Category Archives: Psoriasis

What Are Autoimmune Diseases (like Psoriasis)
tinyurl.com What Are Autoimmune Diseases (like Psoriasis) The immune system, or autoimmune system, prevents the body from getting ill and it also fights off illness when we do get sick. The autoimmune system is set up to attack foreign substances in the body and fights them off so our bodies are constantly protected. An autoimmune disease causes the immune system to turn on itself. This leaves the body vulnerable to diseases, bacteria, and illness with no way to ward it off. The immune system protects every other system in the body keeping you free of parasites, fungus, and viruses that can cause harm to the body. An autoimmune disease slows down or damages the immune system and your body #39;s first line of defense is gone. There are many autoimmune diseases out there. Chronic fatigue syndrome, juvenile diabetes, multiple sclerosis, Rheumatoid arthritis, lupus, and even Psoriasis all fall under the autoimmune disease category. There is no real known cause for autoimmune disease, but research continues on everyday to find the cause and then a cure. Some research has shown that autoimmune disease may be caused by the constant exposure to pollution. Chemicals plague the quality of our air and water; both of which we need and use every day. Even the foods we eat hold many toxins like pesticides and herbicides. All these factors affect the immune system. One other factor that can bring down the immune system is refined sugar we consume every day. Sugars can be found in sodas ...

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What Are Autoimmune Diseases (like Psoriasis) - Video

Jan. 11, 2013 Three per cent of the world's population suffer from the skin condition known as psoriasis. A Norwegian research-based company is close to developing a treatment that could help millions. The research may also prove beneficial in the treatment of other illnesses.

The psoriasis treatment consists of a compound which, when applied to the skin, is absorbed by skin cells much more naturally than most other ointments. It contains a synthesised molecule based on the fatty acid docosahexaenoic acid (DHA) which may prove effective in inhibiting chronic inflammation associated with psoriasis.

Clinical trials soon underway

Avexxin, a Trondheim-based company, is to begin clinical testing of the ointment in early 2013. If the results are positive, Avexxin may find itself on the cusp of an international breakthrough.

Successful tests of the psoriasis compound could also give an important boost to the pursuit of more comprehensive clinical trials to determine whether the technology can be applied to other chronic inflammatory conditions such as rheumatoid arthritis and nephritis, an inflammation in the kidneys.

Combining clinical phases 1 and 2A

Clinical trials often extend over a long period of time. The treatment must first be tested for toxicity on healthy volunteers. Subsequent trials must be carried out on real patients to ensure that the treatment has the desired effect. With an ointment such as this, which is to be applied externally, it is possible to combine trial phases 1 and 2A.

"This enables us to save a lot of time," explains Professor Berit Johansen of the Norwegian University of Science and Technology (NTNU). Dr Johansen has been studying the mechanisms behind inflammatory disease since the end of the 1980s. She launched the company, Avexxin, in 2005.

Potential for treating other conditions

Two Avexxin projects have received funding under the programme for User-driven Research-based Innovation (BIA) at the Research Council of Norway:

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New treatment for psoriasis?

Psoriasis and Vitiligo Center
Psoriasis and Vitiligo Center located at Bay Dermatology in St. Pete Beach. Florida.

By: BayDermSkinExperts

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Psoriasis and Vitiligo Center - Video

Natasha Psoriasis Video

By: HealthMonitor

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Natasha Psoriasis Video - Video

PMG Psoriasis

By: TheKellyBerger

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PMG Psoriasis - Video

Psoriasis Free for Life Review - Psorias
Psoriasis Free for Life Review - Psorias http://www.healthproductreviewcenter.com If you want to get rid of psoriasis fast and naturally than you must visit the link to see what I want to say though this presentation. http://www.youtube.com http://www.youtube.com

By: Patria Tealor

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Psoriasis Free for Life Review - Psorias - Video

BANGALORE: Indian biotech major Biocon has announced that it has received marketing authorization from the Drugs Controller General of India (DCGI) for its novel biologic Itolizumab used for the treatment of psoriasis.

This is the second novel biologic, a medicinal preparation created by a biological process, developed by Biocon at its research and development unit in Bangalore. Biocon's first biologic to enter the market was BioMab EGFR, used in the treatment of cancer.

The company said Itolizumab is a first in class therapy for the treatment of moderate-to-severe psoriasis and has an excellent safety profile as indicated during the 52-week phase III multi-centric clinical study that was conducted in India.

Biocon will market the novel biologic under the name Alzumab in India, during the latter half of 2013. Alzumab will be manufactured and formulated as an infusion drug at Biocon's manufacturing facility at Biocon Park in Bangalore.

Psoriasis is a socially debilitating disease affecting 2% to 3 % of the Indian population. Global estimates suggest that the treatment of psoriasis will have a market value of $8 billion by 2016.

Commenting on the regulatory approval, Kiran Mazumdar-Shaw, CMD, Biocon, said, "This approval paves the way for us to extend clinical development for other indications like rheumatoid arthritis, multiple sclerosis and vitiligo." The biologic Itolizumab has shown promising pre-clinical and clinical efficacy in other auto-immune diseases like rheumatoid arthritis and multiple sclerosis, Biocon said.

Shaw added, "We also intend to file a US IND (Investigational New Drug) filing shortly to enable us to embark on a global clinical development plan. This is a defining moment for Biocon as it reaches a significant milestone in its mission of delivering affordable innovation to patients worldwide."

Biocon plans to develop Itolizumab with a global partner for various markets across the world.

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Biocon's Itolizumab drug for psoriasis gets DCGI approval

Biocon gets nod to sell psoriasis drug in India This approval paves the way for the launch of Biocon?s Alzumab in India, later during 2013 Raghuvir Badrinath / Bangalore Jan 08, 2013, 10:38 IST

Biocon, the publicly held biotechnology company, on Tuesday announced that it has received marketing authorisation from the Drugs Controller General of India (DCGI) for Novel Biologic Itolizumab, an anti CD6 molecule, for the treatment of chronic plaque Psoriasis.

Itolizumab is a first in class therapy with a unique Mechanism of Action (MOA) and has an excellent safety profile as indicated during the 52 week Phase III multi-centric clinical study conducted in India.

This approval paves the way for the launch of Biocons Alzumab in India, later during 2013. Alzumab is a differentiated biologic drug with a better safety profile compared to other approved biologic therapies given its low opportunistic infection rates.

A novel biologic indicated for the treatment of Moderate-to-Severe Psoriasis, Alzumab will be marketed by Biocons Immunotherapy Division.

Alzumab, will be manufactured and formulated as an infusion drug at Biocons Biopharma manufacturing facility at Biocon Park, Bangalore.

Commenting on this development, Kiran Mazumdar-Shaw, CMD, Biocon, said, We are excited to receive this marketing authorisation for Itolizumab from DCGI which will enable Biocon to introduce this novel, first in class biologic for the treatment of psoriasis patients in India. This is our Second novel biologic that we have developed in India, BioMab EGFR, an anti-cancer monoclonal antibody, being the first."

"This approval paves the way for us to extend clinical development for other indications like Rheumatoid Arthritis (RA), Multiple Sclerosis (MS) and Vitiligo. We also intend to file a US IND shortly to enable us to embark on a global clinical development plan. This is a defining moment for Biocon as it reaches a significant milestone in its mission of delivering affordable innovation to patients worldwide, she added.

Alzumab is expected to provide a safe and effective treatment option for Psoriasis, a socially debilitating disease affecting 2-3% of Indian population.

The global market size for Psoriasis is estimated to cross $8 bn by 2016.

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Biocon gets nod to sell psoriasis drug in India

Biocon gets nod to market psoriasis drug in India Drugs Controller General allows marketing of Bangalore-developed Itolizumab BS Reporter / Bangalore Jan 09, 2013, 00:53 IST

Publicly-held biotechnology major Biocon announced on Tuesday that it has received marketing authorisation from the Drugs Controller General of India ( DCGI) for its novel biologic Itolizumab, anti CD6 molecule, for the treatment of chronic plaque psoriasis.

Itolizumab is a first-in-class therapy and the second novel biologic developed by Biocon at Asias largest biotech hub in Bangalore.

Commenting on this development, Kiran Mazumdar-Shaw, chairman and managing director of Biocon, said, This is our second novel biologic that we have developed in India, BioMab EGFR, an anti-cancer monoclonal antibody, being the first. This approval paves the way for us to extend clinical development for other indications like rheumatoid arthritis, multiple sclerosis and vitiligo.

She added that the company will file an IND (investigational new drug) in the US shortly to embark on a global clinical development plan. She termed the approval for Itolizumab a defining moment for Biocon.

Alzumab is expected to provide a safe and effective treatment option for psoriasis, a socially debilitating disease affecting two-three per cent of Indias population. The global psoriasis market size is estimated to cross $8 billion by 2016.

Biocons share price dropped 2.3 per cent on the National Stock Exchange to close at Rs 294.70 per share on Tuesday.

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Biocon gets nod to market psoriasis drug in India

BOUDRY, Switzerland--(BUSINESS WIRE)--

Celgene International Srl, a subsidiary of Celgene Corporation (CELG), today announced that statistical significance for the primary endpoint of PASI 75 at week 16 was achieved for patients receiving apremilast 30 mg BID monotherapy in both the ESTEEM 1 & 2 phase III studies. ESTEEM 1 & 2 are the two pivotal phase III, randomized, placebo-controlled studies evaluating apremilast, the companys oral small-molecule inhibitor of phosphodiesterase 4 (PDE4) in patients with moderate to severe chronic plaque psoriasis.

Patients on apremilast also achieved a statistically significant benefit over placebo in the major secondary endpoint, Static Physician Global Assessment (sPGA).

Psoriasis is a common immune-mediated skin disease affecting nearly 125 million people worldwide, said Kim Papp, M.D., Ph.D. of Probity Medical Research, Canada. Despite advances in treatment over the last decade, a significant proportion of moderate to severe psoriasis patients remain inadequately treated. The primary reason for psoriasis patients not receiving adequate therapy is the burden associated with available treatment options. As a consequence, there is a high unmet medical need for an efficacious, safe, oral option that patients can take long-term.

An NDA submission for psoriasis, based on ESTEEM 1 & 2 data, is expected in the second half of 2013. The company previously announced it expects to file an NDA for psoriatic arthritis (PsA) in the first quarter of 2013 and a combined MAA for psoriasis and psoriatic arthritis in Europe in the second half of the year.

The Phase III safety and tolerability data are improved over previously observed phase II psoriasis data and consistent with results from the phase III psoriatic arthritis trials. The overall psoriasis safety database includes nearly 2,000 patients to date. ESTEEM 1 & 2 are ongoing trials. Subjects are being evaluated for safety and efficacy in the long-term extension studies for up to an additional four years. Approximately one-third of the study population was treatment-nave and two-thirds had prior exposure to either systemic and/or phototherapy; approximately one-third of the overall study population had prior biologic therapy.

To date, the five positive phase III studies from the ESTEEM and PALACE programs represent the most comprehensive clinical data for submission for patients with psoriatic disease. Clinical data from ESTEEM 1 & 2 are planned for presentation at upcoming major medical meetings.

About ESTEEM 1 & 2

ESTEEM 1 & 2 are two pivotal phase III randomized, placebo-controlled study evaluating apremilast in subjects with a diagnosis of moderate to severe chronic plaque psoriasis for at least 12 months prior to the screening, and at baseline, and who are also a candidate for phototherapy and/or systemic therapy. Approximately 1,250 patients were randomized 2:1 to receive either apremilast 30 mg BID or placebo for the first 16 weeks, followed by a maintenance phase from weeks 16-32 in which placebo subjects were switched to apremilast 30 mg BID through week 32, and a randomized withdrawal phase for responders from Week 32-Week 52 based on their initial randomization and PASI response.

About Apremilast

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Apremilast ESTEEM Program Meets Primary and Major Secondary Endpoint in Pivotal Phase III Psoriasis Trials