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How Are Psoriasis and Psoriatic Arthritis Connected? – Self
Posted: May 24, 2021 at 8:00 pm
Psoriasis and psoriatic arthritis do share one common symptom: fatigue, which is likely due to high levels of inflammation, according to NYU Langone Health.
About 7 million Americans have psoriasis, and only a fraction of them will ever develop psoriatic arthritis, according to the Cleveland Clinic. Estimates vary depending on the source, but the Centers for Disease Control and Prevention (CDC) says that roughly 10% to 20% of people with psoriasis go on to develop psoriatic arthritis.
In contrast, the Cleveland Clinic estimates that up to 30% of people with psoriasis will develop psoriatic arthritis. That said, having psoriasis is the single most significant risk factor for developing psoriatic arthritis, Naomi Schlesinger, M.D., chief of the Division of Rheumatology at Rutgers Robert Wood Johnson Medical School, tells SELF.
If you have psoriasis, its extremely important to watch for any joint symptoms, such as swelling, pain, or stiffnessthe most common signs of psoriatic arthritisand report them to your physician, says David Giangreco, M.D., a rheumatologist at Northwestern Medicine Delnor Hospital. Psoriatic arthritis is a progressive disease, meaning it can get worse over time. And if you happen to get diagnosed with psoriatic arthritis in its early stages, then your doctor can prescribe treatments that slow the diseases progression and help preserve your joints.
Medical experts used to believe that people with psoriasis could only develop psoriatic arthritis within 10 years of their initial psoriasis diagnosis, according to the Cleveland Clinic. However, studies have shown that this isnt true. In fact, up to 15% of people with both diseases actually experienced their psoriatic arthritis symptoms first, according to the Cleveland Clinic. Some people may develop psoriatic arthritis before psoriasis, and others may have had psoriasis for years without realizing it, according to Dr. Giangreco. Psoriasis can remain hidden from patients on the back of the scalp or buttock area and go unnoticed for long periods of time, Dr. Giangreco tells SELF. If you have psoriatic arthritis and suddenly notice changes in your skin and nails, then you dont want to rule out the possibility of psoriasis. Rarely do people have psoriatic arthritis without getting psoriasis, too, according to the U.S. National Library of Medicine.
Psoriasis and psoriatic arthritis are clearly connected, but experts dont know why some people develop both conditions. However, genetics appears to be involved. Researchers have pinpointed a family of genes called the human leukocyte antigen (HLA) complex as a possible contributor to psoriasis and psoriatic arthritis, according to the U.S. National Library of Medicine. (The HLA complex helps your immune system recognize your bodys proteins compared to proteins from foreign pathogens such as viruses and bacteria, the organization explains.) People with psoriasis or psoriatic arthritis have HLA genes that are different from people who dont have either condition, according to a May 2021 paper published in The Journal of Rheumatology. And people with psoriasis who have a specific HLA gene mutation are more likely to develop psoriatic arthritis, according to the same paper.
Medical experts also believe that psoriatic arthritis may be inherited. About 40% of people with psoriatic arthritis have a family member with either psoriasis or psoriatic arthritis, according to the U.S. National Library of Medicine.
People with either condition frequently say that their health informs their decision-making, from the clothes they buy to their careers. Thats because both conditions can drastically change your life, making it difficult to sleep, work, and do the things you love, like playing with your children or baking. For example, when you have a psoriasis flare, even rolling over in bed or wearing tight clothing can be extremely painful. Some people with psoriasis choose clothing that hides their flares to avoid getting comments about their skins appearance. Similarly, joint pain from psoriatic arthritis can make it really hard to sit on the floor with your kids, get out of bed for work, or follow through on plans. This can all become overwhelming, and understandably make some people feel self-conscious about their health conditions.
There are no cures for either disease, but an effective treatment plan can minimize symptoms for both psoriasis and psoriatic arthritis. With psoriasis, doctors generally prescribe treatments that prevent your skin cells from growing too quickly, according to the Mayo Clinic. There are many treatment options for this, including creams, light therapy, or oral or injected medications, the Mayo Clinic explains.
As for psoriatic arthritis, treatments generally focus on controlling inflammation to minimize your joint pain and damage. Your doctor might suggest pharmacological options that target your immune system to lower inflammation, along with exercise or other lifestyle modifications, according to the Mayo Clinic. With each condition, the best treatment depends on your particular situation.
Both conditions can cause a lot of physical and emotional painbut you can find some relief with the right treatment plan. If you think you have psoriasis or psoriatic arthritis (or both), talk to your doctor about how you can live more comfortably.
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How Are Psoriasis and Psoriatic Arthritis Connected? - Self
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These Powerful Photos Capture What Its Really Like to Have Psoriasis – Yahoo Lifestyle
Posted: at 8:00 pm
@cienaraenelson / Instagram
Psoriasis is one of those conditions that can be easy to shrug off if youve never experienced it. Even though we write about skin issues all the time, even we have had fleeting thoughts along the lines of Kim Kardashian has it, and wed never have been able to tell.
Of course, the truth is that having psoriasis is more than getting occasional itchy red patches of skin. Its an autoimmune disease with symptoms that can be quite serious. And for more than five years, Los Angelesbased actress Ciena Rae Nelson has reminded the world of that on Instagram.
Nelson started sharing her journey with psoriasis in 2016, posting a selfie in which her skin is red and inflamed after a psoriasis flare-up. This is me 2 years ago just before I went to the hospital for severe dehydration and a fever, she wrote. Skin conditions are not cosmetic issues.
The same day, she shared a side-by-side selfie that showed her made up and nearly flawless in the left image, and red and blotchy in the right, thanks to photo editing that allowed her to increase the saturation of that picture to reveal the skin condition beneath. Most people looked at the left in person and didnt notice much but dry spots here and there, not noticing what was really underneath, she wrote. #psoriaticarthritis is an #invisibleillness and sometimes so is psoriasis (chronic itchiness and chronic fatigue). Not everything is as bad as it looks and sometimes things aremuch worse.
But while the posts were new, Nelsons psoriasis was anything but: Shes been living with psoriasis for nearly my entire life, she wrote in an Instagram post for the National Psoriasis Foundation, which means that I dont really know what life is like without it. As a child with psoriasis, she often felt isolated. I didnt know anyone who understood what I was going through, she wrote. And while her family was supportive, I always felt that unless they had it, theyd never really get it.
Story continues
After her first posts about it in 2016, there was an influx of support from people from all around the world who were going through something similar, she wrote. I started meeting up with people who reached out just to connect about psoriasis, which was something I had never done before. In fact, many of the people I met had neverspoken to someone with psoriasis before.
Since then Nelson has been a vocal social advocate for psoriasis awareness. She wants people to know theyre not alone. For people who suffer with chronic illness, it is so important to be able to connect with other people who have experienced what we have, in order to feel validated and understood, she wrote. Society tells us that we have to show up in the world, at work, at school, with our friends, just like everyone else does. But we are not like everyone else. And so if we are not careful, we can easily end up overexerting ourselves at the expense of our quality of life.
Nelson talks openly about how the condition affects not only her skin but also her mental health. Psoriasis can take a toll on your emotional well-being. Not only is stress a trigger for psoriasis, but, as Nelson shares, the disease can cause stress. Psoriasis can also cause depression.
In a 2019 post, Nelson shared that shed had a breakdown about my skin and thought very seriously for the first time in a long time about going back on medication, but I started therapy instead. Therapy, she writes, has been important in helping her learn to live with psoriasis. Are any of you in therapy? Nelson asked her followers. She pointed out that people with Psoriasis are twice as likely to become depressed as the rest of the population, and therapy can really help. So can meditation, exercise, plenty of sleep, and a nutritious diet, according to the National Psoriasis Foundation.
Nelson admits that sometimes psoriasis gets the better of her and makes her angry. I am losing days of my life to beds and antihistamines, she wrote last year. But that raw vulnerability helps her connect with other people who suffer with psoriasis and allows her to relate to them.
If you have felt this way, youre not alone, she wrote in another post last year. Theres no use in comparing your journey to anyone elses. Youre in a relay race all by yourself and you have to keep showing up for you. If today, it takes all the strength you can gather just to do your morning routine, and that takes you hours instead of minutes, dont worry. Youre winning. Keep going.
But that realness never comes without hope. Nelson knows she and those who have psoriasis will have good days and bad days. (And there are treatment options people can explore to have those good days!) But, she writes, they should never let psoriasis get in the way of living their lives.
Being chronically ill sometimes means you have to mourn the you that you were before your health began to decline, and accept a new normal, Nelson wrote last year. You have to do this because you cant live your life waiting to be normal. Viewing it as some purgatory between good and bad health. You have to live now, to the best of your ability, no matter the circumstance.
Originally Appeared on Glamour
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These Powerful Photos Capture What Its Really Like to Have Psoriasis - Yahoo Lifestyle
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CORRECTING and REPLACING Meiji Seika Pharma: Promising Results of Phase I Clinical Trial of DMB-3115, a Proposed Ustekinumab Biosimilar, and…
Posted: at 8:00 pm
TOKYO--(BUSINESS WIRE)--First paragraph, third sentence of release dated May 20, 2021, should read: Those clinical trials are conducted in collaboration with Dong-A Socio Holdings (Headquarters: Seoul, Korea, CEO: JUNG Jae-Hun, Dong-A). (instead of Those clinical trials are conducted in collaboration with Dong-A Socio Holdings (Headquarters: Seoul, Korea, CEO: Jong Hyun Han, Dong-A).).
The updated release reads:
MEIJI SEIKA PHARMA: PROMISING RESULTS OF PHASE I CLINICAL TRIAL OF DMB-3115, A PROPOSED USTEKINUMAB BIOSIMILAR, AND INITIATION OF PHASE III CLINICAL TRIAL IN PATIENTS WITH PLAQUE PSORIASIS
Meiji Seika Pharma Co., Ltd. (Headquarters: Tokyo, Japan, President and Representative Director: Daikichiro Kobayashi, Meiji) today announced that the bioequivalence of DMB-3115, a proposed ustekinumab biosimilar, has been demonstrated in phase I clinical trial compared to the reference products marketed in Europe and the United States. Meiji also announced the initiation of phase III multi-regional clinical trial in patients with plaque psoriasis. Those clinical trials are conducted in collaboration with Dong-A Socio Holdings (Headquarters: Seoul, Korea, CEO: JUNG Jae-Hun, Dong-A).
DMB-3115 is a proposed biosimilar to ustekinumab, a recombinant monoclonal antibody for the treatment of patients with several inflammatory diseases such as plaque psoriasis, psoriatic arthritis, Crohns disease and ulcerative colitis. Meiji and Dong-A are co-developing DMB-3115 under the strategic collaboration partnership agreement on biosimilars signed in September 2011. DMB-3115 is produced by using Sp2/0 cells, the same as those used in reference products to achieve high similarity in quality aspects.
The Phase I clinical trial is a randomized double-blind, three-arm, single-dose study to compare pharmacokinetics, safety and tolerability of DMB-3115 with its reference products (US- and EU-marketed products) in 296 healthy volunteers at a single site in Europe. As a result, bioequivalence of DMB-3115 compared to reference products was demonstrated in terms of several pharmacokinetic parameters. A single subcutaneous injection of DMB3115 in healthy volunteers was well tolerated. The reported adverse events corresponded with the known safety profile of ustekinumab. There were no new unexpected adverse events.
The Phase III multi-regional clinical trials in patients with plaque psoriasis, with the target number of patient being 590, has been initiated in Europe and the United States. In this study, efficacy, safety, pharmacokinetics and immunogenicity of DMB-3115 and reference products (45 mg or 90mgsubcutaneous injection, respectively) are being compared in randomized, double-blinded controlled trial.
Meiji aims to contribute to medical care and society by developing and launching biosimilars with high quality as well as biologics products.
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Redefining the Future of Psoriatic Arthritis Treatment – Rheumatology Advisor
Posted: at 8:00 pm
Before the modernization of medicine, symptoms of diseases like psoriatic arthritis (PsA) were addressed in interesting ways. In ancient Greece, symptoms were treated with tar and topical arsenic, prescribed by Hippocrates.1 In medieval times, PsA was thought to be contagious, and patients were put in isolation and treated with harmful, ineffective toxins, like sulfur and mercury.1
Medicine has come a long way since then, and although there is still no cure for PsA, weve witnessed significant breakthroughs in the scientific understanding of the disease since the coining of the term in 1860.1
In the US, more than 1 million people are living with PsA, a chronic rheumatologic disease characterized by joint pain, stiffness, and swelling.2,3 PsA can affect any part of the body, such as the fingertips and spine, or wherever your ligaments and tendons connect to the bone.3 Psoriatic arthritis affects approximately 30% of people with psoriasis (PsO), an inflammatory skin disease, and patients with PsA also experience PsO skin lesions and plaques.3
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As we experience rapid advancements in technology from wearables to data science, and combine these advancements with the recent influx of new scientific insights, we are on the verge of another revolution in rheumatic disease medicine.
During the last century, weve learned more about PsA manifestations and taken significant strides in patient care. Previously, physicians treated patients with PsA just as they would patients with rheumatoid arthritis, a more common and well-known rheumatic disease of the joints. In doing so, swollen joints were the only issue of PsA that were being addressed.
We now know that PsA is a heterogeneous disease affecting different domains of the body with varying degrees of severity for each patient some patients have minimal skin issues and more arthritis signs and symptoms, and others, vice versa. Symptoms of PsA go beyond skin and joints too, with many patients experiencing debilitating symptoms, like fatigue and anxiety, which are now being considered when establishing a treatment plan.
Treatment options for PsA can range from disease-modifying antirheumatic drugs (DMARDs) to nonsteroidal anti-inflammatory drugs (NSAIDs) to topical creams. Currently, these options focus on slowing the progression of joint pain to prevent permanent joint damage, combat inflammation, and attain skin clearance.
Although there are many treatment options available today, there is still an incredible unmet need in this space, and rheumatologists face the challenge of providing lasting remission to patients covering the whole diversity of disease manifestations.
To usher in the future of PsA therapy, we must cut across traditional disease area boundaries. First, we must continue to gain a better understanding of the patterns of this complex disease and its multifaceted symptoms. This will allow us to identify and unlock new pathways, mechanisms, and regimens for patients with limited or inadequate treatment options. We must continue to study our medicines in clinical practice settings and include patient, prescriber, and payer insights in our research efforts to reach a significantly broader population of patients with better and safer treatment approaches. Further, we must integrate patients into our decision-making process by engaging them in conversations about their treatment options.
Realworld evidence and patient-reported outcomes are leading to databases of information that are helping to advance therapeutic science. For example, we can now tap into these databases to gain new insights into a treatments safety and effectiveness and show trends across thousands of patients. We are also using connected devices to capture real-time patient health status, including monitoring movement, heart rate, and temperature. In rheumatic disease, wearable technology has enabled clinicians to assess patient flares using activity tracker data.4
A deeper understanding of disease patterns, pathogenesis, and patient-reported symptoms, paired with innovations in data and technology will create a winning combination that will lead to novel therapeutic options that restore immune balance and achieve remission.
Weve come a long way since the days of tar and arsenic treatment for PsA, but we still have a way to go. At Janssen, were driven by a relentless focus on the unmet patient need and are excited by the tremendous opportunity we have to alter the current immunology treatment landscape. Were rapidly advancing our data science capabilities, focusing on scientific insights and innovation, and keeping patients at the center of everything we do.
The future is exciting for us as scientists, but its especially meaningful and motivating to consider what the winning advancements could mean for the millions of people around the world living with PsA. How will we look back on todays treatments for PsA? I cant wait to find out.
Editors Note: To learn more about these efforts, please visit https://www.janssen.com/immunology.
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Redefining the Future of Psoriatic Arthritis Treatment - Rheumatology Advisor
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Chronic Plaque Psoriasis Report, Forecast 2020 2027, Upcoming Trend Analysis and Key Players Novartis International AG, Sun Pharmaceutical…
Posted: at 8:00 pm
The Chronic Plaque Psoriasis Market is expected to grow at a CAGR of 8.9% and is poised to reach US$XX Billion by 2027 as compared to US$XX Billion in 2020. The factors leading to this extraordinary growth is attributed to various market dynamics discussed in the report. Our experts have examined the market from a 360 degree perspective thereby producing a report which is definitely going to impact your business decisions.
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Key Companies Operating in this MarketNovartis International AGSun Pharmaceutical Industries Ltd.Eli Lilly & companyAmgen Inc.Abb Vie Inc.Merck & Co.Pfizer Inc.Boehringer Ingelheim GmbHJanssen Biotech Inc.
Market by TypeTopicalsOralInjectable
Market by ApplicationHospital PharmaciesRetail PharmaciesE-Commerce
The Chronic Plaque Psoriasis Market report provides a detailed view about the growth of focus of the key market players for introducing innovative products which has eventually become one of the key trends in the modern marketing world and well as for future market growth. The report provides a 360-degree view of the varied modern marketing aspects as far as the scope is concerned as well as the different types of marketing parameters that has the potential to change the overall marketing scenario during the forecasted period of 2020-2027.
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The report focuses on essential marketing points for business enhancement such as business revenue growth, ROI and CAGR on variety of market products. The report mentions the key reasons, the consequences of which have led to the way of huge opportunities for contemporary market growth. The report conveys vital information regarding the growth of modern market in different regions for estimating the worth of investment on a variety of market products as well as the opportunities that are yet to come in the forecasted period of 2020-2027 thus providing SWOT analysis of the modern competitive market. The report clearly depicts about the significant efforts made to gather accurate information on the modern marketing world as well as the diverse data collection through a lot of primary and secondary research processes. The report elaborately depicts the effective and efficient techniques that can be adopted to progress at par with the highly competitive modern marketing world and improvement of the potential profit of the businesses in the forecasted period of 2020-2027 thereby using the Porter Five Force Model effectively.
North America US, Mexico, Canada Europe Russia, Ukraine, France, Spain, Sweden, Norway, Germany, Finland, Poland, Italy, United Kingdom, Greece, Austria, Denmark, Switzerland, Netherlands, Belgium, Turkey, Luxembourg Asia-Pacific China, Japan, India, Australia, South Korea, Taiwan, Malaysia, Philippines, Thailand, Singapore South America- Brazil, Argentina, Peru, Chile Middle East and Africa Bahrain, Egypt, Israel, Kuwait, Qatar, Saudi Arabia, United Arab Emirates, South Africa
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An insight into the market size and growth 2020-2027 CAGR: 2020 to 2027, calculating 2019 as the base year Detail information about the dominant players in this segment Demand and supply chain mapped to clearly evaluate the market Apart from primary and secondary research methodology, data triangulation method is used for a clear understanding of the report Analysis by best expert in the industry
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Chronic Plaque Psoriasis Report, Forecast 2020 2027, Upcoming Trend Analysis and Key Players Novartis International AG, Sun Pharmaceutical...
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Psoriasis Treatment Market to Showcase Healthy Expansion of CAGR During 20202027 KSU | The Sentinel Newspaper – KSU | The Sentinel Newspaper
Posted: at 8:00 pm
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Manufacturing Cost Structure Raw Material and Suppliers Manufacturing Process Industry Chain Structure
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Sales Revenue and market share
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Market Share by Type & Application Growth Rate by Type & Application Drivers and Opportunities Company Basic Information
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Key Raw Materials Analysis Upstream Raw Materials Sourcing Marketing Channel
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Chapter 12, 13, 14 and 15: Global Psoriasis Treatment Market Research Findings and Conclusion, appendix and data source
Methodology/Research Approach Data Source (Secondary Sources & Primary Sources) Market Size Estimation
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Psoriatic Arthritis Treatment Market 2021 Industry Trend and Forecast 2026 | AbbVie Inc., Amgen Inc., Bristol-Myers Squibb Company, Eli Lilly And…
Posted: at 8:00 pm
Global Psoriatic Arthritis Treatment Market by Operating System, End User, Enterprise Solution Type, Industry Vertical and Enterprise Size: Opportunity Analysis and Industry Forecast, 20212027,
The osteoarthritis this is certainly psoriatic industry dimensions got appreciated at $7,860 million in 2018, and is also predicted to achieve at $13,744 million by 2026, joining a CAGR of 7.2per cent from 2019 to 2026.
Psoriatic joint disease try an inflammatory ailments that will be mutual with psoriasis, and thats classified inside the gang of spondyloarthritis. They impacts both our skin and program this is certainly musculoskeletal. It really is brought about because of hereditary and issue which happen to be ecological. Bloated feet, hands, and sensitive joints, decreased lumbar pain, pitted fingernails, and tightness were widespread the signs of psoriatic osteoarthritis. Analysis of psoriatic osteoarthritis is accomplished by studies such as for example combined substance examination, X-ray, rheumatoid aspect (RF), and resonance that will be magnetized (MRI). Psoriatic osteoarthritis can usually be treated with medication course such as for example NSAIDs, disease-modifying antirheumatic medication (DMARDs), biologics, and medication which happen to be immunosuppressant.
The psoriatic arthritis treatment market consists of the sale of psoriatic arthritis drugs used for the treatment of psoriatic arthritis by entities producing drugs for psoriatic arthritis. Psoriatic arthritis is a chronic degenerative condition associated with psoriasis. Symmetric psoriatic arthritis, asymmetric psoriatic arthritis, spondylitis, distal psoriatic arthritis, and arthritis mutilans are the different types of psoriatic arthritis. Rise in biological and biosimilar therapies, increase in prevalence of psoriatic arthritis, surge in R&D activities to develop novel drugs for the treatment of psoriatic arthritis, rise in demand for psoriatic arthritis treatment products, surge in geriatric population, strong pipeline of biosimilar & biologic products, and rise in awareness toward psoriatic arthritis treatment are the major factors that drive the growth of the global psoriatic arthritis treatment market.
The Covid-19 impact on demand of global Psoriatic Arthritis Treatment market is projected at global, regional & country level. Due to the Covid-19 pandemic lots of businesses have seen a decrease in their profit. The global Psoriatic Arthritis Treatment report offers actionable procurement intellect insights, tracing plans, and action strategies to ease hazards arising owing to Covid-19. Additionally, the trend and outlook of global Psoriatic Arthritis Treatment market is forecast in optimistic, balanced, and conventional view by taking into account of COVID-19.
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Psoriatic Arthritis Treatment Market competition by top manufacturers as follow:
The report presents the competitive landscape and corresponding detailed profiles of the ten major market players functional in the global Psoriatic Arthritis Treatment market. The selection of top market players has been based on their net sales, R&D expenditure, business segments, regional presence, distributors, and range of products in the market. The competitive analysis offered in the report will assist users in emphasis on the important parameters that will assist to set desired targets to stay competitive in the global Psoriatic Arthritis Treatment market.
AbbVie Inc., Amgen Inc., Bristol-Myers Squibb Company, Eli Lilly And Company., Johnson & Johnson., Merck & Co Inc., Mylan N.V, Novartis AG, Pfizer Inc., UCB S.A.,
Segmentation
The report offers a methodical and detailed analysis of the market segments that are based on main growth factors and key opportunities. The report divides the global Psoriatic Arthritis Treatment market by studying several parameters into corresponding segments and sub-segments. A detailed analysis of every segment will help the user to concentrate on the most lucrative segment in the market also provides a reason for the steady and low growth of other market segments.
By Drug TypeNSAIDsDMARDsBiologicsOthers
By TypePrescriptionOTC
By Route of AdministrationTopicalOralInjectable
Regional Outlook:
Based on geography the Psoriatic Arthritis Treatment market is segmented according to various region and countries as follows:
North America (Countries Includes: U.S., Canada)Europe (Countries Includes: UK, Germany, France, Rest of Europe)Asia Pacific (Countries Includes: China, Japan, India, Rest of Asia Pacific)Latin America (Countries Includes: Mexico, Brazil, Rest of Latin America)Middle East and Africa (Countries Includes: GCC Countries, South Africa, Rest of MEA)
In the region portion each region is considered and is explained in-depth along with the countries as to how the market is participating in the region, the impact of COVID-19 in the region and how it is affecting the Psoriatic Arthritis Treatment market. Thereby, all the relevant information along with graphical representation is provided in the regional section of the report.
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Methodology
This Apex report is derived by detailed analysis, synthesis, and understanding of information about the global Psoriatic Arthritis Treatment market, generated from authenticate sources. Apex analysts produce set of information by applying primary and secondary research strategies to provide overall picture of the market. In addition, latest trends, key driving factors, opportunities, and potential threats have been considered to support the market forecast scenario.
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The Apex reports are designed to offer several benefits to private equity firms, investors, small- and large-scale manufactures, distributors, suppliers operating in the market, and government and regulatory agencies. The scope of the report is designed to provide the most basic details of the Psoriatic Arthritis Treatment market, by which even start-ups can understand the market scenario more efficiently.
TOC for the Global Psoriatic Arthritis Treatment Market:
Chapter 1: Market Overview, Drivers, Restraints and Opportunities, Segmentation OverviewChapter 2: Market Competition by ManufacturersChapter 3: Production by RegionsChapter 4: Consumption by RegionsChapter 5: Production, By Types, Revenue and Market share by TypesChapter 6: Consumption, By Applications, Market share (%) and Growth Rate by ApplicationsChapter 7: Complete profiling and analysis of ManufacturersChapter 8: Manufacturing cost analysis, Raw materials analysis, Region-wise Manufacturing expensesChapter 9: Industrial Chain, Sourcing Strategy and Downstream BuyersChapter 10: Marketing Strategy Analysis, Distributors/TradersChapter 11: Market Effect Factors AnalysisChapter 12: Market ForecastChapter 13: Psoriatic Arthritis Treatment Research Findings and Conclusion, Appendix, methodology and data source
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Psoriatic Arthritis Treatment Market 2021 Industry Trend and Forecast 2026 | AbbVie Inc., Amgen Inc., Bristol-Myers Squibb Company, Eli Lilly And...
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Censorship, surveillance and profits: A hard bargain for Apple in China – Business Standard
Posted: May 22, 2021 at 10:03 am
On the outskirts of this city in a poor, mountainous province in southwestern China, men in hard hats recently put the finishing touches on a white building a quarter-mile long with few windows and a tall surrounding wall. There was little sign of its purpose, apart from the flags of Apple and China flying out front, side by side. Inside, Apple was preparing to store the personal data of its Chinese customers on computer servers run by a state-owned Chinese firm.
Tim Cook, Apples chief executive, has said the data is safe. But at the data center in Guiyang, which Apple hoped would be completed by next month, and another in the Inner Mongolia region, Apple has largely ceded control to the Chinese government. Chinese state employees physically manage the computers. Apple abandoned the encryption technology it used elsewhere after China would not allow it. And the digital keys that unlock information on those computers are stored in the data centers theyre meant to secure. Internal Apple documents reviewed by The New York Times, interviews with 17 current and former Apple employees and four security experts, and new filings made in a court case in the US last week provide rare insight into the compromises Cook has made to do business in China. Apple now assembles nearly all of its products and earns a fifth of its revenue in the China region. But just as Cook figured out how to make China work for Apple, China is making Apple work for the Chinese government.
Cook often talks about Apples commitment to civil liberties and privacy. But to stay on the right side of Chinese regulators, his company has put the data of its Chinese customers at risk and has aided government censorship in the Chinese version of its App Store.
Chinas leader, Xi Jinping, is increasing his demands on Western companies, and Cook has resisted those demands on a number of occasions. But he ultimately approved the plans to store customer data on Chinese servers and to aggressively censor apps, according to interviews with current and former Apple employees. Apple has become a cog in the censorship machine that presents a government-controlled version of the internet, said Nicholas Bequelin, Asia director for Amnesty International, the human rights group. A Times analysis found that tens of thousands of apps have disappeared from Apples Chinese App Store over the past several years, more than previously known, including foreign news outlets, gay dating services and encrypted messaging apps. It also blocked tools for organising pro-democracy protests and skirting internet restrictions, and apps about the Dalai Lama.
And in its data centers, Apples compromises have made it nearly impossible for the company to stop the Chinese government from gaining access to the emails, photos, documents, contacts and locations of millions of Chinese residents, according to the security experts and Apple engineers.
The firm said that it followed the laws in China and did everything it could to keep the data of customers safe. An Apple spokesman said that the company still controlled the keys that protect the data of its Chinese customers and that Apple used its most advanced encryption technology in China . Apple added that it removed apps only to comply with Chinese laws. These decisions are not always easy, and we may not agree with the laws that shape them, the company said.
No Plan B
In 2014, Apple hired Doug Guthrie, the departing dean of the George Washington University business school, to help the firm navigate China, a country he had spent decades studying.
One of his first research projects was Apples Chinese supply chain. Guthrie concluded that no other country could offer the scale, skills, infrastructure and government assistance that Apple required. Chinese workers assemble nearly every iPhone, iPad and Mac. Apple brings in $55 billion a year from the region, far more than any other American company makes in China. This business model only really fits and works in China, Guthrie said. But then youre married to China. China was starting to pass laws that gave the country greater leverage over Apple, and Guthrie said he believed Xi would soon start seeking concessions. Apple, he realised, had no Plan B.
Golden Gate
In November 2016, China approved a law requiring that all personal information and important data that is collected in China be kept in China. It was bad news for Apple, which had staked its reputation on keeping customers data safe. While Apple regularly responded to court orders for access to customer data, Cook had rebuffed the FBI after it demanded Apples help breaking into an iPhone belonging to a terrorist involved in the killing of 14 people in San Bernardino, Calif. Apple encrypts customers private data in its iCloud. But for most of that information, Apple also has the digital keys to unlock that encryption. The location of the keys to the data of Chinese customers was a sticking point in talks between Apple and Chinese officials, two people close to the deliberations said. Apple wanted to keep them in the US; the Chinese officials wanted them in China. The cybersecurity law went into effect in June 2017. In an initial agreement between Apple and Chinese officials, the location of the keys was left intentionally vague, one person said.
But eight months later, the encryption keys were headed to China. It is unclear what led to the change.
Documents reviewed by The Times do not show that the Chinese government has gained access to the data. They only indicate that Apple has made compromises that make it easier for the government to do so.
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Censorship, surveillance and profits: A hard bargain for Apple in China - Business Standard
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Palestinians digital rights violated by censorship on Facebook, Twitter, and Instagram, new report claims – The Independent
Posted: at 10:03 am
There has been a dramatic increase in the censorship of Palestinian political speech on social media over the past two weeks, during the period of intense fighting between Israel and militants in Gaza.
Facebook, Twitter, and Instagram have all been used by Palestinians to share information from, among a variety of areas, the East Jerusalem neighbourhood of Sheikh Jarrah where families face eviction.
However the report from 7amleh, The Arab Center for the Advancement of Social Media, shared exclusively with The Independent, argues that social media companies moderation attempts and codes of conduct have resulted in numerous citizens accounts being taken down.
It comes in the context of huge criticism surrounding the Israeli governments military decisions, which include displacing 52,000 Palestinians via air strikes, causing the deaths of numerous children, bombing the Associated Press and Al Jazeera building, and, on social media, the bizarrely flippant tone of its Twitter account.
Overnight, Israel and Hamas have since entered a mutual and simultaneous truce, after Israels security cabinet agreed to put an end to heavy bombardment which has killed more than 230 Palestinians.
Twelve people have been killed In Israel, including two children and a soldier. The Israeli military said 4,340 rockets were fired at Israel by militants over the course of the 11 days of fighting.
It is unlikely, however, that this will be the last time the conflict rears its ugly head, or that social media companies moderation decisions will not exacerbate future battles in the region as seen by their long-ranging and concerning approaches to Palestinian content in the past.
7amleh documented 500 cases of what it calls the digital rights violations of Palestinians between 6 May and 18 May this year through a form shared via its social media channels with the support of partners including MPower Change, Adalah Justice, Jewish Voice for Peace, and Eyewitness Palestine. These violations include content being taken down and accounts being removed or their visibility restricted.
Half of the 500 instances were on Instagram, the report states, with 179 cases on its parent companys platform Facebook; Facebook also apparently increased geo-blocking, where social media companies target the geographical location of content to help their moderation efforts, with a number of these cases [documented] for activists from the occupied Palestinian territory.
The organisation states that 45 per cent of all reported violations on Instagram were due to deleted Stories, with users receiving no prior warning or notice. While Instagram did not respond to 7amleh about 143 of the cases submitted, it confirmed that only one case violated the community standards. Instagram admitted the removal issues on 7 May, but 7amleh says the majority of reports (68 per cent) occurred after the problem was seemingly addressed.
As well as these holistic problems with content moderation, there have been specific, dramatic cases of harmful flaws in the companys content moderation, such as Instagram removing or blocking posts with hashtags for the Al-Aqsa Mosque, the third-holiest site in the Islamic faith, as its moderation system mistakenly deemed the religious building a terrorist organisation.
We know there have been several issues that have impacted peoples ability to share on our apps, including a technical bug that affected Stories around the world, and an error that temporarily restricted content from being viewed on the Al Aqsa hashtag page. While these have been fixed, they should never have happened in the first place, Facebook told The Independent in a statement.
Our policies are designed to give everyone a voice while keeping them safe, and we apply these policies equally, regardless of who is posting or their personal beliefs, the company added. Our dedicated team, which includes Arabic and Hebrew speakers, is closely monitoring the situation on the ground. It added that it was continuing to review 7amlehs reports.
There have also been instances of Facebook blocking the accounts of Palestinian journalists, a critique which has been also levied at Twitter on which there were 55 cases of violations of Palestinian content, 91 per cent of which were suspension of accounts, according to 7amleh.
Our automated systems took enforcement action on a number of accounts in error by an automated spam filter. We are expeditiously reversing this action to reinstate access to the affected accounts, many of which have already been reinstated, Twitter said in a statement, adding that it had an appeals process for such accounts.
Twitter also temporarily restricted the account of Palestinian-American writer Mariam Barghouti, who was reporting on Palestinians being evicted from Sheikh Jarrah. "We took enforcement action on the account you referenced in error. That has since been reversed," Twitter said in a statement, changing Barghoutis account to say that it was temporarily unavailable because it violates the Twitter Media Policy.
Twitter said that if an accounts profile or media content is not compliant with our policies, we may make it temporarily unavailable and require that the violator edit the media or information in their profile to comply with our rules. We also explain which policy their profile or media content has violated. Twitter did not explain to The Independent which policy was violated.
The issues around social media moderating content, specifically about Israels war against Palestine, are long-running. In 2016, the Israeli government announced a formal collaboration with Facebooks Tel Aviv office, that were meant to force social networks to rein in content that Israel says incites violence.
Internally, Facebook listed globally protected vulnerable groups including homeless people, foreigners, and Zionists a person who supports the re-establishment of and support for a Jewish state in the Holy Land, currently located in Palestine - in documents revealed by The Guardian in 2017.
In January 2021, Facebook apparently proposed a revision of the term Zionist that would make it a proxy for Jew or Jewish, although the company said that no decision had been made. An anonymous Facebook moderator who spoke to The Intercept said the policy, in practise, leaves very little wiggle room for criticism ofZionism.
That decision was criticised by Rabbi Alissa Wise, Deputy Director at Jewish Voice for Peace, who said that restricting the word prevent[s] its users from holding the Israeli government accountable for harming Palestinian people.
Facebook said it understand[s] that the word Zionist is frequently used in important political debate. ... thats why we allow critical discussion of Zionists, but remove attacks against them in specific instances when context suggests the word is being used as a proxy for Jews or Israelis, both of which are protected characteristics under our hate speech policies.
It added: We always work to apply our Community Standards as accurately and consistently as possible, and dont remove content that doesnt break our rules. We have a clear process for handling requests from governments and regulators, which is the same around the world. Were public about how many pieces of content we restrict locally for breaking local law, and publish these numbers in our Transparency report twice a year.
However, much like how western news media headlines have slanted towards pro-Israeli language, reflecting the foreign policies of their national governments, many of the policies put forth by American companies are informed by US culture and norms, Jillian York, Director for International Freedom of Expression at the Electronic Frontier Foundation, told The Independent.
She added that the US has historically been a strong supporter of Israel and has long dehumanized Palestinians, so it isnt surprising that corporate policies would align with that worldview.
For Facebook its more important to censor terrorism than it is to ensure that Palestinians can speak freely, York continued. Amidst the pandemic, this has only gotten worse, as content moderators in some countries are still stuck at home. As such, were seeing more bugs, more keyword filtering, more shadowbanning and other subtle enforcement tactics that arent simply takedowns.
It is for this reason that social media is so important in reframing the conversation of the Israeli-Palestinian conflict, allowing messages that may not come through traditional media to reach the general public.
Snapchats Snap Maps feature, for example, has been used to demonstrate in real-time the difference in the effects of the conflict between Tel Aviv and Gaza, as have TikTok memes.
Snapchat Maps video compares situation in Gaza and Israel
Both companies present a challenge to Facebook and Twitter but, York says, the network effect of these companies is still hard to disrupt and when it comes to bold decisions, such as banning President Trump, many follow one another.
Facebook's rules related to Israel-Palestinian have always been opaque and one-sided. Marwa Fatafta, a policy manager at Access Now, told The Independent.
It's no secret that Facebook often bows to government pressure and converts such demands into rules governing online speech. But thats only half of the story [as] social media platforms rely on algorithms to moderate speech at scale and being blind to context as they are, lots of legitimate content get flagged and taken down. Such issues stress the need for algorithmic transparency, which Fatafta says is clearly biased.
At some big technology companies, employees are very conscious of this power. This week both Jewish Google workers and Apple staff have called on their respective executives to recognise that millions of Palestinian people currently suffer under an illegal occupation,.
In affecting change, 7amleh recommends a number of practises to improve social media companies moderation in the end of its report.
These include hiring fact checkers specifically for Israeli and Palestinian content, allowing people access to geo-spatial information needed to respond to the humanitarian crises, providing transparency on voluntary takedown requests, and conducting human rights assessments that includes the impact of Israel on Palestinians in Israel and the occupied Palestinian territory.
Censorship and bias have been issues for years, however, and the escalation of violence over the past two weeks only scaled it up and made it more pronounced, Fatafta says.
Social media has been a life-linefor Palestinian activists deprived of access to mainstream media, and the despite of the ceasefire, the reality of occupation and oppression continues. So Palestinians will continue to use social media to organise and dissent. The main question here is: would social media companies learn their lessons this time?
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Conservative Jewish Journalists Use False Claims of Censorship to Try to Silence Critics – Common Dreams
Posted: at 10:03 am
The late Village Voice journalist and civil libertarian Nat Hentoff loved telling the story about how three rabbis, gathered in a Massachusetts motel in 1982, officially excommunicated him from the Jewish people for the crime of signing a New York Times advertisement protesting Israel's invasion of Lebanon. That their clerical authority to extinguish Hentoff's Judaism was recognized by no one but themselves is a source of both comedy and anger. In matters political, even the smallest of factions can pretend that their extremism matters, but at the heart of that absurdity is the dark human desire to censor and to silence anyone deviating from the party line.
And so joining the three rabbis in this tragic comedy are the 900+ signers of what's now called the "Jewish Harper's Letter," published by the Jewish Institute for Liberal Values, alleging that an undefined "social justice ideology" holds that there is "only one way to look at the problems we face, and those who disagree must be silenced." They assert that this "suppression of dissent violates the core Jewish value of open discourse" (Jewish Telegraphic Agency, 5/5/21). It's called the "Jewish Harper's Letter" because it echoes and extends a letter signed by journalists and academics about censoriousness, published in Harper's (7/7/20; FAIR.org, 8/1/20).
So far the letter has received some mainstream attention (Newsweek, 5/5/21), given the prominence of some of the rabbis, academics and journalists who signed it, like New York Times columnist Bret Stephens and his former colleague Bari Weiss. The letter never says how their views have been silenced, or names a group, individual or specific school of thought that is implementing such a chilling effect. Nor do the signers, many of whom are prominent journalists associated with the Jewish right, disclose their own unease with free discourse, their own desire to suppress speech and their own extremism.
For example, Weiss (who now maintains her own newsletter at Substack) famously tried to silence critics of Israel at Columbia University (Intercept, 3/8/18). Stephens alerted an academic's boss because he called the columnist a "bedbug" on Twitter (NBC, 8/27/19). Liel Leibowitz, a signer and Tablet writer, said Jews shouldn't go to college because of the ideas they might be exposed to (Tablet, 10/28/18)or, as he put it, because college is a place where "tenured professors train like-minded fanatics, and students are punished or rewarded for their willingness to pledge allegiance to their loony dogma."
The lack of specificity in the letter isn't an accident. Defining an ideological enemy so vaguely will allow these individuals, many of whom are on the right of the political spectrum, to employ the accusation of overly censorious "social justice" talk when they deem it necessary.
Given that so much of the letter aims at racial discordthe letter says that on "racial justice," Jewish organizations do not "encourage discussions that include differing perspectives," because "in some cases, Jewish leaders have even denounced Jews for expressing unpopular opinions"one can assume this is responding to Jewish Americans who have in the last several years aligned with Black Lives Matter, Abolish ICE and Antifa, which have responded to both the rise of far-right extremist groups and the state violence of border enforcement and overly militarized policing. The letter evokes the Republican hype about "cancel culture," the idea that the price of offending "social justice" activists means losing your job or media platform.
"This is not a new phenomenon," said Joshua Shanes, an associate professor of Jewish studies at the College of Charleston. "The idea that [the left] is betraying liberalism is an old trope to stop progress, going back to the '30s, and then to 'neocons' in the '70s and '80s."
The fact is that while the Jewish right claims they are being silenced or vilified in the media by the left, the Jewish right and its allies have levied harsh criticism toward liberal Jews and have in some cases attempted to deplatform them. The right-wing Zionist Organization of America blasted the Jewish immigration group HIAS for opposing the Trump administration (Jerusalem Post, 8/24/20), and the ZOA has also attempted to punish campus Jewish groups for voicing criticism of Israel (American Prospect, 1/4/07). DePaul University rejected tenure to anti-Israel scholar Norman Finkelstein, a result of his famous feud with pro-Israel legal scholar and Trump advocate Alan Dershowitz (Inside Higher Ed, 6/11/07). When New York Gov. Andrew Cuomo announced an executive order against the pro-Palestinian Boycott, Divestment and Sanctions (BDS) movement, he didn't do so in a vacuum, but in "a speech at the Harvard Club in Manhattan to an audience including local Jewish leaders and lawmakers" (New York Times, 6/5/16).
The former US ambassador to Israel likened liberal Jewsthat is, the bulk of US Jewsto Nazi collaborators (New York, 12/16/16). Chicago-based Palestine Legal published a report on the heavily coordinated activity to silence critics of Israel across the countrya report that, unlike the JILV letter, cited specific examples, like how Florida politicians attacked the president of the Florida State student senate because of "social media posts he had made against the Israeli occupation."
The JILV "is a project of an opaque foundation connected to Republican megadonor Adam Beren," the Forward (5/6/21) reported. Lila Corwin Berman, a professor of history and Jewish studies at Temple University, told FAIR, "It is concerning when an initiative claiming to 'stand up for democratic liberal values' is far from transparent about its funding source." She added: "It seems that a basic requirement of supporting free and open debate would be to eschew cloaked or unaccountable modes of influence."
Leo Ferguson, director of strategic projects at Jews for Racial and Economic Justice, told FAIR:
The letter demonstrates a cynical, willful misunderstanding of the liberal political tradition, the meaning of free speech and dissent, and the mechanisms at work in a free marketplace of ideas. Let's be clearthe almost exclusively white signatories to this letter aren't motivated by an ironclad commitment to free political expression. On the contrary, many of these folks have led the charge to pass anti-BDS bills like the Israel Anti-Boycott Act, which is about as illiberal and censorious as you can get in a country with a First Amendment. At the end of the day, the not-so-sub-text of this letter is that conservative white Jews really don't like being called racist. But just because they don't like it doesn't mean it's not true.
It's easy to laugh off academic and journalistic elites who believe that they're being censored, but the true tragedy of the letter is that the signers hold up robust Jewish debate as their guiding tradition, when what they really want is for their ideas to go unchallenged in the marketplace of ideas. These signers have every right, both in the name of free discourse and the US constitution, to say whatever they want, no matter how controversial. But that also means Jewish leftists and "social justice" activists have a right to respond in kind. The anti-woke, antisocial justice right, to quote Hentoff again, wants "free speech for me, but not for thee."
Weiss said in her resignation letter that her conservatism was under attack while at the Times because colleagues ridiculed her, and that she faced viciousness on Twitter (New York Times, 7/14/20). But the gritty world of New York City journalism is home to lots of biting editors, and sources who love to complain to reporters about their coverage.
As for online harassment, that is unfortunately the world that any journalist has to deal with in the social media age. Julie Ioffe received considerable antisemitic harassment after she wrote a critical profile of Melania Trump (GQ, 4/27/16), attacks that Trump, whose husband would later become president, blamed on Ioffe (Washington Post, 5/17/16). I was put on an alt-right hit list (Forward, 10/19/16), and was harassed by Nazis on Twitter when I defended Antifa (Ha'aretz, 6/7/20). Welcome to the club, Bari. If you don't like it here, perhaps the writing profession isn't for you.
This failed attempt to paint "social justice" as some sort of anti-free speech mob is funny only until you put it into the context of a conservative movement that is taking legal moves to ban or threaten certain ideas (such as proposed laws against boycotts against Israel), and to protect violence against protestors. I have previously written for FAIR.org (10/23/20, 2/16/21) that right-wing anger about "cancel culture" and "wokeness" are often merely projections of the right's desire to censor the left. The "Jewish Harper's Letter" is simply another chapter in this disinformation tactic by the right.
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Conservative Jewish Journalists Use False Claims of Censorship to Try to Silence Critics - Common Dreams
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