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Category Archives: Transhuman News

Long-Term Efficacy and Safety of Tofacitinib in Patients With Psoriatic Arthritis Analyzed – Rheumatology Advisor

Posted: April 19, 2021 at 6:59 am

In patients with active psoriatic arthritis (PsA), treatment with tofacitinib is associated with long-term efficacy (up to 36 months) and safety (up to 48 months), according to results of an analysis published in Lancet Rheumatology.

Researchers sought to evaluate the long-term safety and efficacy of tofacitinib in adult patients with active PsA.

The open-label, long-term extension study the final analysis of the Oral Psoriatic Arthritis Trial (OPAL) Balance study (ClinicalTrials.gov Identifier: NCT01976364) was conducted at 124 centers in 16 countries.

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Primary study endpoints included incidence of clinical laboratory abnormalities, changes from baseline in laboratory parameters up to 48 months in patients from the long-term extension study and substudy, and incidence and severity of adverse events (AEs). Eligible patients in OPAL Balance study had also participated in the OPAL Broaden or the OPAL Beyond phase 3 trials.

In the OPAL Balance study, all participants received open-label tofacitinib 5 mg twice daily, with dose escalations to 10 mg twice daily at month 1 for inadequate symptom control, as well as reductions to 5 mg twice daily thereafter for safety. All participants could continue to receive concomitant treatment with specific conventional synthetic disease-modifying antirheumatic drugs. Eligible patients could also enter the randomized, double-blind methotrexate withdrawal substudy, in which participants received open-label tofacitinib 5 mg twice daily plus either masked methotrexate or masked placebo.

A total of 686 participants were enrolled in OPAL Balance study, between February 17, 2014, and March 28, 2016, who received treatment with tofacitinib and were enrolled in the all-tofacitinib group for the safety and efficacy analyses. Ultimately, 66% (n=453) of participants completed this study and 34% (n=233) discontinued their participation in either the long-term extension study or the methotrexate withdrawal substudy. In the all-tofacitinib group, the mean duration of tofacitinib treatment was 794.6 days and the total duration of treatment was 1492.4 person-years in the long-term extension study. Mean age of the participants in the all-tofacitinib group was 48.8 years; 54% of the participants were women; mean duration of PsA was 7.6 years.

Up to month 48, 84% (n=574) of participants reported the occurrence of all-cause AEs, with 17% experiencing serious AEs and 11% discontinuing treatment because of an AE. Overall, 6 patients died, among whom 1 was within the risk period (incidence of death was 0.1 patients with events [95% CI, 0.0-0.3] per 100 person-years). Incidences of AEs of special interest, which was defined as the number of patients with events per 100 person-years, included the following: 1.7 (95% CI, 1.2-2.5) for herpes zoster; 1.0 (95% CI, 0.6-1.6) for serious infections; 0.4 (95% CI, 0.1-0.8) for opportunistic infections; 0.7 (95% CI, 0.4-1.2) for malignancies other than nonmelanoma skin cancer (NMSC); 0.9 (95% CI, 0.5-1.5) for NMSC; 0.2 (95% CI, 0.1-0.6) for major adverse cardiovascular events; 0.4 (95% CI, 0.1-0.8) for arterial thromboembolism; and 0.1 (95% CI, 0.0-0.3) for pulmonary embolism. Efficacy was sustained for up to 36 months.

A major limitation of the current study included the lack of generalizability to patients who are new to tofacitinib treatment. Further, the long-term extension study was open-label and had no placebo group; the analyses used observed values; and evaluations of dose-related effects were conducted post hoc.

Researchers concluded that the data reported in this trial support the use of tofacitinib in the long-term treatment of active [PsA].

Disclosure: This analysis was supported by Pfizer. Please see the original reference for a full list of authors disclosure.

Nash P, Coates LC, Fleishaker D, et al. Safety and efficacy of tofacitinib up to 48 months in patients with active psoriatic arthritis: final analysis of the OPAL Balance long-term extension study. Lancet Rheumatol. 2021;3:270-283. doi:10.1016/S2665-9913(21)00010-2

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Psoriasis Therapeutics Market 2021 Will Reflect Significant Growth in Future with Size, Share, Growth, and Key Companies Analysis- Astellas Pharma…

Posted: at 6:59 am

Up Market Research (UMR) has included a latest report on the Global Psoriasis Therapeutics Market into its archive of market research studies. The report is an amalgamation of detailed market overview based on the segmentations, applications, trends and opportunities, mergers and acquisitions, drivers, and restraints. The report showcases the current and forthcoming technical and financial details of the Psoriasis Therapeutics market. The research study attracts attention to a detailed synopsis of the market valuation, revenue estimation, and market statistics. The study on the emerging trends in the global and regional spaces on all the significant components, such as market capacity, cost, price, demand and supply, production, profit, and competitive landscape. The report also explores all the key factors affecting the growth of the global market, consisting of the demand-supply scenario, pricing structure, profit margins, production, and value chain analysis.

Some of the major companies that are covered in this report:

Astellas Pharma Inc.AstraZeneca plcBoehringer Ingelheim GmbHF. Hofffmann-La RocheGlaxoSmithKline plcMerck & Co.Inc.Valeant Pharmaceuticals InternationalInc.Biocon LimitedEli Lilly and CompanyG & W Laboratories Inc.

*Note: Additional companies can be included on request

Get a free exclusive sample report of Psoriasis Therapeutics market @ https://www.upmarketresearch.com/home/requested_sample/11821

Impact of COVID-19

The report also talks about the impact of the ongoing global crisis i.e., COVID-19 on the Psoriasis Therapeutics market and explains how the future is going to unfold for the global market. Our analysts have researched thoroughly about the effects of the pandemic on the global economy. The outbreak has directly affected production and demand disrupted the demand and supply chain. The report also computes the financial impact on firms and financial markets. Up Market Research (UMR) has accumulated insights from several delegates of the industry and got involved in the primary and secondary research to offer the clients data & strategies to combat the market challenges during and after the COVID-19 pandemic.

Highlights of the report:

Our research analysts who are the building blocks of the company have worked extensively to fabricate the research report which will give that extra edge to our clients business in the competitive market. The market research report can be customized as per you and your needs. This means that Up Market Research (UMR) can cover a particular product, application, or can offer a detailed analysis in the report. You can also buy a separate report for a specific region.

You can buy the complete report in PDF format: @ https://www.upmarketresearch.com/buy/psoriasis-therapeutics-market

The market scenario is likely to be fairly competitive. To analyze any market with simplicity the market is fragmented into the following segments:

By Applications:

OralParenteralTopical

By Types:

TNF InhibitorsPDE4 InhibitorsInterleukin BlockersOthers

By Regions:

Segmenting the market into smaller components helps in analyzing the dynamics of the market with more clarity. Another key component that is integrated into the report is the regional analysis to assess the global presence of the Psoriasis Therapeutics market. You can also opt for a yearly subscription of all the updates on the Psoriasis Therapeutics market.

If you have any questions on this report, feel free to reach us! @ https://www.upmarketresearch.com/home/enquiry_before_buying/11821

Below is the TOC of the report:

Executive Summary

Assumptions and Acronyms Used

Research Methodology

Psoriasis Therapeutics Market Overview

Global Psoriasis Therapeutics Market Analysis and Forecast by Type

Global Psoriasis Therapeutics Market Analysis and Forecast by Application

Global Psoriasis Therapeutics Market Analysis and Forecast by Sales Channel

Global Psoriasis Therapeutics Market Analysis and Forecast by Region

North America Psoriasis Therapeutics Market Analysis and Forecast

Latin America Psoriasis Therapeutics Market Analysis and Forecast

Europe Psoriasis Therapeutics Market Analysis and Forecast

Asia Pacific Psoriasis Therapeutics Market Analysis and Forecast

Asia Pacific Psoriasis Therapeutics Market Size and Volume Forecast by Application

Middle East & Africa Psoriasis Therapeutics Market Analysis and Forecast

Competition Landscape

About Up Market Research (UMR):

Up Market Research (UMR) has a vast experience in making customized market research reports in a number of industry verticals. We strive for complete client satisfaction. We cover in-depth market analysis, which consists of stipulating lucrative business strategies, especially for the new entrants and the emerging players of the market. Our team makes sure that each report goes through intensive primary, secondary research, interviews, and consumer surveys before final dispatch.

We invest in our analysts to ensure that we have a full roster of experience and expertise in any field we cover. Our team members are selected for stellar academic records, specializations in technical fields, and exceptional analytical and communication skills. We also provide ongoing training and knowledge sharing to keep our analysts tapped into industry best practices and loaded with information.

Contact Info UpMarketResearchName Alex MathewsEmail [emailprotected]search.comWebsite https://www.upmarketresearch.comAddress 500 East E Street, Ontario, CA 91764, United States.

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Psoriasis Therapeutics Market 2021 Will Reflect Significant Growth in Future with Size, Share, Growth, and Key Companies Analysis- Astellas Pharma...

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Pediatric Psoriasis Market Compound Annual Growth Rate of 21.38% | Market Trend Growing demand for biologics and natural remedies for child…

Posted: at 6:59 am

The promising drug pipeline will further propel the demand for the advanced medication in the long run. This trend is expected to propel over the forecast period as the prevalence rate has been increasing. Hence, a thorough understanding approach is required for disease management, which would certainly help manage childhood psoriasis better. However, lack of awareness in emerging economies and insufficient research funding may hamper the market.

The global Pediatric Psoriasisreport studies the prudent tactics undertaken by the leading market players, such as partnerships and collaborations, mergers & acquisitions, new product launches, and joint ventures. The global Pediatric Psoriasisis highly consolidated due to the presence of a large number of companies across this industry. These companies are known to make hefty investments in research and development projects. Also, they control a considerable portion of the overall market share, thus limiting the entry of new players into the sector.

To get leading market solutions, visit the link below: https://www.emergenresearch.com/industry-report/pediatric-psoriasis-market

The global Pediatric Psoriasisstudy covers the current COVID-19 scenario that has turned the global business sphere upside down. The coronavirus has resulted in a major economic downturn worldwide, while also adversely impacting the growth of this industrial sector. The pandemic has brought about drastic changes in market conditions. Therefore, the latest report elaborates on the rapidly changing market scenario and conducts preliminary, as well as the future assessment of COVID-19 impact on the market. Moreover, the document contains a broad analysis of prime aspects of the market, with expert opinions on the current market standing and historical data.

Key highlights of the Global Pediatric Psoriasisreport:

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C4X shows being early to the party can bring success – Vantage

Posted: at 6:59 am

C4X Discoverys business model, of out-licensing rather than developing projects in house, looks like it is starting to deliver. This weekthe UK group announced a 414m ($494m) biodollar licensing deal with Sanofi for its oral preclinical IL-17A inhibitor programme. While the upfront payment of 7m was slightly more modest, landing a big name partner was enough help drive shares in the UK biotech up by 8%.

The deal with Sanofifollows an agreement with Indivior in 2018, worth$10m up front,and is all part of a plan by C4X's chief executive, Clive Dix, to hand off assets before they even hit the clinic. Speaking to Evaluate Vantage he said: We think our technology is best placed finding molecules, getting good quality starting points, taking them as far as we can as a candidate and out licensing.

This approach runs counter to that of many UK biotechs, which have traditionally focused on discovering single products usually due to funding constraints and trying to commercialise them. It is an method that Mr Dix thinks might have held some companies back.

We try to avoid thisbecause if your first molecule fails it kills the company, and if it doesnt it changes the company completely, because you then become that molecule, he says.

Shifting the risk

In C4Xs deal with Sanofi, the French company will take on all of the risks and cost of commercialising the oral IL-17 inhibitor, which will be developed initially in psoriasis.

The current leading IL-17 inhibitor forpsoriasis, Novartis's Cosentyx,sold almost $3bn for this use last year, but as a MAb it tends to be reserved for more severe forms of the disorder.

C4X is hoping its small molecule approach will allow the treatment model to move back to milder forms of psoriasis, giving themand Sanofia bigger share of the market, which is forecast to hit $32bn in 2026, according to Evaluate Pharma.

Alongside the 7m upfront payment from Sanofi, C4X is in line for a further 11m if a candidate enters the clinic. The money will be ploughed back into C4Xs current pipeline, which includes a Nrf-2 activator and an oral 47 integrin inhibitor programme, in the hopes of finding partners for these assets. Mr Dix is also on the lookout for another project to bring in to keep the number of internal programmes running at about five.

The deal with Sanofi has brought some renewed investor interest in the company, whose shares had hit historic lows earlier this year. But at 43p the stock isstill a long way off the 130p it hit in 2016, making C4X look relatively cheap.

Staying single

ButMr Dix is not interested in selling anytime soon. The end goal is to make this a sustainable drug discovery engine. Roll forward five or six years and if we have done another three deals, then you have an expectation of revenues coming in all the time and its a fairly chunky business.

And it is gaining scale through deals that generate revenues that Mr Dix hopes will keep C4X independent. All the little [UK] companies that have done well have been bought in the main by an American [group]and disappeared, he says.

Mr Dix blames theinability of UK firms to grow independently on the age-old problem of lack of funding in the country. If there was the right sort of risk-reward funding then we might build a company that becomes the next Celltech or the next Amgen, but the funding model doesnt work at the moment, it just doesnt want to put big money behind clinical development candidates, he says.

As such C4X will have to keep signing more deals with big pharma if it wants to buck the UK biotech trend.

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Jess Wright says coping with heartache of uncle’s tragic death made her psoriasis worse – Mirror Online

Posted: at 6:59 am

Jess Wright has admitted that dealing with her uncle's tragic death has made her psoriasis get worse.

The former TOWIE star, 35, has always been honest with fans about her skin condition - something she's been battling for 14 years.

And it seems as though it's only gotten worse after she was forced to endure major heartbreak when her uncle Edward died from coronavirus.

The reality TV star said that although it's been frustrating to see her psoriasis worsen during the last "really rubbish few months", Jess admits she's glad she was honest with fans.

"My psoriasis has got a lot worse because of the pandemic. With my uncle and all the stress of the past year, it's flared up. It's been a really rubbish few months with everything that's gone on," she told new! mag.

"I'm really glad I did share it. So many people appreciate my openness and it's important to keep it real," Jess added.

Psoriasis is an autoimmune disease that turns skin red, dry and itchy.

Jess last month opened up about how "broken" her beloved uncle's death has left her.

"Broken," Jess began in her social media tribute.

"It still doesnt seem real that youre gone. You leave the biggest hole in our familys heart because you were everything that represented the Wrights & you did everything you could to keep us together as much as possible as it meant so much to you.

Jess continued: "Not just my uncle, but like a second dad to me in so many ways."

She went on: "The best grandad, dad, husband, son & uncle there ever could be. Your smile lights up every room & you are the glue that held us all together.

"I will look after nanny & grandad just like you did so well, I promise. And your children who I love like my own brothers and sister.

"I miss you so much already Ed, see you again some day. Love you uncle Eddie," Jess concluded in her touching message.

Do you have a story to sell? Get in touch with us at webcelebs@trinitymirror.com or call us direct 0207 29 33033

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Party Politics: The Politics of Scandal – Houston Public Media

Posted: at 6:56 am

Congressman Matt Gaetz, R-Fla., speaks at Women for American First event, Friday, April 9, 2021, in Doral, Fla. The House Ethics Committee has opened an investigation of Rep. Gaetz, citing reports of sexual and other misconduct by the Florida Republican. (AP Photo/Marta Lavandier)

This week on Party Politics, co-hosts Brandon Rottinghaus and Jeronimo Cortina discuss the withdrawal of U.S. forces from Afghanistan, the allegations surrounding Florida Rep. Matt Gaetz, Ted Cruzs fight against Major League Baseball, and Ron Pauls jorts, among other stories.

NATIONAL TOPICS

Withdrawal from Afghanistan

GaetzGate

TEXAS TOPICS

Congressman Crenshaw emergency eye surgery

Cruz vs. Americas pastime

Paxton v Biden on "Remain in Mexico Policy"

Bush vs. Paxton 2022?

Congressman Brady Retiring

Ron Paul's Short Shorts

You can subscribe to the podcast on Apple Podcasts. Tweet us using #PartyPoliticsPod or email partypoliticspod@houstonpublicmedia.org. Party Politics is produced by Troy Schulze, the audio engineer is Todd Hulslander.

Fill out the form below to subscribe our new daily editorial newsletter from the HPM Newsroom.

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Ron Price’s coaching longevity will be tough to eclipse – Los Angeles Times

Posted: at 6:56 am

Ron Price is a walking, talking legend in Southern California. Across seven decades and some 60 years, Price has been coaching football.

He was on the same fields with City Section coaching Hall of Famers Chris Ferragamo (Banning), Jack Neumeier (Granada Hills) and Gene Vollnogle (Carson) and players John Elway, Rod Martin and Warren Moon. He was the health teacher for Washington Preps Paul Knox while at Hamilton and coached against Venice coach Angelo Gasca when Gasca was a high school quarterback.

Hes been a head coach at Crenshaw, Palisades and Fairfax. He started as an assistant coach in 1961 at Brentwood Military Academy and now is an assistant coach at St. Monica.

This will be the last decade and could be the last year, he said. When youre 84, youre like all the great athletes day to day. I feel great. As long as I can do it, Ill do it.

Coaching the offensive line has been Prices specialty. Coaching anything has been his life-long passion.

Ive always enjoyed it, he said. Its always been fun. Its what I wanted to do from the time I was a teenager.

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Many years ago his father, who was a doctor, questioned his professional pursuit while living in Chicago. His dream was to coach the Chicago Bears.

He used to look at me and laugh. He said, The only Bears youll ever be coaching will be in a zoo.

Price has been coaching so long that a couple players at St. Monica are sons of former players he coached. St. Monica head coach Geoff McArthur played for him at Palisades.

Gasca said of Prices seven-decade coaching stint:

An incredible accomplishment. Hes an amazing person who I greatly admire and respect. I competed against his teams as a high school player. Competed against him as a coach. Then had the fortune to work with him for many years. Im better for it and so are the lives of all the people whose lives he touched. An icon.

With apologies to Texas and Florida, the best high school football game of the 2020-21 school year will take place Saturday night at Santa Ana Stadium when Bellflower St. John Bosco (5-0) takes on Santa Ana Mater Dei (4-0) to decide the spring Trinity League championship.

If St. John Bosco coach Jason Negro and Mater Dei coach Bruce Rollinson could combine their teams and take them on the road to face any and all challengers, theyd be unbeatable.

The lines are big, powerful and mobile. The running backs are fast and big-play weapons. The quarterbacks are young but future college players. The secondaries are aggressive and fearless.

It has all the makings of another classic game. The last one between these two schools saw St. John Bosco roar back from a seemingly insurmountable 28-5 deficit in 2019 to win 39-34 in the fourth consecutive Southern Section Division 1 final involving the two schools.

For this game, Mater Deis defense will present a lot more problems for the Braves quarterback duo of Pierce Clarkson and Katin Houser. Its probably a good situation that St. John Bosco is still alternating quarterbacks every series, because that gives the Braves options to take advantage of each quarterbacks different strengths.

The big clue about which team will win should come early. Its going to be about which team can run the ball most effectively to open up the passing game.

So break out the popcorn on Saturday night, lay back on the couch at 7 p.m. and turn on Bally Sports West. You can hear Petros Papadakis and Greg Biggins raving about how many future five-star recruits are in the game. MaxPreps.com says theres 59 players on the rosters who have FBS offers. It will be the most entertaining high school football game in America

Joshua Koo, a 16-year-old junior at Cerritos High, shot a final round of 10-under-par 62 to win the two-day Toyota Tour Cup junior golf tournament in Palm Desert on Sunday. He had eight birdies and an eagle.

I hadnt been hitting that well recently and was working on my putting, he said. That day everything clicked. It was a really fun round.

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Rekha Basu: I’ve had a vaccine ‘passport’ since childhood. What’s all the fuss about? – desmoinesregister.com

Posted: at 6:56 am

"That is not normal. That's not what we do in America," Iowa state Sen.Jack Whitver declared emphatically on last week's "Iowa Press" interview show.

I was washing dishesand had missedthe lead-in, but caught the emotion in hisvoice. What unacceptable behavior was theleader of majority Republicans in the Senate denouncing? Was someone driving on a neighbor's lawn? Swearing in church? Giving illegal drugs to a child?

I re-wound to get the context. The senator from Ankeny had beentalking about COVID-19 and the hope for achieving herd immunity to getlife back to normal."I would encourage anyone that is able and willing, to get vaccinated,"he'd said, observing that Iowa had made tremendous progress,with some 23% of people having been fully vaccinated as of then.

So far, so good.

Then Whitver's tone changed."Thegovernment is issuing some sort of piece of paper or smartphone app to prove you've been vaccinated," he said indignantly. "We want to get back to normal, but not this new society where you have to show a piece of paper. That is not normal. That's not what we do in America."

Iowa Gov. Kim Reynolds had previously been even more vocal against such a thing.While she alsoencourages people to get vaccinated, saying, "I believe in the efficacy of the vaccine," she draws the line at so-called "vaccine passports."

Gov. Reynolds stated she opposes vaccine passports and that Iowa "must take a stand as a state against them." Des Moines Register

"I believe that we must take a stand as a state against them, with executive action or through legislation," she said at a news conference.

As I write thisI'm looking down at the old yellow-pagedpassport-size booklet that I've carted around for 33 years.It's called an "International Certificate of Vaccination as approved by the World Health Organization" and issued by the U.S. Department of Health and Human Services. It carries my name, sex and date of birth (I neglected to fill in my address) and has a log of my travel vaccinations since 1988 when my home was in New York state. There's typhoid and immune globulin (2-10-88), typhoid, cholera and something else I can't make out (2-7-89), andthe names of the doctors who administered them. That certificate was replaced by one filled outby the Polk County Health Department in Iowa, with thestamp, "Official Vaccination Iowa."

More: Rekha Basu: In remembering Breasia, the 'village' shows its power to mourn, to heal and to change things

Is this what Whitver and Reynolds areafraid of? I've had one literally since soon after I was born, since my parents crossed continents often. It let officials in those countriesknow my vaccines were up to date. But mostly, I got the vaccines to ward off outbreaks of diseases in the areas we were going to. Among other things, the certificates served asreminders of whichvaccines were due. Wenever considered them an imposition.

What's all the fuss over vaccine passports?(Photo: Rekha Basu/Des Moines Register)

So which government is Whitver talking about?None in America.The federal government has said itwill not mandate digital vaccine passportsfor COVID-19. In fact the federal government keeps no centralized database of Americans' vaccinations. States do that.New York is the only one to have developeda free digital health certificate, which verifiessomeone is fully vaccinated and tested negative;its use is optional.On the other side,Florida and Texas have used executive orders to ban businesses from requiring vaccination certificates, over concerns that they violateprivacy.

It's really businesses that are asking for and requiring that proof, includingairlines, cruise lines and sporting event venues, and that's to keep people safe if they choose to go.The International Air Transport Association is nowtesting a travel pass onto whichpassengers can upload health credentials necessary for international travel.

More: Rekha Basu: A wake-up call? The Iowa Poll shows a big disconnect between Iowans, especially women, and elected officials.

None of that is government interference. It's only if you choose to travel.Andwhile states have legal authority to legislatively restrict whatbusinesses can do,there's some question about whether they can do it by executive order.The only thing Reynolds may could indisputablyorder would be toforbid county and local governments from issuing vaccine passports notthat there's been any move to do so.

Like every other state, Iowa does require proof of vaccination for children to attend public schools, as well it should.And whileIowa'sthree public universities require proof ofmumps, measles and rubella vaccinations to enroll (with medical or religious exemptions),the Iowa Board of Regents won't require students or employees at to get vaccinated against COVID-19 to attend. Why not? The private Grinnell Collegewill.

The New York Times reports thatIsraeli residents are required to show an electronic Green Pass to attendgyms, concerts and indoor restaurants.Israel plans to require foreign visitors to take a blood test upon arrival, to be replaced withvaccine certificates once available. TheEuropean Union has endorsed the idea of an electronic vaccine certificate, though European countries can choose for themselves.

More: Rekha Basu: Des Moines picks not one, but two officers with troubled history to teach de-escalation

Just as people suspicious ofgovernment mandates recoiled at the idea of mandatory masks, some are now jumping on the vaccine reporting techniquesto stir upfears about an invasion of privacy.

It's worth emphasizing that both Whitver and Reynolds encourage Iowans to get vaccinated. Reynolds, though, has done so, whileWhitver hasn't.Asked about it on TV, he said hethought more vulnerable populations should get it first. Reynolds got the Johnson & Johnson vaccine. After officials announced that it had beenassociated with blood clots in a small number of people, Reynolds said thatshe'd do it again.

Everyone is free tomake their own health choices, but her leadership by example ismore compelling advocacy than mereencouragement of an act to benefit public health.

More: Opinion: Change agent Kimberly Graham weighs challenging John Sarcone for Polk County attorney

Further, it's both misleading and harmful to suggest that the federalgovernment is forcing anything like vaccine passports on Americans.Former U.S. Rep.Ron Paul, a Republican fromTexas, tweeted of such documentation, Accepting them means accepting the false idea that government owns your life, body and freedom. Wow.

Maybe pointing out that the issue is not about government but instead about private businesses wouldn't serve the political agenda and could alienate industries in Republican politicians'bases. But distorting the truth shouldn't be what we do in America, either.

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How to improve policing in Florida and beyond | Letters – Tampa Bay Times

Posted: at 6:56 am

Policing needs an upgrade

Minnesota officer who shot man to death meant to draw Taser, not handgun, chief says | April 12

I served as an assistant public defender at the beginning of my legal career for approximately five years. That experience left me aware of one true thing: Being a police officer is the toughest job you can ever imagine. On a daily basis, you are expected to be completely familiar with the latest nuances of constitutional law, a social worker who can defuse volatile situations, and the toughest man or woman in the valley. Ive never gone down a dark alley not knowing who might be there wishing to do me harm, or into a dark house. Unless you have, it may be wise to temper your criticism of our police.

Nevertheless, like so many people, I am dismayed and disheartened to see a continuous stream of African-Americans die at the hands of law-enforcement officers, when the offense that attracted the officers attention was relatively minor. Clearly change is needed in our manner of policing. Clearly the authorities need to understand that it not reasonable to respond to a routine traffic stop with the threat of deadly force, much less its use. New rules are clearly needed, and in making those rules we need to balance the rights of citizens with recognition of the degree of danger we ask police officers to accept as a part of their daily work lives.

Paul Ley, Belleair

DeSantis: Businesses requiring vaccine passports cant get state money | April 2

Gov. Ron DeSantis missed a golden opportunity to help Florida recover from the COVID-19 crisis. If he had encouraged vaccine passports rather than opposing them, many who are sitting on the fence about getting vaccinated might realize there would be places they cant go without one, and might change their minds about getting the jab. As it is, similar vaccination passports, while not for COVID vaccines, have always been required for travel to many countries abroad. A similar requirement for COVID vaccinations would be a powerful incentive for everyone to get vaccinated. Businesses and ticketed events in Florida would have a tool to keep their customers safer from infections, and with a resulting boost in the percentage of the population getting vaccine protection, we might be able to put the pandemic in the rear view mirror sooner.

Betsy Clement, Dunedin

Florida Senate approves anti-riot bill, heads now to DeSantis | April 15

If the Black, brown, progressive and other people who correctly interpret the anti-riot bill (HB1) as a another slap in the face by the white Republicans in Tallahassee, perhaps they should use the energy they would have spent protesting and instead direct it to getting everyone registered to vote, and then to actually vote in every election, every time. Voting is where the real power lies. In 30 years, whites will no longer be such a powerful majority, but we dont have to wait until then; we can vote them out right now.

James Condon, Port Richey

DeSantis wants voters signatures to match. Would his pass the test? | April 13

Thanks for publishing the article by Steve Contorno about Gov. Ron DeSantis signature changing over time. This points to the uselessness of signature matching as proof of identity except as a device and pretext to toss away someones legitimate vote.

Signatures have always been used as a backup method of proving the authenticity of a document when there is question about its validity. No one checks a will to see that the signature matches unless someone is challenging the authenticity of the will. Same with most checks and financial instruments, absent a question of forgery. A signature proves that the named person signed and committed themselves to the contractual obligation implied. Even today the illiterate can sign documents with an X so long as it is noted and properly witnessed.

Matching a signature would be a forensic exercise done by experts usually in a legal proceeding. May I suggest most election board members are not qualified to make a determination about a signature match in the first place? May I also suggest and that this is a process easily abused by the politically unscrupulous or those too easily intimidated by state and even federal officials?

Harley Lofton, Palm Harbor

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How to improve policing in Florida and beyond | Letters - Tampa Bay Times

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Winter’s return, threat of new health restrictions tough blows for businesses – Winnipeg Free Press

Posted: at 6:56 am

The return of winter weather Monday was an expensive disruption for many businesses struggling to recover after a year of public-health restrictions which may tighten again soon.

The past year has battered many local restaurants, and with their patios buried under 10 or more centimetres of snow, the pain continues this week.

"I would imagine that well see probably between 30 and 40 per cent lower sales this week than we saw last week," said Kaely Dyck, a co-owner of four Smittys restaurants.

Until Monday, dine-in restaurants had been capitalizing from generally pleasant early spring weather. Some reported raking in over half their revenue from patio sales. Representatives at Bar Italia, Corrientes and Stone Angel Brewing Co. all said they expect significant drops in sales in the upcoming week.

Jay Kilgour, owner of Fionn MacCools on Grant Avenue, said patio sales have accounted for 70 per cent of sales in recent weeks. Judging from last week's receipts, he estimated the weather will cost his business $20,000.

With sales expected to plummet this week, many restaurants are already cancelling servers' shifts. Some havent returned to full-time hours since the province relaxed restrictions, so they may still qualify for some unemployment benefits, Dyck said. Others may not be so lucky.

"There will be some staff that this is a huge hit for, for sure," she said.

The snow wasnt the only worry weighing on business owners minds Monday. Chief provincial health officer Dr. Brent Roussin told a news conference rising COVID-19 case counts may leave the province with no choice but to reimpose increased restrictions soon.

Manitoba Restaurant & Foodservices Association executive director Shaun Jeffrey said restaurant owners often call him with worries about ramping up restrictions.

RUTH BONNEVILLE / WINNIPEG FREE PRESS

With sales on patios expected to plummet this week, many restaurants are already cancelling servers' shifts.

"It would just be such a defeating blow to our industry," he said. "We just couldnt survive another (lockdown). There would be a lot of towels being thrown in."

Restaurants have been going above and beyond to follow and adapt to restrictions, he said. Many have invested heavily in patio spaces by purchasing additional heaters and tables, he said. Demand has raised prices and that will add to the losses that result from winter's return, brief though it may be.

Garden centres also reported slow business Monday. The main concern, said Ray Dubois, owner of Ron Pauls Garden Centre, is the threat of increased restrictions.

Garden centres were deemed essential services in previous lockdowns, but owners still worry restrictions could cut into profits during their busiest season.

Dubois said he does about 60 per cent of his business in May and June. If restrictions tighten, he could be left on the hook for unsellable merchandise. He said he carries an inventory worth more than $1 million.

"It would be a catastrophic loss," said Dubois, adding he's preparing for the worst.

"I would be shocked if they dont pre-emptively lock this down," he said. To mitigate his losses, he said hes prepared to shift business models. During earlier lockdowns, he said, he started selling groceries, which he can do because hes a member of Federated Co-operatives Ltd. Other centres may not have that option, however.

Mondays snow also had motorists cancelling appointments to swap out their winter tires, several garages around town reported. For most, it was a minor issue, but Rudy Epp of Rudys Auto Service said his slew of cancellations was one more thing after a tough year. And it comes during what is normally his busiest month.

"Its been a little flatter already because of COVID, and now with this little setback, this is going to push things back further again," he said.

Epp said people often use winter-tire appointments to spring for other repairs and maintenance, so losses from the appointments may be greater than just the tire changes if they're not rescheduled.

fpcity@freepress.mb.ca

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Winter's return, threat of new health restrictions tough blows for businesses - Winnipeg Free Press

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