Category Archives: Psoriasis

Mirror, mirror, on the wall. Is it the doctor I should call?

If your lips are looking flaky, it might just be a case of chapped lips. Its pretty rare for psoriasis to break out on your lips. But if you have the signs of a psoriasis rash (scaly plaque or a burning sensation) its a good idea to get it checked out by a doctor or dermatologist.

Heres what you need to know about psoriasis on your lips.

Not just lip service: Psoriasis on lips

Psoriasis is a chronic medical condition that causes red, sometimes itchy or burning patches covered by silver, scaly plaques. During a flare-up you might even find these spots on your lips.

Theres no cure for psoriasis, but your doctor can prescribe effective treatments (like steroids) that can ease your symptoms.

You can also help prevent future by trying to avoid any of your personal triggers. (These might include stress, sudden weather changes, or spicy foods.)

FYI: If youre dealing with a psoriasis rash, exfoliators or makeup could irritate it. Please, step away from the lipstick and let yourself heal.

Although its rare, its possible to get a psoriasis rash on your lips.

Psoriasis is a chronic skin disease that affects 7.5 million people in the U.S. alone. Theres no proven cause, but your immune system and your genetics both seem to have something to do with psoriasis. It often shows up as red, scaly plaques on your skin.

Usually, those plaques show up on your knees, elbows, or chest. But no part of your body is truly immune. That includes the area around your eyes, your cheeks, your genitals, and yep, even your lips.

The rashes are usually thick and whitish-silver, but can come with thick red patches as well. On darker skin, it can appear more purple in color. Sometimes, those patches can crack and bleed.

Psoriasis can be uncomfortable anywhere on your body. When its on your lips, it may affect the way you talk or eat.

How does psoriasis work?

If you have psoriasis, your immune system attacks your own healthy skin cells. Your body hurries to make more skin cells in response, but that leads to overproduction.

When you have so many new skin cells that they dont have time to fall off, these extra cells build up on each other. This causes those flaky scales that can show up across your body and on your lips.

Whats the deal with the redness underneath? The friendly-fire from your white blood cells (the misplaced immune response) can cause inflammation.

First, the bad news: Theres no cure for psoriasis.

Now, the good news: There are effective and safe treatments for managing your symptoms.

There are a few different treatments your doctor might explore with you, according to Dr. Orit Markowitz, Board-Certified Dermatologist.

For example, they may explore topical anti-inflammatory creams, such as corticosteroids. Corticosteroids control the inflammatory responses in the body, she explains. Steroids come in different strengths from strong and super-potent to weak and less potent. Your doctor will decide what kind you need.

If you have psoriasis, you might also be prescribed systemic immunossupressants. These lower the immune response that is telling your system to attack the skin, Markowitz says, and they work on the entire body.

Other treatments could include:

There are also some home remedies that can help you manage the appearance of your symptoms.

Psoriasis PSA

At-home remedies should never replace medical treatments prescribed by your doctor. You should also check in with your doc before starting a new DIY remedy for psoriasis to make sure it wont interfere with your treatment plan.

The best remedies for chronically psoriatic lips are over-the-counter (OTC) hydrocortisone ointment and [hydrating] ointments, Markowitz says.

In addition, youll want to avoid using any scrubs (like a sugar scrub) on your face because these could aggravate your skin. And unhappy skin would make your symptoms worse.

Psoriatic patients are tempted to use scrubs and exfoliants, says Markowitz, but this will further damage their already damaged skin and irritate their psoriasis, possibly causing a flare-up.

You should also avoid most things that cover up your psoriatic lips. Makeup or lipstick arent great ideas at least not every day while youre experiencing a flare-up.

Lips are sensitive, just like most of the skin in and around the face, so its important to treat it carefully, Markowitz says.

Markowitz also recommends using moisturizing products that have SPF. Its important to keep the affected lip area protected from the sun, she says. Look for OTC products with the National Psoriasis Foundations Seal of Recognition program.

If you do use makeup, do so sparingly, so as to not further irritate or infect the lips, Markowitz says. I always recommend keeping the lips moist, especially under makeup.

If you must use a coverup, she continues, try to avoid cosmetics that contain fragrance and drying ingredients. Makeup that is not easily absorbed into the skin, such as water or sweat resistant ones, will most likely work better here.

A psoriasis flare-up can usually be traced to a specific trigger. If you can figure out whats setting off your rashes, it might be possible to avoid it.

Here are some of the most common triggers for psoriasis:

If youre not sure whats triggering your psoriasis, you can try keeping a log of your symptoms to see if you can make any connections.

In general, if this is the first time youre noticing red, flaky lips, give your doc a call. Theyll be able to diagnose whether its a psoriasis rash. Its also important to reach out if your symptoms are getting worse.

If you start to notice symptoms such as pain, swelling, tenderness, stiff muscles and joints, or a noticeable change in the appearance of your nails, says Markowitz, call your doctor.

Never try a new treatment including OTC ones without checking with your doctor either.

The short answer: Yes.

Psoriasis on lips is pretty rare. Here are some more common things that can cause a rash on your lips:

Here are a few examples of what psoriasis and other causes may look like on lips.

Remember, its always best to see a doctor for a diagnosis. That way youll know what kinds of treatments will work best for you.

Psoriasis on your lips is possible but its rare. If you do have psoriasis on your lips, theyll likely be red, inflamed, cracked, or covered in whitish scales.

Just remember that theres other conditions that could be causing your cracked lips. Your doctor is the one who can truly diagnose psoriasis. Theyll also be able to recommend the most effective, safe treatments for you.

Link:
Psoriasis on Lips: Symptoms, Treatment, Other Rashes - Greatist

The following article is part of our coverage of the American Academy of Dermatologys annual meeting (AAD 2021) that is being held virtually from April 23-25, 2021. Dermatology Advisors staff will report on the top research in dermatologic advances and clinical care. Check back for the latest news from AAD 2021.

Treatment with guselkumab was found to be associated with durable, complete skin clearance through 5 years in patients with moderate to severe plaque psoriasis (PsO) and improved disease activity and axial symptoms in adults with active psoriatic arthritis (PsA) through 1 year, according to a recent press release and study results presented at the American Academy of Dermatologys Virtual Meeting Experience (AAD VMX) 2021, held online from April 23 to April 25, 2021.

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In the VOYAGE 2 trial (ClinicalTrials.gov Identifier: NCT02207244), approximately 55.5% of patients who received guselkumab had complete skin clearance, as determined by an Investigators Global Assessment (IGA) score of 0, by week 252. In addition, 53% of patients had a Psoriasis Area Severity Index (PASI) 100 skin clearance response (PASI 100) by the 252-week follow-up. Up to 82% of patients achieved a PASI 90 skin clearance response, and 85% of patients had an IGA score of 0/1, indicating complete skin clearance. Efficacy rates were maintained through the 5-year treatment period.

In the DISCOVER-1 and -2 trials (ClinicalTrials.gov Identifiers: NCT03162796 and NCT03158285, respectively), patients with active psoriatic arthritis (PsA) received either placebo or 100 mg guselkumab every 4 weeks and every 8 weeks. Treatment with guselkumab improved disease activity in the joints as well as across several different domains through 52 weeks. Differences in response rates between the active treatment and placebo groups were observed at 8 weeks of treatment.

In addition, in the phase 3 VOYAGE 2 trial, the researchers showed that a significantly greater percentage of patients who received guselkumab vs placebo for 16 weeks had an IGA 0/1 response (84% vs 9%, respectively; P <.001).

Safety data from the VOYAGE 1 and 2 trials show that 78.3% of patients who received guselkumab continued treatment through week 252. Guselkumab featured a safety profile from year 1 through year 5 that was consistent with its safety profile shown in other studies. Low rates of adverse events due to treatment discontinuation were reported.

The signs and symptom improvement seen with [guselkumab] is noteworthy for both patients who live with fear of disease recurrence and their physicians, as these data add to a growing body of evidence for this first-in-class [interleukin] (IL)-23 inhibitor treatment for moderate to severe plaque [PsO] and active [PsA], noted the lead author of the VOYAGE 2 study.

Disclosure: The clinical trials included in this analysis were supported by Janssen Pharmaceutical Companies of Johnson & Johnson. Please see the original reference for a full list of study authors disclosures.

New phase 3 data showed first-in-class TREMFYA (guselkumab) provided durable complete skin clearance through 5 years in moderate to severe plaque psoriasis (PsO) and robust joint symptom improvement through 52 weeks in active psoriatic arthritis (PsA). Press release. Published April 23, 2021. Accessed April 26, 2021. https://www.biospace.com/article/releases/new-phase-3-data-show-first-in-class-tremfya-guselkumab-achieved-complete-skin-clearance-and-favorable-joint-efficacy-in-adult-patients-with-active-psoriatic-arthritis-psa-through-two-years/

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Complete Skin Clearance and Improved Joint Symptoms With Guselkumab in Moderate to Severe Plaque Psoriasis and Psoriatic Arthritis - Dermatology...

Results from first network meta-analysis based on area under the curve of 52-week clinical trial data. Taltz also helped patients stay on treatment longer and have more days without additional therapy in three real-world analyses of U.S. claims data

TORONTO, April 30, 2021 /CNW/ - Through clinical trial meta-analysis and real-world evidence, Eli Lilly and Company's Taltz (ixekizumab) demonstrated greater success in key measured treatment outcomes compared to other biologics in adults with moderate- to severe plaque psoriasis. In the first one-year network meta-analysis based on area under the curve, Taltz showed numerically greater cumulative benefits on completely clear skin over one year compared to seven other biologics, as measured by Psoriasis Area Severity Index (PASI) 100. In three real-world analyses of U.S. claims data ranging from one to three years, patients treated with Taltz stayed on treatment longer, were more adherent to the prescription and had more days on monotherapy compared to the other biologics studied. These results were presented virtually at the American Academy of Dermatology's Virtual Meeting Experience (AAD VMX), April 23-25, 2021.

"Results of the clinical trial meta-analysis showed Taltz offered more cumulative days of clear skin for patients with moderate- to severe psoriasis, compared to seven other biologics," says Dr. Doron Sagman, vice president, R&D and Medical Affairs, Eli Lilly Canada. "This further anchors Taltz as an important treatment option for patients who are looking for completely clear skin long-term."

Taltz provided patients with longest-lasting complete skin clearance over a one-year period1

In the network meta-analysis to assess the cumulative clinical benefits of biologics in psoriasis, using PASI 100 to measure the early and sustained effect of biologic medications approved for psoriasis over one year, Taltz offered patients with psoriasis the greatest number of cumulative days of completely clear skin compared to adalimumab, brodalumab, etanercept, guselkumab, risankizumab, secukinumab and ustekinumab. In this analysis, Taltz showed one to 18 more cumulative weeks of completely clear skin over one year compared to these seven other biologics.

Taltz provided patients with a total of 159 cumulative days (95% credible interval, 147.4-170.0 days), or 23 weeks of completely clear skin (PASI 100), which translates into a patient having completely clear skin for approximately 44% of the year compared to:

For methodology, see "About the studies" section below.

Taltz helped patients stay on prescribed treatment, and to avoid additional psoriasis therapy significantly longer, compared to secukinumab, ustekinumab, adalimumab and etanercept2

People with psoriasis taking Taltz achieved greater success taking medication as prescribed (adherence) and staying on medication for the prescribed duration (persistence), without needing additional medications (monotherapy), compared to those taking secukinumab, ustekinumab, adalimumab and etanercept up to three years. Patients on Taltz stayed on treatment an observed median of nearly 22 weeks longer vs. all other biologics pooled (414 vs. 259 days, [59 vs. 37 weeks], p<0.001) and approximately 11 to 34 weeks longer vs. individual treatments: secukinumab (335 days [48 weeks]), adalimumab (301 days [43 weeks]), etanercept (181 days [26 weeks]) and ustekinumab (176 days [25 weeks]). Compared with the pooled set of other biologics where patients stayed on prescription for less than half of the year (45.7%), patients on Taltz took treatment as prescribed for over half of the year (53.2%), as measured by proportion of days covered (PDC) by prescribed treatment (p<0.001). Patients taking Taltz also experienced more time (52.7% of the year) on monotherapy compared to the pooled set of other biologics (44.8% of the year) (p<0.001). For methodology, see "About the studies" section below.

Patients on Taltz took treatment as prescribed nearly eight weeks longer than guselkumab, despite more frequent dosing3

Compared to guselkumab, patients with psoriasis on Taltz adhered to treatment for nearly eight weeks more time (Taltz: median of 272 days or 39 weeks [PDC=0.75]; guselkumab: 219 days or 31 weeks [PDC=0.60], p=0.001) and had approximately six weeks more time on monotherapy (Taltz: median of 247 days or 35 weeks [PDC=0.68]; guselkumab: 202 days or 29 weeks [PDC=0.55], p=0.002) over one year. Among those patients who required additional psoriasis therapies, the need for systemic medication was similar for patients taking Taltz or guselkumab over the year. For methodology, see "About the studies" section below.

Patients on Taltz with prior biologic use were more likely to continue treatment as prescribed compared to secukinumab4

Among participants who had previously used a biologic, patients with psoriasis treated with Taltz were more likely to be "highly adherent," which was measured by more than 80% of days where they took treatments as prescribed (Taltz: 42.0% vs. secukinumab: 35.0%, p=0.019). Taltz was associated with 25% lower risk of switching treatments, 20% lower risk of stopping treatment before the end of the prescribed duration (non-persistence), 19% lower risk of discontinuing treatment, and 36% higher odds of taking treatment as prescribed (adherence) than secukinumab. For methodology, see "About the studies" section below.

"When compared to seven other biologics over a period of one year, Taltz provided patients with the greatest number of days of complete skin clearance. This real-world evidence demonstrates the effectiveness of Taltz. Taltz-treated patients had more days without the need for additional therapy," says Dr. Kim Papp, MD, PhD, FRCPC.

More than 175,000 patients have been treated with Taltz worldwide since launch, giving healthcare providers confidence in making informed prescribing decisions for patients with moderate- to severe plaque psoriasis and psoriatic arthritis, as well as in other approved conditions including ankylosing spondylitis and non-radiographic axial spondyloarthritis.

About the studies

About Taltz Taltz is approved for the treatment of patients 6 years of age and older with moderate- to severe plaque psoriasis who are candidates for systemic therapy or phototherapy and for the treatment of adults with active psoriatic arthritis, active ankylosing spondylitis, or active non-radiographic axial spondyloarthritis with objective signs of inflammation.5

About Moderate- to Severe Plaque Psoriasis Psoriasis is a chronic, immune disease that affects the skin. It occurs when the immune system sends out faulty signals that speed up the growth cycle of skin cells. Psoriasis affects approximately 125 million people worldwide, approximately 20 percent of whom have moderate- to severe plaque psoriasis. The most common form of psoriasis, plaque psoriasis, appears as raised, red patches covered with a silvery white buildup of dead skin cells. Patients with plaque psoriasis often have other serious health conditions, such as diabetes and heart disease and experience negative impact on their quality of life.

About Lilly in Dermatology By following the science through uncharted territory, we continue Lilly's legacy of delivering innovative medicines that address unmet needs and have significant impacts on people's lives around the world. Skin-related diseases are more than skin deep. We understand the devastating impact this can have on people's lives. At Lilly, we are relentlessly pursuing a robust dermatology pipeline to provide innovative, patient-centered solutions so patients with skin-related diseases can aspire to live life without limitations.

About Lilly CanadaEli Lilly and Company is a global healthcare leader that unites caring with discovery to make life better for people around the world. We were founded more than a century ago by Colonel Eli Lilly, who was committed to creating high quality medicines that meet people's needs, and today we remain true to that mission in all our work. Lilly employees work to discover and bring life-changing medicines to people who need them, improve the understanding and management of disease, and contribute to our communities through philanthropy and volunteerism.

Eli Lilly Canada was established in 1938, the result of a research collaboration with scientists at the University of Toronto which eventually produced the world's first commercially available insulin. Our work focuses on oncology, diabetes, autoimmunity, neurodegeneration, and pain. To learn more about Lilly Canada, please visit us at http://www.lilly.ca.

For our perspective on issues in healthcare and innovation, follow us on twitter @LillyPadCA and @LillyMedicalCA.

This press release contains forward-looking statements (as that term is defined in the Private Securities Litigation Reform Act of 1995) about Taltz (ixekizumab) as a treatment for patients with psoriasis or psoriatic arthritis and reflects Lilly's current belief and expectations. However, as with any pharmaceutical product, there are substantial risks and uncertainties in the process of research, development and commercialization. Among other things, there can be no guarantee that future study results will be consistent with the results to date or that Taltz will receive additional regulatory approvals or be commercially successful. For further discussion of these and other risks and uncertainties, see Lilly's most recent Form 10-K and Form 10-Q filings with the United States Securities and Exchange Commission. Except as required by law, Lilly undertakes no duty to update forward-looking statements to reflect events after the date of this release.

References

1Blauvelt et al. Cumulative Clinical Benefits of Biologic Treatments for Psoriasis Over 1 Year. American Academy of Dermatology (AAD VMX); Virtual; 23-25 April 2021.

2Blauvelt et al. Ixekizumab Demonstrates Greater Medication Adherence, Persistence, and Longer Monotherapy Duration Than Secukinumab, Adalimumab, Ustekinumab, and Etanercept up to 3 Years in the Treatment of Psoriasis: Real-world Results From IBM MarketScan Databases. American Academy of Dermatology (AAD VMX); Virtual; 23-25 April 2021.

3Blauvelt et al. Real-World Comparison of Monotherapy and Concomitant Medication Use with Biologic Therapies for Psoriasis: Ixekizumab vs. Guselkumab. American Academy of Dermatology (AAD VMX); Virtual; 23-25 April 2021.

4Blauvelt et al. Comparison of Long-Term Treatment Patterns between Ixekizumab and Secukinumab Users among Biologic-experienced Psoriasis Patients. American Academy of Dermatology (AAD VMX); Virtual; 23-25 April 2021.

5Taltz Product Monograph, March 29, 2021

To read Lilly's 2021 AAD disclosures, click here.

SOURCE Eli Lilly Canada Inc.

For further information: Media Contact: Samira Rehman, [emailprotected], 647-617-1994

http://www.lilly.ca

Here is the original post:
Taltz delivers more cumulative days with completely clear skin for adults with psoriasis compared to seven other biologics in novel network...

Objectives:Although causality remains to be established, targeting dysbiosis of the intestinal microbiota by faecal microbiota transplantation (FMT) has been proposed as a novel treatment for inflammatory diseases. In this exploratory, proof-of-concept study, we evaluated the safety and efficacy of FMT in psoriatic arthritis (PsA).

Methods:In this double-blind, parallel-group, placebo-controlled, superiority trial, we randomly allocated (1:1) adults with active peripheral PsA (3 swollen joints) despite ongoing treatment with methotrexate to one gastroscopic-guided FMT or sham transplantation into the duodenum. Safety was monitored throughout the trial. The primary efficacy endpoint was the proportion of participants experiencing treatment failure (ie, needing treatment intensification) through 26 weeks. Key secondary endpoints were change in Health Assessment Questionnaire Disability Index (HAQ-DI) and American College of Rheumatology (ACR20) response at week 26.

Results:Of 97 screened, 31 (32%) underwent randomisation (15 allocated to FMT) and 30 (97%) completed the 26-week clinical evaluation. No serious adverse events were observed. Treatment failure occurred more frequently in the FMT group than in the sham group (9 (60%) vs 3 (19%); risk ratio, 3.20; 95% CI 1.06 to 9.62; p=0.018). Improvement in HAQ-DI differed between groups (0.07 vs 0.30) by 0.23 points (95% CI 0.02 to 0.44; p=0.031) in favour of sham. There was no difference in the proportion of ACR20 responders between groups (7 of 15 (47%) vs 8 of 16 (50%)).

Conclusions:In this first preliminary, interventional randomised controlled trial of FMT in immune-mediated arthritis, we did not observe any serious adverse events. Overall, FMT appeared to be inferior to sham in treating active peripheral PsA.

Trial registration number:NCT03058900.

Keywords:arthritis; inflammation; psoriatic; therapeutics.

Read more from the original source:
Safety and efficacy of faecal microbiota transplantation for active peripheral psoriatic arthritis: an exploratory randomised placebo-controlled trial...

I have psoriasis. Ive had it since I was in elementary school, and I have finally decided Ive had enough. I recently started a new injectable biologic to control it. While I was digging for good news about my skin, I found a video of a guy discussing all the things he tried before turning to injectables. He started off discussing a psoriasis diet he had tried for several months.

It wasnt the diet that caught my attention.

It was the way he talked about it. He was visibly frustrated as he explained that the strict diet he was on actually did help his psoriasis. He saw marked improvement. But he couldnt stick to it long term because it was so all-consuming.

His basic sentiment was, It came to a point where I could do this diet to help my skin, or I could have all the other parts of the rest of my life. I chose a normal life. As a thin person, I am sure this felt like a big revelation to him.

As a fat person, I was like NO EFFING KIDDING.

Limiting your diet is an emotional roller coaster no matter what the reason, but when its motivated by diet cultures hatred for the way your body looks, its literally 24/7 hard. Its maintaining constant focus on the ways your body doesnt stack up to societys standards.

That SUCKS. Its soul-crushing. It hurts. Even when it works.

I know that I could stick to a very strict, very large calorie deficit and lose weight. I could prioritize a time-consuming, intense exercise regimen and change my body to some extent.

Theres a high likelihood that, for me, it would be disordered, motivated by self-loathing, and feel like total misery.

But it would work if you consider success to be shrinking my body into a more acceptable size and shape. Because its not technically impossible for me to become thinner, many people believe that I should be on a perpetual diet every single day of my life until I attain a level of thinness that makes me sexually acceptable to the men who dictate our beauty standards.

Story continues

It doesnt matter that its unreasonably hard for some people. That truth is constantly brushed off as an excuse or laziness. Nobody wants to hear that every body actually doesnt respond the same way to every diet, and that what worked for them might not work for me. A lot of people dont allow a fat person the space and respect to say, Dieting, for me, gets to a point where it controls my life, and I get to choose between that and my own happiness and mental health. We dont get to prioritize our mental health and happiness without judgment.

Fat people are supposed to be constantly in progress until we are thinand then?

We are supposed to spend the rest of our lives working to maintain that thinness.

And we are supposed to do this without any complaint, without any sympathy for how incredibly hard it is because we are supposed to want to be thin more than we want to enjoy food along with everyone else, and relax into our bodies as they are.

Its interesting to me because there actually was one time in my life when people seemed to feel for me when I was on a very restricted diet. I wasnt thin. I was pregnant. In my third trimester with my last baby, I found out I had gestational diabetes. Luckily, I didnt have any trouble controlling my blood sugars, and we both turned out no worse for the wear.

But I had to navigate the holiday season without a single treat, with very few carbs, carefully measuring my portions and ensuring that I created a safe environment for my growing baby.

It is the one time in my life that I did not struggle one little bit. My health and my babys health depended on my restricted diet. It was a no-brainer that I would do what I needed to do in order to keep us both safe.

Its also the one time when I was inundated with compassion. People wanted to tell me that they understood how tough it was. They seemed to fully understand how overwhelmed I must be asking about ingredients, tracking everything I ate, testing my blood, checking my babys weight via weekly ultrasounds. A lot of people even promised to bring my favorite sweet treats to the hospital after my baby was born, realizing how comforting and yummy that would be for me.

The fact that gestational diabetes was largely out of my control seemed to be my golden ticket to understanding.

My higher weight, despite much scientific evidence to the contrary, is still largely regarded as something that is completely within my control, and therefore, I am not entitled to be okay with it.

Why can people muster up sympathy for people who have to limit their diets due to illnesses, but they expect fat people in good health (we do exist!) to be on a perpetual diet, never ever just eating whats available, letting their body exist as it is? Why is it still such a no-go to just accept that youre fat and let that be the case, even if only for a season?

I fought my body for years. For most of my teens and twenties and even a couple years of my very early thirties, I was always on a diet. Every time I ate a meal or treat without knowing how many calories, carbs or fat was in it, I felt a nagging guilt that I was cheating on my diet. Despite my best efforts, I never quite changed my body enough to become acceptable. Not even close.

And then, I decided to see what it felt like to try to make peace with my body instead of constantly fighting it. I didnt gain weight as I always thought I would. Sometimes, I even lose weight without trying. My weight fluctuates naturally almost as much as it did when I was frequently actively dieting.

I still diet once in a while. I have learned to make peace with my body, but I live in this thin-obsessed culture and sometimes I still find myself itching to see if I can get a little closer to thin.

Because dieting isnt all tough. The high of watching the weight come off is enough to keep me going sometimes. When its working and your body is shrinking, dieting can feel good. (But it can also quickly evolve into a really harmful pattern of disordered eating if youre susceptible to that.) Inching closer to societys idea of what you should look like feels hopeful sometimes.

But, for me, theres something really draining about trying to convince myself to frame the experience as a permanent change of lifestyle, when it almost always feels like an unsustainable way to live. Im not alone in that exhaustion.

https://www.instagram.com/p/COGvdHwBhwz/

Most fat people I have spoken to agree that its just really heavy to be so focused on the ways your body doesnt stack up to societys standards. Dieting can bring that to the forefront in ways that are really tough to handle for extended periods of time.

There is so much you dont know about a fat persons health, history and choices just by looking at them. If you know a fat person who seems to you to be letting themselves go or not caring about their health, mind your own business, and let them be. Mental health IS health, and we dont owe anyone a smaller body or an explanation as to why we arent killing ourselves to attain one.

See the original article on ScaryMommy.com

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Fat People Dont Have To Be On A Perpetual Diet - Yahoo Lifestyle

As the United States looks to combat vaccine hesitancy, at least one group is feeling even more confident in a vaccinebut not the COVID-19 shot: Patients with autoimmune rheumatic diseases (ARDs) had a higher rate of flu vaccinations during the pandemic, researchers discovered.

A total of 1,015 patients were interviewed. A greater proportion of patients received the flu shot during the pandemic (2020-21 season) than before (2019-20 season). Fewer than 1% of patients who got the shot reported disease flares.

In the pre-pandemic period, patients were more likely to say their rheumatologist did not recommend the shot compared to during the pandemic. During both flu seasons, other reasons patients skipped out on the shot included they didnt think it would have any benefit, they didnt feel it was safe, and other.

Another study analyzed the prevalence of and risk factors for venous thromboembolism (VTE) in patients with psoriasis and psoriatic arthritis (PsA). Final analysis included 2,433 patients, and there were 26 incident VTEs. The incident rate of the first VTE was 12 events per 10,000 patient-years. By age 80, 4.6% of patients had developed their first VTE. Factors independently correlated with VTE were older age, diabetes mellitus, and corticosteroid usage.

Finally, a study compared golimumab treatment retention among patients with rheumatoid arthritis (RA), axial spondyloarthritis (AxSpA), and PsA. Compared to patients with RA, those with AxSpA or PsA had higher rates of retention. Further, retention rates were higher when golimumab was a first-line treatment instead of third or later. Use as first-line biological therapy, having AxSpA or PsA (instead of RA), and concomitant methotrexate therapy were all correlated with increased golimumab retention, while steroid use reduced retention.

In Case You Missed It

Flu Shot Rates Increased During COVID-19 Pandemic among Patients with Autoimmune Rheumatic Diseases

Risk Factors for VTE in Patients with Psoriasis, Psoriatic Arthritis

Golimumab Treatment Retention Comparison: RA, AxSpA, and PsA

The rest is here:
Rheum Round-up: More Rheumatic Pts Got Flu Shot, VTE in PsA, and more - DocWire News

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Psoriasis Therapeutics Market 2021 Size, Status and Business Outlook Astellas Pharma Inc., AstraZeneca plc, Boehringer Ingelheim GmbH The Courier -...

Last November and then again in February, Bristol Myers Squibb said its oral drug designed to treat psoriasis differently from currently approved medicines had achieved the goals of large Phase 3 clinical trials.

On Friday, the actual data from those two studies were presented publicly for the first time at the annual meeting of the American Academy of Dermatology. The Bristol drug, called deucravacitinib, proved more effective at clearing the chronic skin disease numerically and statistically compared to a placebo and a competing drug from Amgen.

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STAT+ is STAT's premium subscription service for in-depth biotech, pharma, policy, and life science coverage and analysis.Our award-winning team covers news on Wall Street, policy developments in Washington, early science breakthroughs and clinical trial results, and health care disruption in Silicon Valley and beyond.

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New data point to benefits of Bristol's novel psoriasis pill, but safety issues will be scrutinized - STAT

Psoriasis is an autoimmune condition that causes skin cells to build up and form lesions on the skin. Food is one of many potential triggers that may make a persons psoriasis symptoms worsen or flare.

People with psoriasis are at a greater risk of developing other conditions, including obesity, type 2 diabetes, and cardiovascular disease.

Making dietary adjustments may help prevent these secondary conditions and reduce symptoms.

Certain foods may act as triggers for some people.

This article explores what foods may trigger psoriasis flares and how a person can identify them.

Gluten is a protein in certain grains, including wheat. For example, bread, pasta, and baked goods contain gluten in varying amounts.

Celiac disease is an autoimmune disease that causes a reaction to gluten when a person consumes products that contain wheat.

A 2018 study found that people with psoriasis had the same prevalence of an antibody that people with celiac and gluten sensitivities have.

Researchers also found that when people who tested positive for the antibody ate a gluten-free diet, they saw a reduction in their psoriasis symptoms.

Learn more about how a gluten-free diet might help with psoriasis here.

Red meat contains a polyunsaturated fatty acid called arachidonic acid. These fats create byproducts that contribute to psoriasis lesions.

As a result, avoiding red meat, such as hamburgers or steak, may help reduce the severity of psoriasis lesions.

Avoiding red meats has the added benefit of helping to prevent heart disease.

According to some research, red meats create byproducts that increase a persons likelihood of developing heart disease.

For a person living with psoriasis, avoiding red meat may help prevent heart disease even if it does not affect their psoriasis symptoms.

Learn more about red meat and health here.

Like red meat, dairy also contains arachidonic acid.

A 2017 review suggested that the arachidonic acid in dairy products may irritate the intestinal tracts inner lining and worsen psoriasis symptoms.

However, researchers called for more studies to confirm this link.

Anecdotal evidence suggests that some people have experienced fewer psoriasis symptoms after eliminating dairy from their diets.

Another 2017 study investigating the effects of diet on psoriasis, reported that one of the most common food triggers participants chose to remove from their diets was dairy.

Learn about how to replace dairy in the diet.

Processed foods can contribute to various health conditions, including type 2 diabetes, obesity, and heart disease.

Obesity has associations with inflammation and an increase in the severity of psoriasis symptoms.

A person with psoriasis who also has obesity may find that cutting out or reducing processed foods may also help them manage their weight. This could improve their psoriasis symptoms.

The term processed food means any food that manufacturers change during production.

Learn more about processed foods here.

Caffeine may trigger psoriasis flares in some people.

Some research indicates that people with psoriasis could consider avoiding caffeine. However, the researchers state that they do not fully understand the exact relationship between dietary caffeine from coffee, tea, or other sources.

However, some people may find reducing or eliminating caffeine helpful.

Learn more about caffeine here.

Nightshades include the following vegetables:

One study indicated that people living with psoriasis often avoid nightshades because they believe it helps with their psoriasis symptoms.

However, the Global Healthy Living Foundation states that the number of nightshades a person typically eats would not be enough to trigger an inflammatory response. Though they focused primarily on arthritis, researchers believe the same chemicals trigger psoriasis responses.

Still, some people may find that reducing their consumption of nightshades may help reduce their psoriasis symptoms.

Learn whether nightshades worsen inflammation here.

During a 2017 study on the effects of certain foods on psoriasis flares, researchers found the following foods had a positive result on the skin symptoms of participants:

The National Psoriasis Foundation notes that no specific diet will cure psoriasis but may reduce the severity of the symptoms. They also note that eating healthier foods may help a person avoid other conditions, such as obesity and type 2 diabetes. They recommend eating:

Some people may find keeping a food journal helpful.

A food journal can help people look for patterns in what they eat and improve their psoriasis symptoms.

Learn more about how diet can affect psoriasis here.

Several environmental factors, or triggers, can cause psoriasis symptoms to flare.

Some potential psoriasis triggers include:

Some people may find they have other triggers. Others may be unable to identify their triggers.

A person should talk with their doctor about what may trigger their psoriasis flares if they have any questions.

Learn more about psoriasis triggers and how to avoid them here.

Certain foods may trigger psoriasis flares in some people.

A person can take steps, such as keeping a food journal, to help determine what foods may help and which may cause triggers.

Generally, the most helpful diets for psoriasis include fresh fruits, vegetables, lean proteins, low fat dairy, whole grains, and plant-based fats.

These diets may not help prevent a flare, but they may reduce symptom severity and help prevent other conditions, such as diabetes, obesity, or heart disease, from developing.

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Foods to avoid with psoriasis: Types, diets, and more - Medical News Today

Several research articles have shown a positive association between psoriasis and thyroid diseases, including Hashimotos thyroiditis (hypothyroidism) and Graves disease (hyperthyroidism), but the limited number of studies do not provide a complete explanation to prove this association, according to a review study published in Cureus.

This review study included 45 articles that featured psoriasis, hypothyroidism, thyroid function tests, propylthiouracil, and psoriatic arthritis as inclusion keywords. Medical Subject Headings keywords psoriasis, hypothyroidism, and autoimmunity were also imputed into PubMed to identify the relevant articles for review.

A total of 39 of the 45 articles included in this review study demonstrated a positive association between psoriasis and thyroid diseases, although 6 articles found no association.

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In 5 articles, researchers showed that thyroid hormones had an effect on the development of psoriasis. Other articles demonstrated that genetic, immunological, and inflammation were involved in the associations. Reactive oxygen species-related pathogenesis was also reported in 2 articles. In 5 articles, there were reports of positive thyroid peroxidase antibodies, thyroglobulin antibodies, and Hashimotos thyroiditis ultrasound features in patients with psoriasis.

Marked improvement was observed in psoriatic skin lesions following thyroidectomy in 2 articles. In addition, the investigators of this review found that first-line propylthiouracil for hyperthyroidism reportedly clears psoriatic lesions, according to findings in 6 articles. Propylthiouracil did not appear to induce clinical hypothyroidism or lead to any serious adverse effects. The researchers of this review study suggest propylthiouracil could be prescribed as an alternative therapy for patients with psoriasis due to its side effects compared with existing psoriasis treatments that are typically toxic and expensive.

The investigators also noted that a higher prevalence of the association between psoriasis and thyroid diseases in women was reported in some of the articles. However, some articles found no sex preference involved in the prevalence of the association.

Limitations of this study included the small number of articles available for review as well as the lack of a pooled meta-analysis of the data.

The investigators concluded that additional studies are required to establish a connection between these diseases because these findings have a significant impact on both the clinical and research sides.

Eapi S, Chowdhury R, Lawal OS, Mathur N, Malik BH. Etiological association between psoriasis and thyroid diseases. Cureus. 2021;13(1):e12653. Published 2021 Jan 12. doi:10.7759/cureus.12653

This article originally appeared on Dermatology Advisor

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Is There an Association Between Psoriasis/PsA and Thyroid Disease? - Rheumatology Advisor