Category Archives: Psoriasis

Almirall and Happify Health go live with digital therapeutics support for psoriasis patients 08 August 2022

BARCELONA, Spain, and NEW YORK, USA -- May 24, 2022 - Today, Happify Health, the Intelligent Healing Company, and Almirall, S.A. (BME: ALM), a global biopharmaceutical company focused on skin health, announced that Claro, a digital program developed via the innovative partnership of both companies, is live and now available to people with psoriasis in Spain, Italy and United Kingdom.

Claro was built to improve the mental wellbeing of people with psoriasis by providing cognitive behavioral therapy, positive psychology and mindfulness. Since its launch, engagement rates on Claro are high, with active users on the platform completing an average of 2.6 activities per week.

Psoriasis is one of the world's most prevalent skin diseases, affecting about 60 million people worldwide1. It is estimated that 20 to 30% of people, globally, with moderate to severe psoriasis also suffer from mental health issues like anxiety and depression2. Approximately 80% of those affected with psoriasis have mild to moderate symptoms, with direct healthcare costs for treatment of psoriasis exceeding $65 billion annually.

"At Almirall, we are proud to offer psoriasis patients a wide range of medicines that cover the whole spectrum of the disease, from mild to severe. Claro helps us to fulfill our commitment to people living with psoriasis, providing them with an enhanced solution addressed to their wellbeing so they can get their lives back." said Dr. Volker Koscielny, MD, Chief Medical Officer of Almirall.

"Psoriasis is a significant burden in the daily life of 71% of people who suffer from it according to the National Psoriasis Foundation in the UK3," said Theo Ahadome, Senior Vice President of Commercialization at Happify Health."A 2019 study in Maedica, the Journal of Clinical Medicine establishes a clear link between skin-psychology and quality of life for people with psoriasis.3This partnership gives us the opportunity to study how effective digital programs are at keeping psoriasis patients engaged during treatment for psoriasis and improving their quality of life."

About Almirall

Almirall is a global biopharmaceutical company focused on skin health. We collaborate with scientists and healthcare professionals to address patient's needs through science to improve their lives. Our Noble Purpose is at the core of our work: "Transform the patients' world by helping them realize their hopes and dreams for a healthy life". We invest in differentiated and ground-breaking medical dermatology products to bring our innovative solutions to patients in need.

The company, founded in 1943 and headquartered in Barcelona, is publicly traded on the Spanish Stock Exchange and is a member of the IBEX35 (ticker: ALM). Throughout its 79-year history, Almirall has retained a strong focus on the needs of patients. Currently, Almirall has a direct presence in 21 countries and strategic agreements in over 70, with about 1,800 employees. Total revenues in 2021 were 836.5 million euros.

For more information, please visit almirall.com

[1]H.L. Richards, D.G. Fortune, C.E. Griffiths, C.J. Main The contribution of perceptions of stigmatization to disability in patients with psoriasis J Psychosom Res., 50 (2001), pp. 11-15.

[2]The prevalence of comorbid depression in patients with psoriasis is estimated at between 20% and 30%, and rates as high as 62% have been reported. E.A. Dowlatshahi, M. Wakkee, L.R. Arends, T. Nijsten The prevalence and odds of depressive symptoms and clinical depression in psoriasis patients: A systematic review and meta-analysis J Invest Dermatol., 134 (2014), pp. 1542-1551. M. Esposito, R. Saraceno, A. Giunta, M. Maccarone, S. ChimentiAn Italian study on psoriasis and depression Dermatology., 212 (2006), pp. 123-127.

[3]National Psoriasis Foundation 2008 Survey Snapshot. Available from: PTT-24087-quality-of-life-issues-and-measurement-in-patients-with-psor (researchgate.net)

Disclaimer

Almirall SA published this content on 08 August 2022 and is solely responsible for the information contained therein. Distributed by Public, unedited and unaltered, on 08 August 2022 10:24:09 UTC.

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Almirall S A : and Happify Health go live with digital therapeutics support for psoriasis patients - Marketscreener.com

HELLERUP, Denmark, Aug. 4, 2022 /PRNewswire/ -- UNION therapeutics A/S (UNION), a privately-held, multi-asset, clinical stage, pharmaceutical development company focused on immunology and infectious diseases, announces that the first patient has been enrolled in ADESOS, a Phase 2b dose-finding study evaluating the safety and efficacy of orismilast MR tablet in adult patients with moderate to severe AD. The purpose of the study is to identify the appropriate dose regimen for Phase 3 studies.

In November 2021, the US Food and Drug Administration (FDA) granted Fast Track designation to orismilast MR tablet for the treatment of moderate to severe AD. The FDA's Fast Track designation is intended to facilitate the development and review of drug candidates that treat serious conditions and address an unmet medical need. This underscores the need for new treatment options with potential to fulfil the unmet medical needs for people affected by AD.

UNION has recently investigated the inhibitory effect of orismilast on the secretion of various inflammatory cytokines in human peripheral blood mononuclear cells in vitro. Orismilast underlined its potential in AD, psoriasis, and HS by demonstrating broad anti-inflammatory properties with potent inhibition of the main cytokines involved in these indications1). Data from the study will be presented at the 31st EADV (European Academy of Dermatology and Venereology) Congress at 7-11 September 2022.

Kim Kjller, Chief Executive Officer of UNION therapeutics said:"Orismilast modified release tablet holds the potential to become a first-in-class treatment and become an efficacious treatment option for patients who need systemic therapy for atopic dermatitis. The initiation of the ADESOS study marks an important advancement of UNION's pipeline."

Jonathan Silverberg, MD, PhD, MPH, Associate Professor of Dermatology at The George Washington University School of Medicine and Health Sciences and Signatory Investigator for ADESOS adds: "AD is one of the most common chronic skin diseases worldwide. Despite recent advancements in the treatment of AD, there are still many unmet needs for safe and effective oral treatments. Orismilast modified release tablet has the potential to be an effective and patient-friendly treatment option in AD."

About the ADESOS Phase 2b studyThe Phase 2b study is a randomized, double-blind, placebo-controlled, parallel-group, dose-finding study to evaluate the efficacy and safety of orismilast MR tablet in patients with moderate to severe AD. The study will target 210 patients who will be randomized to three active doses (20mg, 30mg, and 40 mg) of orismilast relative to placebo administered twice daily. The study will be conducted in centers in Europe and the US.

About orismilastUNION is developing orismilast, which is a potent next-generation phosphodiesterase type-4 (PDE4) inhibitor operating early in the inflammation cascade to induce a broad spectrum of downstream anti-inflammatory effects. Orismilast has the potential to inhibit many inflammatory pathways involved in dermatological and immunological diseases and holds potential to become a safe and efficacious treatment option in various dermatological and immunological diseases.

UNION has two product candidates with orismilast in its clinical stage pipeline: Orismilast MR tablet currently investigated for the treatment of psoriasis, AD and HS; and topical orismilast with clinical proof of concept established in AD. UNION is progressing orismilast as a modified release tablet to minimize the occurrence of gastrointestinal side effects typically associated with PDE4-inhibition.

In November 2020, the FDA cleared UNION's Investigational New Drug (IND) application for orismilast MR tablet, and in November 2021, the FDA granted Fast Track designation to orismilast MR tablet for the treatment of moderate to severe AD.

In September 2021, UNION entered into a strategic partnership and licensing agreement with Innovent Biologic for orismilast in Mainland China, Hong Kong, Macau and Taiwan2).

About atopic dermatitisAD is a chronic inflammatory skin disease affecting approximately 3% of the adult population worldwide and is the most common skin disease among children, with the disease commonly occurring by five years of age3). There was approximately 26 million diagnosed cases of AD in 2021 in the Seven Major Markets (US, France, Germany, Italy, Spain, UK, and Japan)4). Disease symptoms are characterized by recurrent eczematous skin lesions and intense itch. AD has a substantial psychosocial impact on patients and relatives5). During disease flares, approximately 80% of patients may experience disturbed sleep, which may also disrupt the sleep of family members6). The disease also appears to impact the mood and patients have an increased risk of anxiety and depression7).

Sources

1. In vitro study to assess the effect of orismilast on cytokine production in human PBMCs. Study number: DSK0001

2. https://uniontherapeutics.com/union-therapeutics-and-innovent-biologics-enter-into-strategic-collaboration-and-license-agreement-for-orismilast-a-next-generation-pde4-inhibitor-for-inflammatory-dermatology-conditions-1/

3. https://pubmed.ncbi.nlm.nih.gov/25925336/

4. Decision Resources Group (2020): Atopic Dermatitis Disease Landscape & Forecast. Published November 12, 2020

5. https://pubmed.ncbi.nlm.nih.gov/33006135/

6. https://pubmed.ncbi.nlm.nih.gov/24290431/

7. https://pubmed.ncbi.nlm.nih.gov/27616422/

ContactsMorten Boesen, Chief Financial Officer, UNION therapeutics A/S+45 2381 5487morten.boesen@uniontherapeutics.com

Sarah Toft-Jrgensen, Director of Communications and IR, UNION therapeutics A/S+45 5385 3044stj@uniontherapeutics.com

About UNION therapeuticsUNION therapeutics is a privately held, multi-asset, clinical stage, pharmaceutical development company focused on immunology and infectious diseases. The company is currently working with two complementary chemistry classes, spanning immunology and microbiology with multiple candidates in clinical development. UNION is headquartered in Hellerup, Denmark, and led by an international team combining biotech entrepreneurs and seasoned pharma executives, with a track record of developing and launching more than fifteen marketed drugs. Read more at http://www.uniontherapeutics.com

This information was brought to you by Cision http://news.cision.com

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The U.S. Food and Drug Administration (FDA) approved Zoryve (roflumilast) cream 0.3 percent for the treatment of plaque psoriasis, including intertriginous areas (where skin rubs against other skin) in people 12 years of age and older, according to a press release issued by Arcutis, the manufacturer of the drug. Once-daily Zoryve is the first and only approved topical phosphodiesterase-4 (PDE4) inhibitor, the first and only FDA-approved steroid-free cream in its class.

PDE4 inhibitors suppress the immune system by reducing the action of an overactive enzyme (phosphodiesterase 4), thereby reducing inflammation.

It is always great to have another topical option to treat psoriasis, so this approval is exciting, says Marisa Garshick, MD, a board-certified dermatologist at MDCS Dermatology in New York City. Zoryve will be a good choice for those patients who prefer to avoid a topical steroid, she adds.

This approval offers yet another steroid-free option for people with plaque psoriasis; in May, the FDA approved Vtama (tapinarof) cream 1 percent for topical treatment of mild, moderate, or severe plaque psoriasis in adults.

FDA approval is based on data from two phase 3 randomized, double-blind, vehicle-controlled (Zoryve was compared to a placebo or dummy cream) trials that included a total of 881 people, called the DERMIS1 and DERMIS2 studies, presented at the 2021 Clinical Dermatology Conference in Las Vegas, Nevada.

The primary endpoint wasInvestigator Global Assessment (IGA)success, defined as clear or almost clear skin with at least a 2-grade improvement from baseline, and at least a 2-grade IGA score improvement from baseline at eight weeks. In the 2 trials, 42.4 percent and 37.5 percent of the patients treated with Zoryve achieved an IGA success rate, compared with 6.1 percent and 6.9 percent in the control groups, respectively.

Nearly 3 in 4 people (73.5 percent) completed 52 to 64 weeks of treatment, and fewer than 1 percent of participants discontinued because the medication didn't work.

In addition to clearing the skin, Zoryve improved the severity and impact of itch. Of participants with a Worst Itch-Numerical Rating Score (WI-NRS) of 4 or higher at baseline, 2 out of 3 people using Zoryve achieved at least a 4-point reduction at week 8. The WI-NRS is a questionnaire that asks patients to rate their itch from 0 (no itch) to 10 (worst imaginable itch) in the past 24 hours, according to an article published October 23, 2021, in BMC Health and Quality of Life Outcomes.

While topical steroids are a very effective option for psoriasis, their use over time should be limited, says Dr. Garshick. There are certain locations on the body, including the face and skin folds, where their use should be limited to prevent thinning of the skin, she adds.

Zoryve is the only topical that has data specifically focusing on the treatment of intertriginous plaques (those found in skin folds), said Frank Watanabe, the president and CEO of Arcutis, in the statement. For people who have psoriasis in those areas, which can include areas such as the underarms, under the breasts, or the groin area, Zoryve can be a safe and effective option, says Garshick.

Unlike steroids, there is no restriction on how long Zoryve can be used to treat plaque psoriasis, according to the approval statement. When used chronically (over a long period of time), topical steroids can cause stretch marks in areas like the thighs or the armpits, according to the American Academy of Dermatology (AAD).

In general, Zoryve is safe and easy to tolerate for those with psoriasis, says Garshick. The most commonly reported side effects in people using Zoryve were diarrhea (3.1 percent), headache (2.4 percent), insomnia (1.4 percent), nausea (1.2 percent), application site pain (1 percent), upper respiratory tract infection (1 percent), and urinary tract infection (1 percent).

The current wholesale acquisition cost (WAC) pricing is $825 for a 60 gram (g) tube of Zoryve, according toArcutis. The actual cost to the patient will depend on insurance coverage.

The company offers a savings program; people with commercial insurance that provides Zoryve coverage will pay $25 a tube, and those with commercial insurance that does not cover Zoryve will pay $75 a tube. Financially eligible patients who dont have insurance or who are underinsured may access the cream through the Arcutis Cares Patient Assistance Program.

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FDA Approves New Treatment for People With Plaque Psoriasis - Everyday Health

Bri Morrell from Leicester was diagnosed with psoriasis, an irritating skin condition which causes red, scaly patches to appear on her skin

Image: mediadrumimages/@thatgirlpatches)

A woman who says 70 percent of her body is covered in red marks has opened up about having psoriasis.

Bri Morrell from Leicester was diagnosed with the irritating condition, which causes red, scaly patches to appear on her skin, earlier this year.

The customer service advisor believes the condition was triggered after suffering a period of depression.

Psoriasis causes the skin cells to grow at a rapid rate, with new skin cells growing every three days, instead of at a one-month rate.

As a result, there is an excess of skin cells that pile up on the surface, causing inflammation, swelling and redness.

These patches cover nearly 70 per cent of Bri's body, causing itching, soreness and in some cases bleeding when her skin splits open.

Psoriasis affects every inch of Bri's body. It doesn't just affect her bare skin, but also her scalp and even her fingernails and toenails.

To ease the psoriasis and irritation, Bri wears baggy and loose-fitting clothes, lessening her contact to tight-fitting materials.

Bri's psoriasis started in her early 20s, slowly appearing before taking over her body.

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She believes it was triggered by a low period of her life when Bri suffered a period of depression.

Psoriasis can be brought on by stress, depression, or changes in hormones, as well as many other things.

Despite visiting the doctors, Bri says she didn't receive any treatment for her skin.

She was offered an immune-suppressing drug, however, she turned down the treatment due to the multitude of harsh side effects that accompany the drugs.

Instead, to manage the irritation, Bri uses a cream which reduces the soreness and dryness of the skin.

Bri wants to inspire others, using her Instagram as a platform to spread body positivity to others and reduce the stigma around the skin disease.

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"I never got psoriasis until I was in my early twenties," said Bri.

"There isn't one part of my body it doesn't affect.

"I have it on my scalp, face, back, chest, stomach, legs, toes, hands, nails.

"Around seventy percent of my body is covered.

"It was triggered by a low period in my life.

"My condition can cause me low periods, but that's generally when other things are bothering me, and the psoriasis is like a straw that broke the camel's back.

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"I find the itchiness and flakiness the most annoying part.

"It can be embarrassing when it's in my scalp or ears as I worry people may think it's down to me not washing my hair.

"When I'm not using my cream, I struggle to get about as my skin is so sore and literally splits open, but I used the regularly which helps control my psoriasis."

Bri says she has had to change her attitudes and has spoken about the amazing support she has had in place through her journey.

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"I've had to overcome caring what people think and learn to love myself despite not fitting into European beauty standards," she said.

"I've always been very fortunate to date understanding people who not only accept my psoriasis, but actually find it attractive as they say it's different and unique.

"If I dated a guy who was embarrassed or irritated by my skin then he wouldn't last long.

"My family is extremely supportive of my skin and have helped me to embrace it, as well as my ex-partner.

"I've never received hate online, but I have had funny stares from people before.

"I think there is a lack of education on skin conditions, so a lot of the time people don't know what they're dealing with."

Bri hopes to educate people about psoriasis and help people accept their individual beauty, regardless of their skin.

"I was confident enough to embrace it," said Bri.

"I'm proud of the fact that I embrace my skin and have helped others to feel less embarrassed about having a skin condition.

"I'm proud of building my Instagram with content that I've been told by others has inspired them not to hide their own skin.

"I think it's important to learn to love yourself so much that something like a skin condition won't get you down.

"Stop comparing yourself to other people on social media. I am really bad for that, and it's never done me any good. Ever since I stopped, I've felt so much better within myself."

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Woman says 70% of her body is covered in red marks due to rare condition - The Mirror

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Spending time in the sun can be good for eczema or psoriasis, but doctors say don't overdo it - Your News Now

KIM Kardashian has shown off her real skin texture in her daughter North's latest TikTok.

The reality star, 41, displayed her visible pores and psoriasis in a video the nine-year-old shared on Sunday.

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Kim, 41, posted a new clip over the weekend to the TikTok account she shares with her eldest daughter.

In the video, the preteen gave her famous mom a very distinctive makeover.

At the start of the clip, Kim's pores could be seen on her cheeks as well as pink patches on her neck from psoriasis.

Psoriasis is a skin condition that causes flaky patches of skin which can look pink or red.

North gave her mom the full Minions treatment complete with yellow face paint, purple lips, and black lines around her eyes to resemble the characters famous goggles.

Kim added the text Mommy Minion, to describe the finished result.

The Keeping Up With the Kardashians-alum has previously revealed that North loves makeup and special FX, so its no surprise that she has to volunteer as a model sometimes.

North is one of four children that Kim shares with Kanye, along with Saint, six, Chicago, four, and Psalm, three.

Kanye has said in the past that he is not happy with his daughter being on TikTok, although the account is managed by an adult.

But the new video comes amid fan rumors that Kim and Kanye might have rekindled their relationship.

Many fans believe that a number of clues recently suggest that Kim and Kanye have reconciled.

On Friday, Kim took to her Instagram Stories to post a photo ofNorth modeling a pair of Yeezy sunglasses designed by her rapper dad.

Similarly,Kris Jennerwas spotted on Wednesdaywearing a pair of Yeezy sneakerswhile preparing for a Christmas photoshoot withKhloe Kardashian.

But thats not all.

Kim posted on social media earlier this week to reveal that she waswatching The Truman Show, which the Donda star has previously said is one of his favorite movies.

It came after she had alsoshared an image from American artist James Turrell, whom Kanye has previously collaborated with.

The dad-of-four was recently spotted looking so happy as he took North to her basketball game with Chicago.

Meanwhile, Kims new boyfriend Pete Davidson wasspotted looking downcastin Australia this week, where he is away filming a movie.

The actor will now be away from Kim for even longer than he had planned because his new movie, Wizards, has suffered a delay in production.

Kim hadtraveled to Australiaearlier this month to spend time with her beau, who has a busy work schedule just like her.

Things appear to have to been going well between the two in recent months, with Pete even hinting that hewould like to get married and have childrenwith the Hulu star.

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Although people can be diagnosed with PsA without skin involvement, they will most likely have a family member with skin psoriasis. For example, my mother has psoriasis, my two siblings and I have psoriasis, and one out of three of my daughters has shown signs of psoriasisall on our scalp, and I sometimes get it on my face in small patches.

Psoriasis is an inflammatory skin condition, while psoriatic arthritis is an inflammation of the joints and entheses (enthesitis).

Symptoms of psoriasis depend on what kind you have and how bad it is. Psoriasis makes knees, elbows, and fingernails red, itchy, flaky, and pitted. Most peoples psoriasis symptoms get worse for a few weeks or months, and then they get better. This could get better during remission too.

Unlike Psoriasis, PsA has symptoms in the joints, spine, and enthesea. The symptoms are like psoriasis in that they vary by type and severity.

If you have Psoriasis and suspect PsA, there are several warning signs for when to contact a rheumatologist:

RELATED: 10 Psoriasis Myths Debunked

For every ten people who walk in the door with psoriasis, about three or four of them will eventually get PsA, saysElaine Husni, MD, MPH, vice chair of the department of rheumatic & immunologic diseases at the Cleveland Clinic in Ohio. Skin and joint problems can happen simultaneously, or the joint problems can show up first. Most of the time, joint pain comes seven to ten years after the skin issue.

Psoriasis can show up in places that are hard to see or are close to the body, like the scalp, intergluteal cleft, belly button, or ear. Small psoriasis spots on the scalp and buttocks could be missed, which would make the diagnosis take longer.

Psoriasis could be the cause of a bit of dandruff on your head. Studies show that Psoriasis of the scalp, nails, and groin is linked to PsA. Your PsA risk may be higher if you have psoriasis in these hidden places.

Experts think a malfunctioning immune system contributes to psoriasis and PsA. The psoriatic illness causes

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If I Have Psoriasis, Am I Going To Get Psoriatic Arthritis? - BlackDoctor.Org

Research shows that unmanaged anxiety and depression can reduce the likelihood of achieving psoriatic arthritis remission. Since psoriatic arthritis and mental health are so distinctly connected, particularly anxiety and depression, those diagnosed with the condition may want to consider talk therapy as part of their treatment plan.

In fact, up to 20% of people with psoriatic arthritis have been diagnosed with depression as well.

Choosing therapy as part of a treatment plan isnt always easy. But therapy can be an important tool in managing anxiety and depression, and ultimately, stress, which is considered to be a major trigger for psoriatic arthritis flares.

Now, with so many different types of mental health therapy available, theres no such thing as one size fits all when it comes to what type of treatment is right for you.

If youre considering talk therapy as a way to manage your psoriatic arthritis, heres everything you need to know about the connection between the two, the benefits and types of therapy, and the outlook.

Symptoms of psoriatic arthritis, like joint and skin problems, can have a major impact on quality of life. Fatigue, pain, and skin patches can all cause mental distress, which can ultimately lead to anxiety or depression.

In fact, people diagnosed with psoriatic arthritis have a higher risk of developing depression for that reason. Research shows this can lead to unhelpful coping mechanisms, creating a cycle where ones behavioral responses to things like stress or flares can worsen existing symptoms.

Dr. Jacob Hascalovici, chief medical officer and pain specialist at Clearing, a telehealth platform for those with chronic pain, says psoriatic arthritis and depression can feed each other. Exhaustion, fatigue, social stigma, and pain that can accompany psoriatic arthritis can both hasten and worsen depression, he explains.

Conversely, depression can increase stress levels, in turn worsening arthritis symptoms. In both conditions, pain may be felt more intensely, stress may be more difficult to manage, inflammation may be higher, and chemical signaling that supports a good mood may be impaired.

Thats where therapy comes into the picture. Not only can therapy help you learn healthy coping mechanisms for psoriatic arthritis, but it can also teach you how to identify and manage triggers associated with anxiety or depression, among other mental health concerns.

Plus, therapy offers a safe space and outlet to discuss your feelings. Since inflammation, pain, fatigue, and mental health are all intertwined, therapy can be used to address mental health, ultimately benefiting the other elements of the condition.

Therapy can have a huge impact on psoriatic arthritis. For starters, therapy is an important way to promote a positive representation of the condition.

It can help you flip the switch from a negative viewpoint of psoriatic arthritis to a neutral view, like acceptance, or even a positive one. It can help you understand your thought patterns and behaviors, essentially teaching you skills to prevent the condition from making you feel powerless (or crummy in other ways).

Therapy can also be a great way to develop strategies to manage pain and fatigue, in addition to helping you learn how to successfully stick to those strategies.

In fact, psychosocial interventions like therapy have actually been associated with improved immune system functioning, which is important in managing and preventing psoriatic arthritis flares.

Regaining your power over anxiety and depression can yield a ton of benefits, improving everything from sleep, to mood, to even the severity of your symptoms.

There are several types of therapy available, many of which can be beneficial for those with psoriatic arthritis. Here are a few to consider that experts recommend trying:

Hascalovici says cognitive behavioral therapy, or CBT, is hailed as a leading therapeutic approach for depression and insomnia, among other mental health needs.

CBT is largely based on recognizing unhelpful thought patterns and behavioral habits, and learning to substitute new patterns and habits, he explains. It can even help control inflammation.

How? By reducing stress, people eliminate one of the main triggers for inflammation.

As an alternative to CBT, a newer form of therapy called acceptance and commitment therapy (ACT) can be helpful for people living with chronic pain.

The goals of ACT therapy are to help people:

A 2017 review suggests ACT may be an effective method for helping people cope with chronic pain.

Brief psychodynamic therapy can provide a window into your inner monologue.

With psychodynamic therapy, people can learn more about their own thoughts and feelings, so they can better understand how they tend to handle stress, loneliness, and other potentially negative experiences, Hascalovici says.

Through this heightened understanding, people can learn more about their own strengths and abilities to problem-solve, including with problems related to psoriatic arthritis.

Mindfulness-based therapy can be used to help stay in the now, so to speak.

Mindfulness-based therapy encourages patients to focus more on each moment, maintaining awareness in a way that tends to reduce pain and promote more enjoyment, Hascalovici says. Mindfulness-based therapy can help counter depression and negativity that may accompany psoriatic arthritis.

Up to 1 in 5 people with psoriatic arthritis have also been diagnosed with depression. Thats why making mental health a priority matters.

Talk therapy can help you not only cope with anxiety and depression but also with flares or symptoms of psoriatic arthritis.

To learn more about the benefits of talk therapy for psoriatic arthritis, ask your doctor if exploring this treatment option may be right for you.

Its important to keep in mind there are therapists who specialize in working with people with chronic pain and chronic medical conditions. Not all therapists are qualified to do this work, so you should look for these specific qualifications and experience.

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Talk Therapy for Psoriatic Arthritis? Here's How It Can Make a Difference - Greatist

Is psoriasis more common in women or men? Researchers dont necessarily agree on the answer, but according to one study in the journal JAMA Dermatology, 3.2 percent of women in the United States have a formal psoriasis diagnosis versus 2.8 percent of men.

These women may face challenges that the men dont. Women with psoriasis have unique considerations. I feel like [these issues] are under-addressed, says Jennifer Soung, MD, director of clinical research at Southern California Dermatology in Santa Ana, California, and a clinical professor at Harbor-UCLA Medical Center.

What can women with psoriasis do to make sure their medical, emotional, and mental health needs are met? Here are a few important things to keep in mind if you are a woman with psoriasis.

According to the National Psoriasis Foundation (NPF), women are more likely than men to feel the stigma of having a visible skin condition, particularly untreated or undertreated individuals who experience frequent flare-ups.

This can cause stress, which can lead to more flare-ups. The mind and the body are inextricably connected with the skin. If someone has a history of psoriasis, if they are stressed, the psoriasis can flare up. When the stress is better controlled, the psoriasis will improve. It works in both directions, says Amy Wechsler, MD, a New York Citybased psychiatrist and dermatologist.

Research suggests that women with psoriasis are more likely than men to experience depression, even though psoriasis tends to be more severe in men than in women, and that psoriasis can have a greater impact on womens quality of life.

Does the start of your menstrual cycle, when estrogen and progesterone levels are at their lowest monthly levels, automatically lead to a psoriasis flare-up? Not necessarily. The effect of hormonal changes on psoriasis will differ from person to person.

That said, a womans estrogen level on any given day can raise or lower the risk of a flare-up. Research backs this up, showing a correlation between skin inflammation and hormone levels.

The dramatic hormonal changes that come with pregnancy appear to have a particular impact on psoriasis,research indicates. Many (though not all) women experience a significant improvement in psoriasis symptoms during pregnancy, when estrogen and progesterone levels rise, and a worsening of psoriasis symptoms after giving birth, when these hormone levels plummet.

According to theNPF, as many as two-thirds of men and women with psoriasis may experiencegenital psoriasis at some point in their lives. It definitely happens, says Dr. Soung.

Some women may feel extremely self-conscious if they are experiencing a psoriasis flare-up on or around the vagina, anus, or genital fold area.

Its important to properly identify if the skin condition is psoriasis or something else, says Soung. The No. 1 question my patients ask is, Are you sure its not a STD? Another question her patients ask is, Can I still have sex? (TheAmerican Academy of Dermatology Association offers useful tips on sex with genital psoriasis.)

There are two forms of psoriasis that can occur in the genital area: plaque psoriasis and inverse psoriasis. Plaque psoriasis often appears on the scalp, knees, elbows, and torso, as well as the genital area. According to the NPF, plaque psoriasis in Caucasian skin can look red, with a scaly, silvery-white buildup of dead skin cells. Among people of color, the plaques may be darker and can range in color from purple to gray to dark brown.

Inverse psoriasis usually occurs in body folds such as the underarms, under breasts, and in the genital area. Symptoms include skin that looks smooth, glossy, and tight.

Both forms of psoriasis can hurt, itch, or crack.

Dermatologists may treat genital psoriasis with topical steroids, generally low-potency formulations for mild to moderate cases. Since the skin of the genital area is thin and extremely sensitive, its important for patients on topical drugs to talk to their doctor immediately about any issues involving pain, bleeding, or stinging, including during urination or defecation.

If topical steroids arent working or are causing side effects, or if the genital psoriasis is severe, doctors might consider oral medication or injectable biologics instead.

Call your dermatologist if you think you are pregnant or actively trying to conceive in order to potentially adjust any medications you are taking, including but not limited to oral medication used for psoriasis, says Soung.

The concern is that certain psoriasis drugs could potentially harm a fetus.

For instance, while doctors dont commonly prescribe the psoriasis medicationacitretin (Soriatane) anymore, women whove taken the drug should wait three years after their last dose before trying to conceive in order to reduce the risk of serious birth defects.

Soung says that pregnant patients should apply high-potency topical steroids sparingly or not at all during pregnancy. She notes that before a breast-feeding session, a patient should use a damp cloth to gently wipe off any steroid creams or ointments on the skin.

In extremely rare cases, people may experiencepustular psoriasis of pregnancy, also known as PPP, a potentially life-threatening condition that requires immediate treatment.

PPP can impact both the pregnant person and the fetus and typically occurs during the third trimester of pregnancy. Skin lesions that look like open, infected sores may start on the stomach or abdomen, then spread.

The NPF estimates that of the nearly 8 million Americans with psoriasis, a third will develop psoriatic arthritis. While the prevalence of psoriatic arthritis is the same in women and men, someresearch has shown that the so-calledburden of disease is greater for women than men: Women tend to have more disease activity, higher levels of joint pain, and lower functional capacity.

Soung says that physicians should keep gender-specific considerations in mind (concerning cardiovascular and bone health, for instance) when prescribing psoriatic arthritis treatment.

Allan Avendao is a Hollywood makeup artist who has psoriasis. He thinks that while people with psoriasis may want the option of camouflaging any plaques on their face with makeup, its important to focus on how cosmetics can showcase your best features.

Here he lays out the basics of apsoriasis-friendly makeup routine:

One last piece of advice: When choosing makeup, listen to your skin. If a certain brand is making you flare up, you may need to switch, a process that may require some trial and error. During a bad flare you might also need to take a short break from cosmetics.

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Psoriasis in Women: Special Concerns - Everyday Health

Seth Singer of Salem, Oregon, was diagnosed with psoriasis at 18. After years of topical steroids, phototherapy, and countless dermatologist appointments, he decided to try a different approach to managing the condition.

Treatment was tedious, and I was constantly looking in mirrors to see if my eyebrow had a huge flake in it, says Singer, now 27. It felt like insanity three years of using ointments every day and being a regular at the dermatologists office and I only achieved a heightened sense of paranoia and insecurity.

Singer turned to products derived from CBD, the component of cannabis that does not produce a high. Today, he uses topical and ingestible CBD products as part of his daily psoriasis treatment routine and is CEO and founder of Muddy Boot Botanicals, a wellness company based in Salem that sells CBD products.

As a treatment for certain skin disorders, CBD has been drawing a lot of attention. Theres general interest in the dermatology community and more and more patients in recent years are asking about CBD, says Adam Friedman, MD, professor and chair of dermatology at George Washington School of Medicine and Health Sciences in Washington, DC.

Studies echo a growing interest in both prescribed and over-the-counter CBD for dermatology and research shows a high level of support among dermatologists.

Although CBD products are widely considered safe, few studies have been performed on humans using CBD, which makes it challenging to determine whether or not CBD can offer improvement, says Geeta Yadav, MD, a dermatologist and the founder of Skin Science Dermatology, in Toronto, Ontario. And while there are many potential benefits to CBD treatment, further study is needed, as is regulation.

CBD is a nonintoxicating cannabinoid (a compound found in cannabis and hemp) that has been studied for years for its medicinal properties.

CBD interacts with the endocannabinoid system in the body which, among other functions, is involved in regulating inflammation, according to Dr. Friedman. The body continuously produces endocannabinoids, and CBD, as a similar cannabinoid, can bind to the same receptors.

We know certain cannabinoids bind to receptors in the human endocannabinoid system that are responsible for inflammation and can downregulate an inflammatory response, says Dr. Yadav. One endocannabinoid in particular, anandamide, can help inhibit the rapid growth of skin cells in the epidermis called keratinocytes, which is a key aspect of psoriasis, she adds.

Research points to the idea that CBD may help reduce inflammation and relieve overall joint pain and discomfort. [CBD] is a promising adjuvant or supplementary treatment, says Yadav. CBD may help reduce plaques and improve the quality of life for those managing psoriatic disease, and in some cases reduce the discomfort caused by psoriatic arthritis.

CBD may also help relieve stress and anxiety. Studies show a strong relationship between psoriasis and anxiety and depression, with the relationship often causing a damaging cycle of flares caused by emotional stress and emotional stress being worsened by successive flare-ups.

In a study published in September 2020 in Cannabis and Cannabinoid Research, CBD was shown to decrease anxiety, which can trigger physical symptoms of psoriasis. We know cannabinoids can have a positive effect on wound healing, and its possible if you improve someones skin disease, anxiety and frustration goes down overall, says Friedman. Chronic inflammation can make you feel down and low energy and have an impact on almost every organ system so when you remove inflammation, you may feel better.

Friedman notes people who may be the best fit to try CBD for treating psoriasis are those who havent seen results with conventional therapies, have a fear of other invasive treatments, or are looking for a natural alternative or complement to conventional treatment.

Psoriasis can be challenging to treat because it can affect so many aspects of a persons life, says Yadav. Newer targeted prescription therapies like biologics can be safe and clear the skin, but that doesnt take away the lifestyle factors that can trigger psoriasis like anxiety and stress.

CBD comes in many forms edibles, oils, ointments, tinctures, and more. Each has different potential physical and mental benefits that cater to individual needs in regards to the percentage of CBD, type of product, and frequency of use.

Its crucial to note not all products marketed as CBD treatments are made of pure CBD, nor do all products accurately list their percentages and ingredients.

Concern arises from the lack of current approval from the U.S. Food and Drug Administration and related oversight. CBD is not regulated in the United States, meaning products formulated with CBD are not subject to testing, including testing that would accurately determine the percentage of CBD in the formula, says Yadav. This makes it challenging to find products that are of medical quality.

Another problem arises with companies that add other ingredients to their products that may trigger a negative reaction. Some people, for example, may experience an allergic reaction to vapors or contact dermatitis from topicals.

Its important to make sure there are no impurities in what you buy, says Friedman. He recommends checking the Department of Health website in your state that covers medical marijuana and cannabis to learn more about products and companies.

Some clinical trials have also found evidence that high concentrations of CBD may have the potential to damage the liver. But these are preliminary findings and the doses of CBD found to affect the liver were extremely large, according to Friedman. Over-the counter CBD or whats sold or recommended from an oral CBD perspective usually 500 milligrams once or twice a day is well below the threshold where they saw liver complications in clinical trials.

Theres little doubt CBD has potential as a supplementary or alternative treatment for psoriasis. That said, its important to do your own research, speak to your doctor, and only use well-researched products that fit your lifestyle and treatment goals.

Its not buyer beware, its buyer be mindful, says Friedman. Be a conscientious buyer know what you need to ask and think about when youre buying these products.

Seth Singer stresses that while CBD has not been a cure-all, its become an important part of his treatment. I do my best to learn about my own body and approach treatment from a holistic, guided approach. I believe it is a variety of good choices, not just CBD, thats fueling my ability to ward off flare-ups and heightened achiness.

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What to Know About CBD for Treating Plaque Psoriasis - Everyday Health