Colorado Rockies at San Diego Padres odds, picks and predictions – USA TODAY Sportsbook Wire

The Colorado Rockies (25-32) open a 4-game road series against the San Diego Padres (35-22) Friday. First pitch is scheduled for 9:40 p.m. ET at Petco Park. Lets analyze Tipico Sportsbooks lines around the Rockies vs. Padres odds with MLB picks and predictions.

This will be the first matchup between the two teams this season. The Rockies won the season series 11-8 last year but were 4-6 in San Diego.

The Rockies finished the first leg of their 7-game, 6-day road trip by taking 2 of 3 games from the San Francisco Giants. They lost 4 straight games heading into that series.

The Padres won the final 2 games of their 3-game series against the New York Mets to pick up a series win and have won 5 of their last 6 contests.

RHP Chad Kuhl vs. RHP Joe Musgrove

Kuhl (4-2, 3.17 ERA) makes his 11th start. He has a 1.26 WHIP, 3.3 BB/9 and 6.8 K/9 through 54 IP.

Musgrove (6-0, 1.64 ERA) makes his 11th start. He has a 0.92 WHIP, 1.9 BB/9 and 8.7 K/9 through 66 IP.

Odds provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 11:08 a.m. ET.

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Padres 5, Rockies 2

PASSon the money line.

The Padres have been dominant with Musgrove and he is rolling, having allowed only 1 run in his last 3 starts.

San Diego is only 15-11 at home but Colorado is 9-16 on the road. Only 3 teams have fewer road wins in all of baseball, so a Padres win seems almost certain, but it isnt worth the action at -250.

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The Rockies are 27-30 ATS and the Padres are 32-25 ATS overall. The Rockies are 12-13 ATS on the road and the Padres are 9-17 ATS at home. Only 2 teams have fewer covers at home.

The Padres have won 7 of Musgroves 10 starts by at least 2 runs and their last 5 wins have been by at least 2 runs.

The Rockies last 2 losses were only by 1 run but their previous 4 defeats were by multiple runs.

Both pitchers are playing well, but the Rockies have the second-worst bullpen ERA in the majors at 4.95.

Take the PADRES -1.5 (-110).

Five of Musgroves last 6 starts have had fewer than 8 runs.

Six of Kuhls last 7 starts and 8 of 10 overall have had totals of fewer than 8 runs.

Half of the Padres last 10 games have had 7 or fewer runs.

Take UNDER 7.5 (-115).

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Colorado Rockies at San Diego Padres odds, picks and predictions - USA TODAY Sportsbook Wire