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Corresponding author Rubn Queiro, MD, PhD, of the Central University Hospital of Asturias, in Spain, and colleagues explained that secukinumab (SEC), a human monoclonal antibody targeting interleukin 17A, had a favorable safety profile in clinical trials. In addition, postmarketing surveillance has shown the therapy has a low frequency of discontinuation.

However, we currently have no consistent data on long-term survival of SEC in patients with AxSpA and PsA in routine clinical practice, the investigators wrote.

They therefore performed a multicenter retrospective observational study of patients with AxSpa or PsA who were prescribed and received at least 1 dose of SEC. The primary end points were AEs and drug retention rates.

Altogether, 154 patients were included in the study: 59 had PsA and the remaining 95 patients had AxSpA. The overall disease duration was 6.5 years, and most of the enrollees (61%) had previously been treated with at least 2 biologics before being prescribed SEC.

After 1 year, the data showed that 66% of patients were still taking SEC. However, by the end of the second year, the retention rate was 43%. Those who quit primarily stopped taking SEC due to lack of efficacy (59%), and 36% said they stopped the therapy because of AEs. Nearly three-quarters (71%) of patients who quit the therapy due to AEs did so in the first 6 months of treatment.

The most common AEs were gastrointestinal (GI) disorders, which occurred in 6 patients and included symptoms such as nausea, vomiting, and abdominal pain. There were 2 cases of Crohn disease. All 6 patients with GI AEs withdrew, as did 4 of 5 patients who reported infections. Five patients had disorders of the skin and subcutaneous tissue, and all 5 withdrew as well.

Queiro and colleagues found a number of factors that made a patient less likely to discontinue SEC, and these included male gender, obesity, hypertension, and diabetes. The investigators said the finding that obesity was linked with better drug survival was interesting, since previous reports have suggested patients who are obese and who have psoriasis tend to have a poor therapeutic response to SEC.

However, we found that obesity, and other components of metabolic syndrome, were predictors of longer survival for SEC therapy, they wrote. Therefore, SEC could be a good therapeutic choice in obese patients with AxSpA and PsA as opposed to [tumor necrosis factor inhibitor] agents.

Factors associated with discontinuation included number of previous biologics and depression.

Queiro and colleagues acknowledged some limitations, including the relatively small sample size and the retrospective nature of the study. They said their findings ought to be replicated in larger cohorts, but that they still show SEC appears to be performing well in clinical practice.

Treatment persistence has been optimal even in third line treatment, independent of underlying disease, and obesity does not seem a marker of poor treatment response, they concluded.

Reference

Alonso S, Villa I, Fernndez S, et al. Multicenter study of secukinumab survival and safety in spondyloarthritis and psoriatic arthritis: SEcukinumab in Cantabria and ASTURias study. Front Med (Lausanne). Published online May 26, 2021. doi:10.3389/fmed.2021.679009

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Secukinumab Retention High in Real-world Study of Patients With PsA, AxSpA - AJMC.com Managed Markets Network

Psoriasis Drug Market Growth Opportunities and Forecast to 2026:

The Global Psoriasis Drug Market industry research report begins with an elementary prologue to Psoriasis Drug showcases alongside product definition, product scope, market overview, product characterization, and specification. The global Psoriasis Drug Market was valued at a billion USD in 2018 and is expected to reach a billion USD by 2026 with an anticipated CAGR of during the forecast period, 20192026. The information mentioned in the Global Psoriasis Drug Market research report presents an overview of the latest trends observed in the global market. Besides, this intelligence study focuses on the latest events such as the technological developments and the product launches and their consequences on the Global Psoriasis Drug Market. Furthermore, the research report presents the potential industry supply, market demand, market value, market competition, key market players and the industry estimate from 2019-2026.

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The Major Players Covered in this Report: Amgen Inc., Celgene Corporation, AbbVie Inc., Johnson & Johnson, Novartis, Eli Lilly, AstraZeneca, and Pfizer are some of the key market players.

These players are focusing on expanding their business in developing countries or emerging markets, like India, China, and South Korea, through coalitions and acquisitions for the development of novel products. The development of biosimilars is more commonly adopted By these companies. & More.

A comprehensive analysis of contemporary trends, demand spectrum, growth rate, and key region-wise Psoriasis Drug market exploration has also been embodied in this report. There are speculations about Global Psoriasis Drug Market to strongly dominate the global economy with a substantial growth rate in the coming years. Promptly developing industry infrastructure, increased product commercialization, and drifting demands of the Psoriasis Drug are strengthening Psoriasis Drug industrys footholds to become more influential and significantly contribute in international revenue generation.

The report is a valued asset for the active players, new participants, and future investors, and provides a comprehensive assessment across regions such as:

Growing Domestic Demand and Expanding Pharmaceutical Sector to Drive the Demand for Psoriasis Drug in the APAC RegionAsia-Pacific region is anticipated to hold the largest market share in the global Psoriasis Drug market during the forecast period 2017-2026. The growth in this region can be attributed to the presence of emerging economies like India, China, Japan, Vietnam, and Indonesia, which account for the largest share in this region. India is one of the largest producers of Psoriasis Drug and a major exporter of the product to various countries across the globe. India accounts for around 80% of the worlds exports of Psoriasis Drug. The favorable climatic conditions and growth of agricultural inputs and allied services like cold storage and warehousing in India are prompting higher production.

COVID-19 Impact Analysis: The COVID-19 pandemic had a significant impact on the on trade segment and Industry. Manufacturers are comprehending strategies to revive from the current situation by means of reshaping their sales channels as well as product innovation. The duration of the virus outbreak remains a key factor in assessing the overall impact of the pandemic. However, the global Railway Suspension System industry is expected to stabilize after 2019. The liquor industry was not impacted severely due to the pandemic.

Full Report Link @ https://straitsresearch.com/report/Psoriasis Drug-market

2 Research Methodology2.1 Primary Research2.2 Research Methodology2.3 Assumptions & Exclusions2.4 Secondary Data Sources

3 Executive Summary4 Market Overview4.1 Report Segmentation & Scope4.2 Value Chain Analysis: AR and VR Headset Market4.2.1 Vendor Matrix4.3 Key Market Trends4.3.1 Drivers4.3.2 Restraints4.3.3 Opportunities4.4 Porters Five Forces Analysis4.4.1 Bargaining Power of Suppliers4.4.2 Bargaining Power of Buyers4.4.3 Threat of Substitution4.4.4 Threat of New Entrants4.4.5 Competitive Rivalry4.5 Environment & Regulatory Landscape4.6 Forecast Factors & Relevance of Impact4.7 Macro-Economic & Geopolitical Scenario4.8 Parent Market Overview4.9 Technology Landscape4.10 Market Share Analysis4.11 Potential Venture Analysis4.12 Regional Price Trends4.13 Raw Material Trends4.14 Covid-19 Impact Analysis4.14.1 Pre Covid-19 Market Scenario Analysis4.14.2 Post Covid-19 Market Scenario Analysis4.14.3 Measures Taken by Top Players4.14.4 Quarterly Market Revenue and Growth Forecast till 20194.15 Cost Structure Analysis4.15.1 Labor Cost4.15.2 Consumables4.15.3 Maintenance Cost

5 Type Overview5.1 Introduction5.1.1 Market Size & Forecast (Value & Volume)5.2 AR Headset5.2.1 Market Size & Forecast (Value & Volume)5.3 VR Headset5.3.1 Market Size & Forecast (Value & Volume)5.4 AR/VR Headset5.4.1 Market Size & Forecast (Value & Volume)

6 Product Type Overview6.1 Introduction6.1.1 Market Size & Forecast (Value & Volume)6.2 Standalone6.2.1 Market Size & Forecast (Value & Volume)6.3 Tethered6.3.1 Market Size & Forecast (Value & Volume)6.4 Screenless Viewer6.4.1 Market Size & Forecast (Value & Volume)Continue..

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Trend Expected to Guide Psoriasis Drug Market from 2019-2026: Growth Analysis by Manufacturers, Regions, Type and Application. KSU | The Sentinel...

Psoriasis Marketresearch report is the new statistical data source added byOneup Business Insights.

In 2019, the global Psoriasis Market size was xx million US$ and it is expected to reach xx million US$ by the end of 2025, with a CAGR of xx% during 2020-2025.

The current environment of the ever-evolving business sector, as well as the existing and prospective implications of COVID-19 on the market, are examined in this research. Each business covered in the research report is examined in terms of product and application portfolios, market share, growth potential, future plans, and development activities such as mergers and acquisitions, product introduction, and so on.

Note In order to provide more accurate market forecast, all our reports will be updated before delivery by considering the impact of COVID-19.

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Top key players @ Eli Lilly and Company, Pfizer Inc., Johnson and Johnson (Janssen Global Services, LLC), Novartis AG, and Amgen Inc.

The main goal for the dissemination of this information is to give a descriptive analysis of how the trends could potentially affect the upcoming future of Psoriasis market during the forecast period. This markets competitive manufactures and the upcoming manufactures are studied with their detailed research. Revenue, production, price, market share of these players is mentioned with precise information.

This report provides pinpoint analysis for changing competitive dynamics. It offers a forward-looking perspective on different factors driving or limiting market growth. It provides a five-year forecast assessed on the basis of how they Psoriasis Market is predicted to grow. It helps in understanding the key product segments and their future and helps in making informed business decisions by having complete insights of market and by making in-depth analysis of market segments.

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What will the market size and the growth rate be in 2026?

What are the key market trends impacting the growth of the Global Psoriasis Market?

What are the challenges to market growth?

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What are the market opportunities and threats faced by the vendors in the Global Psoriasis Market?

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It helps in making informed business decisions by having complete insights of market and by making in-depth analysis of market segments

TABLE OF CONTENT:

1 Report Overview

2 Global Growth Trends

3 Market Share by Key Players

4 Breakdown Data by Type and Application

5 United States

6 Europe

7 China

8 Japan

9 Southeast Asia

10 India

11 Central & South America

12 International Players Profiles

13 Market Forecast 2019-2025

14 Analysts Viewpoints/Conclusions

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Psoriasis Market 2021-Competitive Insights: Eli Lilly and Company, Pfizer Inc., Johnson and Johnson (Janssen Global Services, LLC), Novartis AG The...

New research shows that switching from a Western diet to a balanced diet could help you reduce skin and joint inflammation. The study led by UC Davis Health researchers states that the reduction may be due to a better-balanced gut microbial culture.

Published in the Journal of Investigative Dermatology, the study suggests that cutting out sugar and fat and consuming a more balanced diet can help you restore gut health, which can suppress skin inflammation that may otherwise contribute to inflammatory skin diseases such as psoriasis.

Psoriasis is a chronic skin condition linked to the bodys immune system. Healthy skin cells are attacked mistakenly by immune cells, which cause skin inflammation and the formation of scales and itchy red patches.

Approximately 30% of patients with psoriasis also have psoriatic arthritis, which causes morning stiffness and fatigue, pain in joints, swollen fingers and toes, and changes to nails.

Previous studies have shown how diet can influence psoriasis through microbial balance in the intestines and skin inflammation. Consuming a traditional Western diet can cause a rapid change to the guts microbial community and its functions. This disruption, called dysbiosis, can contribute to gut inflammation.

For the new study, researchers wanted to test whether intestinal dysbiosis affects skin and joint inflammation. A mouse model was used to study the effects of diet on psoriasis and psoriatic arthritis. The mice were injected with Interleukin-23 (IL-23) minicircle DNA to induce a response mimicking psoriasis-like skin and joint diseases.

IL-23 is a protein created by the immune cells responsible for many inflammatory autoimmune reactions. This includes psoriasis and inflammatory bowel disease (IBD).

Researchers found that a short-term Western diet appears sufficient to cause microbial imbalance and to enhance susceptibility to IL-23 proteins that can lead to skin inflammation.

There is a clear link between skin inflammation and changes in the gut microbiome due to food intake, said Sam T. Hwang, study author. The bacterial balance in the gut disrupted shortly after starting a Western diet, and worsened psoriatic skin and joint inflammation.

The study went on to show that eating a diet high in sugar and fat is a major contributor to skin and joint inflammation. However, it can be changed by switching to a more balanced diet. The improvement in skin inflammation seen in mice taken off the Western diet indicated a short-term impact of the Western diet on skin inflammation.

Researchers concluded the study by suggesting that changes in diet could partially reverse the proinflammatory effects and alteration of gut microbiota caused by the Western diet.

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Study States That Diet Rich in Sugar and Fat Contributes to Skin & Joint Inflammation - Bel Marra Health