Category Archives: Psoriasis

Market Dynamics of the Global Psoriasis Drugs Market: Understanding the segments helps in identifying the importance of different factors that aid the market growth.

The statistics highlights the numerous factors which are primary purpose for the short-paced enlargement of the Psoriasis Drugs Market. The facts include a look at the pricing history of the product and retail pricing that is in offering in current scenario to better understand primary reason behind demand and supply. In addition to the price of the goods or the offerings, various developments to study supply chain and production volume is closely examined in the file moreover embody the influential mounting of the population at the global degree. In addition to it, the product additionally researches the impact of the several projects of the government in the forecast duration.

While global mega trends influencing the market routing the primary direction of growth, regional markets are swayed by more granular locally unique market drivers. The market study is sized with regional and country level break for historical and forecast period by revenue and volume and price analysis, stay tuned with the latest updates from the research insights know more which territory is stealing market share gains in coming years.

Major Geographies Covered: North America Country (United States, Canada), South America, Asia Country (China, Japan, India, Korea), Europe Country (Germany, UK, France, Italy) & Other Country (Middle East, Africa, GCC) etc.

***Sub Regions Included: North America [United States, Canada, Mexico], Asia-Pacific [China, India, Japan, South Korea, Australia, Indonesia, Malaysia, Philippines, Thailand, Vietnam], Europe [Germany, France, UK, Italy, Russia, Rest of Europe], South America [Brazil, Argentina, Rest of South America], Middle East & Africa [GCC Countries, Turkey, Egypt, South Africa, Rest of Middle East & Africa]

The document also tends of inculcating the information of the profiling of the several distinguishable vendors which have been prevailing in the international marketplace of Psoriasis Drugs. The analysis additionally has a tendency of talk me about the numerous strategies that have been adopted by using numerous market place game enthusiasts for the gaining of the competitive side over the friends and inside the boom of the reach in the worldwide marketplace.

Top Players in the Market are:

AbbVie Inc., Amgen Inc., Johnson & Johnson, Novartis AG, Eli Lilly & Company, AstraZeneca, Celgene Corporation, UCB, Merck, Boehringer Ingelheim, LEO Pharma

The study is a source of reliable data on

Market segments and sub-segments:

Product Type Segmentation

Application Segmentation

Market trends and dynamics Supply and demand

Market sizing, growth & estimates considering current trends/opportunities/challengesCompetitive landscapeTechnological breakthroughsValue chain and stakeholder analysis

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With the given market data, We offers customizations as per the companys specific needs. The following customization options are available for the report:Product Analysis: : Product matrix, which gives a detailed comparison of the product portfolios of each companyGeographic Analysis: : Further breakdown of the European, Asia Pacific, and the Rest of the World segments into their respective countries for this marketCompany Information: : Detailed analysis and profiling of additional market players (up to 5)Volume Data: : Customization options for volume data* (number of units sold) and customization options for volume data [* if applicable]1-year analyst support, along with the data support in excel format.Opportunities Assessment: A detailed report underlining the various growth opportunities presented in the market

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Psoriasis Drugs Market with Emerging Technologies, Business Opportunity and Industry Forecast to 2030 Bloomingprairieonline - Bloomingprairieonline

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Showering is one of the biggest uses of water in a typical residential home, according to the EPA. You dont want to use too much water in your shower, but you do need more than a few minutes to get fully clean. So where is the balance?

Dermatologists recommend keeping showers short. If you have skin conditions like eczema or psoriasis, hot water can be irritating, and so can soaps and other products you use in the shower. The American Academy of Dermatology recommends keeping showers under 10 minutes if you have itchy skin, and if you have psoriasis, you may want to go further and limit showers to just five minutes. (Lukewarm water is better than hot, which will also help you save energy.)

A five-minute shower doesnt mean you should stand under the showerhead for four minutes and then do a cursory lather in the last minute. Good hygiene is important; if youre getting into the shower, make sure youre washing what needs to be washed.

That may mean taking a lot more than five minutes. Those of us with long hair may need to be in there 10 to 20 minutes to wash and condition properly, and comb out the tangles (a job best done while conditioner is in wet hair), not to mention shaving our legs. Arguably some of these jobs can be done while the water is off, but if you arent willing to give up your long hot showers, perhaps you can counter the detrimental effects on your skin and the environment by taking fewer of them. One shower a week is hygienic enough for most of us, and better for our skin anyway.

A lot of shower advice out there seems to center around five minutes as the ideal shower time. But if dermatologists are okay with five to 10 minutes, and some of us need more time, perhaps we should aim for the middle of that range. Eight minutes turns out to be the average length of a shower for most of us, which means that if you can get through your next shower in seven minutes or less, you can feel like an overachiever. Five minutes? Great, Im proud of you.

When it comes to water usage, standard showerheads use 2.5 gallons per minute, but showerheads with the WaterSense label all use 2.0 gallons per minute or less. So you can shower for 6.2 minutes with a low-flow head and use as much water as someone showering for five minutes with a standard head. Since youre also using less hot water, youll also save energy.

So to benefit both your skin and the environment, get an efficient showerhead, turn down the heat, and dont spend any longer in there than you really need to.

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This Is the Ideal Amount of Time to Spend in the Shower - Lifehacker

Two abstracts presented at the 2022 American Academy of Dermatology (AAD) Annual Meeting explored the health-related quality of life (QOL) and mental health impact of psoriasis disease burden by severity and affected body region.

The health-related quality of life (HRQOL) impact of psoriasis was shown to be associated with severity of disease and location of lesion manifestations, according to findings of 2 abstracts presented at the 2022 American Academy of Dermatology (AAD) Annual Meeting.

As the prevalence, incidence, and morbidity of psoriasis has risen over the last 3 decades, prior research investigated the growing discussion regarding mental health and QOL in patients.

Patients with psoriasis have been shown to be at a heightened risk of depression and adverse behavioral health symptoms, in which comorbidities such as psoriatic arthritis and disease severity have been shown to exacerbate risk. The incidence of psoriasis in special areas (face, scalp, palms/soles, nails, genitals) was noted by researchers to also potentially increase disease burden.

Leveraging the multinational UPLIFT survey, a web-based survey of adults with self-reported health care providerdiagnosed psoriasis that was conducted from March 2 to June 3, 2020, they evaluated the impact of special area involvement on QOL outcomes and depression screening.1

A total of 3614 patients with psoriasis who did and did not have special area involvement were compared via Dermatology Life Quality Index (DLQI) total score and Patient Health Questionnaire-2 (PHQ-2) depression screen measurements.

Of the study cohort, 76.8% (n = 2776) had psoriasis in att least 1 special area (face, 28.1%; scalp, 53.4%; palms/soles, 24.6%; nails, 16.7%; genitals, 12.2%).

Compared with patients without special area involvement, the mean (SD) DLQI scores were shown to be higher in patients who had psoriasis in 1 or more special areas overall (9.9 [8.5] vs 7.3 [7.3]). DLQI scores were shown to be highest for those with psoriasis in the face (12.4 [8.9]), palms/soles (11.7 [9.0]), and genitals (11.7 [9.0]), followed by nails (11.6 [9.1]) and scalp (9.5 [8.4]).

Patients with involvement in 1 or more special areas were also more likely than those without special area involvement to report that their psoriasis had at least a moderate effect on QOL (DLQI 6; 57.9% vs 47.5%) and to have a positive depression screen (PHQ-2 3; 53.2% vs 44.1%).

A greater proportion of patients with psoriasis in 1 or more special areas (43.3%) had a DLQI scores of 6 or above and PHQ-2 of 3 or higher vs patients without special area involvement (32.8%).

Results of the UPLIFT survey underscore the additional QOL and psychological burdens of psoriasis for patients with special area involvement vs those without involvement in special areas, concluded the researchers.

The HRQOL impact on patients with psoriasis was further investigated by another analysis that assessed how improvements in Psoriasis Area and Severity Index (PASI) were associated with the achievement of DLQI 0/1 (no impact of skin disease on patients life).2

Pooled data from the initial 16-week periods of the BE SURE, BE VIVID, BE READY, and BE RADIANT phase 3/3b trials evaluating the use of several biologics in plaque psoriasis was included in the analyses.

Analyses included 2223 randomized patients with psoriasis who presented with a mean baseline PASI of 20.4 and a mean baseline DLQI of 10.7 (bimekizumab, n = 1362; placebo, n = 169; ustekinumab, n = 163; adalimumab, n = 159; secukinumab, n = 370).

Findings indicated that incremental PASI improvements translated to higher rates of patients achieving DLQI 0/1:

These data highlight the importance of complete skin clearance for patients with plaque psoriasis and suggest that for patients who respond to treatment, but do not achieve complete skin clearance, residual disease may still negatively impact HRQOL, said the researchers.

References

1. Langley RG, Augustin M, McBride S, et al. Impact of psoriasis in special areas on patient quality-of-life outcomes and depression screening: Findings from the multinational UPLIFT survey. Presented at: 2022 American Academy of Dermatology Annual Meeting; March 25-29; Boston, MA. Abstract 33950.

2. Blauvelt A, Lebwohl M, Gottlieb A, et al. Complete skin clearance for patients with moderate to severe plaque psoriasis: The relationship between improvements in Psoriasis Area and Severity Index and health-related quality of life. Presented at: 2022 American Academy of Dermatology Annual Meeting; March 25-29; Boston, MA. Abstract 33884.

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Examining the Impact of Psoriasis Disease Burden on QOL, Mental Health - AJMC.com Managed Markets Network

Psoriasis may be a skin condition, but its impact is more than skin deep. Research has shown psoriasis can increase the risk of mental and emotional issues such as depression, anxiety, low self-esteem, and loneliness.

The condition characterized by itchy, discolored patches of skin that most often develop on the knees, elbows, and scalp can cause you to feel self-conscious about exposing your skin in public, says Ahmad Amin, MD, an assistant professor of dermatology at Northwestern Medicine in Chicago. This, in turn, can prevent you from participating in activities such as going to the gym or socializing with friends, which can lead to depression or anxiety.

The physical symptoms of psoriasis can lower your quality of life as well. When someone has psoriasis, the patches on the skin can be uncomfortable painful, itchy, and troublesome, explains Dr. Amin. The skin is often very flaky, and patients can shed excess skin [leaving] flakes on their clothes, on their desk, or on the floor.

Problem is, if youve been living with psoriasis for a long time, you may not realize how much the condition is impacting your mental and emotional health. Take this short quiz to find out and learn how to deal with any challenges it reveals.

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Quiz: Is Psoriasis Affecting Your Mental and Emotional Health? - Everyday Health

The results from the scan didnt fit in with any sort of injury, or any sort of wear and tear damage, and with a few other nagging bits in my history, it meant that I was referred straight to the rheumatology team, Wilson says. Despite inconclusive blood tests, Wilson was diagnosed with rheumatoid arthritis. It wasnt until she was 28 that she had what she describes as her largest breakthroughshe moved to another part of the country and saw a new doctor. A fresh pair of eyes meant my diagnosis changed to psoriatic arthritis, and with that my treatment changed too, she says.

Unlike Parker, Wilson doesnt have skin psoriasis, which is possible (though less common) and another factor that may contribute to a delayed diagnosis. In some cases, PsA symptoms may present before the skin symptoms show up, especially in young patients, Dr. Fors Nieves adds. The skin psoriasis may also be present in less visible parts of the body, like the scalp, under the arms, or on the groin or genitals.

The first hurdle of treatment is typically finding the right specialist, which can be a struggle for some. While Parkers first rheumatologist wasnt the right fit, she eventually found a provider she felt comfortable with. I wanted someone who I could relate to and feel heard, she says. I wanted to see someone who understood a person of color may have different experiences with medical staff, and a professional who knew how to communicate with me in a way that was helpful and hopeful.

The next step is finding a treatment method that works for you. In the decade since she first saw a doctor for her joint pain and swelling, Wilson has tried several different treatments with varying levels of success. A few years ago, she underwent arthroscopic surgery to try to reduce some of the inflammation of her knee joint. Wilson says it helped for a while, but it certainly wasnt a cure. She currently manages her condition with a combination of anti-inflammatory medications, biologic injections, exercise, and sleep.

Early and mild PsA is often treated with non-steroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen and naproxen. For some patients, sporadic use of these medications is sufficient to control their symptoms, Dr. Fors Nieves says. But in more severe cases, and in patients who are experiencing joint damage from the inflammation, stronger medications are often required.

In the case of a patient who is having regular flares with attacks of swollen joints and severe stiffness, we may need to add immunomodulatory medication since PsA is an autoimmune condition, says Dr. Fors Nieves. These might include conventional disease-modifying antirheumatic drugs (DMARDs), biologics, or enzyme inhibitors.

Some patients may require multiple medicines to have their skin and joint disease under control, Ronald Yglesias, MD, a rheumatologist in Aventura, Florida, tells SELF.

Managing this condition isnt just about taking medicationslifestyle changes can actually be life-changing for people with PsA. The key is listening to your body to get an idea of what it needs (or what it really needs a break from.) For instance, Wilson started to cut back on alcohol when she realized it was a major trigger for pain and stiffness the next morning.

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The Winding Road to Psoriatic Arthritis Relief - Self

2022 APR 05 (NewsRx) -- By a News Reporter-Staff News Editor at Insurance Daily News -- New research on Biotechnology - Biologics is the subject of a report. According to news reporting originating from Creteil, France, by NewsRx correspondents, research stated, Treatment options for psoriasis (PsO) and psoriatic arthritis (PsA) have evolved significantly throughout the era of biologics. Clinical trials are inadequate to assess the relative long-term efficacy of biologics and are often insufficient regarding safety.

Our news editors obtained a quote from the research from University Paris Est Creteil, To assess the long-term persistence of different biologic classes to treat PsO and PsA. This nationwide cohort study involved the administrative health care database of the French health insurance scheme linked to the hospital discharge database. All adults with PsO and PsA who were new users of biologics (not in the year before the index date) from January 1, 2015, to May 31, 2019, were included and followed up through December 31, 2019. Patients hospitalized for PsA in the PsO cohort and for PsO in the PsA cohort in the year before the index date were excluded. Data were analyzed from June 1 to October 31, 2021. Persistence was defined as the time from biologic therapy initiation to discontinuation and was estimated using the Kaplan-Meier method. Comparison of persistence by biologic class involved using propensity score-weighted Cox proportional hazards regression models and adjustment on specific systemic nonbiologics (time-dependent variables). A total of 16 892 patients with PsO were included in the analysis (mean [SD] age, 48.5 [13.8] years; 9152 men [54.2%] men). Of these, 10 199 patients (60.4%) started therapy with a tumor necrosis factor (TNF) inhibitor; 3982 (23.6%), with an interleukin 12 and interleukin 23 (IL-12/23) inhibitor; and 2711 (16.0%), with an interleukin 17 (IL-17) inhibitor. An additional 6531 patients with PsA (mean [SD] age, 49.1 [12.8] years; 3565 [54.6%] women) were included; of these, 4974 (76.2%) started therapy with a TNF inhibitor; 803 (12.3%), with an IL-12/23 inhibitor; and 754 (11.5%), with an IL-17 inhibitor. Overall 3-year persistence rates were 40.9% and 36.2% for PsO and PsA, respectively. After inverse probability of treatment weighting and adjustment, the IL-17 inhibitor was associated with higher persistence compared with the TNF inhibitor for PsO (weighted hazard ratio [HR], 0.78 [95% CI, 0.73-0.83]) and PsA (weighted HR, 0.70 [95% CI, 0.58-0.85]) and compared with the IL-12/23 inhibitor for PsA (weighted HR, 0.69 [95% CI, 0.55-0.87]). No difference between the IL-17 inhibitor and IL-12/23 inhibitor for PsO was noted. The IL-12/23 inhibitor was associated with higher persistence than the TNF inhibitor for PsO (weighted HR, 0.76 [95% CI, 0.72-0.80]), with no difference observed for PsA. The findings of this cohort study suggest that IL-17 inhibitors are associated with higher treatment persistence than the TNF inhibitor for PsO and PsA. Interleukin 17 inhibitors were also associated with higher persistence than the IL-12/23 inhibitor for PsA, with no difference for PsO.

According to the news editors, the research concluded: However, the persistence rates of all biologics remained globally low at 3 years.

This research has been peer-reviewed.

For more information on this research see: Long-term Persistence of First-line Biologics for Patients With Psoriasis and Psoriatic Arthritis in the French Health Insurance Database. JAMA Dermatology, 2022. JAMA Dermatology can be contacted at: Amer Medical Assoc, 330 N Wabash Ave, Ste 39300, Chicago, IL 60611-5885, USA.

The news editors report that additional information may be obtained by contacting Laetitia Penso, EpiDermE, University Paris Est Creteil, Creteil, France. Additional authors for this research include Laura Pina Vegas, Pascal Claudepierre and Emilie Sbidian.

Publisher contact information for the journal JAMA Dermatology is: Amer Medical Assoc, 330 N Wabash Ave, Ste 39300, Chicago, IL 60611-5885, USA.

(Our reports deliver fact-based news of research and discoveries from around the world.)

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University Paris Est Creteil Reports Findings In Biologics (Long-term Persistence Of First-line Biologics For Patients With Psoriasis And Psoriatic...

WESTLAKE VILLAGE, Calif., April 06, 2022 (GLOBE NEWSWIRE) -- Arcutis Biotherapeutics, Inc.(Nasdaq: ARQT), a late-stage biopharmaceutical company focused on developing meaningful innovations in immuno-dermatology, today announced the enrollment of the last subject in its ARRECTOR pivotal Phase 3 trial of topical roflumilast foam in adolescents and adults with scalp and body psoriasis. Roflumilast foam is a once-daily, topical formulation of a highly potent and selective phosphodiesterase-4 (PDE4) inhibitor (roflumilast). The foam formulation was designed to treat all areas of the body, including the face and particularly hair-bearing areas such as the scalp. If successful, the Company believes that this trial will provide sufficient basis to file a supplemental New Drug Application (sNDA) in the U.S. for roflumilast foam in scalp and body psoriasis.

Scalp psoriasis occurs in approximately 40% of individuals with plaque psoriasis and can cause physical and emotional distress, with 97% of individuals with scalp psoriasis reporting that the condition impacts their daily life.i

The scalp and hair-bearing areas of the body create unique treatment challenges, not easily solved through creams or ointments, and often requiring patients to use multiple therapies, complicated treatment regimens or resort to expensive systemic or biologic therapies. This can result in lack of compliance to treatment and worsening symptoms. Roflumilast foam has been formulated to overcome these challenges and provide a once-daily treatment option for use on all areas of the body, said Patrick Burnett, MD, PhD, FAAD. We are proud of the continued execution of our clinical development program as demonstrated by the completion of enrollment in a second pivotal phase 3 program for roflumilast foam this year. More importantly, we move one step closer to providing an important treatment option to millions of individuals impacted by scalp psoriasis.

About ARRECTORThe A Randomized tRial Employing topiCal roflumilasT foam to treat scalp psORiasis (ARRECTOR) study is a parallel group, double blind, vehicle-controlled pivotal Phase 3 study of the safety and efficacy of roflumilast foam 0.3% or a matching vehicle administered once-daily in subjects with scalp and body psoriasis ages 12 and older. A total of 432 subjects have enrolled in the study. The co-primary endpoints of the study are the proportion of subjects achieving Scalp-Investigators Global Assessment (IGA) success and the proportion of subjects achieving Body-IGA success, with IGA success defined as an IGA score of clear or almost clear plus a 2-point improvement from baseline after eight weeks.

About Scalp and Body PsoriasisScalp psoriasis is a manifestation of plaque psoriasis characterized by raised, red areas of skin (plaques) covered with a silver or white scale that occurs in the hair-bearing area of the scalp and sometimes extending to the forehead, back of the neck, or behind or inside the ears. Patients with scalp psoriasis commonly have plaques on other areas of the body as well. Approximately 40 percent of the estimated 8.6 million Americans with plaque psoriasis have involvement of the scalp. Scalp psoriasis plaques are identical to psoriatic plaques on other areas of the body; however, topical treatment of scalp plaques is complicated by the difficulty of delivering topical drugs under the hair and onto the skin. As with psoriatic plaques on other parts of the body, psoriasis on the scalp is often itchy and is sometimes painful. Scalp psoriasis can also be associated with hair loss, likely due to damage to the hair from excessive scratching, rubbing, or combing of the affected area. Often, patients require two or more medications to manage their disease when they have scalp involvement.

About Topical Roflumilast Foam Topical roflumilast foam is a once-daily, topical formulation of a highly potent and selective PDE4 inhibitor (roflumilast), which the Company is developing for both seborrheic dermatitis and scalp and body psoriasis. The unique foam formulation is designed to penetrate and treat inflammatory dermatoses in hair-bearing areas of the body, such as the scalp, although it is usable on all areas of the body. Arcutis has also submitted a New Drug Application (NDA) for a closely related cream formulation of topical roflumilast for the treatment of plaque psoriasis, with a Prescription Drug User Fee Actaction date of July 29, 2022. Roflumilast has been approved by the U.S. Food and Drug Administration (FDA) for oral treatment to reduce the risk of exacerbations of chronic obstructive pulmonary disease (COPD) since 2011. PDE4 is an intracellular enzyme that increases the production of pro-inflammatory mediators and decreases production of anti-inflammatory mediators; it has been implicated in a wide range of inflammatory diseases including psoriasis, atopic dermatitis, and COPD. PDE4 is an established target in dermatology, and other PDE4 inhibitors have been approved by the FDA for the topical treatment of atopic dermatitis and the systemic treatment of plaque psoriasis.

About ArcutisArcutis Biotherapeutics, Inc. (Nasdaq: ARQT) is a medical dermatology company that champions meaningful innovation to address the urgent needs of patients living with immune-mediated dermatological diseases and conditions. With a commitment to solving the most persistent patient challenges in dermatology, Arcutis harnesses our unique dermatology development platform coupled with our dermatology expertise to build differentiated therapies against biologically validated targets. Arcutis dermatology development platform includes a robust pipeline with multiple clinical programs for a range of inflammatory dermatological conditions, with one NDA under review with the FDA and three Phase 3 clinical data readouts anticipated by the end of 2022. The companys lead program, topical roflumilast, has the potential to advance the standard of care for plaque psoriasis of the body and scalp, atopic dermatitis, and seborrheic dermatitis. For more information, visitwww.arcutis.comor follow Arcutis on LinkedIn and Twitter.

Forward-Looking StatementsThis press release contains "forward-looking" statements, including, among others, statements regarding the potential for roflumilast to be approved for the treatment of adults and adolescents with scalp and body psoriasis, the potential to use roflumilast foam over a long period of time, or chronically, the potential to use roflumilast foam anywhere on the body, including the face and scalp, and the potential for roflumilast to advance the standard of care in scalp and body psoriasis and other inflammatory dermatological conditions. These statements involve substantial known and unknown risks, uncertainties and other factors that may cause our actual results, levels of activity, performance, or achievements to be materially different from the information expressed or implied by these forward-looking statements and you should not place undue reliance on our forward-looking statements. Risks and uncertainties that may cause our actual results to differ include risks inherent in the clinical development process and regulatory approval process, the timing of regulatory filings, and our ability to defend our intellectual property. For a further description of the risks and uncertainties applicable to our business, see the "Risk Factors" section of our Form 10-K filed with U.S. Securities and Exchange Commission (SEC) on February 22, 2022, as well as our subsequent filings with the SEC. We undertake no obligation to revise or update information herein to reflect events or circumstances in the future, even if new information becomes available.

Contacts:MediaAmanda Sheldon, Head of Corporate Communicationsasheldon@arcutis.com

InvestorsEric McIntyre, Head of Investor Relationsemcintyre@arcutis.com

i Crowley J. Scalp psoriasis: an overview of the disease and available therapies. J Drugs Dermatol. 2010 Aug;9(8):912-8. PMID: 20684141.

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Arcutis Completes Enrollment in ARRECTOR Pivotal Phase 3 Trial of Topical Roflumilast Foam in Scalp and Body Psoriasis - GlobeNewswire

Sustained adoption of conventional disease modifying anti-rheumatic drugs (DMARDs), especially in cost sensitive regions, is projected to push the demand forpsoriatic arthritis treatmentin coming years.

Nearly 70% of the psoriasis patient population is prone to psoriatic arthritis, and up to 20% of arthritis patients are susceptible to acquire psoriasis, according to the recent findings of the Arthritis Foundation.

The rate of increasing burden of psoriasis and psoriatic arthritis on healthcare industry has been boosting clinical research in the field of psoriatic arthritis, in recent years.

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Role of Strong Product Pipeline & Mounting Clinical Research Investments

Over 20 drugs for psoriasis and psoriatic arthritis are currently in the phase II of pipeline, whereas more than 28 are in phase III of clinical trial, as indicated by the National Psoriasis Foundation. However, around 24 drugs have already received FDA approval for inclusion in the treatment for psoriasis and psoriatic arthritis.

While such a strong product pipeline continues to drive the demand for psoriasis and psoriatic arthritis treatment, a new research points to the shifting focus of several drug manufacturers to competitive pricing strategies, in an effort to attain widespread acceptance in coming years. Recently, Future Market Insights released a new intelligence based on the analysis of global psoriatic arthritis treatment market. The study forecasts a robust over-7% yearly growth for the market in 2022.

Industry Behemoths Cover More than 55% Market Value Share

In a fairly consolidated global landscape of psoriatic arthritis treatment market, more than 55% share of the total revenue is accounted by industry giants such as Novartis AG and AbbVie Inc. that include biologics in their core portfolio. While market leaders are maintaining focus on FDA approvals and clinical trials, research also points to the increasing importance of diverse pricing strategies.

Moreover, prominent players in psoriatic arthritis treatment market are likely to augment investments in R&D of biosimilars, biologics, and TNF (tumor necrosis factor) inhibitors to target regional markets. A number of leading drug manufacturers are also maintaining sizable investments in DMARDs that are scheduled for market entry in next few years. This is perceived as a strong factor improving growth prospects of psoriatic arthritis treatment market, according to the report.

Besides all these, strategic acquisitions, partnerships, and collaborations will remain the preferred expansion strategies adopted by a majority of prominent operators in psoriatic arthritis treatment landscape, says a senior research analyst at the company.

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Demand for Biologics & DMARDs Gaining Momentum

Research-driven understanding of the pathophysiology of psoriatic arthritis is fueling the introduction of innovative therapies in psoriatic arthritis treatment market, triggering innovations among the market participants thereby supporting the growth of psoriatic arthritis treatment market. Targeted biological therapy has been demonstrating a decent success rate in terms of inducing temporary pain relief resultant of psoriatic arthritis, and thus continues to represent an attractive position in the psoriatic arthritis treatment market.

The report says that the demand for biologics accounts for more than 55% share of the global market revenue, whereas DMARDs demand makes up for more than 3/4thof the total market value. Although a majority of psoriatic arthritis patients opt for injectable as a preferred route of administration of psoriatic arthritis treatment, increasing introduction of innovative oral drugs is uplifting the popularity of orally administered psoriatic arthritis treatment.

Development of novel oral treatments for psoriatic arthritis is likely to favor the growth of North Americas market. Growing availability of combination therapies and relatively economical biosimilar antibody therapeutics are identified to be the primary boosters for the growth of Europes market. Collectively, North America and Europe account for over 60% share in the global value of psoriatic arthritis treatment market. The report indicates that the psoriatic arthritis market in Asia Pacific is likely to display high growth potential in the course of next few years.

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Psoriatic Arthritis (Psa) Treatment Market Growing at a Healthy 7.1% CAGR, and Projected a Valuation - PharmiWeb.com

The immune system is the body's first line of defensewhen infection-causing pathogens invade, the immune system springs into action, launching substances designed to neutralize the invaders. But that process can go haywire, and the immune system can actually attack the body's own tissues and organs. That's what's known as autoimmune disease. There are several of them, and their symptoms can be wide-ranging, from uncomfortable to potentially debilitating. These are the most common signs your body is attacking itself, according to doctors. Read on to find out moreand to ensure your health and the health of others, don't miss these Sure Signs You've Already Had COVID.

Could be: Rheumatoid arthritis

When the immune system attacks the linings of the joints, rheumatoid arthritis can develop, causing painful swelling. Smaller joints tend to be affected first, followed by larger ones; about 40 percent of people affected by rheumatoid arthritis experience symptoms that don't involve the joints, such as issues with the eyes or skin. "In some people, the condition can damage a wide variety of body systems, including the skin, eyes, lungs, heart and blood vessels," says the Mayo Clinic.

Could be: Lupus, Arthritis

"The classic sign of an autoimmune disease is inflammation, which can cause redness, heat, pain and swelling," says the U.S. National Library of Medicine. Inflammation is a hallmark of a number of autoimmune conditions, the most common being lupus, a complex disease most often diagnosed in women between the ages of 15 and 44. It has a wide range of symptoms, including fatigue, fever, joint pain, stiffness and swelling, and a facial rash.

Could be: Multiple sclerosis

Multiple sclerosis is an autoimmune disorder that causes the body's immune system to mistakenly attack its own healthy cells, damaging the sheath that covers the nerves. This can lead to various neurological symptoms. Numbness and tingling is one of the most common first signs, doctors say, as are vision problems (which tend to affect only one eye). Other symptoms include balance problems, trouble walking, stiffness or weakness in the limbs, and fatigue.

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Could be: Crohn's disease

Crohn's disease is a type of inflammatory bowel disease (IBS) in which the immune system attacks the digestive tract, causing chronic inflammation. That can lead to abdominal pain, diarrhea, blood in the stool, fatigue, weight loss, and even malnutrition. Symptoms can range from mild to severe and might involve any part of the small or large intestine. It's treated with anti-inflammatory drugs, immunosuppressants and antibiotics.

RELATED: 6 Signs You Might Have Multiple Sclerosis

Could be: Psoriasis, Lupus6254a4d1642c605c54bf1cab17d50f1e

Skin-related symptoms are another common sign of autoimmune disorders. A red "butterfly rash" that develops over the nose and both cheeks is a common sign in lupus. In psoriasis, the body's skin cells go into overproduction mode and build up on the skin in rough, red patches or silvery scales. In psoriatic arthritis, joint pain, redness and swelling accompany the scaling. Both conditions are treatable with medication.

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Could be: Type 1 diabetes

Type 1 diabetes develops when the immune system destroys cells in the pancreas that are responsible for generating insulin, the hormone that helps the body process sugar and turn it into energy. Without that processor, blood sugar can rise to dangerous levels, damaging blood vessels and increasing the risk of heart disease, stroke, dementia, and blindness. Although it's most commonly diagnosed in childhood, type 1 diabetes can develop at any age. Other symptoms include frequent thirst, increased urination, fatigue, constant hunger, and intentional weight loss.

And to protect your life and the lives of others, don't visit any of these 35 Places You're Most Likely to Catch COVID.

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Signs Your Body Is Attacking Itself, Say Doctors Eat This Not That - Eat This, Not That

Hair loss can be hard. For many people, losing something that is a such a big part of their identity can make them feel uncomfortable in their own skin. Some thinning hair is inevitable with aging, but luckily, it can also be caused by many other factors that are more under your control like hormonal imbalances, stress, or even what type of hair brush you use. With so many possible culprits, though, it may seem impossible to get to the root of the problem. But if you're struggling with hair loss in your sixth decade and beyond, it is likely that a common condition is to blame. Read on to discover what could be making you lose your hair if you're over 50, and how to turn things around.

RELATED: If You're Over 65, Not Doing This in the Shower Is Causing Hair Loss.

One of the most common culprits of hair loss after age 50 is inflammation, a natural response in the body that helps protect from infection and diseases. But if you are chronically inflamed, serious health issues can occur. According to Ben Behnam, MD, FASD, and medical director at hair loss treatment brand Happy Head, inflammation can damage the hair follicles, which can cause strands to fall out. Inflammation can also damage the hair shaft, making it difficult for new hair to grow.

Examples of inflammation on the scalp include dandruff, psoriasis, alopecia areata, and redness and flakiness. Each of these conditions varies, but some of the most common symptoms are itchiness, burning, and even hair loss. However, Behnam notes that not all patients will experience these symptoms.

One of the many causes of inflammation in the bodywhich can ultimately lead to hair lossis an autoimmune reaction. An autoimmune reaction is when the body's immune system mistakenly attacks healthy tissue. "This can happen in a number of autoimmune diseases like lupus erythematosus or alopecia areata, both of which can cause patchy hair loss," says Cheryl Rosen, MD, board-certified dermatologist and director of dermatology at BowTiedLife.

Note that these conditions are somewhat rare: Only about 1.5 million Americans have lupus, per the Lupus Foundation of America. And alopecia areata affects about 2.1 percent of Americans, according to the National Alopecia Areata Foundation. Rosen says autoimmune reactions can also be triggered by things like infections, stress, or certain medications.

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According to the American Academy of Dermatology Association, psoriasis is an inflammatory skin condition in which your immune system turns over skin cells too quickly, causing scaly patches. A common area for these patches to develop is the scalp. The National Psoriasis Foundation says that about 8 million Americans suffer from this condition.

Dandruff, on the other hand, is a condition that causes the skin on the scalp to flake. According to Mayo Clinic, it can be triggered by dry skin, a yeast-like fungus, or sensitivity to hair products. Per The International Journal of Trichology, the condition impacts around 50 percent of adults.

Hair loss can occur with both psoriasis and dandruff due to intense itching that manually pulls out the hair. The inflammation of the follicle that causes the conditions can also slow or stop hair growth.ae0fcc31ae342fd3a1346ebb1f342fcb

Fortunately, there are treatments available to improve the condition of the scalp and promote new hair growth. Rosen says they include anti-inflammatory medications, topical treatments, and light therapy.

For example, if you have psoriasis, you may be prescribed a topical steroid to reduce your symptoms, says Behnam. If you have dandruff, you may be offered an anti-dandruff shampoo, such as Nizoral, to soothe the inflammation. For cases of alopecia areata, there are injectable drugs available to reduce inflammation. Over time, hair growth can be restored. "If you are suffering from hair loss due to inflammation, talk to your doctor about the best treatment option for you," says Rosen. That way, you can restore your strands to their healthiest state.

RELATED: If Your Hair Is Thinning, This Food Could Be to Blame, Study Says.

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If You're Over 50, Inflammation Is Making You Lose Your Hair Best Life - Best Life