PUBLIC RELEASE DATE:
9-Jan-2014
Contact: Bonnie Ward contact@liai.org 619-303-3160 La Jolla Institute for Allergy and Immunology
SAN DIEGO (January 9th, 2014) Researchers from the La Jolla Institute for Allergy and Immunology have revealed a critical player in the cellular interactions leading to eczema a chronic inflammatory skin condition affecting more than 14 million U.S. children and adults.
In a study published today, Toshiaki Kawakami, M.D., Ph.D., and his research team provide information which supports for the first time in humans the long-held theory that mast cells are a key culprit in causing eczema, also known as atopic dermatitis. Further, the team showed that a cellular protein, known as STAT5, plays a pivotal role by triggering major increases in mast cells in the skin of some eczema sufferers. The discovery opens the door to creating new therapies to prevent or better treat eczema based on blocking STAT5 in mast cells.
The team conducted its studies using skin samples from eczema patients. "We found that the number of mast cells, which we have previously shown to be important in mouse atopic dermatitis, is increased in human patients," says Kawakami. "We also showed that these mast cells contain high levels of the active form of STAT5."
Kawakami says the researchers also tested their theory on STAT5's importance in mice. "When STAT5 is knocked out in the mast cells (of specially engineered mice), the mice become resistant to atopic dermatitis," says Kawakami. "This indicates that STAT5 regulatory mechanisms in mast cells are important for the pathogenesis of this disease."
The findings were published online in Cell Reports in a paper entitled "Critical role for mast-cell Stat5 activity in skin inflammation." The study was supported in part by the National Institute of Allergy and Infectious Diseases (NIAID), a component of the National Institutes of Health, under contract number N01 AI40030.
Eczema is a condition in which the skin becomes inflamed or irritated and is marked by redness, itchiness and dry, cracked skin. The exact cause of eczema is unknown, but it's thought to be linked to an overactive response by the body's immune system to allergens and irritants, similar to other allergic diseases such as asthma and food allergy. Eczema is more common in children than adults, since it sometimes resolves with age. About 10.7 percent of U.S. children and 3 percent of adults are estimated to be affected.
Kawakami says this finding is a continuation of his nearly 10-year effort to pinpoint the cascade of key cellular actions involved in eczema. Initially working in mice, his latest study enabled human confirmation of his key findings. "We now know that, in eczema, the mechanisms we found in mice are also operative in human disease," says Kawakami. Along with showing that mast cells and STAT5 drive the eczema process in humans, this study also found an enzyme -- Phospholipase C-beta3 (PLC-3) that can block the activation. PLC-3 has a calming effort on STAT5 and can prevent it from driving up the mast cell numbers, explains Kawakami. "The mast cell numbers are inversely correlated with PLC-3 levels," he says. "The more PLC-3, the fewer the mast cells."
See the rest here:
La Jolla Institute scientist identifies pivotal cellular protein underlying eczema
- How To Cure Eczema: Tips To End The Pain And Discomfort Once And For All - Video [Last Updated On: September 7th, 2012] [Originally Added On: September 7th, 2012]
- Helping Kids with Severe Eczema - Video [Last Updated On: September 7th, 2012] [Originally Added On: September 7th, 2012]
- Eczema - Going Dairy Free - Video [Last Updated On: September 7th, 2012] [Originally Added On: September 7th, 2012]
- Eczema Treatment - Start Your Eczema Treatment Today - Video [Last Updated On: September 7th, 2012] [Originally Added On: September 7th, 2012]
- CURED ECZEMA! - Video [Last Updated On: September 7th, 2012] [Originally Added On: September 7th, 2012]
- Eczema Cure - Eczema Cure With The Eczema Diet - Video [Last Updated On: September 7th, 2012] [Originally Added On: September 7th, 2012]
- Treatment for Eczema - Video [Last Updated On: September 7th, 2012] [Originally Added On: September 7th, 2012]
- How To Get Rid Of Eczema Treatment - Video [Last Updated On: September 7th, 2012] [Originally Added On: September 7th, 2012]
- Eczema: Three Foods That Cause Eczema Breakouts - Video [Last Updated On: September 7th, 2012] [Originally Added On: September 7th, 2012]
- Understanding Baby Eczema - Video [Last Updated On: September 7th, 2012] [Originally Added On: September 7th, 2012]
- Dermatology Treatments : How to Get Rid of Eczema on the Scalp - Video [Last Updated On: September 7th, 2012] [Originally Added On: September 7th, 2012]
- Dermatology Treatments : How to Treat Severe Eczema - Video [Last Updated On: September 7th, 2012] [Originally Added On: September 7th, 2012]
- eczema or atopic dermatitis - Video [Last Updated On: September 7th, 2012] [Originally Added On: September 7th, 2012]
- Dealing with Eczema - Video [Last Updated On: September 7th, 2012] [Originally Added On: September 7th, 2012]
- Itchy Skin and Eczema - Video [Last Updated On: September 7th, 2012] [Originally Added On: September 7th, 2012]
- How to Treat Eczema [DermTV.com Epi #178] - Video [Last Updated On: September 7th, 2012] [Originally Added On: September 7th, 2012]
- Spot the Difference: Eczema Versus Fungal Skin Infection [Last Updated On: September 8th, 2012] [Originally Added On: September 8th, 2012]
- HayleyBee90 published Miracle Skincare from Liz Earle [Last Updated On: September 8th, 2012] [Originally Added On: September 8th, 2012]
- 10 Easy Ways to Prevent Eczema Flare-Ups [Last Updated On: September 10th, 2012] [Originally Added On: September 10th, 2012]
- Malaya Business News Online | Philippine Business News [Last Updated On: September 10th, 2012] [Originally Added On: September 10th, 2012]
- Don't Stress about Eczema [Last Updated On: September 13th, 2012] [Originally Added On: September 13th, 2012]
- Time to Bid Eczema Good Night [Last Updated On: September 15th, 2012] [Originally Added On: September 15th, 2012]
- CapriClear® Awarded the National Eczema Association NEA Seal of Acceptance™ [Last Updated On: September 20th, 2012] [Originally Added On: September 20th, 2012]
- The Sensitive Skin Diaries: Acne, Rosacea & Eczema Explained [Last Updated On: September 27th, 2012] [Originally Added On: September 27th, 2012]
- Priority Health: Eczema [Last Updated On: September 28th, 2012] [Originally Added On: September 28th, 2012]
- Itchy protease! [Last Updated On: September 30th, 2012] [Originally Added On: September 30th, 2012]
- The International Topical Steroid Addiction Network Patient’s Story About Curing Eczema Featured in the Eczema ... [Last Updated On: October 3rd, 2012] [Originally Added On: October 3rd, 2012]
- The Eczema Company Pledges Donation for National Eczema Awareness Month [Last Updated On: October 5th, 2012] [Originally Added On: October 5th, 2012]
- 8 new susceptibility loci for eczema identified [Last Updated On: October 8th, 2012] [Originally Added On: October 8th, 2012]
- Probiotic found to reduce eczema symptoms over long-term period [Last Updated On: October 9th, 2012] [Originally Added On: October 9th, 2012]
- Now available: Naturally sourced eczema treatment for babies [Last Updated On: October 10th, 2012] [Originally Added On: October 10th, 2012]
- Research and Markets: Atopic Dermatitis (Eczema) - Pipeline Review, H2 2012 [Last Updated On: October 12th, 2012] [Originally Added On: October 12th, 2012]
- Stopping the itch: New clues into how to treat eczema [Last Updated On: October 12th, 2012] [Originally Added On: October 12th, 2012]
- Scratching does make itch worse [Last Updated On: October 12th, 2012] [Originally Added On: October 12th, 2012]
- Eczema Treatments for Men, Women and Infants Published by Medical Researcher [Last Updated On: October 13th, 2012] [Originally Added On: October 13th, 2012]
- Winterize Your Skin: 5 Essential Skin Care Tips for Eczema Sufferers [Last Updated On: October 31st, 2012] [Originally Added On: October 31st, 2012]
- "Good bacteria" during pregnancy may ward off eczema: study [Last Updated On: October 31st, 2012] [Originally Added On: October 31st, 2012]
- "Good bacteria" during pregnancy may ward off eczema [Last Updated On: October 31st, 2012] [Originally Added On: October 31st, 2012]
- Probiotics May Help Fight the Growing Eczema Epidemic [Last Updated On: October 31st, 2012] [Originally Added On: October 31st, 2012]
- Jack, Age Thirteen, Once Hospitalized for “Incurable” Eczema, Finally Finds Cure [Last Updated On: October 31st, 2012] [Originally Added On: October 31st, 2012]
- Likewise Skincare Releases Statement as Eczema Awareness Month Comes to Close [Last Updated On: October 31st, 2012] [Originally Added On: October 31st, 2012]
- Babies Cradle Amber Teething Necklaces - Video [Last Updated On: October 31st, 2012] [Originally Added On: October 31st, 2012]
- Turmeric/Olive Oil mask for Hyperpigmentation/Eczema Scars - Video [Last Updated On: October 31st, 2012] [Originally Added On: October 31st, 2012]
- Eczema Remedies 2 - Video [Last Updated On: October 31st, 2012] [Originally Added On: October 31st, 2012]
- Eczema Cure Natural Way - Eczema Cure Natural Remedies - Download Ebooks - Video [Last Updated On: October 31st, 2012] [Originally Added On: October 31st, 2012]
- Beat Eczema Review - Video [Last Updated On: October 31st, 2012] [Originally Added On: October 31st, 2012]
- Naticura Products - Shea Nut Butter - Video [Last Updated On: October 31st, 2012] [Originally Added On: October 31st, 2012]
- HOW TO CURE ECZEMA NATURALLY #6 - Video [Last Updated On: October 31st, 2012] [Originally Added On: October 31st, 2012]
- Eczema Remedies - Video [Last Updated On: October 31st, 2012] [Originally Added On: October 31st, 2012]
- Wow New Seacret Product 602-793-0701 - Video [Last Updated On: October 31st, 2012] [Originally Added On: October 31st, 2012]
- Making 5 Flower Tea for Reena's Eczema - Video [Last Updated On: October 31st, 2012] [Originally Added On: October 31st, 2012]
- Tiny LUSH Haul..Reena's Eczema Treatment [Last Updated On: October 31st, 2012] [Originally Added On: October 31st, 2012]
- Bad eczema advice needed - Video [Last Updated On: October 31st, 2012] [Originally Added On: October 31st, 2012]
- Mysterious Symptoms of Morgellons Disease - Video [Last Updated On: October 31st, 2012] [Originally Added On: October 31st, 2012]
- New Hepatitis C Treatment - Week 1: First Interferon Shot - Video [Last Updated On: October 31st, 2012] [Originally Added On: October 31st, 2012]
- Probiotics in pregnancy may prevent baby's eczema [Last Updated On: November 2nd, 2012] [Originally Added On: November 2nd, 2012]
- Effective Eczema Cure - Get Rid Of Eczema Treatment - Video [Last Updated On: November 2nd, 2012] [Originally Added On: November 2nd, 2012]
- Mayday - Video [Last Updated On: November 2nd, 2012] [Originally Added On: November 2nd, 2012]
- Eczema Remedie... - Video [Last Updated On: November 2nd, 2012] [Originally Added On: November 2nd, 2012]
- Eczema - Video [Last Updated On: November 2nd, 2012] [Originally Added On: November 2nd, 2012]
- Eczema Remedies 4 - Video [Last Updated On: November 2nd, 2012] [Originally Added On: November 2nd, 2012]
- Eczema Wet Dressing Instructional Video by Allerchic - Video [Last Updated On: November 2nd, 2012] [Originally Added On: November 2nd, 2012]
- New Hepatitis C Treatment - Week 1: First Dose of INCIVEK - Video [Last Updated On: November 2nd, 2012] [Originally Added On: November 2nd, 2012]
- Eczema Treatment In ElectroHomoepathy - Video [Last Updated On: November 2nd, 2012] [Originally Added On: November 2nd, 2012]
- Stop suffering from dry skin and Eczema - Video [Last Updated On: November 2nd, 2012] [Originally Added On: November 2nd, 2012]
- Eczema Diet Secrets | Natural Eczema Treatment - Video [Last Updated On: November 2nd, 2012] [Originally Added On: November 2nd, 2012]
- Journey toward Wholeness Dry Skin - Video [Last Updated On: November 4th, 2012] [Originally Added On: November 4th, 2012]
- New Hepatitis C Treatment - Week 2: INTERFERON INJECTION - Video [Last Updated On: November 4th, 2012] [Originally Added On: November 4th, 2012]
- October Favorites 2012 - Video [Last Updated On: November 4th, 2012] [Originally Added On: November 4th, 2012]
- Arthritis, Fibromyalgia, Infections, Acne, Bunion, etc. - 5000Hz Isochronic Tones - Pure Series - Video [Last Updated On: November 4th, 2012] [Originally Added On: November 4th, 2012]
- Vanish Eczema! - Video [Last Updated On: November 4th, 2012] [Originally Added On: November 4th, 2012]
- Treating Skin Eczema Guide - Video [Last Updated On: November 4th, 2012] [Originally Added On: November 4th, 2012]
- Deafness, Eczema, Epilepsy, Gallstones, Gingivitis, etc. - 20Hz Isochronic Tones - Pure Series - Video [Last Updated On: November 4th, 2012] [Originally Added On: November 4th, 2012]
- Forever Living Products for Animals - Video [Last Updated On: November 4th, 2012] [Originally Added On: November 4th, 2012]
- Eczema made my childhood a misery. I'm so devastated I've passed it on to my son [Last Updated On: November 7th, 2012] [Originally Added On: November 7th, 2012]
- Baby learns to beatbox - Video [Last Updated On: November 7th, 2012] [Originally Added On: November 7th, 2012]
- Slender! (10/22/2012) #61 - Video [Last Updated On: November 7th, 2012] [Originally Added On: November 7th, 2012]
- Top 3 Best Eczema Treatment Guides Online - Video [Last Updated On: November 7th, 2012] [Originally Added On: November 7th, 2012]
- iWANT to see Grandma El's products in Target stores! - Video [Last Updated On: November 7th, 2012] [Originally Added On: November 7th, 2012]
- Harley Wrap - Discovery Channel Feature - Video [Last Updated On: November 7th, 2012] [Originally Added On: November 7th, 2012]