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Category Archives: Transhuman News

How a genetic ‘CopyCatcher’ could open the door to CRISPR-based precision gene therapy – FierceBiotech

Posted: May 14, 2021 at 6:56 am

Gene therapies such as Novartis spinal muscular atrophy treatment Zolgensma deliver a surrogate copy of a gene to replace a dysfunctional one in the body. The CRISPR gene editing tool could offer an alternative strategyone that could allow for a mutated gene to be fixed on site. But scientists arent sure whether such a technique, known as gene drive, would work at scale.

Researchers at the University of California, San Diego (UCSD) say they may have found a way to make CRISPR efficient in gene therapy. They have developed a technology called CopyCatcher, which candetect and quantify events in which a genetic element is copied precisely from one chromosome to another during CRISPR-based gene editing.

In fruit flies, CopyCatcher revealed unexpectedly high rates of gene conversion, according to results published in Nature Communications. With help of the new tool and DNA screening, the team also identified the c-MYC gene as an inhibitor of genetic copying in human embryonic cells. The researchers said the findings lay the groundwork for developing CRISPR-based gene therapy for humans.

The promise of CRISPR-based gene drives is that one chromosome bearing the drive can cutthe other chromosome, which uses the drive as a template torepair the damage. UCSD used CopyCatcher to measure the efficiency of such a system in living animals.

CopyCatcher carries a highly sensitive detectorgene that produces fluorescent proteins only if the target genetic element copies itself onto a sister chromosome, allowing investigators to detect and quantify gene conversion.

In fruit flies, the frequency of gene conversion was unexpectedly high, at 30% to 50% of cells in the targeted tissues of the eye and thorax, the team reported.

RELATED: MIT and UCSF researchers create CRISPR 'on-off switch' that controls gene expression without changing DNA

But the rates of chromosome copying dropped sharply to just 4% to 8% of cells in human cells. That may be because mammalian chromosomes dont typically engage in chromosome pairing but rely instead on a different mechanism to fix DNA cuts. The researchers showed they could use certain techniques to improve copying, suggesting that human cells might be induced to perform efficient gene conversion.

By using a genetic screen, the team identified several factors affecting how DNA selects a repair pathway. The gene c-MYC emerged as a prime inhibitor of templated gene conversion. Cutting the expression of c-MYC by half increased the production of fluorescence marker expression by 2.5-fold in human embryonic cells compared with control cells, the team showed.

If high-efficiency gene editing could be achieved in human cells, CRISPR-based gene therapies could be developed to treat a variety of genetic disorders including blood diseases, hearing loss, spinal muscular atrophy, congenital heart defects and others, the researchers suggested.

These studies provide a clear proof of principle for a new type of gene therapy in which one copy of a mutated gene could be repaired from a partially intact second copy of the gene, Ethan Bier, Ph.D., the studys senior author, said in a statement. The need for such a design occurs in genetic situations with patients with inherited genetic disorders, if their parents were carriers for two different mutations in the same gene.

For future studies, the researchers plan to use CopyCatcher to identify additional factors that can be manipulated to push the choice of DNA repair toward the chromosome-pairing mechanism. That could improve the efficiency of CRISPR-based editing, they believe.

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Dallas County prosecutor who withheld evidence disbarred after two 2 men cleared of murder – The Dallas Morning News

Posted: at 6:56 am

This story was updated at 1:20 p.m. with comments from Dallas County District Attorney John Creuzot.

A former Dallas County prosecutor quietly surrendered his law license last month after the State Bar of Texas said he withheld evidence that led to the wrongful convictions of two men in the slaying of a South Dallas pastor.

The State Bar concluded that Richard E. Rick Jackson failed to inform Dennis Allen and Stanley Mozees defense attorneys about evidence that could have cleared them at their 2000 capital murder trials. As a result, the courts say, Allen and Mozee wrongfully spent 14 years in prison for the murder of Rev. Jesse Borns Jr.

This case is not about someone disbarred for making a mistake or a prosecutor who accidentally or even sloppily failed to turn over favorable evidence, said Nina Morrison, a lawyer with the Innocence Project in New York, who worked to clear Allen and Mozee.

This is someone who repeatedly and intentionally hid favorable evidence from two defendants who were on trial for their lives.

Texas judges found Jackson withheld several pieces of evidence that could have helped Allen and Mozee. The men were freed from prison in 2014 and declared actually innocent in 2019 after DNA testing helped clear them.

Secret deal negotiations with jailhouse informants, witness descriptions that didnt match Allen and Mozee and false information that witnesses positively identified the men were among the evidence Jackson kept from defense lawyers, judges who reviewed the cases found.

The Innocence Project in New York and the Innocence Project of Texas filed a 196-page grievance with the State Bar in 2018 against Jackson.

Jackson has long maintained that he handed over the evidence to the defense and still believes Allen and Mozee are guilty, said Jacksons lawyer Bob Hinton.

He wasnt at all guilty of any of the things he was charged with in that stupid grievance complaint, Hinton said. If he had the financial wherewithal and he fought it, we would win it. Theres no question in my mind.

Hinton said that against his advice, Jackson chose not to spend his retirement savings fighting the accusation at a disciplinary hearing where he faced losing his law license.

The state bar told the Texas Supreme Court, which oversees all attorneys practicing law, that Jacksons resignation is in the best interest of the public and of the profession.

Jackson joins a short list of only four prosecutors nationwide disbarred for egregious misconduct in wrongful convictions, according to the Innocence Project.Three of the four prosecutors are from Texas. Ken Anderson was jailed five days for withholding a bandana that DNA testing later led to Michael Mortons exoneration in the killing of his wife in Williamson County. Charles Sebesta concealed that the actual killer in the slaying of six family members repeatedly denied that Anthony Graves was an accomplice until he struck a deal with the prosecution and testified against Graves in Burleson County. Anderson and Sebesta were the elected district attorneys in their counties. The other former prosecutor, Kenneth Peasley, was a deputy county attorney in Tucson, Arizona when he allowed a detective to lie on the stand in two capital murder trials.

Jackson retired from practicing law in 2013 after he was fired from the Denton County district attorneys office. While testifying in proceedings for Allen and Mozees cases, Jackson said he was terminated because he wanted to be tougher on crimes than his boss. The district attorneys office did not respond to requests for comment.

Jackson was also among a slew of prosecutors who were not invited to remain in the Dallas County district attorneys office after former DA Craig Watkins won the 2006 election. Jackson, who had spent 17 years as a Dallas County prosecutor, sued Watkins in federal court, claiming his termination was race-based. Jackson is white and Watkins is Black. A judge tossed the suit.

Hinton said Jackson didnt want to comment. He is angry over what he considers false accusations against him and was physically ill in Hintons office when he decided to surrender his law license, Hinton said. The career prosecutor now spends summers in Alaska where he drives tour buses that work with cruise ships, Hinton said.

Jacksons decision is just as good as an admission of guilt to me, said Allen, now 57.

If youre actually innocent, why would you not fight for that? Allen said. His lawyers -- what would you expect them to say?

Mozee, now 62, said he is relieved Jackson wont practice law again and feels the punishment is fair.

Thats a harsh accountability because he took some harsh tactics to convict me, Mozee said.

Allen, who says he lives a simple life in DeSoto, has spent the last few years studying the Bible more and drawing closer to God, he said. His Christianity helped him cope with the deaths of his parents last year, just seven months apart. His mother passed first from pneumonia and his father of COVID-19.

Allen participates in speaking engagements with both Innocence Project organizations and recently championed wrongful conviction reform bills that are being debated in the Texas legislature.

Mozee lives with his wife in Mesquite and spends much of his time volunteering in South Dallas.

Mozee, who is legally blind, does work cleaning up neighborhoods with former Councilwoman Diane Ragsdales nonprofit Innercity Community Development Corporation. This year, he published a book of African American folklore stories that he mostly wrote while in prison.

On April 6, 1999, Borns was stabbed 47 times and left for dead in his leather and woodworking store on Martin Luther King Jr. Boulevard. The real killer has not been caught.

Just two years before, Borns himself was released from prison on parole for fatally shooting a woman outside his church where he said theft and vandalism led him to keep a gun there. Borns returned to his South Dallas neighborhood and tried to minister to the homeless and downtrodden. Borns paid Mozee to clean his shop.

Allen and Mozee werent arrested until July 1999. Two other men were investigated for the crime before detectives focused on Allen and Mozee.

There were no eyewitnesses to the killing and forensic evidence at the time didnt lead to a suspect, according to court records. A store clerk who saw two people using Borns credit cards hours after the murder was called to testify. But after seeing Allen in court, the clerk testified he wasnt one of the people. Prosecutors relied on testimony from jailhouse informants and an alleged confession that a detective wrote and Mozee signed.

Allen and Mozee were sentenced to life in prison. New DNA tests conducted on evidence while the men were behind bars found that DNA that didnt match either man or Borns.

The Dallas County district attorneys office under Watkins re-opened the file and found evidence that defense lawyers said theyd never received, such as accounts from witnesses who saw two men argue with Borns outside the store the evening he was killed. Witnesses said one man was distinctly taller than the other and one had a noticeable scar across the side of his neck. Allen and Mozee are about the same height, about 6 feet, and neither had a scar.

The file also included previously undisclosed letters from people in jail who agreed to testify against Allen in exchange for favors in their cases.

Watkins and his three successors Susan Hawk, Faith Johnson and current District Attorney John Creuzot two Democrats and two Republicans supported the actual innocence claims for Allen and Mozee.

In March 2017, state District Judge Everett Young ruled the mens convictions should be vacated because Jackson withheld evidence. The Texas Court of Criminal Appeals, the highest criminal court in Texas, agreed in January 2018.

Creuzot, who took office in 2019, said he extended a personal apology to Allen and Mozee and asks their forgiveness for what this office did many years ago. He said he is praying for Borns family.

Its disappointing that a member of the Texas bar and a former employee of this office has been found to have violated his oath to his profession and to the constitutions of the United States and Texas to the extent that he deprived two innocent people of their freedom, Creuzot said.

The exonerees said they dont harbor ill will for Jackson.

I didnt like what he did, of course. But I did not allow Rick Jacksons wrongs to dictate and control and maneuver me, Allen said. God holds us accountable for what we do and how we act, so if you allow others to draw you into their wrongdoings or their miseries, then hell hold you accountable.

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DNA Explainer: What is black fungus or Mucormycosis? Know about its symptoms and treatment – DNA India

Posted: at 6:56 am

India is not just fighting the second wave of the COVID-19 pandemic but a new calamity has also put the lives of corona patients at risk across the country. Doctors in India have been recording a big spurt in cases of aggressive, hard-to-treat fungal infection calledblack fungus or Mucormycosis.

While mucormycosis cases have been seen in the country earlier, the current increase in infections is among people infected with COVID-19 and those who have recovered from the disease. The numbers are far above cases before the COVID-19 pandemic came into India.

Doctors believe mucormycosis, which has an overall mortality rate of 50%, maybe being triggered by the use of steroids, a life-saving treatment for severe and critically ill COVID-19 patients.

Mucormycosis, also known as black fungus or zygomycosis, is caused by a group of mould called mucormycetes.

These fungi live in the environment, particularly in soil and in decaying organic matter, such as leaves, compost piles, or rotten wood, according to the Center for Disease Control and Prevention.

When someone breathes these fungal spores, they are likely to get an infection that commonly affects the sinuses or lungs.

Medical experts say mucormycosis attacks people who are battling illnesses or are on medications that lower the body's ability to fight infections.

Patients with COVID-19 have weak immunity and a large number of them are put on steroids in order to control a hyperimmune response, thus making them susceptible to other fungal infections such as mucormycosis, say experts.

The majority of mucormycosis infections have been seen in COVID-19 patients with diabetes or those with underlying and undetected high blood sugar.

Patients suffering from the fungal infection typically have symptoms of a stuffy and bleeding nose.

Swelling of and pain in the eye, drooping of eyelids, and blurred and finally, loss of vision.

There could be black patches of skin around the nose.

An anti-fungal intravenous injection which costs Rs 3,500 a dose and has to be administered every day for up to eight weeks is the only drug effective against the disease.

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Rand Paul clashes with Fauci over coronavirus origins | TheHill – The Hill

Posted: at 6:50 am

Anthony FauciAnthony FauciFauci says school should be open 'full blast' five days a week in the fall Watch live: White House holds briefing with COVID-19 response team The Hill's 12:30 Report - Presented by Facebook - Colonial pays hackers as service is restored MORE on Tuesday clashed with Sen. Rand PaulRandal (Rand) Howard PaulFauci on Rand Paul: 'I just don't understand what the problem is with him' Buckingham Palace requests 'Trump Train' remove image of queen from bus The Hill's Morning Report - Presented by Facebook - Cheney poised to be ousted; Biden to host big meeting MORE (R-Ky.) over the role of the Wuhan, China, virology lab in the origins of COVID-19.

During a Senate hearing on the pandemic response, Paul alleged that the National Institutes of Health (NIH) had been sending funding to the Wuhan lab, which then "juiced up" a virus that was originally found in bats to create a supervirus that can infect human cells.

Paulpressed Fauci on the theory that the novel coronavirus was created in the Wuhan lab, and then somehow escaped, either because of an accident or because it was deliberately released.

"Sen. Paul, with all due respect, you are entirely, entirely and completely incorrect," Fauci said. "The NIH has not ever, and does not now, fund 'gain of function research' in the Wuhan Institute."

Paul continued to argue with Fauci, who is the director of the NIH's National Institute of Allergy and Infectious Diseases (NIAID), accusing him of cooperating with the Chinese government, and supporting the laboratory that bioengineered a deadly virus.

Fauci noted that although the NIH did fund a project at the Wuhan lab, it was not meant for "gain of function" research into human-made superviruses.

The NIH gave a grant to a group called EcoHealth Alliance, which hired the virology lab in Wuhan to conduct genetic analyses of bat coronaviruses and examine how they spread to humans. The Trump administration last year forced the NIH to terminatethe grant.

The false link between Fauci, the NIH and the Wuhan lab has been circulating amongright-wing media and politicians likePaul and Sen. Ron JohnsonRonald (Ron) Harold JohnsonImmigration experts say GOP senators questioned DHS secretary with misleading chart GOP split on counteroffer to Biden's spending Rand Paul clashes with Fauci over coronavirus origins MORE (R-Wis.) for months.

"Let me explain to you why that was done, the SARS COV-1 originated in bats in China. It would have been irresponsible of us if we did not investigate the bat viruses and the serology to see who might have been infected," Fauci said.

Gain of function research is a controversial form of study that involves boosting the infectivity and lethality of a pathogen. Fauci has advocated for the research in the past, but he denied that the NIH was funding it in China.

But Paul interrupted him, and hinted that not only was the virus introduced to the world because of a lab accident, it was also biologically engineered.

"Government scientists like yourself who favor gain function Paulsaid.

I dont favor gain of function research in China and you are saying things that are not correct, Fauciinterrupted.

The White House said it believes that China has "not been transparent" in releasing its findings on the origins of COVID-19, and the World Health Organization was severely limited in its investigation.

Fauci said he supports further investigation into the origin of the virus, but denied the NIH had any role in funding controversial research.

"I do not have any accounting of what the Chinese may have done, and I'm fully in favor of any further investigation of what went on in China," Fauci said."However, I will repeat again, the NIH andNIAID categoricallyhasnot funded gain of function research to be conducted in the Wuhan Institute."

Paul, a libertarian ophthalmologist, has clashed repeatedly with Fauci throughout the pandemic on a wide range of topics including the idea of herd immunity and the effectiveness of restrictions.

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Positive Technology And The Cosmic Mission: How AI Is Helping Humans Achieve States Of High Energy And Success – Forbes

Posted: at 6:39 am

Trans-humanism is not merely some geeky tech subculture, nor a futuristic daydream, but a pervasive phenomenon that is already impacting our humanness itself. Were talking about the merging of human beings with technology, and not just at the physical level, but possibly a merging that encroaches upon the most intimate dimensions of the soul.

And energy is the currency of the soul. Without it, stressors can overwhelm you, leaving self-doubt and anxiety in control. But by raising your field of energy, you live an elevated life: one of true transformation, high achievement, and success.

Stefanie Bruns, the founder of Business Flow Academy, believes that states of high energy are paramount in finding fulfillment in life. A psychologist and business mentor for 16 years, Bruns has dedicated herself to helping successful people break through their self-limitations and soar to new heights in business.

People buy into your level of energy. Its not only about your marketing strategy or your gift, she begins. Sometimes, people want to stay in the aura of an expert. If you raise your energy, you elevate your life.

Stefanie Bruns, Founder of Business Flow Academy

However, with transhumanism comes potential risks to our mental health, and therefore a potential dampening of our vibrational frequency. We have already seen this with the unintended negative impacts of screen-time, social media, and more advancements have on our lives. This is where positive technology comes in.

Although many scientific efforts have been devoted to acknowledging the risks of digital technologies, the question of how computers could be used to improve people's well-being has been much less explored.

This was the main motivation for the development of a novel research areaPositive Technologywhich aims at investigating how ICT-based applications and services can be used to foster positive growth of individuals, groups and institutions.

Positive technology or technology designed to improve the quality of our lives has boomed over the last few years. Now we have everything from happiness apps to physiological sensors that detect stress to digital objects that remind you to practice gratitude.

Through a discussion with Bruns, it became clear that while technology, particularly artificial intelligence, is often used to benefit mental health or business success separately, by combining the two use cases.

Reaching Your True Transformation

People rely on their past experiences to dictate their future actions and give unlimited gravity to the words of others. There are chains of the past. And when you get free from the past, you can create a better future, Bruns explains. Everybody tells themselves a story, and its our duty to find out whether the story is useful or dysfunctional.

Whether we hold on deeply to what we were told as a child or allow negative thoughts to sow seeds in our lives, this behavior can be highly damaging to our mental state. In letting past behaviors and actions define us, we rob ourselves of the energy needed to grow. But regression and victimhood will work against you in manifesting the life of abundance you envision. If you see yourself in these patterns of negativity, its time to create a new story.

Up until now, we have been on our own to deal with these emotions. But there are promising indications that AI can help.

Emotion regulationa person's ability to effectively manage and respond to an emotional experienceis a key aspect of psycho-social functioning and well-being. How could digital tools be used to support this process?

A study titled, New Technologies for the Understanding, Assessment, and Intervention of Emotion Regulation addresses this discusses the potential of integrating technologies such as AI-enabled virtual reality, wearable biosensors, smartphones, and biofeedback for improving understanding, assessment, and intervention of emotion regulation.

Every thought, and every action, has a special electromagnetic energy. If you tell yourself or others who you are every day, you will become that person, Bruns says. She believes that people in any stage of life can fall victim to this. Despite a successful career and an abundance of wealth, a lack of guidance can be all that stands between you and greater states beyond high achievement.

Whether youre a business owner, a coach, a doctor, or otherwise, AI has shown promising in developing a new perspective to overcome your doubt and elevate your life.

This all being said, a human touch will always be needed. True spirituality is and has always been the exploration of the wider field of reality; true spirituality cannot be other than true humanness.

Everything starts with you. If you have guidance on this path, you can reach your goals easily. Even with years of expertise, we all have blind spots where we fail to self-reflect. You need a mirror to explore your blind spots and find areas to grow and improve. A mentor can be that mirror for you, Bruns explains.

The Path of Joy

Bruns believes that overcoming doubt has everything to do with your personal identity: a crucial detail that many disregard when building or expanding their business. People may create a website, produce a product, and find the right price point, but in stepping into the vast field of marketing, they begin to get lost. On the surface, many people appear to have everything they need to build a successful business. But when we dig deep, step in and find their weakest point, we often discover that there are limitations in their personal life that manifest in their business, Bruns says. If your electromagnetic field is in a bad place, you wont be ready to work when you wake up - even if you slept for eight hours or more.

This is why it is crucial for all business leaders to implement a positive integration of human and technological support. For example, Rocky.ai is combining the strengths of a virtual assistant and a leadership coach and brings this together in a soft-skill training application, which is available at all times.

In another example, clinical research psychologist Dr. Alison Darcy created Woebot, a Facebook-integrated computer program that aims to replicate conversations a patient might have with his or her therapist. Woebot is a chatbot that resembles an instant messaging service. The digital health technology asks about your mood and thoughts, listens to how you are feeling, learns about you and offers evidence-based cognitive behavior therapy (CBT) tools.

If psychology pertains to the connection between our emotions, psychiatry explains their involvement in our biochemical processes. Our microbiome has a significant involvement in the biomagnetic field of our body, and every cell needs a special voltage. Without the right level of energy, our cells dont have that voltage and fail to operate at their maximum potential. The consequences manifest in all areas of our life, from our emotional regulation and wellbeing to the manner in which we make decisions. Bruns believes in the importance of seeing our mind, brain, and energy field as one, but many are unconsciously able to do so.

There are definite signs that machine learning, algorithms, and data can be utilized to effectively align these aspects of being in a way that was previously left for us to do on our own. In other words, AI can speed up the process of energy and life enhancement.

AI in psychiatry is a general term that implies the use of computerized techniques and algorithms for the diagnosis, prevention, and treatment of mental illnesses, and could be applied similarly to enhance our lives. For example, current approaches for the diagnosis of psychiatric disorders largely rely on physician-patient questionnaires that are most of the time inaccurate and ineffective in providing a reliable assessment of symptoms.

These limitations can, however, be overcome by applying artificial intelligence (AI) to electronic medical database and health records. This indicates that we can aggregate data from our everyday lives to eventually eradicate negative thought patterns.

Bruns explains, People are still making unhealthy divisions in their life. Often, people repeat and reinforce negative outlooks and behaviors and justify them by saying, Its only a thought. But however intrusive or untrue it may be, our thoughts still have electromagnetic voltage, Bruns explains. Every emotion has a special vibration. If you feel guilt and shame, your vibrational energy is very low. If you feel unconditional love, its much higher. But you cant access these higher planes of emotional vibration if your body is not in good condition. You cant use antidepressants or wait idly for the problem to go away on its own. You have to step deeper and heal from within to raise your field of energy. Then, and only then, will you follow the path of your joy and serve your cosmic mission.

Stefanie Bruns, Founder of Business Flow Academy

Music is an excellent example of not only the physical manifestations of vibrations, but also evidence of how AI can impact our vibrational levels in the future. Studies now repeatedly show that music engages the brain at almost every level. The term for these studies is now referred to as Musical Neuroscience or Cognitive Musicology, It is this awareness, amongst others, that this article seeks to uncover, including music's healing qualities.

In one study, researches used an artificial intelligence system to study the catalog of melodies produced by a wide variety of different proteins. They had the AI system introduce slight changes in the musical sequence or create completely new sequences, and then translated the sounds back into proteins that correspond to the modified or newly designed versions.

Elevated Business Success

Now that we have uncovered the evolving potential of AIs ability to impact our body and minds energy vibrations positively, how can these be applied to create physical manifestations such as business success?

The path of your joy is unique to you and you only. But in reaching the destination, many have certain prerequisites in common: fulfillment in ones relationship, an abundance of free time, and a thriving autonomous business. Its a fact: your professional success and your energy levels are intrinsically correlated.

Bruns remarks of the phenomenon, It makes a huge difference to your market if you write copy in a higher zone of your energy. If your level of energy is high, its infectious, and people will want to be a part of it. They will choose you because it feels right. However, if you post because you feel you have an obligation to do so, it will come from a place of low energy. Your audience will feel that, too, she explains.

The HeartMath Institute proved this concept conclusively: people can feel other people. That would mean when you speak, release a video, or write copy, youre putting out your unique electromagnetic impulses into the universe. Ensure that your authenticity, level of expertise, and enthusiasm for what you do remain congruent in all marketing materials. If you do, youll reach a state of self-alignment. And youll never have to guess what your audience wants to hear next.

How does/would HeartMath Institute use AI to capture, and analyze data related to 1) impact of their services and 2) the energy/thoughts/electromagnetic impulses of clients.

Alignment with ones self is something that many people neglect. But in the pursuit of an elevated life, consider how you nourish your body in all forms: emotionally, mentally, and nutritionally. These small details eventually amount to a much greater picture. Bruns discusses these concepts in her free training program, Crushing Your Energy Identity Code, which delves into both the importance of Hawkins Scale of Emotion and how it influences your life in lower stages of vibrancy.

Your Energetic Impact

As Bruns explains, after persistent burnout and frustration over a lack of progress, many people ask themselves whether theyre even in the right field. They wonder whether their true calling is in something else and consider making a complete pivot. However, when faced with energetic incongruence, changing your career path is merely an escape, not a solution. Bruns shares that everything starts with a connection to your real purpose - your cosmic mission.

If there were no limit to what Artificial Intelligence could know about you, it could not only supply you with reading materials, but with foods, medical suggestions, social events, interesting ideas, friends, and lovers. It could also begin to help you make decisions in your life much the same way as Google maps now sets the fastest route for travel, avoiding traffic congestion. Perhaps one day there will be an app called Google Life, which will know you better than you know yourself, or at least claim to, and guide you through life decisions.

What will be increasingly missing is human self-awareness, the inner life as the domain of aspiration, wisdom, conscience, and what will increasingly disappear are the possibilities of true individuality, creativity, moral striving, selfless sacrifice, and transcendent awareness.

Instead our focus will be adding more information to the glut of information, posting more self-conscious images of ourselves, authoring more self-preoccupied narratives of our lives, repeating formulaic opinions, floating on the surface of a never-ending river of external data.

The cosmic mission is a vision bigger than yourself. When I ask people what their biggest vision is, I often hear responses alluding to luxury: a bigger house, a nicer car, or life in a warmer country. But I ask them once again - whats your biggest vision? Then, they understand. Their eyes light up. Your biggest vision, and your ultimate driver, is what you can do for others. We are all on this earth to help in any way we can. To help with something or somebody, she explains. Bruns believes that if you are connected with your cosmic mission in a way that enriches lives, youll jump out of bed every morning without wishing the day away. The power of a purpose-filled life allows you to overcome trauma, heighten your energy, live a joyful life, and enrich the world.

We are energetic beings. Ancient cultures have held this truth far longer than any modern civilization. And as energetic beings of light, each and every cell has an electromagnetic field to keep in alignment. As Bruns observes, This is not new knowledge; this is old knowledge. But we have new evidence. Experts have explored the effects of meditation on our human brain, and there are remarkable differences in our synaptic activity before and after reaching heart congruence.

Quantum computers are predicted to be capable of accomplishing things ordinary computers cannot, which reminds us of how our brains can achieve things that are still beyond artificial intelligence.

After embracing what it means to be an energetic being, were better equipped to thrive in business from our highest zone of genius: an area of complete fulfillment and true transformation. This means that were able to send our ideal messaging into the market, leverage our unique selling point, and succeed in business in a way that stays congruent with our energy signature.

In doing so, we attract our ideal clientele. We earn what we deserve to earn. And most of all, we reclaim our time.

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Positive Technology And The Cosmic Mission: How AI Is Helping Humans Achieve States Of High Energy And Success - Forbes

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We’ve Had Great Success Extending Life. What About Ending It? – The New Yorker

Posted: at 6:39 am

Throughout most of the seventeenth century, residents of London could buy, from street hawkers who fought one another for sales territory, a peculiar sort of newspaper. It cost a penny, sold about five or six thousand copies a week, and consisted of a single page. On one side, readers would learn how many of their neighbors had died the previous week, in each parish. On the other, readers would learn what was believed to have killed them.

Jaundice was common, as was Apoplex, an old word for a stroke, and Dropsie, which meant swelling. Other entries seemed to answer the question How did he die? with descriptionsDead in the Streets or Stilborn or Suddenlyinstead of actual causes. The deaths were usually assessed and recorded by pairs of older women, who were employed by parishes to go to the local church whenever its bell tolled a death. During one February week in 1664, these searchers, as they were known, recorded three hundred and ninety-three burials across the city. Death causes and counts ranged from Aged (thirty-two victims) and Consumption (sixty-five) to Scalded in a Brewers Mash (one).

For the same reasons that todays newspapers report coronavirus case numbers on their front pages, the London papers, known as Bills of Mortality, became particularly popular when disease swept through the city. During the 1665 plague, Samuel Pepys wrote in his diary about feeling saddened or cheered by the latest numbers from the Bills, while a contemporary named John Bell noted that the Bills allowed people to know the places which are therewith infected, to the end such places may be shunned and avoided. But most of the time, according to the London merchant John Graunt, the Bills were little more than matters of curiosity, especially if there were deaths that were rare, and extraordinary in the week current. He didnt consider this to be odd or unseemly. Death, after all, was the most basic fact of life.

Eventually, though, Graunt began to wonder if the Bills could be put to other, and greater uses. He painstakingly collected and organized decades of the death records, creating long tables of numbers. These first known tabulations of population-level health data are now widely recognized as the birth of epidemiology. Graunt pored over them. What types of death were most common? Which groups did they afflict? Why did some causes spike at certain times, while others stayed fairly constant? And, most of all, what could a lot of separate, individual deaths, taken together, tell him about the society in which they occurred? Although Graunt wanted, as he put it in a treatise, to understand the fitness of the Country for long Life, he believed that it was in its deaths that he would find answers.

In Extra Life: A Short History of Living Longer (Riverhead), Steven Johnson credits John Graunt with creating historys first life tableusing death data to predict how many years of remaining life a given person could expect. (One Dutch contemporary, a proto-actuary, took Graunts tables a bit too literally, writing confidently to his brother, You will live to until about the age of 56 and a half. And I until 55.) In fact, Graunts estimates were more of a guess than a calculation: when he wrote his treatise, in the sixteen-sixties, the Bills of Mortality didnt record peoples age at death, and they wouldnt for another half century. Yet his guesses about survival rates for different age groups turned out to be remarkably accurate in describing not just London at the time but humanity as a whole. For most of our long history as a species, our average life expectancy was capped at about thirty-five years.

Johnson calls this phenomenon the long ceiling. Analysis of ancient burial sites, of modern people living in hunter-gatherer societies, and of pre-industrial city dwellers all tell a similar story, Johnson writes: Human beings had spent ten thousand years inventing agriculture, gunpowder, double-entry accounting, perspective in painting, but these undeniable advances in collective human knowledge had failed to move the needle in one critical area.

That began to change in the eighteenth and nineteenth centuries. In what the economist Angus Deaton has named the great escape, average life expectancies broke the ceiling: what had been a very long, flat line finally rose, at first gradually and then dramatically. Between the Spanish flu of 1918 and the coronavirus pandemic of 2020, global life expectancy doubled. These developments, Johnson argues, should be printed in newspaper headlines and hawked on street corners like the old Bills of Mortality. Extra, extra: The average human has received thousands and thousands of extra days in which to live.

Johnson tries to account for those days. Which scientific or civilizational advancements should we thank for them? He groups innovations by those which have saved millions of lives (this list begins with the AIDS cocktail, anesthesia, and angioplasty), hundreds of millions of lives (here the roster goes from antibiotics to pasteurization), and, finally, billions of lives, a small but illustrious pantheon of three: artificial fertilizer, hygienic plumbing, and vaccines.

Johnson gives a hasty tour of the stories behind a few of these life-giving innovations. He explains how centuries-old practices in China, India, and the Middle East eventually inspired a vogue for smallpox variolation among the British aristocracy in the eighteenth centuryeven then, you needed an influencer to start a trend. And he returns to the same well, or, rather, pump handle, that featured in his 2006 book, The Ghost Map, about the disease detectives who investigated a cholera outbreak in the early days of germ theory. Yet he cautions that its shortsighted to think of these advancements in terms of a few brilliant geniuses having eureka moments.

Instead, the innovations that have saved the most lives are the product of piecemeal improvements, built on networks of support and inspiration, and spread by social movements. Most were not blockbuster therapies or expensive medicines but unsexy, low-tech ideas, like water chlorination or better techniques for treating dehydration. Almost none, he points out, came from profit-seeking companies. And many were just advancements in basic bureaucracythe creation of public institutions that could systematically track health data, require that drugs be tested and regulated, or enforce simple safety measures.

The most effective changes have to do with saving the lives of children. When Graunt analyzed London deaths, he estimated that, for every hundred children conceived, about 36 of them die before they be six years old. Twenty-four more died before reaching the age of sixteen, fifteen more before turning twenty-six, and so on, the rate of attrition falling slightly with each decade until perhaps but one surviveth 76. For much of human history, our early years were so stalked by disease and infection and diarrhea that between a third and a half of us never escaped our own perilous childhoods. Especially in the long years before smallpox was eradicated, Johnson writes, being a child was to forever be on the brink of death.

And the peril was universal. Before the advent of proper hygiene and effective medicine, the children of the lite died just as often and just as early as those of the poor. The rich may even have died more often, since they could pay for the treatments of the time, which generally did them more harm than good. (Readers are given grim descriptions of the illnesses of George III and his foe George Washington, both of whom were made sicker by the medical care they received, and reminded that George III became king only because the Stuart line had ended with Queen Anne, a half century earlier. Despite her wealth and power, and despite eighteen pregnancies, only one of her children survived past the age of twoand he died at age eleven.) Extra life was one thing money could not buy.

But that equality of loss would soon change. Deaton showed that the great escape was accompanied by another trend, which is now known as the great divide. In the past couple of centuries, as changing conditions increased life expectancies within wealthy nations, average life expectancies in poorer onesthe ones bearing the brunt of imperialism, resource extraction, and disease imposed by the wealthygot shorter. Eventually, average lives lengthened around the world, narrowing the gap, but they still lengthened substantially more for some people, in some places, than for others. Of all the forms of inequality, Martin Luther King, Jr., said in 1966, by which time the divide was entrenched, injustice in health is the most shocking and the most inhuman. Even in modern American cities, people born into poor neighborhoods can expect to live as many as thirty years fewer than people who are born in affluent ones across town. And that was before the covid-19 pandemic further widened our existing gaps.

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Step ‘Into The Darkness’ with the Double-Barrel Shotgun Overview – The Nerd Stash

Posted: at 6:39 am

Back in February, the VR horror shooter Into The Darkness was first announced. Since then, eager fans have been waiting patiently for further updates. In the first of several videos to come out, the developers are releasing overview videos to share the progress with Into The Darkness.

The video series will showcase various aspects of the game to come. These can range from experimenting with the physics mechanics, combat demonstrations, and the dark corners of the world.

The first video presents the powerful double-barrel shotgun. Apparently a frequent request from hungry fans, the video displays the weapon in all of its glorious usefulness. It can be utilized as a blunt weapon to knock robotic foes down, blast deadly shots from a certain critical distance, and be held as a defensive item to fend off against aggressive adversaries. The anticipation elevates for the double-barrel shotty with the rockin music to back up the action scenes.

Into The Darkness blasts the player into the near future. Humanity is attempting immortality; in other words, recent science experiments permit the process of transferring human consciousness onto machines. As Agent Frank, youre on a mission to investigate a facility that specializes in the said process, dubbed transhumanism. As fate would have it, trouble begins to stir beyond the shadows.

With a physics-based system, Into The Darkness allows the player to mess around with the games sandbox. For one thing, you can climb and hold onto a railing with one hand while the other hand can gun down an enemy. Another example is simply breaking the glass to traverse from one window to another.

Some of its VR horror shooter gameplay is similar to Stress Level Zeros experimental VR experience, BONEWORKS. Into The Darkness seems to be more fast-paced and chaotic than the previously mentioned title (think BONEWORKS with a dash, slash, and DOOM Eternal greatest action moments). Be sure to keep a lookout for the other videos to eventually release by going to the publishers (GameBoom VR) YouTube channel here.

Are you looking forward to the next overview videos from the developers? Be sure to leave a comment down below on what special items you would like to see from future videos on Into The Darkness.

C. Anthony Rivera is a content writer from the city of Chicago. His articles and reviews have been published on Gamemite, GamingBolt, and now on The Nerd Stash. And yes, deep dish pizza is the best.

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Jeff Bezos Is Reportedly Very Jealous of Elon Musk’s SpaceX – Futurism

Posted: at 6:33 am

He even tried to poach SpaceX's Gwynne Shotwell.Frenemies

The recent book Amazon Unbound, by Brad Stone, details Amazon founder Jeff Bezos meteoric rise to power and business triumph, but it also includes a striking point of vulnerability: Bezos is reportedly deeply jealous of Elon Musks success with SpaceX.

Back in 2016, Bezos was already deeply concerned about how his own spaceflight company, Blue Origin, didnt seem to be progressing at nearly the same pace as SpaceX. As Ars Technica independently confirmed, Bezos even went as far as trying (and failing) to poach Gwynne Shotwell, the SpaceX COO whod been with the company since nearly the beginning, and hire her as Blue Origin CEO to try and whip the company into shape.

The story only gets worse, as the book goes on to describe how Bezos attempts to compete with SpaceX seemed to move the company in the wrong direction.

Bezos executive hires took Blue Origin in a more traditional, cautious direction than that of the industry-disrupting SpaceX, which resulted in the company making considerably fewer launches and missing out on government contracts.

Those missed contracts were a huge source of frustration for Bezos, Stone wrote. But with the same executives still in charge of the company, it seems that Bezos didnt take the added step to pivot and more aggressively compete with SpaceX made clear by the fact that Blue Origin will only be launching its first crewed flight by this July.

And Musk, for his part, seems to delight in besting Bezos at every turn even insulting the Amazon founders sexual potency in one recent post.

READ MORE: A new book, Amazon Unbound, reveals Jeff Bezos envy of SpaceX [Ars Technica]

More on Blue Origin: In Stunning Reversal, NASA Halts $2.9 Billion Contract With SpaceX

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China Will Attempt to Land on Mars Tomorrow – Futurism

Posted: at 6:33 am

The stakes couldn't be higher.Seven Minutes of Terror

China will attempt to land its Zhurong Mars lander some time late Friday evening, as part of its Tianwen-1 mission.

Speaking at a Thursday morning conference, Ye Peijian, China Association for Science and Technologys chief adviser of Interplanetary Exploration, revealed that the capsule will start its seven minutes of terror at around 11 pm UTC on May 14, around 7:11 pm EDT.

The landing is the culmination of decades of advances in space exploration for the country, and could mark the first time a rover that wasnt built by NASA has softly touched down on the surface of Mars.

The Tianwen-1 mission launched in July 2020, with an orbiter, lander, and rover in tow. The orbiter entered a parking orbit around the Red Planet back in February and has been circling the planet ever since, preparing for the descent of the countrys first-ever Mars lander and rover by mapping the surface below.

The rover and lander will enter the thin Martian atmosphere tucked behind a heat shield. The duo will then eject the shield and deploy a parachute to slow its descent.

Rather than using a skycrane that NASA has successfully used on a number of occasions to softly lower a its most recent Mars rovers, Chinas descent module will power thrusters to slow its descent prior to touchdown.

Zhurong is scheduled to land in the same region where NASAs Viking 2 lander touched down back in 1976, the Utopia Planitia. The region is a large plain believed to be an impact basin some 3,300 kilometers across.

Scientists believe there are massive ice deposits under its surface, making it particularly interesting for further study.

We will be closely following Chinas historic attempt, so stay tuned.

READ MORE: Chinas Tianwen-1 set to attempt Mars rover landing on Friday [CNET]

More on Tianwen-1: Chinas Mars Probe Takes Breathtaking Picture of Crescent Mars

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Doctors Alarmed by Outbreak of "Black Fungus" That Infects Patients’ Brains – Futurism

Posted: at 6:33 am

India, already in the midst of a catastrophic wave of COVID-19 infections, is now facing a dual health crisis: dangerous black fungus infections developing in recovered patients brains.

Typically, mucormycosis is an extremely rare infection caused when mold takes root in a persons brain, lungs, or sinuses, The BBC reports. A healthy persons immune system can typically fend it off the actual fungus is surprisingly common but India is now seeing a surge of infections among COVID patients and survivors and doctors are struggling to save patients from the disease and its horrifying 50 percent mortality rate.

We are already seeing two to three cases a week here, Renuka Bradoo, the head of the ear, nose, and throat wing at Mumbais Sion Hospital told the BBC. Its a nightmare inside a pandemic.

The problemappears to be is that doctors are treating severe coronavirus patients with steroids, which are life-saving in the moment but weakens their immune systems after the fact. Thats especially the case among people with diabetes, who make up a large percentage of Indias mucormycosis patients.

Diabetes lowers the bodys immune defenses, coronavirus exacerbates it, and then steroids which help fight Covid-19 act like fuel to the fire, Mumbai-based eye surgeon Akshay Nair told the BBC.

Nair says he treated 40 mucormycosis patients in April alone, most of whom either died or needed urgent surgical intervention like removal of an infected eye.

Experts seem to think that the coronavirus and the ways its treated are causing blood sugar levels to go haywire, exacerbating diabetic patients underlying health conditions and making them particularly vulnerable. But not every patient is diabetic, and there were way fewer cases mucormycosis cases during Indias first wave of COVID-19, leaving doctors and experts scrambling to find answers.

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