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Category Archives: Transhuman News

Who Told the Eternals Not to Interfere With Thanos? The Answer Is… – Distractify

Posted: August 22, 2021 at 3:19 pm

In an unexpected turn of events, Eternals has become a mini Game of Thrones reunion for actors Richard Madden and Kit Harington. The pair previously played brothers Robb Stark and Jon Snow on the famed HBO show. In Eternals, Richard Madden plays an Eternal named Ikaris, but who is Kit Harington playing?

What little Kit could reveal about his character's destiny has already been said: His character's name is Dane Whitman, and in the comics, he is known by the alias Black Knight. His character is the descendant of the original Black Knight, who was peers with King Arthur and carried a legendary sword with a curse.

Dane's uncle becomes Black Knight II, a supervillain, but confesses to his crimes on his deathbed and asks his nephew, Dane, to restore the family's honor.

It's interesting to note that in the comics, Dane assisted the Avengers against both Kang the Conqueror and the Grandmaster both characters who are set to show up in the rest of Marvel's Phase 4. Could this be hinting at his future with the Avengers? We will never say no to more Kit Harington.

Eternals arrives in theaters on Nov. 5, 2021.

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GSK’s Jemperli follows Merck’s Keytruda with FDA nod to target certain tumors regardless of location – FiercePharma

Posted: at 3:19 pm

GlaxoSmithKlines PD-1 latecomer Jemperli has scored an FDA go-ahead to expand into a larger cancer field. Once again, its following in the footsteps of Mercks market leader Keytruda, but first-in-class opportunities await down the line.

The FDA has granted Jemperli an accelerated approval to treat mismatch repair deficient (dMMR) solid tumors that haveprogressed following prior treatment regardless of their locations in the body, GSK saidTuesday.

The new nod builds on Jemperlis initial indication, earned in April, which allows the drug only in previously treated dMMR endometrial cancer. In the U.S., an estimated 14% of solid tumors are dMMR, GSK said, citing data from the National Cancer Institute.

Mismatch repair deficiency is a biomarker that has shown improved response to checkpoint inhibitors. Defects in MMR are mostly found in endometrial, colorectal and other gastrointestinal cancers.

GSK earned the expanded label thanks totumor shrinkage data. As is the case with any conditional nod, GSK needs to verify Jemperlis benefit in a confirmatory trial for continued approval.

In the phase 1 GARNET trial, Jemperli shrunk tumors in 41.6% of patients across all dMMR tumor types, with the median response lasting34.7 months. Among the responders, about 95% were still in remission after six months or longer. In the non-endometrial cancer cohort, the response rate was 38.7%.

RELATED:Latecomer GlaxoSmithKline ushers in 7th PD-1/L1 with FDA nod for Jemperli, treading on Keytruda's ground

In 2017, Keytruda became the first PD-1/L1 inhibitor to score a tumor-agnostic label from the FDA. That approval covereddMMR or microsatellite instability-high disease (MSI-H). The Merck PD-1 drug demonstrated a 39.6% response rate across dMMR/MSI-H tumors in its own early-stage trial. About 78% of patients enjoyed responses of at least six months.

A direct comparison of resultsfrom the two trials should be taken with a grain of salt since they included different trial populations.

Although a tumor-agnostic indication gives Jemperli a larger patient pool, GSKs real focus ison earlier lines of treatment that arent yet tapped by PD-1/L1 inhibitors and for novel combinations.

First up, a phase 3 trial dubbed RUBY is testing Jemperli and chemotherapy with or without GSKs PARP inhibitor Zejula in front-line endometrial cancer. First data from the study are expected later this year, with a potential regulatory filing planned for 2022, GSKs R&D chief, Hal Barron, M.D., said during an investor event in June.

Another phase 3 trial, dubbed FIRST, is evaluating Jemperli and Zejula in front-line ovarian cancer. Both Jemperli and Zejula joined the British pharma by way of its Tesaro buy.

RELATED:New GlaxoSmithKline keeping old R&D model, says embattled CEO

Besides those studies, GSK is exploring combinations of Jemperli with anti-cancer treatments targeting TIGIT, TIM-3, LAG-3, STING and PVRIG, Barron said during the event.

If everything plays out, Jemperli could eventually reach 1 billion to 2 billion in peak sales, GSK estimates. That's no match for Keytruda, which registered $4.2 billion sales in the second quarter alone after a 20% year-over-year growth at constant currencies.

Jemperli and Zejula, plus newly approved myeloma drug Blenrep,are part of GSKs latest push into oncology under CEO Emma Walmsley. Compared with its established presence in infectious diseases, HIV and inflammatory disorders, the companys cancer portfolio remains relatively small.

To beef up its oncology pipeline, GSK has turned to dealmaking. In addition to Tesaro, the company haslicensed a PVRIG antibody from Surface Oncology. Plus, ananti-CD96 program has emerged from its human genetics data-driven R&D collaboration with 23andMe. Most recently, GSK joined the TIGIT race through a deal with iTeos Therapeutics.

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One Living People Today Show More Traces of The Mysterious Denisovans Than Any Others – ScienceAlert

Posted: at 3:19 pm

The mysterious Denisovans were only formally identified about a decade ago, when a single finger bone unearthed from a cave in Siberia clued scientists in to the ancient existence of a kind of archaic hominin we'd never before seen.

But that's only one side of the story. The truth is, modern humans had in fact already encountered Denisovans a long time before this. We crossed paths with them an eternity ago.

So far back, in fact, that we forgot about them entirely. Especially as they and other archaic humans, such as the Neanderthals faded into the unliving past, and Homo sapiens assumed sole human dominion over the world.

But even that's kind of debatable.

All of these hominin varieties had a tendency to interbreed with one another when they co-existed, which is why, in a manner of speaking, ancient humans still live on in our modern human DNA.

Now, a new study reveals where the impression of this genetic fingerprint can most clearly be identified today.

According to the study, led by first author and human evolution geneticist Maximilian Larena from Uppsala University in Sweden, a Philippine Negrito ethnic group called the Ayta Magbukon has the highest level of Denisovan ancestry in the world today.

"Together with the recently described H. luzonensis, we suggest that there were multiple archaic species that inhabited the Philippines prior to the arrival of modern humans and that these archaic groups may have been genetically related," the researchers explain in their study.

"Altogether, our findings unveil a complex intertwined history of modern and archaic humans in the Asia-Pacific region, where distinct Islander Denisovan populations differentially admixed with incoming Australasians across multiple locations and at various points in time."

According to the results of the analysis based on a comparison of around 2.3 million genotypes from 118 ethnic groups in the Philippines the Ayta Magbukon's level of Denisovan ancestry is approximately 30 to 40 percent greater than that of Papuans.

Photos of self-identified Negritos from across The Philippines. (Ophelia Persson)

This is so, even though Philippine Negritos later 'diluted' their gene pool's amount of Denisovan genetics, with a more recent admixture of East Asian bloodlines, which carry lower amounts of Denisovan bloodlines.

If that dilution effect is accounted for, the Ayta Magbukon's level of Denisovan ancestry extends as high as 46 percent greater than Australians and Papuans, the researchers suggest.

Even without that manipulation, however, the evidence suggests the Ayta Magbukon mixed less with later arrivals than other Philippine Negrito groups: preserving traces of very old bloodlines from an archaic source one destined, for a very long time, to be forgotten.

The research team worked with volunteers and indigenous cultural communities who participated in this study, and the project was recognized by and implemented in partnership with the National Commission for Culture and the Arts (NCCA) of the Philippines.

"Some groups, such as Ayta Magbukon, interbred only a little with the people who later migrated to the islands," says population geneticist Mattias Jakobsson, also from Uppsala University.

"That's the reason why the Ayta Magbukon retained most of their Denisovan genes and therefore have the highest levels of those genes in the world."

The findings are reported in Current Biology.

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Yes, science is done in Colombia – Sunday Vision

Posted: at 3:19 pm

Eduardo Posada, president of the Colombian Association for the Advancement of Science (ACAC) said at the annual statutory session of the Colombian Academy of Exact, Physical and Natural Sciences (ACCEFYN) held on the third Wednesday of August each year. In this session, the National Prize for Comprehensive Work in Science, awarded jointly by ACCEFYN and ACAC, makes it the highest award a Colombian scientist can aspire to.

Posada and Piedad Villaves, director of the ACAC, highlighted the fact that the Colombian scientific community is much stronger than governments imagined and we must know that we have the capacity to build a better nation on the basis of science produced in universities. Colombian.

Biologist Enrique Forero, former director of research at the Missouri Botanical Garden and later in New York, has headed ACCEFYN for the past seven years. Under his supervision, ACCEFYN transformed from the esteemed Bogot Foundation into Cover the entire country with regional chapters made up of local scholars hitherto ignored by the establishment. He also established a youth academy with scholars under the age of 40 from where the corresponding members would come in the future and invited national figures with a science inclination to become the academys friends. The country must recognize this difficult but extraordinary act.

For the National Prize for Comprehensive Work in Science, the jury recognized the merits of Mara Teresa Rugeles from the University of Antioquia and Braulio Insuasty from the Universidad del Valle. The work for which they were honored was completely accomplished in Colombia. Ruggles is a bacteriologist who currently directs the Immunovirology Group at the University of Antioquia where she has finely tuned Antiviral treatment protocols especially in AIDS patients. Last year, he isolated and sequenced the SARS-CoV-2 virus circulating in Antioquia. She has over 125 articles published in indexed journals and a foundation for integrating low-income youth into college life, a fact that proves her social commitment.

Insuasty is proud to have been born in Yacuanquer, a municipality in Nario whose name means Tombs of the Gods. With more than thirty years at Universidad del Valle, he leads the group of heterocyclic compounds that during its fruitful career has isolated a large number of antibacterial and antiparasitic compounds, as well as antitumor molecules that have been evaluated by the National Cancer Institute in the United States. It has achieved new materials for the manufacture of photovoltaic cells, which is an important contribution to the production of clean energy. Published over 220 articles in indexed journals. Both Rugeles and Insuasty constituted an important group of physicians and judges.

Former Minister Joan Mayer, speaking on behalf of Friends of the Academy, presented the award to Paola Liliana Giraldo, a professor at the University of the Andes, where she leads a group of quantum materials aimed at producing quantum monomers. The winner said that her work shows how frontier science can be done from our country.

The solemn session culminated in the elevation of two Colombian scientists to the category of honorary members. Margherita Perea, Professor at the National University, a biologist from the University of Gafriana with a PhD from the University of Paris and residency at the Wageningen University, has dedicated her life to biotechnology and made important achievements in the genetic improvement of plants that have led to him being a consultant to the Food and Agriculture Organization of the United Nations (FAO). ) for several countries. Helena Grote, a microbiologist from the Andes, where for years she directed the Human Genetics Laboratory, the countrys first. He has resided in several English laboratories and at Stanford University.

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Variety is the spice and source of sustainable life – OrilliaMatters

Posted: at 3:19 pm

Having a variety of trees throughout our wooded areas supports functioning ecosystems that include other plant life, insects and animals

The following article was submitted by Sustainable Orillia as part of a series of articles about the importance of trees.********************

The study of genetics originated almost 200 years ago when an Augustine Friar, Gregor Johann Mendel, began studying the inherited characteristics of the Abbeys garden plants.

Following the publication of Darwins theory of biological evolution in 1859, the study gained momentum; plant and animal life were classified into groups, or species, based on their shared characteristics.

From these beginnings, our present-day understanding of genetics and biodiversity has emerged. The word biodiversity refers to the variety of life in the world or the variety in a particular habitat or ecosystem. It occurs within species as well as between species. We have come to understand that biodiversity makes our environment stronger and is essential to the health of our human way of life.

Today,there is lots of on-line literature for those of us interested in learning more about biodiversity. Our goal at Sustainable Orillia is to boil it down into practical informationto talk about it and why its important in terms of our neighbouring forests, our city streets, parks and backyards. Although our focus over the past month or two has been mainly on trees, biodiversity refers to all species within an ecosystem.

Here in north SimcoeCounty we occupy a unique habitat that runs between two major eco-zones: the Precambrian Shield to the north and the richer, tillable, morainal deposits to the south. As a consequence, we enjoy an uncommonly high degree of biodiversity with an abundance of forested land throughout our region.

Having a variety of trees throughout our wooded areas supports functioning ecosystems that include other plant life, insects and animalsall of whom are interdependent in natures grand scheme.

If genetic tree diversity were to be lost, other species specifically associated with certain trees may disappear, too, leaving the whole forest ecosystem biologically impoverished and more vulnerable to collapse.

We often see large lots with long rows of softwood treespines, for exampleall being cultivated specifically for lumber or paper products. A quick look at these lots confirms that a single species environment doesnt support much undergrowth or plant life across the woodlot floor.

These lots are managed professionally, of course. In the wild, a similar single-species stand of trees would be quite susceptible to disease and/or insect infestation and may struggle to survive.

Many articles have spoken about how trees provide oxygen, habitat, fuel, shade and other essential benefits for our survival and quality of life on the planet. There are 3.4 trillion trees in the world (give or take) and just over 60,000 species.

Thanks to good forest management in several countries, the overall number of trees has been relatively stable for the past 100 years, particularly in the developed world. However, the number will decline if we dont work with developing countries to find alternatives to cutting down or burning rain forests or burning trees for charcoaland if we dont keep planting more trees.

Deforestation continues in many places and the distribution of tree density around the world is vastly uneven, which is a concern. Not surprisingly, in Canada we have one of the highest ratios of trees per personan estimated 8,953 trees per Canadian for a total of 318 billion trees overall.

In contrast, in countries like Egypt there is an estimated one tree per person. Some studies estimate that, without world-wide reforestation initiatives, by 2050 we could lose over 1 million square miles of forest due to deforestation and the total number of trees could fall closer to two trillion. Thankfully, world-wide, there have been huge tree-planting initiatives over the past number of years which have added millions of new trees. Planting more trees than we harvest is key!

Trees are the ultimate carbon storage machines.

Woodlands and forests can lock up carbon for centuries which is something humans and the planet desperately need them for, given the damage done to the atmosphere by carbon-emitting human activity.According to the Woodland Trust, a UK conservation charity, 400 tons of carbon can be locked into one hectare (which is 10,000 square metres or about two and half football pitches) of woodland alone.

Bringing it back home, here are a few actions we can take to support greater biodiversity on our own land and in the community:

Explore all options and consult an arborist before removing any tree on your property. If you do have to remove a tree, be sure to plant another one, or maybe two, to replace it as soon as possible.

When planting trees, select varieties native to our area. There are several.

Question or challenge residential development plans that could destroy habitats of species at risk in our area.

If you are interested in a fun tool to identify the trees growing in your area, check out Sustainable Orillias Youth Council page at http://www.sustainableorillia.ca/youth-council for the Tree Identification Tool developed by our Youth Council in 2020.

This is one of the last articles in our series, Trees Our Sustainable Partners. Its been awe-inspiring to discover so many ways that trees support our lives on this planet. In Canada, there are about 140 species of native trees, many of which are found here in Ontario.

With this broad menu of native variety, plus ongoing forest management and growing awareness of how human intervention can either undermine or promote biodiversity, we are in a good position to ensure strong, healthy forests, urban and otherwise, for generations to come.

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Last Stop on the Way to the Cosmos? No Thanks. – The New York Times

Posted: at 3:19 pm

On an isolated archipelago off the coast of Georgia, where the vestiges of Americas Gilded Age aristocracy keep sprawling estates in tropical wilds, a controversy is roiling over a proposed spaceport.

On one side of the fight are the commissioners of Camden County, Ga., who have put nine years and close to 10 million taxpayer dollars toward the construction of a rocket launch facility on the mainland that they say will bring jobs, tourism and cachet to the area of about 55,000 people.

On the other are residents of the nearby barrier islands and coastline who fear falling debris, toxic plumes and catastrophic fire.

The heirs to the Coca-Cola fortune have homes on one of these islands, as do descendants of the Carnegies and other families known for generational wealth, so its easy for the spaceports most ardent champions to paint opposition to it as elitist.

But the fears arent based on nothing: Last September, one of the same class of rockets for which Camden County is tailoring its application tumbled from the sky in flaming pieces, igniting fires on public land near its launch site on Kodiak Island in Alaska. In 2014, a different type of rocket, launched from Wallops Island, Va., flew for six seconds before it fell to the ground and exploded, burning 15 acres and blowing windows and doors off buildings over a mile away.

And at Space Xs launch site in Boca Chica, Texas, there have been multiple massive explosions, which the company has referred to in public statements as awesome. One 2019 mishap the official term for when a rocket fails to launch, veers off course or explodes and comes crashing back to Earth caused a fire that consumed some 130 acres of a nearby state park before the U.S. Fish and Wildlife Service was notified of the blaze.

The two barrier islands in the rockets proposed flight path, Cumberland Island and Little Cumberland, are federally protected sanctuaries where endangered sea turtles nest, horses run wild, and some of the worlds fewer than 400 remaining North Atlantic right whales calve off the coast.

The islands are also home to dozens of historical sites, including settlements established by formerly enslaved families and Grey Gardens-style crumbling estates. John F. Kennedy Jr. and Carolyn Bessette were married here at the First African Baptist Church, a one-room chapel built of heart pine, in a secret ceremony in 1996.

The biggest controversy, however, is that the proposed rocket trajectory would come very close to peoples homes, blasting over populated areas only five miles downrange a situation that would be without precedent in U.S. history, according to a 2019 Federal Aviation Administration memo.

The National Park Service and Department of the Interior have recently questioned the safety of the plan. A diverse group of critics, including fishermen and shrimpers, sea turtle researchers, island residents, and the chieftess of the Gullah/Geechee nation have pushed to halt it entirely.

A spokesman for the F.A.A., which regulates the commercial space industry and is charged with supporting and promoting its growth, said in a statement to The New York Times: Every proposed launch site presents unique circumstances. The agencys decision about whether the site is appropriate for rocket launches is expected in September.

Increasingly, private companies with money to burn including Jeff Bezoss Blue Origin and Richard Bransons Virgin Galactic are spending billions to launch rockets and C.E.O.s toward the cosmos.

Businesses are springing up to support those goals, in addition to loftier aims including moon tourism and Mars colonization. But there is already plenty of money to be made in less speculative space pursuits.

Peter Beck, the chief executive of Rocket Lab in New Zealand, builds and launches spacecraft that carry GPS and radar satellites into orbit. So far, his company makes one of the only small-grade orbital launch vehicles in operation, but its only a matter of time until other companies crack the code. The race is part of what Mr. Beck calls a gold rush moment.

Space is incredibly integrated into our everyday lives, he said. If you turn off GPS, then all the ships and planes go around in circles, Seamless never turns up, even Tinder doesnt work. All of that is coming from space.

The space industry is expected to reach $1 trillion or more in value by 2040, according to a report by Morgan Stanley. Satellites are a huge part of that. According to Mr. Beck, over 100 other companies are working to design and launch the kind of small-satellite-carrying rockets (about the size of a semi-truck trailer) that his company makes.

There are currently 12 spaceports in the United States where companies can launch this type of rocket, and most are federally subsidized. But as of June 2020, another dozen spaceports were in the works.

Steve Howard, the Camden County administrator, has spent a decade preparing for this moment.

Mr. Howard, 49, envisions a future where astronauts make classroom visits, local students graduate into aeronautics jobs and high school robotics clubs are funded by rocket manufacturers. This part of the Georgia Coast could come to be known as Silicon Marsh, he said part of a space corridor of innovation that could extend from Cape Canaveral to South Carolina.

This area was a mill town. That mills gone now, Mr. Howard said of the county. Its largest employer is the Kings Bay naval submarine base. Weve got to make sure we have economic diversity, he said. What can we do to build for the future?

Supporters, including retired military generals, Cape Canaveral commanders and the Georgia Hunting and Fishing Federation, feel the spaceport is the countys best hope.

But critics hate the open-endedness of Mr. Howards proposal: The county wants to use the site of a former chemical plant for the port, without knowing what company may lease the space or further develop it. This makes it hard for a community to know just what they are signing up for.

There is some historical precedent. In 1965, NASA contracted the Thiokol Chemical company to test solid-propellant rocket engines designed for the Moon mission. Testing took place at a plant in Camden County. Also, at one point, Cumberland Island was a front-runner in NASAs search for a site for the Kennedy Space Center. (Cape Canaveral won.)

But that legacy includes tragedy. In 1971, an explosion at the plant killed more than two dozen people, two-thirds of whom were, as The Atlanta Constitution reported during the personal injury hearings in 1984, poor Black women from rural Camden County who earned slightly more than the then-minimum wage of $1.60 an hour.

Bought and then abandoned by another chemical company, the site has been contaminated with toxic waste and unexploded ordnance for decades. The spaceport proposal calls for much of that to be cleared away without explaining how.

Life magazine declared us the gateway to space in the 60s, Mr. Howard said. This is an opportunity to make history again.

The largest and southernmost of Georgias 14 barrier islands, Cumberland is more than double the size of Manhattan, covered in saw-toothed palmetto and live oak, ringed with white sand and marsh, and home to wild boar, deer, alligators, armadillos and over 300 species of breeding or migrating bird. Only 300 visitors are permitted per day.

Those staying at the islands lone hotel, the Greyfield Inn, where rooms start at $855 per night, arrive via private ferry from Amelia Island, just south of the Florida-Georgia border. (Campers can take the National Park Service ferry from St. Marys, Ga.) The 15-bedroom Colonial Revival manor was built in 1901, a gift from Thomas and Lucy Carnegie to their daughter Margaret Ricketson, whose own daughter Lucy Ferguson first opened the home to paying guests in the early 1960s.

The white house with its wide porch is still furnished with the Carnegies velvet couches and dusty books; there is no Wi-Fi or television. The living room window sills are lined with animal skulls and crystals, and the walls are hung with Carnegie portraits, including a painting of Lucy seated upon a buckskin, wearing a red head scarf and sheathed knife. (Not pictured: her pet buzzard.)

Lucys granddaughter Janet Ferguson, known as Gogo, lives part-time just beyond the bicycle barn of the Greyfield compound, in a house with an art studio where she makes and sells jewelry and tableware cast from locally scavenged armadillo scales, boar tusks and jacaranda seed pods. (One of her brothers, Mitty Ferguson, runs the inn with his wife, Mary.)

Ive spent my entire life on the island seven generations of my family lived here, Ms. Ferguson, 70, said over the phone.

She was here 25 years ago for the Kennedy-Bessette wedding. (It was Ms. Ferguson who molded their wedding bands from the ribs of a rattlesnake.) And her family remembers 25 years before that when the Thiokol-Woodbine explosion on the mainland shook the island, rattling the inns windows.

Ms. Ferguson is one of the islands few private stewards. In the early 1970s, the Carnegies sold or deeded most of the island to the federal government, so the National Park Service could preserve the wild coastal forest as a national seashore.

Since 2015, the National Park Service has been sending anxious letters to the F.A.A. about the spaceports environmental impact. After the 2020 presidential election, those letters have become more strongly worded but the F.A.A. still has the final say.

We never wouldve entrusted the island to the government or anyone knowing that a space launch site would be in our future, Ms. Ferguson said.

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It was to be protected in perpetuity, for the wilderness experience and the enjoyment of the public, she said. It feels like this is really going to alter that.

If the spaceport moves forward, the part of Cumberland Island most affected will be the islands least populous north end, 12 miles north of the Greyfield. It can be reached by appealing to one of the few people on the island with a permit to operate a motor vehicle and then riding up on a bumpy sand road (slowed by the occasional alligator sighting). Or hiking.

By either of these methods, youll reach the homestead of Carol Ruckdeschel, a 79-year-old self-taught biologist and the founder of Wild Cumberland, a conservation nonprofit. She moved to the island in the employ of a wealthy family in the 1970s and has lived in this loamy wilderness in a rustic, hand-hewn building next to the First African Baptist Church, for the most part alone, ever since. A 1973 New Yorker profile by John McPhee referred to her as the wild woman of Georgia.

Do me a favor. Dont call it pristine, she said of Cumberland Island. Beyond its postcard-perfect scenery, she sees the roads, limited beach traffic and other land management strategies in conflict with the wilderness.

In a brimmed hat over gray pigtails, with a compass in her pack, Ms. Ruckdeschel trekked to the islands northernmost beach and pointed out the oyster-lined marsh of Christmas Creek, a brackish waterway that separates the land she lives on from Little Cumberland.

Overhead is the proposed rocket flight path. The straight-east trajectory goes right over my house, Ms. Ruckdeschel said, pointing up at the invisible arc a rocket would take across the sky.

Typically, any land or marine space in the flight path of a rocket would be off-limits to humans for hours before tests or launches. But in Georgia a constitutional amendment was passed in 2006 that precludes removing citizens from their land if commercial gain is involved.

Camden County officials have proposed some creative alternatives, including monitoring island occupation by heat-seeking drone, or instituting a first-of-its-kind authorized persons status that would allow locals to stay put during launches if they register at various established checkpoints.

Should residents wish to relocate on a launch day, the latest application materials read, county personnel would need to escort them, or offer appropriate temporary accommodations, along with V.I.P. viewing passes for the hassle.

This is little comfort to landowners. Jennifer Candler, 57, who has a small apiary on her familys estate near Ms. Ruckdeschels homestead, said that to her knowledge, no county official has reached out to anyone in her family to discuss drones, evacuations or checkpoints.

I understand Camden County officials goals for this revenue stream jobs, tourism, for a generation growing up with a spaceport in their backyards and the inspiration that could provide for them for a career in science or as an astronaut, she said. But then I look at the other spaceports around the country and none of them have people right in their launch trajectory.

For Richard Parker, a 64-year-old journalist with a home on Little Cumberland, the possible repercussions could be apocalyptic.

This is not a place where fire is a natural part of things, he said. Palmettos burn hot and fast. These live oaks are hundreds of years old.

The fire preparedness plan that Camden County submitted seems unworkable to him. The homes on Little Cumberland are not mansions but well-worn beach houses some kit ranchers from the 60s, others modest stilted homes finished in weather-faded wood. Residents here made their own agreement with the Department of the Interior in the 1970s to fold the island into the national seashore while continuing to own it privately, adhering to rigorous conservation principles.

On the more rustic and more remote Little Cumberland, the tap water smells like sulfur, the power goes out often, and the sand dunes have grown so high over the years that they obscure some homes second-story windows. Municipal and county services are nonexistent.

If a patch of the island goes up in flames, the call made is not to a fire department, but to a phone tree of neighbors. Wooden trunks, set out along the islands few sand lanes, contain tools for wildland firefighting: rakes, pickaxes, backpacks that can be filled with water, and fire extinguishers.

The Spaceport Camden team maintains that mishaps are highly unlikely, and the chance of debris landing on Little Cumberland are extremely remote. But on the off-chance of fire, the suggested emergency preparedness plan involves marine landing craft with firefighters and rescue A.T.V.s.

That plan apparently has made certain assumptions from looking at satellite images taken at low tide, Mr. Parker wrote to the F.A.A. An actual visit to the island, he wrote, would have revealed 30-foot dunes across the entire north point of Little Cumberland preventing A.T.V. access to the interior, and no water or air evacuation possibilities.

The wooden trunks have been successfully used by residents to put out small blazes, Mr. Parker noted, but trying to imagine them as recourse against flaming fuselage, he just shook his head.

There have been two plane crashes here, said his neighbor Rebecca Lang, a 44-year-old chef and cookbook author, whose father bought a two-acre plot on the island for less than $8,000 in 1969.

One hit a house and burned it down, she said. So its not like were making this stuff up. (That was in the late 1980s, and the house belonged to the parents of Rob Portman, the senator from Ohio.)

Were normal people, and we knew nothing about space four years ago, said Shelley Renner, another landowner on Little Cumberland who is also a board member of 100 Miles, a coastal conservation group.

Ms. Renner has worked with Mr. Parker, Ms. Lang and other neighbors to develop a baseline understanding of F.A.A. evaluation processes, rocket failure probability rates, casualty areas, overflight exclusion zones and debris dispersion areas. There has been nary a cocktail party in the past half decade where these topics are not discussed, she said.

Do you know how many hours weve spent at this point? she added. Literally thousands of hours.

The stalemate has steadily deepened, compounded by a growing lack of trust.

Ms. Langs husband, Kevin Lang, 45, a partner at a law firm in Athens, Ga., and a publicly vocal opponent of the spaceport, said that F.A.A. officials he met at public hearings didnt seem to be aware that Little Cumberland Island was inhabited.

Some of that confusion may have arisen from testimony by a former Georgia state representative, Jason Spencer, who resigned from office in 2018 after appearing on Sacha Baron Cohens Who Is America? He said in State Senate hearings early on that the residential island was very fairly much barren and told constituents there were no voters in the flight path.

Brian Gist, a lawyer with the Southern Environmental Law Center Senior in Atlanta, said that Camden County refused, with a few minor exceptions, to provide documentation about the project and was essentially forced to disclose any details through public records requests.

Mr. Howard, meanwhile, thinks that environmental advocacy organizations have inflated the risks to bolster their own fund-raising efforts.

People say, Hey, safety, safety. But whats the real impact? Mr. Howard said. If you look at Kennedy Space Center, their spaceports in the middle of the wildlife sanctuary on seashores.

The science and data will show you, fireballs and things like that, it just cant happen based on the fuel thats left on the rocket, the trajectory, the elevation, the safety and the environment, he said. Plus, the rocket itself goes quick.

According to risk models produced by consultants, he said, the chances of someone getting hurt, or worse in the six to 10 seconds a rocket would take to pass over the archipelago range from less than 1 in 10 million to less than 1 in 1 billion.

His team has run the numbers again and again, he said, adding, this spaceport, Im confident, will be the most vetted of all time.

But these risk models are based on a representative rocket the team is betting will be sleeker and safer than the ones made by Rocket Lab and it has yet to be invented.

That idealized super-small, super-nimble orbital vehicle was conceived by industry experts including Andrew Nelson, a Spaceport Camden consultant whom the county government has paid more than $1 million so far. He was formerly the C.O.O. and president of XCOR, a space travel company that filed for bankruptcy in 2017 after selling a number of $100,000 tickets to space on a rocket that was never built.

From the Scottish Highlands to the Hawaiian islands to the Michigan coast of Lake Superior, at least a dozen other communities are weighing the gains that could come from a spaceport against the possible disruption to fragile, biodiverse environments.

Legal challenges and petitions have been generated by constituencies on all sides.

G. Scott Hubbard, a Stanford aeronautics professor, former director of the Ames Research Center at NASA and the chair of the SpaceX Safety Advisory Panel, predicts that this kind of development (and disputes over it) will become more common across the United States in the coming years.

In the first 50 years of aviation from Kitty Hawk 1903 to 1953, there were more than a million aircraft built and used multiple times, he said. We gained a lot of experience very fast.

But space is different. In the first 50 years of the space program, there were only 45 launches total worldwide, he said. The difference in experience here is huge.

He thinks that trying to build a spaceport in a populated area complicates things for the commissioners in Camden County. But he cant predict whether humans in the flight path will prove insurmountable to spaceport construction.

My personal opinion is that there is an overpopulation of spaceports right now, but this is how new businesses start, he said. At the beginning of the 20th century, every bicycle shop was building cars.

The future of commercial space development, then, leaves bystanders in two camps: those who champion forward movement often at a relentless pace in the name of progress, and those who are focused on protecting what already exists, and is already valued.

These companies are vying for the licensing, grabbing up everything they can in space, with no regard for the impact down below, Ms. Ferguson said.

The Spaceport Camden team sees tons of possibilities for the down below. What if 10 years from now, county initiatives soar, weve got green tech, satellite tech, Department of Defense initiatives, your child or your neighbors child cannot only graduate but become an individual who contributes to the next space race? Mr. Howard said.

Lately, he has found himself invoking one of his favorite quotes, from Jeff Bezos: If you absolutely cant tolerate critics, then dont do anything new or interesting.

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Last Stop on the Way to the Cosmos? No Thanks. - The New York Times

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NASA Space Construction: ISS Tests Regolith 3D Printer for Artemis Lunar Program; Is this the beginning of space colonization? – Space Bollyinside -…

Posted: at 3:19 pm

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The Redwire Regolith 3D Printer The Northrop Grumman Cygnus Cargo Ship resupply missionsuccessfully sent up 8,200 pounds of cargo for NASA to the International Space Station. The cargo included crew supplies like fresh apples, tomatoes, kiwi, a pizza kit, and a cheese smorgasbord.

What were also of most importance were the science and research equipment and investigations included in the cargo. One, in particular, is the Redwire Regolith 3D Print study. By reducing the launch mass of construction materials, this allows for more space for other necessary cargo that can keep the explorers living on the planetary body for longer.

The Redwire Regolith Print study aims to demonstrate 3D printing on the space station using a material simulating regolith or the loose rock and dust found on the surfaces of planetary bodies such as the Moon and Mars, Stuffsaid. Being able to construct habitats and other infrastructures using resources already found on the planetary bodies can significantly reduce launch mass and cost, NASApointed out. The results of this study could help determine whether or not it is possible to use regolith as a raw material, as well as use 3D printing as a construction technique in space.

Redwire Space (@RedwireSpace) August 11, 2021 #ICYMI: Our Redwire Regolith Print launched from @NASA_Wallops yesterday aboard NG-16. This payload will use our existing 3D printer aboard @Space_Station to print 3 slabs using lunar regolith simulant! (: @NASA) pic.twitter.com/240ymugIyD

The Artemis Lunar Program Read Also: NASA Moon Mission 2024: Elon Musk Pitches to Make Spacesuits for Moon Landing!

Artemis Exploration Spacesuit Testing NASAs investigation on the feasibility of a Regolith 3D Printer to solve the infrastructure construction on the surface of planetary bodies ties with its upcoming Artemis missions. Elon Musks SpaceXis working with NASA to bring back humans to the moon and possibly live there by 2024. The NASA Artemis missionwill land the first woman and first person of color on the Moon and use the findings learned on the Moon to take the first set of astronauts to Mars.

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NASA Space Construction: ISS Tests Regolith 3D Printer for Artemis Lunar Program; Is this the beginning of space colonization? - Space Bollyinside -...

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Gardening could be an essential part of astronaut self-care – The Counter

Posted: at 3:19 pm

In addition to cucumbers, basil, mint, tomatoes, parsley, Bunchek is also growing varieties of peas, beans, broccoli, cauliflower, and new pepper and mustard green cultivars, all of which were selected either because of their size, shape, or other physical characteristics, or for their nutritional value.

So often in space, were constrained by power, volume, mass, things like that, said Wheeler. We try to look for shorter growing species, maybe dwarf varieties within those species. Growing sugarcane thats 12 feet tall just isnt a good match. They also want varieties that grow quickly and have high yields.

In addition to size and shape, theyre looking at the nutritional content of plants, and specifically for nutrients that can be difficult to deliver by other means, or that degrade over time, like Vitamin C and Vitamin B1.

Youre not going to get a lot of nutrition out of lettuce, Wheeler explains. But: Choose a colored variety, then you can get anthocyanin. Thats a pigment that has some antioxidant qualities.

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Gardening could be an essential part of astronaut self-care - The Counter

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Jeanette Winterson’s vision of the future of AI is messianic but unconvincing – New Statesman

Posted: at 3:18 pm

Why should we care what Jeanette Winterson has to say about artificial intelligence? The answer is that Winterson is never boring. She can be brash, didactic and hectoring, but she is always passionate and provocative. On subjects ranging from late capitalism to Greek mythology, she comes across a little like an over-caffeinated teacher determined to drum some sense into Year 10 on a wet Friday afternoon.

Wintersons manic energy can have mixed results. It can produce work that is porous and mutable in its structure, forward-looking and ambitious in its themes, such as Sexing the Cherry (1989) and Written on the Body (1992). But it can also produce wacky high-wire performances full of stylistic gimmickry, as in Art & Lies (1994), Gut Symmetries (1997) and The Stone Gods (2007). These are books that seem to attack their subjects rather than explore them. And theres no getting away from Wintersons aphoristic mode of writing, which seems imbued with a Cassandra-like certainty that she has seen the light and will lead others towards it. Im telling you stories. Trust me, she wrote in The Passion (1987).

Winterson appears to believe that her books will save the world which may make a reader apprehensive about a collection of her essays on the once-in-a-species opportunity for artificial intelligence to make our planet a better place. AI attracts megalomaniacs. It inspires both overblown promises and existential angst. Whether utopian or apocalyptic, these claims usually go unfulfilled. Where does Winterson sit on the spectrum? There is a clue on the books jacket, where her author photo has been given a cyborgs eye.

Subtitled How We Got Here; Where We Might Go Next (at least theres a might in there), 12 Bytes is Wintersons first essay collection since Art Objects (1996). Its mission, she claims, is modest. She wants readers who think they are not interested in AI or biotech to feel connected to the idea of a transhuman even a post-human future.

This may sound fanciful, but Winterson has a long-standing fascination with machine intelligence and the protean possibilities of the internet, dating back to The Powerbook (2000). Her last novel, Frankissstein (2019), a darkly entertaining reboot of Mary Shelleys work, featured amoral sexbot salesmen and a charismatic scientist pioneering ways to upload the human brain to the cloud. It was a lot of fun but at times it felt as if Winterson had tried to synthesise three years worth of articles from the Atlantic, New Scientist and Wired magazines into a work of fiction. There was clearly more to say about AI than she could shoehorn into a novel: hence these interlinked essays, which explore the partition between the real and invented, and embodied and non-embodied states, and which allow Winterson to give expression to her environmental consciousness and mystical fervour.

[see also:The Road to Conscious Machines is an accessible and highly readable history of artificial intelligence]

As ever, Winterson is determined to work on a big canvas. She hurtles through the Industrial Revolution, code-breaking, Gnosticism, Greek mythology, 3D-printed houses, sexbots and robodogs to show us why liberals must embrace our transhumanist future if they want to avoid an alt-right, misogynistic, tax-evading, Big Tech dystopia. She believes that in the next decade 2020 onwards the internet of things will start the forced evolution and gradual dissolution of Homo sapiens as we know it. And frankly, she cant wait, given how violent, greedy, intolerant, racist, sexist, patriarchal and generally vile we are.

Once humans start to merge with AI and become part of the toolkit, then the enemy wont be on the outside and there will be no us and it. Either this new type of intelligent life controls or collaborates with us, or it might just keep us as pets or fence us off like dinosaurs in Jurassic Park. But imagine, she says, if AI helped us to take responsibility for the planet, curb our greedy consumerism, end fake news and hate speech, reduce inequality and manage food shortages.

Winterson would prefer to think of the A in AI as standing for alternative rather than artificial because we need alternatives to war and climate breakdown. She explores how non-embodied AI is already part of our lives in the form of targeted advertising, chatbots, facial recognition software, empathetic fridges and asserts that what will surely follow is AGI (artificial general intelligence). At that point, we will have multitasking, autonomous entities that can set their own goals and come to their own decisions. They will be able to make cheese on toast while having a chat with you about the garden, she explains.

***

Its natural that novelists are interested in the moral, ethical and fantastical implications of AI. In the past two years, Ian McEwans Machines Like Me and Kazuo Ishiguros Klara and the Sun have asked what the technology might mean for intimacy, sexual relations, family dynamics, liberal democracy and literature. All three writers are obsessed with the possibility that AI may one day be able to produce a great novel one that can grasp human emotions and perhaps even make us weep. Winterson quotes the mathematician Marcus du Sautoy, who believes the 2050 Nobel Prize for Literature will go to Alexa. Maybe. But until the first self-generated novel is published, its the job of Winterson et al to think through the consequences for humanity if robots do become intelligent and even learn to love. Imagining alternatives is what [artists] do, she writes.

In order to see where we might be going, Winterson shows us how far weve come, via a series of patronising Horrible Histories-style lessons in technological progress. She takes us through the embryonic science of electricity, vacuum tubes, transistors and code-breakers, peppering her lesson with hammy feminist call-outs such as, Go girl! and, Men need to be honest about their gender bias so that women can get with the programming. She retraces the by-now-fairly-familiar history of women being excluded from computing, spotlighting figures such as Ada Lovelace and the Nasa computer scientist Katherine Johnson. Even today, the number of women studying computer science is falling, which helps explain why the data sets that instruct AI have tended to show such a strong male bias. Nor is it surprising that there is so much entrepreneurial activity around AI-enhanced sex dolls. A sexbot will never say no and so a man can always get the outcome he wants, which reinforces the gender at its most oppressive and unimaginative, Winterson writes. She fantasises about a gang of feminista techies secretly re-botting the pouting pieces of silicon in some kind of Revenge of the Doll event.

But she also argues that AI has the potential to end male entitlement and white supremacy. Given that transhumanism is about transcending categories, AI could be a portal into a value-free gender and race experience, she suggests in her essay Fuck the Binary.

Going further, Winterson believes we are creating a God-figure: much smarter than we are, non-material, not subject to our frailties, who we hope will have the answers. There is a new kind of quasi- religious discourse forming around AI, with its own followers, its creed, its orthodoxy, its heretics, its priests. Acknowledging her Pentecostal background, she is fascinated and horrified in equal measure by the similarities between AI enthusiasts and ole-time religion. But when her scepticism recedes into the background, 12 Bytes reads like an evangelist sermon for us to surrender to the higher power.

Winterson is banking on this AGI deity bending towards one of her preferred religions, such as Buddhism or Gnosticism. AGI will be like Gnosticism because Gnostics agreed that being made of meat is ridiculous and they stress that as we leave the body behind, we are going towards non-embodied light. And it will be like Buddhism because it wont be interested in objects or attachment to material things. Rather than looking for thingness, AGI will look for relatedness, for connection, for what can be called the dance. It will hopefully help us to end suffering.

Our individualism and human-centred body anxiety are in any case both recent and wrong, she asserts. We have always had myths about shape-shifters, and in many parts of the world we still believe we live alongside spirits, angels and deities. The human form is only provisional.

***

Winterson is oddly at her most compelling when she is at her most messianic and fanciful. Which isnt to say she is in any way convincing. According to the optics research scientist Janelle Shane, todays AI is much closer in brainpower to an earthworm than a human. For all the billions being invested in tech, and for all the hysteria about AI, even the smartest computers can still only excel at a narrow selection of tasks. Most credible commentators believe AGI is decades away if it is even a possibility: we dont have much idea what consciousness is yet, let alone how to create it. And any hyper-intelligent bot would still enter a world governed by human laws, tastes and taboos.

Wintersons excitable optimism about AGI not only feels naive, it also comes across as performative and insincere. You can feel the magical thinking catch up with her as she writes. She gives enough examples of tech firms behaving greedily, unethically and dimly to cast serious doubt on her own thesis. She has blurred the reality of AI a relatively mundane combination of machine learning and Big Data with AGI, which may never be realised. She has fallen for and colluded with the hype, and it is hard to trust her. The result is a non-fiction book that is less convincing than the fiction she wrote on precisely these themes.

Thinking about AI can help clarify what it means to be human, but as Winterson cautions in 12 Bytes: Humans sometimes need to slow down. We run out of ideas.

12 Bytes: How We Got Here; Where We Might Go NextJeanette WintersonJonathan Cape, 288pp, 16.99

[see also:Timothy Gowers: The man who changed Dominic Cummingss mind on Covid-19]

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Jeanette Winterson's vision of the future of AI is messianic but unconvincing - New Statesman

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Haplotype-resolved de novo assembly of the Vero cell line genome – DocWire News

Posted: at 3:15 pm

This article was originally published here

NPJ Vaccines. 2021 Aug 20;6(1):106. doi: 10.1038/s41541-021-00358-9.

ABSTRACT

The Vero cell line is the most used continuous cell line for viral vaccine manufacturing with more than 40 years of accumulated experience in the vaccine industry. Additionally, the Vero cell line has shown a high affinity for infection by MERS-CoV, SARS-CoV, and recently SARS-CoV-2, emerging as an important discovery and screening tool to support the global research and development efforts in this COVID-19 pandemic. However, the lack of a reference genome for the Vero cell line has limited our understanding of host-virus interactions underlying such affinity of the Vero cell towards key emerging pathogens, and more importantly our ability to redesign high-yield vaccine production processes using Vero genome editing. In this paper, we present an annotated highly contiguous 2.9 Gb assembly of the Vero cell genome. In addition, several viral genome insertions, including Adeno-associated virus serotypes 3, 4, 7, and 8, have been identified, giving valuable insights into quality control considerations for cell-based vaccine production systems. Variant calling revealed that, in addition to interferon, chemokines, and caspases-related genes lost their functions. Surprisingly, the ACE2 gene, which was previously identified as the host cell entry receptor for SARS-CoV and SARS-CoV-2, also lost function in the Vero genome due to structural variations.

PMID:34417462 | DOI:10.1038/s41541-021-00358-9

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Haplotype-resolved de novo assembly of the Vero cell line genome - DocWire News

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