 (2020).

Article Google Scholar

Kachuri, L. et al. The landscape of host genetic factors involved in immune response to common viral infections. MedRxiv Preprint Server Health Sci. https://doi.org/10.1101/2020.05.01.20088054 (2020).

Article Google Scholar

Smatti, M. K., Al-Sarraj, Y. A., Albagha, O. & Yassine, H. M. Host genetic variants potentially associated with SARS-CoV-2: A multi-population analysis. Front. Genet. 11, 578523. https://doi.org/10.3389/fgene.2020.578523 (2020).

CAS Article PubMed PubMed Central Google Scholar

Kuo, C.-L. et al. APOE e4 genotype predicts severe COVID-19 in the UK Biobank community cohort. J. Gerontol. Ser. A 75(11), 22312232 (2020).

CAS Article Google Scholar

Morton, A. M., Furtado, J. D., Mendivil, C. O. & Sacks, F. M. Dietary unsaturated fat increases HDL metabolic pathways involving apoE favorable to reverse cholesterol transport. JCI Insight. 4(7), e124620 (2019).

Article Google Scholar

Pang, S., Li, J., Zhang, Y. & Chen, J. Meta-analysis of the relationship between the APOE gene and the onset of Parkinsons disease dementia. Parkinsons Disease https://doi.org/10.1155/2018/9497147 (2018).

Article PubMed PubMed Central Google Scholar

Phillips, M. C. Apolipoprotein E isoforms and lipoprotein metabolism. IUBMB Life 66(9), 616623 (2014).

CAS Article Google Scholar

Uddin, M. S. et al. APOE and Alzheimers disease: Evidence mounts that targeting APOE4 may combat Alzheimers pathogenesis. Mol. Neurobiol. 56(4), 24502465 (2019).

CAS Article Google Scholar

Knouff, C. et al. Apo E structure determines VLDL clearance and atherosclerosis risk in mice. J. Clin. Investig. 103(11), 15791586 (1999).

CAS Article Google Scholar

Liu, S., Liu, J., Weng, R., Gu, X. & Zhong, Z. Apolipoprotein E gene polymorphism and the risk of cardiovascular disease and type 2 diabetes. BMC Cardiovasc. Disord. 19(1), 16 (2019).

Article Google Scholar

Wang, Q. Q., Davis, P. B., Gurney, M. E. & Xu, R. COVID-19 and dementia: Analyses of risk, disparity, and outcomes from electronic health records in the US. Alzheimers Dement. 17, 12971306. https://doi.org/10.1002/alz.12296 (2021).

CAS Article Google Scholar

Goldstein, M. R., Poland, G. A. & Graeber, C. W. Does apolipoprotein E genotype predict COVID-19 severity?. QJM Int. J. Med. 113(8), 529530 (2020).

CAS Article Google Scholar

Xiong, N., Schiller, M. R., Li, J., Chen, X. & Lin, Z. Severe COVID-19 in Alzheimers disease: APOE4s fault again?. Alzheimers Res. Therapy. https://doi.org/10.1186/s13195-021-00858-9 (2021).

Article Google Scholar

Wu, W., Wang, A. & Liu, M. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet 395(10223), 497506 (2020).

Article Google Scholar

Tsai, P.-H. et al. Clinical manifestation and disease progression in COVID-19 infection. J. Chin. Med. Assoc. 84(1), 38 (2021).

MathSciNet CAS Article Google Scholar

Zhou, F. et al. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: A retrospective cohort study. The Lancet. 395(10229), 10541062 (2020).

CAS Article Google Scholar

Chan, J. F. W. et al. A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: A study of a family cluster. Lancet 395(10223), 514523 (2020).

CAS Article Google Scholar

Onder, G., Rezza, G. & Brusaferro, S. Case-fatality rate and characteristics of patients dying in relation to COVID-19 in Italy. JAMA 323(18), 17751776 (2020).

CAS PubMed Google Scholar

Ellinghaus, D. et al. The ABO blood group locus and a chromosome 3 gene cluster associate with SARS-CoV-2 respiratory failure in an Italian-Spanish genome-wide association analysis. MedRxiv Preprint Server Health Sci. https://doi.org/10.1101/2020.05.31.20114991v1.full (2020).

Article Google Scholar

Wang, F. et al. Initial whole-genome sequencing and analysis of the host genetic contribution to COVID-19 severity and susceptibility. Cell Discovery 6(1), 116 (2020).

Google Scholar

Velavan, T. P. et al. Host genetic factors determining COVID-19 susceptibility and severity. EBioMedicine 72, 103629 (2021).

CAS Article Google Scholar

Kuo, C.-L. et al. ApoE e4e4 genotype and mortality with COVID-19 in UK Biobank. J. Gerontol. Ser. A 75(9), 18011803 (2020).

CAS Article Google Scholar

Gkouskou, K. et al. COVID-19 enters the expanding network of apolipoprotein E4-related pathologies. Redox Biol. 41, 101938 (2021).

CAS Article Google Scholar

Kosmicki, J. A. et al. Genetic association analysis of SARS-CoV-2 infection in 455,838 UK Biobank participants. MedRxiv Preprint Server Health Sci. https://doi.org/10.1101/2020.10.28.20221804v1 (2020).

Article Google Scholar

Wang, C. et al. ApoE-isoform-dependent SARS-CoV-2 neurotropism and cellular response. Cell Stem Cell 28(2), 33142 e5 (2021).

CAS Article Google Scholar

Wang, H., Yuan, Z., Pavel, M. A. & Hansen, S. B. Cholesterol and COVID19 lethality in elderly. BioRxiv. https://doi.org/10.1101/2020.05.09.086249v1.full (2020).

Article PubMed PubMed Central Google Scholar

Figueroa, D. M., Gordon, E. M., Yao, X. & Levine, S. J. Apolipoproteins as context-dependent regulators of lung inflammation. In Mechanisms and Manifestations of Obesity in Lung Disease (eds Johnston, R. A. & Suratt, B. T.) 301326 (Academic Press, Berlin, 2019). https://doi.org/10.1016/B978-0-12-813553-2.00013-0.

Chapter Google Scholar

del Ser, T. et al. Residence, clinical features, and genetic risk factors associated with symptoms of COVID-19 in a cohort of older people in Madrid. Gerontology 67(3), 281289 (2021).

Article Google Scholar

Espinosa-Salinas, et al. Potential protective effect against SARS-CoV-2 infection by APOE rs7412 polymorphism. Sci. Rep. 12(1), 7247 (2022).

CAS Article Google Scholar

Mwer, S., Dykes, D. & Polesky, H. J. N. A simple salting out procedure for extracting DNA from human nucleated cells. Nucleic Acid Res. 16(3), 1215 (1988).

Article Google Scholar

Yang, Y. G. et al. Apolipoprotein E genotyping by multiplex tetra-primer amplification refractory mutation system PCR in single reaction tube. J. Biotechnol. 131(2), 106110 (2007).

CAS Article Google Scholar

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