PureTech Provides End of Year Report on Key Progress Across Wholly Owned Programs and Founded Entities – Business Wire

BOSTON--(BUSINESS WIRE)--PureTech Health plc (Nasdaq: PRTC, LSE: PRTC) (PureTech or the Company), a clinical-stage biotherapeutics company dedicated to discovering, developing and commercializing highly differentiated medicines for devastating diseases, today reported on the key progress made across its Wholly Owned Programs1 and Founded Entities2 in 2021, including some updates that were not previously reported.

Daphne Zohar, Founder and Chief Executive Officer of PureTech, commented: 2021 has been a year of profound achievements and fundamental growth across our Wholly Owned Programs and our Founded Entities. With the support of our shareholders, we have pioneered a unique R&D model that has been successful in identifying, inventing and advancing novel therapeutic candidates for serious diseases and creating wholly-owned programs as well as both public and private Founded Entities with substantial value. We are proud of our execution and successes and are excited about using that strong foundation to catalyze value as we enter into an important, milestone-rich 2022, having the benefit of a strong balance sheet from which to drive value.

PureTechs Wholly Owned Programs are comprised of six therapeutic candidates and four lymphatic and inflammation platforms. Additionally, PureTechs Founded Entities are advancing 19 therapeutics and therapeutic candidates, of which two have been cleared for marketing by the U.S. Food and Drug Administration (FDA) and granted marketing authorization in the European Economic Area, and 14 are clinical stage. Key highlights include the following:

Wholly Owned Programs

Founded Entities:

About PureTech HealthPureTech is a clinical-stage biotherapeutics company dedicated to discovering, developing and commercializing highly differentiated medicines for devastating diseases, including inflammatory, fibrotic and immunological conditions, intractable cancers, lymphatic and gastrointestinal diseases and neurological and neuropsychological disorders, among others. The Company has created a broad and deep pipeline through the expertise of its experienced research and development team and its extensive network of scientists, clinicians and industry leaders. This pipeline, which is being advanced both internally and through PureTech's Founded Entities, is comprised of 25 therapeutics and therapeutic candidates, including two that have received both U.S. FDA clearance and European marketing authorization, as of the date of PureTech's most recently filed Half Year Report and corresponding Form 6-K. All of the underlying programs and platforms that resulted in this pipeline of therapeutic candidates were initially identified or discovered and then advanced by the PureTech team through key validation points based on the Company's unique insights into the biology of the brain, immune and gut, or BIG, systems and the interface between those systems, referred to as the BIG Axis.

For more information, visit http://www.puretechhealth.com or connect with us on Twitter @puretechh.

Cautionary Note Regarding Forward-Looking StatementsThis press release contains statements that are or may be forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. All statements contained in this press release that do not relate to matters of historical fact should be considered forward-looking statements, including, without limitation, those related to our anticipation of catalysts in 2022 and beyond, the treatment potential of our Wholly Owned Programs, our expectations around the completion of enrollment and the timing for results with respect to the Phase 2 and Phase 2a clinical trials for LYT-100, our plans to provide further detail around our development plans for LYT-100, our anticipation of results from the Phase 1 portion our clinical trial for LYT-200, our expectations related to the potential uses of the results from the LYT-300 Phase 1 clinical study, the plans to file an Investigation New Drug Application for LYT-503, our evaluation of potential therapeutics candidates leveraging the Alivio Technology Platform, our expectation for data generation and potential approaches utilizing the Orasome Technology Platform, the treatment potential of therapeutic candidates of our Founded Entities, our expectations related to the business combination between Gelesis and Capstar Special Purpose Acquisition Corp., our expectations with respect to Karunas Phase 3 clinical programs, and our expectations regarding Follicas potential commencement of Phase 3 registration program. The forward-looking statements are based on current expectations and are subject to known and unknown risks, uncertainties and other important factors that could cause actual results, performance and achievements to differ materially from current expectations, including, but not limited to, those risks, uncertainties and other important factors described under the caption Risk Factors in our Annual Report on Form 20-F for the year ended December 31, 2020 filed with the SEC and in our other regulatory filings. These forward-looking statements are based on assumptions regarding the present and future business strategies of the Company and the environment in which it will operate in the future. Each forward-looking statement speaks only as at the date of this press release. Except as required by law and regulatory requirements, we disclaim any obligation to update or revise these forward-looking statements, whether as a result of new information, future events or otherwise.

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PureTech Provides End of Year Report on Key Progress Across Wholly Owned Programs and Founded Entities - Business Wire