Category Archives: Psoriasis

PRINCETON, N.J., April 22, 2021 /PRNewswire/ --Sun Pharmaceutical Industries Inc., USA (Sun Pharma) today announced that 12 data abstracts for ILUMYA (tildrakizumab-asmn) in patients with moderate-to-severe plaque psoriasis will be presented at the American Academy of Dermatology Virtual Meeting Experience (AAD VMX) 2021, taking place April 23-25. The data to be highlighted at this year's meeting reinforce Sun Pharma's commitment to continuing to research the long-term efficacy and safety of ILUMYA, one of the most studied IL-23 inhibitors in market.

Click to TweetNEWS: @SunPharma_Live announces 12 data abstracts revealing long-term sustained efficacy and safety results for its treatment in moderate-to-severe plaque psoriasis at #AADVMX2021. Read more: bit.ly/3tu3UmR

"We are proud to be presenting data abstracts on ILUMYA for patients with moderate-to-severe plaque psoriasis at this year's AAD VMX," said Abhay Gandhi, CEO, Sun Pharma, North America. "The data being presented underscore our dedication to providing ongoing clinical insights into the long-term efficacy and safety of ILUMYA, an IL-23 inhibitor that helps balance the immune system from the inside out to help patients keep their moderate-to-severe plaque psoriasis under control."

ILUMYA abstracts to be presented at AAD VMX 2021

*Abstract sponsored byAlmirallwho marketstildrakizumab-asmnin the EU.

The AAD Virtual Meeting Experience 2021 is accessible via registration here.

About thereSURFACEExtensionStudies

The Phase-3 studies (reSURFACE 1 and reSURFACE 2) were randomized, placebo-controlled, multicenter, three-part studies designed toevaluateefficacyand safetyof ILUMYA100 mg and 200 mgin moderate-to-severe plaque psoriasis compared to placebo and comparative drugand to assess safety and tolerability.Participants with at least a PASI 50 response at base study completion who received ILUMYA within 12 weeks of base study end (week52 or64) were eligible to enroll in the extension study andcontinuedonthe same ILUMYA dose once every 12 weeks.Researchers evaluated PASI responses and PGA score of 0 or 1 with 2 grade reduction from baseline, and incidence rates for adverse events, including severe infections, cardiovascular events, and drug-related hypersensitivities.

About ILUMYA(tildrakizumab-asmn)

ILUMYA (tildrakizumab-asmn) is a humanized lgG1/k monoclonal antibody designed to selectively bind to the p19 subunit of interleukin-23 (IL-23) and inhibit its interaction with the IL-23 receptor, leading to inhibition of the release of pro-inflammatory cytokines and chemokines. ILUMYA is indicated for the treatment of adults with moderate-to-severe plaque psoriasis who are candidates for systemic therapy or phototherapy, in the United States. ILUMYAhas also been approved for moderate-to-severe plaque psoriasis in Australia and Japan, and under the brand name ILUMETRI in Europe.

IMPORTANT SAFETY INFORMATION

ILUMYA is contraindicated in patients with a previous serious hypersensitivity reaction to tildrakizumab or to any other excipients.

Cases of angioedema and urticaria occurred in ILUMYA-treated subjects in clinical trial. If a serious hypersensitivity reaction occurs, discontinue ILUMYA immediately and initiate appropriate therapy.

ILUMYA may increase the risk of infection. Treatment with ILUMYA should not be initiated in patients with a clinically important active infection until the infection resolves or is adequately treated. Consider the risks and benefits of treatment prior to prescribing ILUMYA in patients with a chronic infection or a history of recurrent infection. Instruct patients receiving ILUMYA to seek medical help if signs or symptoms of clinically important chronic or acute infection occur. If a patient develops a clinically important or serious infection, or is not responding to standard therapy, closely monitor and discontinue ILUMYA until the infection resolves.

Evaluate patients for TB infection prior to initiating treatment with ILUMYA. Do not administer ILUMYA to patients with active TB infection. Initiate treatment of latent TB prior to administering ILUMYA. Consider antiTB therapy prior to initiation of ILUMYA in patients with a past history of latent or active TB in whom an adequate course of treatment cannot be confirmed. Patients receiving ILUMYA should be monitored closely for signs and symptoms of active TB during and after ILUMYA treatment.

Prior to initiating therapy with ILUMYA, consider completion of all age-appropriate immunizations according to current immunization guidelines. Patients treated with ILUMYA should not receive live vaccines.

Most common (1%) adverse reactions associated with ILUMYA include upper respiratory infections, injection site reactions, and diarrhea. Adverse reactions that occurred at rates less than 1% but greater than 0.1% in the ILUMYA group and at a higher rate than in the placebo group included dizziness and pain in extremity.

About Sun Dermatology

Sun Dermatology (the branded dermatology division of Sun Pharmaceutical Industries Inc. in the United States) is committed to expanding its dermatology portfolio to bring more treatment options and ongoing support for healthcare providers and patients around the world. For more than 30 years, it has been dedicated to advancing the science of dermatology for a variety of conditions like plaque psoriasis, severe nodular acne, minimally to moderately thick actinic keratoses of the face, scalp or upper extremities, and locally advanced basal cell carcinoma. Sun Pharmaceutical Industries Ltd., along with its subsidiaries, is ranked second in dermatology prescription volume within the U.S. per IQVIA and is the fourth largest specialty generic pharmaceutical company globally.

About Sun Pharmaceutical Industries Inc., USA

Sun Pharma is a wholly owned subsidiary of Sun Pharmaceutical Industries Limited (SPIL). SPIL is the world's fourth largest specialty generic pharmaceutical company and India's top pharmaceutical company. A vertically integrated business and a skilled team enables it to deliver high-quality products, trusted by customers and patients in over 100 countries across the world, at affordable prices. Its global presence is supported by manufacturing facilities spread across 6 continents and approved by multiple regulatory agencies, coupled with a multi-cultural workforce comprising over 50 nationalities. SPIL fosters excellence through innovation supported by strong R&D capabilities across multiple R&D centers, with investments of approximately 6% of annual revenues in R&D. For further information, please visit http://www.sunpharma.com & follow us on Twitter @SunPharma_Live.

DisclaimerStatements in this "Document" describing the Company's objectives, projections, estimates, expectations, plans or predictions or industry conditions or events may be "forward looking statements" within the meaning of applicable securities laws and regulations. Actual results, performance or achievements could differ materially from those expressed or implied. The Company undertakes no obligation to update or revise forward looking statements to reflect developments or circumstances that arise or to reflect the occurrence of unanticipated developments/circumstances after the date hereof.

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Gaurav Chugh

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+91 22 4324 4324, Xtn 5373

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SOURCE Sun Pharma

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Sun Pharma to Present Clinical Data Abstracts for ILUMYA (tildrakizumab-asmn) in Patients with Moderate-to-Severe Plaque Psoriasis at the AAD Virtual...

WESTLAKE VILLAGE, Calif., April 19, 2021 (GLOBE NEWSWIRE) -- Arcutis Biotherapeutics, Inc.(Nasdaq: ARQT), a late-stage biopharmaceutical company focused on developing and commercializing treatments for unmet needs in immune-mediated dermatological diseases and conditions, or immuno-dermatology,will present new data from three studies evaluating the safety, efficacy, and tolerability of its once-daily, topical roflumilast cream and foam at the American Academy of Dermatology Virtual Meeting Experience (VMX) April 23 - 25,2021.

Patients suffering from plaque psoriasis, scalp psoriasis, and seborrheic dermatitis have significant unmet needs given the lack of efficacious, safe, tolerable topical options for long-term use, said Patrick Burnett, M.D., Ph.D., FAAD, Chief Medical Officer, Arcutis. We are pleased to share these new data that further reinforce the potential of roflumilast cream and foam in various inflammatory skin diseases. If approved by the FDA, our therapies could change the treatment paradigm for patients and their providers in addressing challenging inflammatory dermatological conditions that can significantly impact quality of life.

The data include positive results from a Phase 2b study of roflumilast foam for the treatment of scalp and body psoriasis, as well as a Phase 2 study of roflumilast foam in patients with seborrheic dermatitis.

Two additional poster slide presentations will feature sub-analyses from the previously published Phase 2b study of roflumilast cream in the treatment of chronic, mild-to-severe plaque psoriasis: 1) the correlation of itch response toroflumilast creamwithdisease severity andpatient-reported outcomes, and 2) the treatment of steroid-sensitive areas of the body including the face, neck, and intertriginous areas.

Finally, Dr. Kim Papp will present results from a new measurement, PASI-HD, which he developed in conjunction with the Arcutis medical team and which was used in the Phase 2b study of roflumilast cream in plaque psoriasis. In areas where the affected body surface area is low (<10%), PASI-HD better distinguishes disease severity than the traditional Psoriasis Area and Severity Index (PASI), which is a gold standard measure in psoriasis clinical trials.

Details of Arcutis AAD Virtual Congress presentations include:

Roflumilast is a highly potent phosphodiesterase-4 (PDE4) inhibitor in development for plaque psoriasis (PsO). Arcutis is investigating roflumilast as a once-daily, nonsteroidal, topical treatment for plaque psoriasis, atopic dermatitis, seborrheic dermatitis, and scalp psoriasis.

For more information, visithttps://www.arcutis.comor follow the company onLinkedInandTwitter. Join the conversation with the hashtag #AADVMX2021.

About PsoriasisPsoriasis is a common, non-contagious, immune-mediated skin disease that affects approximately 8.6 million patients in the United States. About 90% of patients develop plaque psoriasis, which is characterized by raised, red areas of skin covered with a silver or white layer of scale. Psoriatic plaques can appear on any area of the body, but most often appear on the scalp, knees, elbows, trunk, and limbs, and are often itchy and sometimes painful.

Scalp psoriasis is a manifestation of plaque psoriasis characterized by plaques in the hair-bearing area of the scalp and sometimes extending to the forehead, back of the neck, or behind or inside the ears. Patients with scalp psoriasis commonly have plaques on other areas of the body as well. Scalp psoriasis is present in nearly half of Americans with psoriasis. As with psoriatic plaques on other parts of the body, scalp psoriasis is often itchy and sometimes painful. It can also be associated with hair loss.

About Seborrheic DermatitisSeborrheic dermatitis affects more than 10 million people in the United States, and is a common, chronic, or recurrent inflammatory skin disease that causes red patches covered with large, greasy, flaking yellow-gray scales, and persistent itch. Seborrheic dermatitis occurs most often on the scalp, face (especially on the nose, eyebrows, ears, and eyelids), upper chest, and back.

About Topical Roflumilast Cream and FoamRoflumilast Cream and Foam are once-daily, topical formulations of a highly potent and selective PDE4 inhibitor (roflumilast). The foam formulation was developed to treat inflammatory dermatoses in hair-bearing areas of the body, such as the scalp, although it is usable in all areas of the body. Roflumilast has been approved by the U.S. Food and Drug Administration (FDA) for oral treatment to reduce the risk of exacerbations of chronic obstructive pulmonary disease (COPD) since 2011. Roflumilast has shown greater potency (25- to 300-fold) than the two other FDA-approved PDE4 inhibitors for dermatology. PDE4 is an intracellular enzyme that increases the production of pro-inflammatory mediators and decreases production of anti-inflammatory mediators and has been implicated in a wide range of inflammatory diseases including psoriasis, atopic dermatitis, and COPD. PDE4 is an established target in dermatology, and other PDE4 inhibitors have been approved by the FDA for the topical treatment of atopic dermatitis and the systemic treatment of plaque psoriasis.

About ArcutisArcutis Biotherapeutics, Inc. (Nasdaq: ARQT) is a late-stage biopharmaceutical company focused on developing and commercializing treatments for unmet needs in immune-mediated dermatological diseases and conditions, or immuno-dermatology. The company is leveraging recent advances in immunology and inflammation to develop differentiated therapies against biologically validated targets to solve persistent treatment challenges in serious diseases of the skin. Arcutis robustpipelineincludes four novel drug candidates currently in development for a range of inflammatory dermatological conditions. The companys lead product candidate, topical roflumilast, has the potential to revitalize the standard of care for plaque psoriasis, atopic dermatitis, scalp psoriasis, and seborrheic dermatitis. For more information, visithttps://www.arcutis.comor follow the company onLinkedIn andTwitter.

Forward Looking StatementsThis press release contains "forward-looking" statements, including, among others, statements regarding the potential for roflumilast to revolutionize the standard of care in plaque psoriasis and other inflammatory dermatological conditions. These statements involve substantial known and unknown risks, uncertainties and other factors that may cause our actual results, levels of activity, performance, or achievements to be materially different from the information expressed or implied by these forward-looking statements and you should not place undue reliance on our forward-looking statements. Risks and uncertainties that may cause our actual results to differ include risks inherent in the clinical development process and regulatory approval process, the timing of regulatory filings, and our ability to defend our intellectual property. For a further description of the risks and uncertainties applicable to our business, see the "Risk Factors" section of our Form 10-K filed with U.S. Securities and Exchange Commission (SEC) on February 16, 2021, as well as any subsequent filings with the SEC. We undertake no obligation to revise or update information herein to reflect events or circumstances in the future, even if new information becomes available.

Investor and Media Contact:Heather Rowe Armstrongharmstrong@arcutis.com805-418-5006 ext. 740

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Arcutis Biotherapeutics to Present New Roflumilast Data at The American Academy of Dermatology (AAD) Virtual Meeting Experience (VMX) - GlobeNewswire

Inflammatory skin conditions may be associated with higher risk for COVID-19, study data published in the Journal of Allergy and Clinical Immunology suggests. In a subsequent gene expression analyses, shared genetic components were also identified in certain skin conditions and the immune response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

Investigators conducted an epidemiological study of patients with COVID-19 followed by an analysis of bronchial epithelial cells infected with SARS-CoV-2. Medical records data were extracted from a health system in Michigan. COVID-19 and inflammatory skin conditions were identified using the appropriate diagnostic codes. Multiple logistic regression was used to identify the medical comorbidities were associated with COVID-19 and with severe disease outcomes. Models were adjusted for age, sex, race/ethnicity, obesity, and socioeconomic status. For the transcriptome analysis, investigators compared gene expression across 9 inflammatory skin conditions and bronchial epithelial cells infected with SARS-CoV-2. Data were also abstracted from a prior genetic meta-analysis of COVID-19 susceptibility to identify potential shared loci between COVID-19 and inflammatory skin conditions.

Medical data were available for 1115 patients with COVID-19, of whom 105 (9.4%) had acne, 38 (3.4%) had atopic dermatitis, 36 (3.2%) had psoriasis, and 35 (3.1%) had rosacea. In logistic regression models, atopic dermatitis (odds ratio [OR], 1.48; 95% confidence interval [CI], 1.06-2.06; P =.020) and psoriasis (OR, 1.48; 95% CI, 1.06-2.07; P =.0.22) were associated with increased odds of COVID-19. However, inflammatory skin conditions appeared to be associated with lower risk for severe COVID-19 outcomes. Specifically, having any skin condition appeared to substantially decrease the odds for ventilation (OR, 0.22; 95% CI, 0.11-0.47; P = 8.5 10-5).

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In the transcriptome portion of the study, substantial overlap was observed in gene expression between bronchial epithelial cells infected with SARS-CoV-2 and lesion cells with inflammatory skin disease. In addition, epidermal differentiation complex (EDC) genes were found to be upregulated in both SARS-CoV-2 infection and in inflammatory skin conditions. A shared locus in the EDC was also detected between psoriasis and COVID-19 infection (P = 3.3 10-7).

Findings from this multi-omics study underscore a potential association between inflammatory skin conditions and COVID-19. Interestingly, diagnosis with psoriasis or atopic dermatitis appeared to decrease the risk for ventilation with COVID-19. Preliminary genetic data also highlight a potential shared genomic component. [Although] the epidemiological and genetic findings require additional validation and replicationthis work will serve as an important study to reveal individuals that are more susceptible to infection of SARS-CoV-2, and how their pre-existing conditions may affect the course of the disease, investigators wrote.

Disclosure: Two study authors declared affiliations with the pharmaceutical industry

Please see the original reference for a full list of authors disclosures.

Patrick MT, Zhang H, Wasikowski R, et al. Associations between COVID-19 and skin conditions identified through epidemiology and genomic studies Published online January 21, 2021. J Allergy Clin Immunol. doi: 10.1016/j.jaci.2021.01.006

This article originally appeared on Dermatology Advisor

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Investigating the Relationship Between Inflammatory Skin Diseases and COVID-19 - Rheumatology Advisor

Rich Insights into Plaque Psoriasis Market, Patient Pool, Pipeline Therapies, Key Companies working in the Space and Emerging Trends

DelveInsights Plaque Psoriasis Market Insights Report offers a detailed analysis of disease, its causes, symptoms, diagnostics modalities and treatment options.

The report also offers comprehensive insights into Plaque Psoriasis market size, epidemiology, emerging therapies, market drivers, market barriers, ongoing clinical trials, key collaboration in the space, and key pharmaceutical companies actively pushing the growth of market size forward.

Some of the key highlights from the Plaque Psoriasis Market Insights:

Learn more by requesting for sample @ Plaque Psoriasis Market Landscape

Plaque Psoriasis: Overview

Psoriasis is a common skin condition that speeds up the life cycle of skin cells. It causes cells tobuild up rapidly on the surface of the skin. The extra skin cells form scales and red patches that are itchy and sometimes painful.

The characteristic signs and symptoms of psoriasis are small scaly, red bumps. These bumps generally join together into elevated plaques of skin and most often are visible on the elbows, knees, and scalp, although any area of skin can be involved. Frequently, these plaques are quite itchy. Rarely, most of the patients skin surface is affected.

For more insights into Disease, causes and treatment, reach out @ Plaque Psoriasis Treatment Landscape

Plaque Psoriasis Epidemiology Segmentation

The Plaque Psoriasis Market report proffers epidemiological analysis for the study period 2017-30 in the 7MM segmented into:

Visit for more @ Plaque Psoriasis Epidemiological Insights

Plaque Psoriasis Market

Plaque Psoriasis Market size is expected to expand owing to the launch of several emerging therapies, key companies working in the space, rising prevalence, increment in R&D in the field, medical advancements happening in the Plaque Psoriasis market domain.

Plaque Psoriasis Pipeline Therapies and Key Companies

For more information, visit Plaque Psoriasis Market Analysis, Patient Pool and Emerging Therapies

Plaque Psoriasis Market Drivers

Scope of the Report

Key Questions Answered in the Report

Get in touch with our Business executive @ Plaque Psoriasis Market Landscape Analysis

Table of Contents

Learn more about the report offerings @ Plaque Psoriasis Market Outlook

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Rich Insights into Plaque Psoriasis Market, Patient Pool, Pipeline Therapies, Key Companies working in the Space and Emerging Trends Wall Street Call...

Psoriasis Drugs Market

Global Psoriasis Drugs Market Insights, Forecast To 2027 provides a specific tool for evaluating the global market, specifying the growth potentials, and supporting tactical and strategic decision-making. This report identifies that in this quickly developing and competitive world, the latest marketing information is essential, in order to monitor performance and make strategic decisions for development and profitability. This report provides information on the overall market trends and development patterns, as well as focuses on the markets and materials, capacities and technologies, and on the dynamic nature of the Psoriasis Drugs market.

UCB, Amgen, Novartis, AbbVie, Johnson & Johnson, Cytech Industries, Merck

The Psoriasis Drugs Market is separated according to Types and End Users.

On the basis of the Types, the market is classified as:Interleukin Inhibitors, Tumor Necrosis Factor Inhibitor, Others,

On the basis of the application, the market is classified as:Topicals,Systemic,Biologics,

For market chain analysis, the report focuses on the upstream raw materials, downstream demand analysis, distribution/marketing channels, market trends, governing factors, development patterns, and proposals, which particularly include relevant data on the Psoriasis Drugs key applications and consumption, major geographies, consumption and production rate, supply chain relationship analysis, major global distributors, major raw material suppliers and manufacturing equipment suppliers, key consumers, as well as the contact information of all the major suppliers and distributors.

2015

2020

2027

Share (%)

This report assesses the growth rate and the market value on the basis of the key Psoriasis Drugs market dynamics, as well as the growth inducing factors. The complete study is based on the up-do-date industry news, growth potentials, and market trends. It also contains an in-depth analysis of the market and competitive scenario, together with the SWOT analysis of the leading competitors.

This research Psoriasis Drugs study consists of the historical data from 2015 to 2020 and forecasts until 2027, which makes it a valuable source of information for all the individuals looking for relevant market information in readily accessible documents with clearly presented graphs and statistics, including but not limited to the industry executives, analysts, consultants, and marketing, sales, and product managers.

Mention your questions here to receive a call from our industry experts@sales@regalintelligence.com

About Us:We, Regal Intelligence, aim to change the dynamics of market research backed by quality data. Our analysts validate data with exclusive qualitative and analytics driven intelligence. We meticulously plan our research process and execute in order to explore the potential market for getting insightful details. Our prime focus is to provide reliable data based on public surveys using data analytics techniques. If you have come here, you might be interested in highly reliable data driven market insights for your product/service, reach us here 24/7.

Contact Us:Regal Intelligence: http://www.regalintelligence.comPh no: +1 231 930 2779 (U.S.) | +44 141 628 8787 (UK)

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Key Vendors of Psoriasis Drugs Market: UCB, Amgen, Novartis, AbbVie, Johnson & Johnson, and others The Courier - The Courier

Strictly Come Dancing star Aljaz Skorjanec has revealed the huge impact skin condition psoriasis has had on both his confidence and his time on the BBC show.

Speaking exclusively to Entertainment Daily, Aljaz revealed hes suffered from the skin condition for 10 years but only decided to speak about it for the first time this year.

He said that he hopes that hell break the taboo by talking about it and help others suffering from the same complaint.

Aljaz revealed that hes suffered from psoriasis since he was in his early twenties and he said its been exacerbated by work over the years.

Right when I turned 20, thats when I started getting patches on my elbows and my knees and that progressed with work.

Read more: Gregory Piper joins rumoured line-up for Strictly 2021

Touring is stressful on your body with all the travel and it was getting worse and worse.

I used to have to manage it with different creams as well as steroid creams that tend to help it over a short period of time. But as soon as you stop using them it comes back and comes back worse.

Aljaz added that it has had a huge impact on him, both mentally and physically.

We always see ourselves and our imperfections more than others and its a huge confidence killer, he admitted.

I would avoid wearing T-shirts, wearing shorts in public is one of the biggest no-nos of the last 10 years for me.I always cover it up.

Four years ago it flared up just before Strictly and I pretty much wore turtlenecks for the whole season.

But the team are so understanding, theres never a problem. Theyve always been really supportive and put me in long-sleeved tops if that makes me feel more comfortable.

And Janette has been my rock. She is so supportive.

However, Aljaz has recently been working with Medovie and, after using the products, he said he noticed an almost immediate difference.

Read more: Oti Mabuse confirms shes leaving Strictly after the 2021 series

This is the first time in my life I can manage it and stay on top of it without using these very aggressive steroid creams.

When it appears on your face it gets a bit tricky with what you want to put on it, you dont want to make it worse.But I tried it for almost a month it was amazing.

When it comes to Strictly, make-up, sweat and the stress on the body made things worse for Aljaz.

He admitted: I let the team know on Strictly that its better for my skin to use natural products if possible because they dont have as many chemicals.

But its when you take the make-up off that my skin is irritated the most.

Its always the worst on the days after shows after youve been sweating and on your feet the longest and putting your body through stress.

However, the dancer isnt letting that put him off of signing up for another series.

He and wife Janette Manrara have confirmed theyll appear in the 2021 series and theyre very excited for it all to kick off.

So how much longer will the couple stick around?

I dont know. We always say as long as they want to have us on the show.

The show is such a big part of our careers. I dont see myself stopping any time soon, but well see.

You never know what life brings. But Strictly has been amazing and I wouldnt change it for anything.

Strictly is, for now, definitely the priority in our lives. Hopefully were going to stay there for a little bit longer.

Strictly is, for now, definitely the priority in our lives. Hopefully were going to stay there for a little bit longer.

However, once his time on the dance floor is up, Aljaz does have one ambition.

In 10 years it would be lovely to be the first Slovenian judge of Strictly Come Dancing, he said.

Away from the show Aljaz admitted hes always loved the radio something former partner Gemma Atkinson helped to fuel.

He said: Ive always loved it, it was my dream to be on the radio. When I danced with Gemma she was doing her radio show and Id go in with her and I fell in love with that industry and type of work.

I know Janettes huge dream is to be a presenter one day.

The couple have one of the strongest marriages in showbiz, with Aljaz admitting there isnt one celebrity who Janette would feel jealous of him dancing with.

The word curse, it seems, just isnt in their vocabulary.

He does have a dream partner hed love to be paired with on the show, though.

Id love to be paired with Janette one day. That would be lovely.

We wouldnt have to train as much, it would be lovely, he laughed.

Asked whod be the boss of the partnership, Aljaz confirmed: Janette would be in charge, definitely. She isnt here with me now but the answer would be the same if she was here or not Janette.

There is another lady the dancer has in his sights though, although wed take our hats off to the BBC if they managed to sign her

Ive actually thought about it before, we should have a royal season one year, Aljaz mused.

Obviously it would be an incredible opportunity to dance with the Queen but Im not sure she would be up for doing Strictly.

Im a huge admirer of the royal family, I always have been. Im sure there would be a few of us fighting to dance with the Queen.

Medovie is a new skincare brand, backed by science that provides long-term solutions to skin conditions. For more, visit the website here.

Head to our Facebook page @EntertainmentDailyFix and tell us what you think of our story.

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Aljaz Skorjanec admits 'huge impact' his illness has had on his confidence and how it's affected him on Strictly - Entertainment Daily

Psoriasis is a skin condition that can cause areas of skin to become flushed, inflamed, and flaky.

The appearance of psoriatic lesions may cause a person to feel anxious, depressed, or embarrassed. However, resources are available that may help people manage these conditions.

Scientists do not fully understand the link between psoriasis and anxiety or depression. However, some research has suggested that psoriasis and mental health conditions are strongly linked.

In one study, researchers found that several factors, including a persons age at psoriasis onset, can directly affect social anxiety and depression.

They found that people who developed psoriasis before the age of 18 years experienced social anxiety related to feelings of stigmatization.

They also found that people who developed psoriasis after the age of 18 years developed social anxiety related to feelings of their appearance affecting their self-worth.

Social anxiety disorder is a type of anxiety disorder. A person with social anxiety and psoriasis may not want to spend as much time with friends or family due to possible feelings of embarrassment or shame.

According to the National Institute of Mental Health, social anxiety can cause a person to:

There is also a strong link between stress and psoriasis.

The American Psychological Association (APA) describes a fine line between stress and anxiety.

Both cause similar symptoms, but stress is typically a response to a trigger, such as overworking or having exposure to conflict. On the other hand, anxiety is associated with long-term worry over situations with no obvious triggers related to a specific situation.

Some research has suggested that perceived stress does not affect the severity of psoriasis symptoms. However, the researchers noted that stress can increase the level of perceived impact on a persons daily life. They also stated that people who associated psoriasis with psychological factors such as stress were more likely to be anxious.

The National Psoriasis Foundation states that stress can affect the severity of psoriasis symptoms and make itchiness worse. As a result, it recommends that individuals manage stress as part of their overall treatment plan.

Having psoriasis can cause a person to develop anxiety.

The APA defines anxiety as persistent and excessive worries that continue and do not go away even with no stressor causing the worry.

Anxiety affects people in several ways. It may lead to:

For example, a person with psoriasis may avoid going to a social gathering because they believe that others may make fun of them or find their psoriasis gross.

By avoiding social gatherings, the person may feel more alone and could develop symptoms of depression due to social isolation.

Psoriasis is a condition independent of stress or anxiety. However, stress or anxiety can trigger or worsen psoriasis symptoms.

One study has suggested that anxiety and psoriasis have a cyclical relationship. This means that psoriasis can cause anxiety and that anxiety can cause the symptoms of psoriasis to worsen.

As a result, a person with both conditions may notice symptoms of psoriasis during a period of stress or anxiety.

The Psoriasis and Psoriatic Arthritis Alliance provides several strategies to help a person deal with general anxiety and social anxiety. These include taking steps such as:

A person can also ask a doctor about mental health services. They may recommend a psychologist or psychiatrist to help the person cope with stress and anxiety related to psoriasis.

The National Psoriasis Foundation offers a service called One to One. It connects people with psoriasis to mentors who can help them learn to cope with the condition. This may be helpful for people who feel that they do not have anyone to relate to.

Psoriasis is linked to several mental health conditions, including anxiety, stress, and depression. Some evidence has suggested that anxiety and stress can trigger psoriasis flares and that psoriasis flares can trigger anxiety or stress.

A person with psoriasis should work with a healthcare professional to develop effective mental health treatments so that they can live their life without fear of social stigmatization or negative judgment.

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Psoriasis and social anxiety: What is the link? - Medical News Today

Living with a chronic condition can be stressful. Thats especially true of any visible condition, like psoriasis.

Psoriasis is an autoimmune disease that causes inflammation in the body and red, scaly, itchy patches on the skin. Often, these patches are in visible places like the knees, elbows, and scalp.

While theres no cure for psoriasis, treatments can prevent skin flares and relieve related stress.

The connection between stress and psoriasis is complex, and it goes both ways. Stress is a known trigger of psoriasis flares. And people who develop these patches may stress about the way psoriasis makes them look and feel.

Could stress actually cause psoriasis? In and of itself, stress is not going to be something that causes psoriasis to develop out of the blue, says Evan Rieder, MD, assistant professor of Dermatology at NYU Langone Health.

He adds, But it could cause a flare of the disease in someone who is already genetically predisposed to having psoriasis.

Researchers have discovered more than 80 genes linked to psoriasis. When your relatives have this condition, youre more likely to get it. If both of your parents have it, your risk is 75 percent. If only one parent has it, your risk is 15 percent.

Exactly why stress causes flares, researchers dont know. People with psoriasis seem to have a problem with the hypothalamic-pituitary-adrenal (HPA) axis, the system that controls their bodys reaction to stress.

They have lower levels of the stress hormone cortisol, which normally helps tame inflammation. So when they are under stress, inflammation starts, and psoriasis flares up.

The stress of living with psoriasis can escalate this process and make symptoms even worse. Psoriasis patches are itchy and cause discomfort. There is also a stigma from having plaques on your skin.

People you meet might react to the redness by making comments or by shrinking away from touching you. You can imagine what that does to someones self-esteem, Rieder says.

One effective way to manage stress is with relaxation techniques such as meditation and deep breathing. Exercise is also a good stress reliever, and its great for boosting self-esteem.

Hypnosis and biofeedback are other techniques to help ease stress. It takes regular practice of relaxation techniques for them to be effective.

Self-advocacy is important when it comes to managing psoriasis, according to Rieder. Your dermatologist may focus only on your skin and not ask questions about your mental health.

People with psoriasis can get depression and anxiety, and it doesnt necessarily correlate with whats going on with their skin. Their skin can look clear, he says.

In addition to seeing your dermatologist, he recommends talking to a therapist. Focus on whatever is getting in the way of you being able to live your best life, he says.

You might want to consider seeing a therapist who has experience working with people with psoriasis or other chronic conditions.

A support group is a place where you can connect with other people who have psoriasis, and learn from their experiences. I think they can be very helpful, Rieder says. Unless youre living with the condition, its very hard to truly empathize.

Support groups are held in places like hospitals, community centers, and churches. Youll also find them online. The best place to start looking for a support group is through an organization like the National Psoriasis Foundation.

It may be hard to talk to people about your psoriasis, even those closest to you. But starting the conversation can help the people that love you most give you the support you need.

For people in your outer circle, your explanation can be brief and to the point. Say something like, Its not infectious and you cant get it from me, Rieder suggests.

Be more open and honest with friends and family. Help them understand what its like for you to live with this disease. Once they understand, they can be better allies.

Having clearer skin can go a long way toward emotional improvement. When youre less stressed about your skin, you may find you get fewer flares.

At least one psoriasis treatment biologic drugs serves double duty. Biologics are genetically engineered medications that target certain molecules in the body involved in causing inflammation, helping your immune system to operate properly.

In the case of psoriasis, these medications help relieve depression and improve quality of life while they clear the skin.

You have many options for treating psoriasis. The treatment dermatologists usually try first is a topical steroid, which slows cell production and brings down inflammation in your skin. Other, nonsteroidal topicals include anthralin, synthetic vitamin D3, and vitamin A.

Phototherapy exposes your skin to UV light to stop skin cells from growing. You can get this treatment at your doctors office or at home.

Systemic (body-wide) treatments such as biologics, methotrexate, and cyclosporine stop your immune system from causing inflammation in your skin. You may get one of these treatments if your psoriasis is severe or it doesnt respond to topical treatments.

The key to getting on the right treatment is to find a doctor you trust. Make sure you see a board certified dermatologist and get the best recommendations, Rieder says.

Psoriasis is a difficult condition to live with, but theres never been a better time to live with psoriasis. We can get people clear or almost clear in the majority of cases.

These treatments can really improve peoples quality of life and the way that they feel, he adds.

Stress and psoriasis are closely linked. Youre more likely to have flare-ups when youre stressed, and psoriasis can increase your stress levels.

Seeing a dermatologist and getting on the right treatment can lead to clearer skin and less stress. A counselor or other mental health provider will help you manage the emotional symptoms of psoriasis while your treatment goes to work.

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Stress and Psoriasis: What's the Link? - Healthline

Several research articles have shown a positive association between psoriasis and thyroid diseases, including Hashimotos thyroiditis (hypothyroidism) and Graves disease (hyperthyroidism), but the limited number of studies do not provide a complete explanation to prove this association, according to a review study published in Cureus.

This review study included 45 articles that featured psoriasis, hypothyroidism, thyroid function tests, propylthiouracil, and psoriatic arthritis as inclusion keywords. Medical Subject Headings keywords psoriasis, hypothyroidism, and autoimmunity were also imputed into PubMed to identify the relevant articles for review.

A total of 39 of the 45 articles included in this review study demonstrated a positive association between psoriasis and thyroid diseases, although 6 articles found no association.

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In 5 articles, researchers showed that thyroid hormones had an effect on the development of psoriasis. Other articles demonstrated that genetic, immunological, and inflammation were involved in the associations. Reactive oxygen species-related pathogenesis was also reported in 2 articles. In 5 articles, there were reports of positive thyroid peroxidase antibodies, thyroglobulin antibodies, and Hashimotos thyroiditis ultrasound features in patients with psoriasis.

Marked improvement was observed in psoriatic skin lesions following thyroidectomy in 2 articles. In addition, the investigators of this review found that first-line propylthiouracil for hyperthyroidism reportedly clears psoriatic lesions, according to findings in 6 articles. Propylthiouracil did not appear to induce clinical hypothyroidism or lead to any serious adverse effects. The researchers of this review study suggest propylthiouracil could be prescribed as an alternative therapy for patients with psoriasis due to its side effects compared with existing psoriasis treatments that are typically toxic and expensive.

The investigators also noted that a higher prevalence of the association between psoriasis and thyroid diseases in women was reported in some of the articles. However, some articles found no sex preference involved in the prevalence of the association.

Limitations of this study included the small number of articles available for review as well as the lack of a pooled meta-analysis of the data.

The investigators concluded that additional studies are required to establish a connection between these diseases because these findings have a significant impact on both the clinical and research sides.

Eapi S, Chowdhury R, Lawal OS, Mathur N, Malik BH. Etiological association between psoriasis and thyroid diseases. Cureus. 2021;13(1):e12653. Published 2021 Jan 12. doi:10.7759/cureus.12653

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Is There an Association Between Psoriasis and Thyroid Disease? - Dermatology Advisor

Learning about the relationship between diet and inflammation helped me make long-term changes and have fewer flare-ups.

After suffering from early-onset arthritis and thick, scaly, itchy patches of skin on my hands for years, some recent unexplained changes in my fingernails led me to request a referral to a rheumatologist.

X-rays and bloodwork confirmed my suspicions I have psoriatic arthritis (PsA).

While my 20-year search for an answer was over, the fight to reduce the inflammation causing my pain was just beginning.

I knew from experience that sugar was a trigger for my joint pain, and for years Id eaten a healthy Mediterranean diet.

But were there other foods that might be contributing to the sudden flare-ups that I experienced?

After reading about the success of others who had tried Whole30, a popular elimination diet, I decided it was worth finding out.

Whole30 isnt a weight loss diet. Its a short-term eating program, created by Melissa Hartwig Urban in 2009, to help people change their relationship with food and determine whether specific foods may be negatively impacting their health.

For 30 days, the following foods are off-limits:

Whats left is whole foods that come from an animal or plant, such as meat, fish, fruit, vegetables, healthy fats like olive oil, and herbs and spices.

After youve been on the plan for a full 30 days comes the reintroduction period. One food is reintroduced at a time, allowing several days to pass between eating the food and reintroducing another food.

This is intended to give your body time to let you know if that particular food causes any unwanted symptoms.

Whole30 is very restrictive, so it isnt recommended as a long-term diet. And while there arent any scientific studies touting health benefits of the Whole30 program, it is similar to though stricter than the popular paleo diet, which has some research to back it up.

To be safe, I asked my provider if she recommended the program, and she gave me the green light to get started.

I decided to take the program one step further and removed nightshades from my diet. Nightshades, including tomatoes and peppers, are packed full of nutrition but I suspected they were triggering some of my joint pain.

There is no scientific evidence that nightshades increase inflammation, but some people do find that their joints hurt more when they eat them.

I found the program fairly easy to follow, as long as I cooked most of my own food. The easiest meals were breakfast and lunch.

I eat the same thing almost every morning: eggs, spinach, and avocado. If I added a sweet potato and some extra olive oil, I was satisfied for 4 hours.

Lunch for me is usually a simple salad, or fruit, prosciutto, and olives, or both. As long as the dressing was on-plan, this was still a good option.

My favorite time hack involved preparing extra food for dinner that I could repurpose the next day for lunch.

I found dinner to be the most challenging meal. Since I was no longer eating nightshades, I reworked some of my favorite recipes. I found a wonderful nightshade-free taco seasoning recipe online that made Mexican night possible.

Since I didnt want to cook every single night for a month, I needed to find a takeout restaurant that could accommodate my restrictions.

A local Mediterranean restaurant listed their ingredients online, and I was able to get a meal that was Whole30 compliant. Having this option available felt like a life saver.

Snacks are generally discouraged on the Whole30 program, but as long as the snack is just a smaller version of a meal, its allowed. On-plan turkey slices and mayo layered with lettuce and sprouts became my go-to afternoon pick-me-up.

After being on the program for about a week, I noticed I wasnt in as much pain.

On the other hand, about halfway through the month, I had a moment of weakness. I ate a bite of white potato and some takeout food that had been seasoned with red pepper flakes.

By the time I went to bed that night, I had developed full-body joint pain. These foods are nightshades, so I was pretty sure Id identified one of my triggers.

After getting back on track and completing the 30 days, my pain had improved so much that I cut my anti-inflammatory medication back to once a week.

I saw my rheumatologist while I was completing the Whole30 program to discuss whether I would need another medication for psoriatic arthritis. I told him that I had cut back on my NSAID and that the rough patches on my skin had smoothed out and were no longer cracked and peeling.

My doctor knew that I was doing a Whole30 round and credited my improved symptoms to the elimination of inflammatory foods. He also said I was doing so well that I didnt need to go on medication.

To kick off the reintroduction phase of the program, I had a glass of wine on day 31 with dinner. While it didnt trigger any pain, it also wasnt the feel-good end-of-day solace I remembered.

Next I added sourdough bread and a small amount of sugar in the form of honey. Again, I found I didnt enjoy them as much as I used to. And the joint pain was back.

The last food I officially reintroduced was spicy pepper seasonings and spices, like red pepper flakes. Maybe I didnt need to test nightshades again, but I love spicy foods. And yes, I had a flare-up of full-body joint pain.

At this point, I went off plan. I had already identified a few foods that were causing me pain, and it was time for a break from all the restrictions. But I felt so good after finishing my first Whole30 that I knew I would go through the program again.

The reintroduction phase not only cemented my belief that some foods cause inflammation in my body, but also that my relationship with certain foods was built on habit, rather than need or joy.

I have hereditary high cholesterol and find it hard to keep my numbers in a good range. At the end of my Whole30 round, my total cholesterol was down 60 points and my triglycerides were finally within normal range.

While weight loss wasnt my goal, I was thrilled to discover that Id lost 5 pounds. My clothes were fitting looser and I felt lighter.

The no snacking rule made it easier to fall asleep at night, and I had more energy in the evenings.

As a short-term eating program designed to reset both the body and the mind, I feel the Whole30 program was a success.

It also worked very well as an elimination diet. I felt less pain and had more energy by the end of the Whole30 program.

If you want to explore the Whole30 program, I recommend reading over the official website and having a conversation with your doctor to make sure the program is appropriate for your situation.

Cindy Blye is a nurse and health writer/journalist in North Carolina. Her works have appeared in various nursing blogs and online health news websites. Shes passionate about helping people live a healthier and more energetic life. When she isnt writing, you can find her gardening, cooking, hiking, biking, reading, or eating dark chocolate.

Originally posted here:
I Tried the Whole30 for Psoriatic Arthritis and This Is What Happened - Healthline