DNA riddle: how cells access data from ‘genetic cotton reels’ – News – The University of Sydney

Professor Joel Mackay.

Professor Mackay said: This protein effectively remodels our DNA to allow access to the information that determines the fate of a cell and its ability to respond to signals from the outside. It is a critical protein for almost all the work that cells do, including cell division and DNA repair.

Understanding this process will be critical in the long term for developing treatments for neurodevelopmental disorders and some cancers.

These illnesses are in part triggered by defects in the remodelling of the DNA that is driven by this process, Professor Mackay said.

The protein CHD4 and its close partners are emerging as important risk factors inpolygenic neurodevelopmental disorders, schizophrenia and bipolar disorder, as well as inrare monogenic disorders, such as GAND, which causes severe mental disability, Professor Mackay said.

He said that mutations in the CHD4 protein that impair its function are also associated with endometrial carcinoma.

The research was in collaboration with scientists at the University of Wollongong and the Australian National University.

The work was funded by the following grants from the National Health and Medical Research Council of Australia: APP1012161, APP1063301, APP1126357 and a fellowship from the same organisation to Professor Joel Mackay (APP1058916). Antoine van Oijen is an Australian Research Council Laureate Fellow.

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DNA riddle: how cells access data from 'genetic cotton reels' - News - The University of Sydney