DNA origami: The shape of things to come

Dongran Han

Scientists have coaxed DNA into self-assembled shapes such as spheres and corkscrews.

By Tia GhoseLiveScience

Scientists have bent DNA into bizarre, basket-woven shapes, from spheres to corkscrews.

The new DNA origami, described Thursdayin the journal Science, is one of the first steps in designing tiny nano-robots that could carry medicines or repair cells in the body.

"These are just the basic elements for device construction," study co-author Dongran Han, a chemistry doctoral candidate at Arizona State University, told LiveScience. "For future applications, we need a much bigger toolbox."

Mini-machinesIn the past, scientists have used DNA to write out words, made spaceships from tiny DNA bricks and even stored all of Shakespeare's sonnetsin the genetic code. Many of these methods are essentially proofs-of-concept to demonstrate that DNA (deoxyribonucleic acid) can be used to make microscopic machines for the body.

The new technique relies on DNA's unique ability to self-assemble. The molecule is usually bound into a double helix made of two strands with complementary base pairs, or letters representing nucleotides: A's bind to T's, and G's bind to C's. By manipulating the DNA sequence, the team can create single strands of DNA that will bind to each other in specific ways, forming unique shapes.

DNA's base pairs "recognize each other automatically," Han said. "If you design the things right, they will grow into the right things."

From single strands of DNA, Han and his colleagues created a wireframe structure that could then fold into several other shapes, such as corkscrews, spheres and scissors.

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DNA origami: The shape of things to come