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Early-Infancy Meningitis Infection Linked With Increased Risk of … – AJMC.com Managed Markets Network
Posted: May 18, 2023 at 1:28 am
Epilepsy should be added to the list of neurological outcomes following an infection of invasive Group BStreptococcus(iGBS)particularly meningitisin early infancy, new study results suggest.
Findings from a population-based cohort study, published in JAMA Network Open, revealed iGBS disease was linked with a higher incidence of epilepsy in later childhood, notably after meningitis. The risk of epilepsy in later childhood was higher among those born prematurely, males, or those born to a mother belonging to a low socioeconomic position (SEP).
iGBS disease is a leading cause of neonatal and young infant mortality around the world. In 2020, it was estimated that 500,000 cases of iGBS disease occurred within the first 3 months after birth, the authors wrote.
Although epilepsy has been reported as an outcome following iGBS disease, particularly meningitis, the risk of the condition after neonatal iGBS disease has yet to be investigated further, the researchers said. To address this knowledge gap, they studied children with iGBS born in Denmark between 1997 and 2017. Follow-up continued until the end of 2018.
A total of 1432 children with iGBS disease (sepsis, n = 1264; meningitis, n = 168) were included in the study and compared with 14,211 unaffected children. All participants were aged between 0 and 89 days, 55.3% were male, and nearly 79% had a gestational age of at least 37 weeks. The mothers SEP was determined via income and education level.
Analyses revealed:
Overall, we found a significantly higher risk of epilepsy in children with iGBS meningitis in later childhood compared with children not exposed to iGBS, the authors wrote. The risk of epilepsy for iGBS sepsis was not significant.
Compared with those without iGBS, the cumulative incidence of epilepsy was higher within the first 5 years after diagnosis of iGBS.
To the authors knowledge, the study is the first to examine the long-term risk of epilepsy as an individual outcome after iGBS sepsis or meningitis.
The large cohort of children with iGBS disease and comparison group, in addition to long-term follow-up until adolescence, mark strengths of the current investigation. Researchers were also able to match groups on all matching variables with small differences between cohorts, helping to reduce residual confounding.
However, data for iGBS onset were defined based on admission date, meaning the study may have excluded iGBS infections from the day of birth. Results should also be interpreted with caution, due to the small size of the iGBS meningitis cohort, the authors noted. Data also did not account for childhood accidents, infectious diseases, or head trauma that took place after the index date.
Our findings have implications for estimating the global burden of iGBS and should be considered in relation to the cost-effectiveness of interventions, such as intrapartum antibiotic prophylaxis and maternal vaccination, the authors concluded. Importantly, these data also have implications for affected individuals and underline the need for better long-term follow-up and care.
Reference
Lykke MR, Srensen HT, Lawn JE, Horvth-Puh E. Long-term risk of epilepsy following invasive group B Streptococcusdisease in neonates in Denmark. JAMA Netw Open. Published online April 21, 2023. doi:10.1001/jamanetworkopen.2023.9507
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NOVN: Counting Down to PDUFA – Yahoo Finance
Posted: at 1:28 am
By John Vandermosten, CFA
NASDAQ:NOVN
READ THE FULL NOVN RESEARCH REPORT
1Q:23 Financial and Operational Results
On May 15th, 2023, Novan Inc. (NASDAQ:NOVN) reported 1Q:23 financial and operational results in a press release and in the filing of Form 10-Q. A conference call and webcast were subsequently held to update investors on recent developments. The call highlighted the performance of the EPI Health assets and efforts related to SB206s New Drug Application (NDA) which has been assigned a target action date of January 25th, 2024. Novan is increasingly focused on potential funding or strategic arrangements and alternatives to address short-term cash needs and access to capital is necessary to progress development of SB206. Since the report of 2022 results in late March, Novan held an analyst and investor day and announced a publication supportive of patient use of Wynzora.
Highlights for 2023 include:
SB206 NDA submitted for molluscum contagiosum January 2023
NDA accepted for SB206 assigning 5JAN24 PDUFA date March 2023
$6 million registered direct offering March 2023
Investor KOL event with Dr. Sugarman on molluscum unmet need April 2023
Publication of survey on patient needs for psoriasis medication April 2023
With respect to financial performance, Novan generated $3.2 million in 1Q:23 revenues versus $1.9 million in 1Q:22, and posted a net loss of ($14.1) million or ($0.54) per share compared to a loss of ($13.4) million or ($0.71) per share in the prior year period.
For the quarter ending March 31, 2023 and versus the same prior year period:
Revenues were $3.2 million, up 64% from $1.9 million. The increase is predominantly due to revenue contribution from sales of dermatology products Wynzora, Rhofade, Minolira and Cloderm and recognition of a full quarter of sales in 1Q:23 compared with 20 days of sales in 1Q:22. Year over year increases were tempered by Rhofade suffering a manufacturing delay which led to a to lack of inventory and loss of sales in 1Q:23; however, management noted that a rebound in orders was experienced in the second quarter as units were restocked. Furthermore, deductible resets for 2023 contributed to the sequential slowdown in scripts and revenues for Novans three leading products.
Story continues
License and collaboration revenues of $585,000 were down 50% due to the absence of revenues from the distribution and supply agreement for Cloderm. Research and grant revenues were up 370% to $170,000 from $36,000 on recognition of multiple federal grants;
Cost of goods sold was $1.3 million vs. $0.2 million;
Research & development expenses totaled $4.8 million, essentially flat with prior year levels. Declines in spending on the SB206 program were offset by increases in other research and development expenses related to a $1 million milestone payment to Ligand;
Selling, general & administrative expenses were $10.0 million, also flat with prior year amounts. 1Q:22 expenses related to the EPI acquisition were replaced by greater commercialization spending for the product portfolio in 1Q:23;
Net loss was ($14.1) million, or ($0.54) per basic and diluted share, compared to ($13.4) million, or ($0.71) per share.
As of March 31, 2023, cash and equivalents on the balance sheet totaled $12.5 million. This compares to cash holdings of $12.3 million at the end of 2022. Cash burn was ($4.3) million which was partially offset by $4.1 million of net contributions from financing. $6.0 million of this amount was from the direct offering which was executed in mid-March. $5.0 million was also received from Sato related to the license agreement for Rhofade. $1.25 million of the Sato/Rhofade upfront is owed to a third party tempering the impact from this cash flow. Novan anticipates that there is sufficient liquidity to support operations until late second quarter 2023.
Corporate Updates
Psoriasis Publication
Findings from a National Psoriasis Foundation study were published in the Journal of Drugs in Dermatology which surveyed more than 400 US patients on patient adherence to topical psoriasis medications. The title of the April 2023 publication is Patient Preferences in Topical Psoriasis Treatment by Curcio, et al.1 The 17-question survey was administered in March 2022 and queried participants on psoriasis severity, bothersome signs and symptoms, current treatment modalities, frequency of topical therapy use, and vehicle preferences.
84% of the participants reported moderate psoriasis with 72.5% of participants using oral medication and 8% topical treatment alone. 76% used topical therapy at least once weekly and 80% reported that they would wait two weeks after starting a new topical treatment before considering discontinuation. Participants preferred water-based creams (75.7%), followed by oil-based foam (70.8%), gel (48.7%), solution (42.8%), lotion (21.2%), non-oil-based foam (17.5%), ointment (16.5%), and spray (6.3%). Other desirable features were formulas that did not stain, were absorbed quickly, were not sticky and were easy to apply. 75% said they would continue to use a psoriasis medication for a week before stopping if they didnt like its topical formulation.
Novans press release continued with a summary of Wynzoras features. Novans product, which is commercialized jointly with MC2 Therapeutics, offers a rapid onset of action with results seen in efficacy, scale and itch as early as one week after application and continued improvement at 8 weeks. Additional detail on Wynzoras profile are included in an analysis by Han, et al.2 and in the products label.
A Discussion of Molluscums Unmet Need
Novan held a stakeholder event on April 25th, 2023 featuring pediatric dermatologist Jeffrey Sugarman, MD, PhD to discuss molluscums unmet need with investors and analysts. The presentation began with an introduction by CEO Paula Brown Stafford who summarized the companys pipeline and the status of lead candidate SB-206, which is now being considered for approval by the FDA. She was followed by Chief Commercial Officer Brian Johnson who quantified the unmet need for molluscum patients. Existing options for patients include potentially painful in-office procedures and non-approved approaches that have limited efficacy. Health care providers (HCPs) want to see solutions for MC and are willing to prescribe an effective medicine if available.
To provide the HCP perspective, pediatric dermatologist Dr. Jeffrey Sugarman was featured who also served as the safety monitor for the Phase III clinical trials for SB-206. MC is commonly seen in children from 3 to 8 years of age, but does move outside of this range. Children with MC frequently also experience eczema, which can make the disease uncomfortable in addition to unsightly and contagious. Dr. Sugarman identified some of the features that physicians would like to see in an MC treatment. These include a safe, effective and well-tolerated product that is convenient to use. SB-206 achieves these objectives for patients, including convenience as it is a prescribed product that can be used at home.
Further discussion detailed the manufacturing and commercialization activities that have been taking place and that will take place over the next quarters. Pediatric dermatologists and primary care pediatricians will be the target audience for the anticipated marketing effort. The panel participants brought up the pending target action date for Verricas cantharidin treatment for MC which is in late July. Having two companies commercializing simultaneously could be beneficial for educating providers on the available options.
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1. Curcio, A., et al. Patient Preferences in Topical Psoriasis Treatment. Journal of Drugs in Dermatology, April 2023.
2. Han, G., Feldman, S., Bhatia, N., & Prstegaard, M. (2022). Dipropionate (Bdp) Cream (Cal 0.005%/Bdp 0.064% W/W) Improves Plaque Psoriasis At Week One In A Phase 3 Trial. SKIN The Journal of Cutaneous Medicine, 6(4), s42. https://doi.org/10.25251/skin.6.supp.42
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Psoriatic Arthritis (PsA) Treatment Market is likely to register CAGR … – Future Market Insights
Posted: at 1:28 am
In 2022, the global Psoriatic Arthritis (PsA) Treatment Market sales is expected to exceed US$ 10.3 billion. The market is expected to reach US$ 15.6 billion by 2028, growing at a strong 7.1% CAGR.
According to Future Market Insights, the Psoriatic Arthritis (PsA) Treatment Market would grow at a 7.1% CAGR between 2022 and 2028, up from a 6.7% CAGR between 2013 and 2021.
According to the Arthritis Foundation, nearly 70% of psoriasis patients are predisposed to psoriatic arthritis, and up to 20% of arthritis patients are predisposed to psoriasis.
For more insights into the market, request a sample of this report@ https://www.futuremarketinsights.com/reports/sample/rep-gb-2718
In recent years, the increasing burden of psoriasis and psoriatic arthritis on the healthcare industry has boosted clinical research in the field of psoriatic arthritis.
Sustained adoption of conventional disease modifying anti-rheumatic drugs (DMARDs), especially in cost sensitive regions, is projected to push the demand forpsoriatic arthritis treatmentin coming years.
Role of Strong Product Pipeline & Mounting Clinical Research Investments
According to the National Psoriasis Foundation, around 20 medicines for psoriasis and psoriatic arthritis are now in phase II clinical trials, with another 28 in phase III. However, around 24 medicines have already been approved by the FDA for use in the treatment of psoriasis and psoriatic arthritis.
While a solid product pipeline continues to boost demand for psoriasis and psoriatic arthritis treatment, recent data indicates that numerous drug manufacturers are moving their focus to competitive pricing methods in an effort to achieve general adoption in the future years. Future Market Insights recently published new insight based on its analysis of the worldwide psoriatic arthritis therapy market. According to the analysis, the market would grow at a rate of more than 7% per year by 2022.
Industry Behemoths Cover More than 55% Market Value Share
In a largely consolidated worldwide landscape of psoriatic arthritis treatment market, industry giants such as Novartis AG and AbbVie Inc., which include biologics in their core portfolio, account for more than 55% of total revenue. While market leaders continue to focus on FDA clearances and clinical trials, data indicates that different pricing strategies are becoming increasingly important.
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Moreover, prominent players in psoriatic arthritis treatment market are likely to augment investments in R&D of biosimilars, biologics, and TNF (tumor necrosis factor) inhibitors to target regional markets. A number of leading drug manufacturers are also maintaining sizable investments in DMARDs that are scheduled for market entry in next few years. This is perceived as a strong factor improving growth prospects of psoriatic arthritis treatment market, according to the report.
Besides all these, strategic acquisitions, partnerships, and collaborations will remain the preferred expansion strategies adopted by a majority of prominent operators in psoriatic arthritis treatment landscape, says a senior research analyst at the company.
Demand for Biologics & DMARDs Gaining Momentum
Research-driven understanding of the pathophysiology of psoriatic arthritis is fueling the introduction of innovative therapies in psoriatic arthritis treatment market, triggering innovations among the market participants thereby supporting the growth of psoriatic arthritis treatment market. Targeted biological therapy has been demonstrating a decent success rate in terms of inducing temporary pain relief resultant of psoriatic arthritis, and thus continues to represent an attractive position in the psoriatic arthritis treatment market.
The report says that the demand for biologics accounts for more than 55% share of the global market revenue, whereas DMARDs demand makes up for more than 3/4thof the total market value. Although a majority of psoriatic arthritis patients opt for injectable as a preferred route of administration of psoriatic arthritis treatment, increasing introduction of innovative oral drugs is uplifting the popularity of orally administered psoriatic arthritis treatment.
Development of novel oral treatments for psoriatic arthritis is likely to favor the growth of North Americas market. Growing availability of combination therapies and relatively economical biosimilar antibody therapeutics are identified to be the primary boosters for the growth of Europes market. Collectively, North America and Europe account for over 60% share in the global value of psoriatic arthritis treatment market. The report indicates that the psoriatic arthritis market in Asia Pacific is likely to display high growth potential in the course of next few years.
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Psoriatic Arthritis (PsA) Treatment Market by Category
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Future Market Insights, Inc. (ESOMAR certified, Stevie Award recipient market research organization and a member of Greater New York Chamber of Commerce) provides in-depth insights into governing factors elevating the demand in the market. It discloses opportunities that will favor the market growth in various segments on the basis of Source, Application, Sales Channel and End Use over the next 10-years.
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New campaign raises awareness of topical steroid withdrawal – Professional Beauty
Posted: at 1:28 am
Topical steroid withdrawal TSW campaign launched to raise awareness in eczema and psoriasis sufferersTo raise awareness of Topical Steroid Withdrawal (TSW), bath salt brand Westlab has announced its TSW Awareness Campaign.
The campaign is targeted towards those who suffer from TSW, including parents and carers of those with the condition.
It has been developed alongside experts to raise awareness of the urgent need for research to aid GPs, pharmacists, and dermatologists in diagnosing and treating their patients safely, while helping prevent the long-term risks of topical steroid misuse.
Topical corticosteroids, a steroid treatment applied directly to the skin, help reduce inflammation and irritation for conditions such as eczema and psoriasis. When used continuously over long periods of time, the body can become dependent.
TSW refers to the symptoms that occur when a patient reduces or ceases the use of topical steroids, including painful redness, burning, swelling, itching, flaking, and oozing of the skin.
Not only is this extremely painful for the patient, but it can also lead to mental health issues such as depression, insomnia, anxiety, and PTSD.
With limited research around TSW and no definitive NHS guidelines for GPs and dermatologists to follow in supporting their patients, one of the main aims of Westlabs campaign will be education to help prevent accidental misuse or prescription of corticosteroids.
The campaign will also see Westlabeducate TSW parents with digestible bite-size information on managing childhoodeczema and psoriasismore naturally, protecting the skin barrier right from the outset of triggers to avoid TSW.
The brand will donate 1,000kg of Dead Sea Salts to the TSW community, providing support to those starting on their journey and those who are acutely in need of relief.
Through expert panels and sponsorship, the brand says it will also dedicate its time and expertise to educate skin care specialists and pharmacists around the UK.
Westlab's campaign will aim to prevent future generations from experiencing the devastating physical and psychological effects of TSW, says the brand.
Anecdotal evidence suggests that soaking in a salt bath may help reduce the severity ofeczemasymptoms,particularly in cases of oozing a lot or where secondary infection is common.
Westlab says that their microbiome-gentle Dead Sea Saltshelp to soothe, protect and repair the skins natural barrier, which is essential for eczema,psoriasis and recovery from TSW.
This is thanks to the abundance of minerals within them, inparticular magnesium, calcium and potassium.
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Crazy Town: Episode 73. How Longtermism Became the Most … – Resilience
Posted: at 1:13 am
Jason BradfordI'm Jason Bradford.Asher MillerIm Asher Miller.Rob DietzAnd I'm Rob Dietz. Welcome to Crazy Town, where we can't wait to meet our 80 trillion descendants on the other side of the cosmic wormhole.Melody AllisonHi, This is Crazy Town producer Melody Allison. Thanks for listening. Here in season five, were exploring Phalse Prophets and the dangerous messages theyre so intent on spreading. If you like what youre hearing, please let some friends know about this episode, or the podcast in general. Now on to the show.Asher Miller Hey Jason, I gotta ask before we start today, when I was pulling up in front of your house, I noticed, you have all these excavators out in the field?Jason Bradford Yes, I do. Asher Miller Like a dozen of them.Jason Bradford Yep. Big deal.Asher Miller What's going on, man?Jason Bradford Well, you know, there's a lot of stuff going wrong in the world, or potentially wrong. What we call existential risks, you know. The gray goo AI kind of stuff, pandemic, nuclear war, all kinds of things. And if we're going to basically fulfill our potential as beings in the universe, we've got to make sure that if civilization goes under, they can come back. Rob DietzThat's good thinking.Asher MillerThis is insurance?Jason Bradford Yeah. A lot of people think that either you're gonna go hide out in a bunker and be able to come out and re-boot civilization. But no way. Unless you're a hunter gatherer or a subsistence farmer, us moderns don't have the skills. So what I'm doing is I'm creating basically bunkers for groups of subsistence farmers and hunter gatherers that I'm going to import from various parts of the world. I'm not going to just get a single group of hunter gatherers or a single group of peasants. I'm mixing them together. We want that diversity. And they're going to live here.Asher Miller So not a monoculture of hunter gatherers. Jason Bradford No I'm not. I'm bringing in - Actually, I've got some New Guineans lined up. Some recently contacted tribes from the Amazon. I'm working on getting some Sentinelese from the Bay of Bengal. That's really tough. They try to kill you when you land. And I've got Andean peasants. I've got some Romanians. We're getting some Amish in here. So really, really solid crews, and they're going to be on 12 hour shifts. Asher Miller I was just thinking that you're doing rotational farming, basically?Jason Bradford Well, if things go wrong, you know, if the asteroid strikes, whatever, we need half of them at least in the bunkers at any one time, right? But they also have to come out to maintain their skills, get the vitamin D, etc. So I feel like I'm fulfilling my potential by doing for, you know, humanity, and the future generations. Rob Dietz Okay, I'm getting close to getting sick here. I'm near the vomit point. So I gotta call a little timeout on this - What do we even call it? A sales pitch? Jason Bradford Yep, this is legendary. This is going to be huge. Rob Dietz Well, let's just say for now that this is not Jason's cockamamie idea. He's making fun of a cockamamie idea that we're going to get to in a little bit. But in order to get there, we got to tell you about a guy named William MacAskill. Okay? He's our phalse prophet for today. And let me just start running through a little bit of his life to say, get a sense of him. And then we'll move on to the cockamamie ideas. Jason Bradford I was kind of getting excited about it, actually. Rob Dietz Yeah, I know. I know. Sorry. Okay, so McCaskill is probably the youngest of our phalse prophets so far. Jason Bradford Congratulations. Asher Miller What is he, 12?Rob Dietz Yeah, yeah. 11. No, he was born in 1987 in Scotland. His actual name when he was born was William Crouch, but - I don't know why that's funny.Asher Miller I just imagined he was crouching. Jason Bradford He was stooping a little. Asher Miller William, crouch!Rob Dietz Oh, it's a sentence. I gotcha.Asher Miller You gotta do it with a Scottish accent. William, crouch!Rob Dietz I thought we decided no more accents. After the Bill Clinton episode we had to put that away.Asher Miller You say this now. You're the one who gets to do all of the accents. Jason Bradford Yeah, I know. Only you can do accents.Rob Dietz Oh, no. This show is off to a bad start. Okay, back to William Crouch/MacAskill. He actually was kind of a progressive guy. So he and his partner both changed their last names when they got married. So that's how he ended up being William MacAskill.Asher Miller I gotta say I appreciate going with a new name versus the hyphenation thing. That gets long.Rob Dietz Yeah, it can get tedious. Yeah. Well, and so I think he had a pretty kind heart. When he was 15, he learned about the scope of people who are dying from the HIV epidemic and he kind of made this resolution, when I get older, I'm gonna make a ton of money so that I can give it away and become a philanthropist. So he went to Cambridge. So I guess he's got the academic chops. He studied philosophy. And he got impacted by this guy, Peter Singer, who wrote a pretty famous, influential essay called "Famine, Affluence, and Morality." And we're gonna get more into that later. And then he goes on to get his PhD in philosophy. Yes, that's a Doctor of Philosophy in philosophy. And now he's an associate professor at Oxford, and he's the chair of the advisory board of the Global Priorities Institute. Pretty highfalutin.Jason Bradford We've been making fun of a lot of the Ivy League schools in the U.S. I'm so happy we get to - Asher Miller Yeah, we get to make fun of the Brits. Jason Bradford I know the Brits. Like Cambridge, Oxford. This is great.Rob Dietz The true Ivy right? Jason Bradford Oh yeah. This is old school Ivy. This is great.Rob Dietz I mean, the the buildings were probably actually made of ivy at this point.Jason Bradford They were cloaked in ivy. Okay, so he's founded a few organizations, including the Centre for Effective Altruism. If you look it up it's spelled "t-r-e." Just be ready. Asher Miller Yeah, all about British - Jason Bradford Oh yeah, yeah. It's confusing. It argues for bringing database rational decision making to philanthropy. Rob Dietz Well, it sounds alright. Jason Bradford Yeah, a group called, Giving What We Can. And this is sort of like tithing your earnings to effective charities. Rob Dietz Sounds alright too.Jason Bradford Yeah. 80,000 hours, which is sort of the ideas that represents how many hours you're likely to work in a professional capacity. And so it is advising people on how to think through career choices that have the greatest social impact. Rob Dietz That sounds alright too.Jason Bradford I know, this guy's a star. He's a vocal supporter of animal welfare. This led him into vegetarianism. Nice. Live by your principles. He's best known, however, for being the leading voice of what is known as Longtermism. And he laid out what this means, his philosophy, in a very recent a apparently best selling book called, "What we Owe the Future: A Million Year View. And I remember getting ads like this like crazy through New York Times and stuff. I mean, this was really, really pushed. And it's this longtermism that we are sort of bringing up, and he's representing that as our phalse prophet.Rob Dietz If we were to just stop here, you'd have to say, "You know what? Maybe this guy is an actual prophet instead of a phalse prophet."Jason Bradford What's not to love, right? Yeah. Yeah. But we hinted at that with my fantasy about the bunker.Rob Dietz So it was a fantasy then? We're clear on this now.Asher Miller Some strange fantasies. So our Crazy Town devotees who listen to every one of our episodes may recall that I did an interview with Douglas Rushkoff, and we talked a little bit about the longtermism stuff. But we're going to really unpack that here today, and talk about why it's such a dangerous philosophy. So we're going to focus on longtermism, but, and this is - Part of what's really tricky about it is I think we have to place it in the context of a lot of other concepts. And that's partly because it helps people sort of like understand we're dealing with. And also because some of these other terms are also commonly used, or they're sometimes used interchangeably. They're used in different contexts. But what's important about them is that they're all connected sort of in an overarching philosophy, right? So the key thing is, if you hear any of these terms - It's not only understanding, like we want to present some of these concepts so you understand where longtermism comes from, but for your ears to be tuned to these terms that you might hear. Because then you'll know, "Oh, this represents this certain type of thinking."Rob Dietz Alright, if we're gonna start throwing around terms, can I just make the request that we don't use the word ontology or ontological at any time during this?Jason Bradford I was not planning on it, but you just did that. Asher Miller You actually did do that. Jason Bradford Okay? Okay, so someone who's really helped us understand how these are all connected, how these terms are conneceted, is Emile Torres, one of the most vocal critics of Effective Altruism and longtermism. And Emile is a reformed longtermist who actually had been a research fellow for our previous phalse prophet, Ray Kurzweil.Rob Dietz Wow. So Emile has escaped from the cults.Jason Bradford Yes. And Emile goes by they, and they have an actual acronym for this mishmash of all these related philosophies and concepts.Jason Bradford It's B-U-L-L-S-H-I-T. Easy to remember.Jason Bradford Okay, that's the easiest to remember. Unfortunately, this one's not as easy but - It's what's called TESCREAL. Okay? It sounds like something you'd push out.Jason Bradford It sounds like a hormone.Rob Dietz Some sort of disease, maybe. I went down to the public bathhouse and came away with TESCREAL. Jason Bradford And now you're on antibiotics. Okay, well it stands for - I might have some trouble with these words so I need you to step in if I flounder.Rob Dietz Okay, yeah. You almost said an anachronism for acronym.Asher Miller Well because there's so many "isms" in this acronym.Jason Bradford Oh my god. This is ridiculous. Are you ready for all the isming? Rob Dietz Yeah, okay. Jason Bradford Okay, we got transhumanism. Jason Bradford Weve got extropianism. We've got, oh this one is going to be rough, singularitarianism. We've got cosmism. We've got rationalism, Effective Altruism, and longtermism. So that's what TESCREAL all stands for.Asher Miller Okay. Rob Dietz Right. I'm gonna say that's a lot. So, I don't think we've got to cover what every single one of those means.Asher Miller We're just gonna do an episode on each one. Rob Dietz We want to get to longtermism, but like you said earlier, Asher, we've got to set some context here.Jason Bradford And a few of them, they are so related that it kind of covers the bases.Rob Dietz So, why don't we hit unilater - I've got Jason disease. No. Utilitarianism, Transhumanism, Effective Altruism, existential risk, and then we'll be safely arriving at our destination of longtermism.Jason Bradford Okay, and some of these are not exactly in TESCREAL, but they're related important ideas in lots of these, so. . . Asher Miller Alright. Well, let's start with utilitarianism. And I think, let's go in a certain order, because I think the order is almost like these are building blocks of concepts. So utilitarianism is probably the oldest of these. And it's a philosophy that dates back to Jeremy Bentham snd John Stuart Mill, you know, the late 18th century, early 19th century. And basically, all you need to know about utilitarianism is that it argues that the most ethical choice you can make is the one that will produce the greatest good for the greatest number of people. Okay? Pretty basic. Jason Bradford Pretty basic.Rob Dietz Pretty easy to agree with. I mean, just generally.Rob Dietz For the most part. Rob Dietz In general. Jason Bradford You know, devils in the details, maybe of like, who decides and how do you decide and -Asher Miller Ah, that's what we're gonna be getting into later.Jason Bradford Okay. Alright, then we're gonna go to my favorite, transhumanism. According to Emile Torres, transhumanism is, and I quote, "Ideology that sees humanity as a work in progress. It is something that we can and should actively reengineer using advanced technologies like brain implants, which could connect our brains to the internet, and genetic engineering, which can enable us to create super smart designer babies." So we cover this a lot with Ray Kurzweil.Rob Dietz I've also seen a lot of sci-fi, and it usually doesn't end well.Jason Bradford Yeah, usually not really.Asher Miller It's interesting, the first part of that, humanity is a work in progress, something that we should actively, you know, re-engineer. Like, okay. Took a little turn there.Jason Bradford Some red flags start waving in the wind here.Asher Miller Alright, let's talk about Effective Altruism, because I think Effective Altruism is really probably the most commonly used term to sort of define this space of philosophy and initiatives that people are working on. It's something that is really intrinsic, I think, to our phalse prophet MacAskill. So, according to the Center for Effective Altruism, which is something again, that Jason, you talked about MacAskill co-founded. Effective Altruism is quote, "About using evidence and reason to figure out how to benefit others as much as possible, and taking action on that basis. Jason Bradford Yeah, sounds good. Asher Miller So you can see how it builds off of utilitarianism. Jason Bradford Love it. Rob Dietz Agree. Asher Miller It promotes using data and dispassionate reason to identify what giving would have the greatest impact, right. So you see, and this is actually pretty common in philanthropy, where people like to use metrics and you know, different ways -Where you're not just being tugged by heartstrings, or whatever. You're trying to think about the greatest impact you can make. Okay/ And it comes from the Australian moral philosopher, Peter Singer. You know, you talked, I think you mentioned him, Rob, when you were talking about the influences on William MacAskill. He's commonly viewed as the founder of EA when he published that paper in 1972, "Famine, Affluence, and Morality." And basically, he wrote it in response to this humanitarian crisis that was happening in East Bengal where there were many people that are suffering from famine, huge humanitarian crisis that was happening there. And he was arguing that there was insufficient aid coming from wealthy nations looking at this situation. So in the paper, he argued, quote, "If it is in our power to prevent something bad from happening without thereby sacrificing anything of comparable moral importance, we ought morally to do it." So basically, like, if it's not going to create an equally bad outcome consequence, it's our moral responsibility to help, right. And he also argued that quote, "If we accept any principle of impartiality, universal ability, equality or whatever, we cannot discriminate against someone merely because he is far away from us, or we are far away from him." Right? So he's saying, let's say the life of a child in East Bengal is worth the equivalent of the life of someone in your neighborhood. Rob Dietz Well, let the distortions begin now, shall we. If he's the kind of originator of this philosophy, it's started to take a turn for the worse. And this is one of the core ideas behind modern day Effective Altruism philosophy is that you got to earn to give. So it kind of goes back to MacAskill's youth of I want to grow up to be kind of philanthropist, right?Jason Bradford I know. It's amazing.Rob Dietz And you have this sort of rationale that whatever your job is, just go out and do it and get as much money as you can so that you can then become an effective altruist.Jason Bradford I think they also do say like, they asked a question, I saw this in some of Nick Bostrom writings, we'll talk about him a little bit. That, of course, you don't necessarily want to be engaged in like gun running or something like that.Jason Bradford There are limits. Jason Bradford There are limits. Right. Rob Dietz But there's kind of an irony here, because what you just said, Asher, of the life of a child in one part of the world is equivalent to the life of a child in your neighborhood. This kind of rationale is sort of doing this weird time thing where it's saying, the suffering of people today is not worth thinking about when you're talking about the potential well-being of all these future people.Asher Miller That will get us straight into longtermism, which we'll get to in a second. One thing I wanted to say about this earn to give philosophy, I've encountered this quite a bit in my own life. Asher Miller Yeah. So after college, I went and I worked at the Shoah Foundation, where we were documenting stories of Holocaust survivors. I didn't necessarily think I was going to be somebody who dedicated my career to doing nonprofit work. At the time, I wanted to be a writer, right. And I was going to write this book about a family of Holocaust survivors I was really close to. And in the process of preparing for that, I was writing a book for another Holocaust survivor. I was burned out. And I was living in Europe with my future wife, and then came back to the United States. I was like, what am I going to do now? And I was lucky enough to get interviews with folks, some really interesting people that that my dad was connected to in the Bay Area. And I remember meeting with this one guy, and you know, he was just kind of like asking me, he did a favor to my dad talking to me in my mid 20s about what I wanted to do. And I was like, you know, the .com boom was in effect at the time. Jason Bradford Really? Jason Bradford Oh, yeah. Asher Miller And I was like, I really want to do well. But I really want to do something meaningful and worthwhile. And basically, this guy, I'll never forget him. He like a VC guy, venture capitalist guy. He's like, "That's fucking stupid." He's like, "That's ridiculous. Make your money now and then you can give it away later. That's a way more effective way of helping the world." You know, he like just literally told me I was a fucking idiot. Jason Bradford For even imagining. Just go make piles of money.Asher Miller Go make your money.Rob Dietz I love it too, because he's also putting that message out with just sell your soul. You know, go do some work that you don't give a shit about as long as the piles of money are rolling in.Asher Miller And he was completely convinced that that was the right thing to do.Jason Bradford Okay, okay. Well, alright. So the other important thing to look at with this is what's called existential risks. And I remember when I first actually started learning about this whole philosophy, TESCREAL whatever, through the lens of existential risks. I remember being just struck by the fact that these folks in Oxford were like publishing about existential risk. Like wow, that's cool. You know?Asher Miller Because a lot of our work is about risks too, right?Jason Bradford I know, I'm like, Oh my God. We've got well funded Oxfordians is out there doing stuff. This is fantastic. So Nick Bostrom, also at Oxford, MacAskill's colleague. You know, he's also considered to be one of these fathers of longtermism. Introduced the concept of existential risk in 2002. And, I mean, of course, people have been worried about these kinds of things for a long time.Asher Miller Sure. We've been aware about nuclear, you know, nuclear holocaust for a long time.Jason Bradford Exactly. But he kind of brought it forward and started defining it and bringing in all the potential lists of things that could go wrong. And so he defines it as an adverse outcome that would either "Annihilate Earth originating intelligent life or permanently and drastically curtail its potential. An existential risk is one where humankind as a whole is imperiled. Existential disasters have major adverse consequences for the course of human civilization for all time to come." And that's a key thing, for all time to come. And so he lists top existential threats. And you know, I agree with a lot of these. Nuclear holocaust or runaway climate change. Then it gets a little esoteric and a little bit more hard to kind of relate to you. For example, misguided world government, or another static social equilibrium that stops technological progress. So this is interesting. This is a hint. This is telling. Anything that ends up stopping technical progress, or some -Asher Miller Is an existential risk? Jason Bradford Yes. Or a world government that doesn't allow medical progress to happen.Rob Dietz Doesn't even consider the potential existential threat from overdoing it on the technology.Jason Bradford Well, this is the irony we'll get into, okay. And also, what he calls technological arrests. And this is that if for some reason we can't overcome the technical needs we have to transition to a post human world. Alright? So they pretty much make explicit that they're dealing now with what you would call like this - What was it? The singulatarianism? Asher Miller Right. Okay, so let's jut look at these building blocks, right? Utilitarianism, transhumanism, Effective Altruism, existential risks. You know, that brings us to longtermism. And we're gonna unpack this more in a minute. But basically, the essential thing to know is that longtermism is used for valuing all potential human lives in the future. Asher Miller Yeah. So any potential life, right? And look, we know it's a confusing bit of word salad, TESCREAL. We'll see if that takes off. But again, I think the key thing here is that these are all terms of philosophical beliefs that that are used interchangeably. And they're part of this sort of collective worldview that is becoming increasingly influential. Jason Bradford Yeah.Asher Miller So basically, you're advocating whenever any one of those isms is mentioned the little alarm bell starts to go off. Asher Miller Your antennae should go off. Asher Miller "This is TESCREAL. This is TESCREAL."Asher Miller Yeah. So what is longtermism really? I guess I would summarize it like this. It takes utilitarianism right, which is the moral argument for prioritizing the greatest sum of well being. Do the thing that does the most good. And it combines that with Singer's, Effective Altruism, which is like, we can't prioritize our own interests, or just those that people were familiar with over complete strangers. And it basically puts it into like, the space time continuum, right? With a little dash of the singularity thrown in.Jason Bradford Yes, that's a great summary of this stuff.Rob Dietz Yeah. Can I ask you, Jason, resident biologist? Is that even a thing where you could value some other life out there more than say, yourself or your kin?Jason Bradford It's hard to do. Asher Miller Well, it's not more. It's equal, right?Jason Bradford Well, that's the thing. If you think about everything that we think of normal from an evolutionary point of view suggests that this is kind of impossible from a root level of, I mean, you can probably, in your head conceptualize this, but I think it's very hard to do in practice. And we were talking about, you know, if there's a burning building, and your kid is in it, you're willing to run into that building, right? But if it's not your kid, what are the odds you're just gonna run into that building? Rob Dietz Some of us will. Jason Bradford But it's very hard. And so -Asher Miller I will just say, though, I mean, I think Singer wrote about that, in his article that he wrote in 1971, and he was basically saying, we live in a global world now. We actually have agency to do something. And he was basically saying, look, if we have surplus, we should use it to help other people. So you could sort of see the logic of it, rational logic. As long as we're, and this is the key thing, as long as we act rationally, which brings us in a sense back to Pinker, right? Like hey, if we can all be rational and we've got you know, the spirit capacity, then we can do all these things.Rob Dietz And not to confuse everybody with too many names, but our beef is not with Singer, right. I mean, it's more the distortions that have occurred since he wrote that article. And you know, with longtermism, it argues for starters, don't discount the fate of people on the other side of the planet. Well, that's right in line with Singer so that's fine. Right? But then it goes deeper and says we shouldn't discount future lives, which also is pretty okay until you take it to some absurd level.Jason Bradford I think we gotta call back to - we had a whole in season, what was it, Season 3: Hidden Drivers? Rob Dietz Yeah.Jason Bradford We had a whole episode about discounting the future in episode 37 of Crazy Town. So anyway, I think in many ways, we're like, yeah, okay. We agree.Rob Dietz Yeah, even hitting the technical side, the discount rate and how basically, our money system discounts the future. And we're saying no, you can't discount the future. Asher Miller It's interesting with some of these philosophies and these terms. When you first heard about existential risks, you're like, oh, they're probably talking about the same thing I am worried about, you know, And we hear longtermism and we're like, yeah, we agree. We shouldn't discount the future. We should be concerned about future generations.Rob Dietz Don't just take it as quarterly returns, you know. Don't just focus on the thing that's right in front of you.Jason Bradford Okay. So here's where they remember, we kind of hinted that the devils in the details with a lot of this stuff. Okay. So MacAskill And he's got this recent book we mentioned. And in that he goes through some math. He says, "If we assume that our population continues at its current size - " Okay, so 8 billion or whatever - "And we last as long as typical mammals that would mean there would be 80 trillion people yet to come. Future people would outnumber us 10,000 to one." So that's where you start to go, okay, right. I can see that conceptually. But now you're like, we're going to value those 10,000 futures as much as the present.Rob Dietz And that's where he starts saying that every action we take right now in the present should be for the sole purpose of ensuring the existence and the wellbeing of that 80 trillion, or however many it is in the future. And even if that means sacrificing wellbeing and the lives of people today, such as the 1.3 billion people that are living in poverty and suffering today. It's just the math, right? You just look at the numbers. Who cares? Usually you would say, let the one sacrifice for the many. I guess this would be, let the 1.3 billion sacrifice for the 80 trillion.Asher Miller I'm sure that goes over well.Rob Dietz Yeah, as long as you're not in the 1.3 - If you're at Oxford, you're safe. Okay?Asher Miller Now, and this is where it brings it back to existential risks, right? So if we have to say, look, the simple math says there's gonna be 10,000 people in the future for every one of us alive today. Then we have to do everything in our power to prevent the risks to their existence happening. And so we've got to have all kinds of investments and focus on trying to prevent some of these risks. But of course, you know, sometimes we need to have a backup plan, which is, Jason, you were talking about, you're invested in some of these backup plans with what you're doing here on the property. I think you got that idea from one of MacAskill's colleagues, Robin Hanson. Jason Bradford Yes, very good guy. Asher Miller He wrote, and I'm quoting here, "That it might make sense to stock a refuge or a bunker with real hunter gatherers and subsistence farmers together with the tools they find useful. Jason Bradford Buying those. Asher Miller Of course, such people would need to be disciplined enough to wait peacefully in the refuge until the time to emerge was right. So perhaps such people could be rotated periodically from a well protected region where they practice simple lifestyles so they could keep their skills fresh. Now, you're bringing them here and rotating them on the farm. Well,Jason Bradford Well, that's my upgrade from this. I took his idea and - Asher Miller Well, the carbon emissions of flying them back and forth from Amazon or the Bay of Bengal . . . Jason Bradford Exactly. Exactly. Rob Dietz Yeah, I'm sorry. Like what kind of convoluted thinking to get - I'm pulling a one you two guys. I'm about to have an aneurysm here. Like what hunter gatherer or farmer signs up for this shit? Like, yeah, I'm gonna sit in your bunker waiting for your Holocaust to happen so that when it does, I can come out and teach you how to live again.Jason Bradford Okay, if there any longtermist billionaire effective altruists out there, just don't listen to Rob. Please DM me about funding this project. Alright? You'll find me no problem.Rob Dietz I'm so sad.Jason Bradford Alright. So there is tons of money being thrown at Effective Altruism And longterism. MacAskill's over 80,000 hours claimed in 2021 that 46 billion was committed to further the field.Rob Dietz That's that's roughly, what? Two times the annual budget of Post Carbon Institute.Jason Bradford And I only need a few 100 million for my project. Okay? I'm just letting you know, okay. Elon Musk has given 10's of millions to support Bostrom's work and others. And most infamously, you got this guy, you know, Sam Bankman-Fried. He actually worked at the Center for Effective Altruism and was very closely tied to MacAskill. And maybe you can explain what happened?Asher Miller Well, he's thrown a lot of money at Effective Altruism in different ways. He also robbed people blind. And then his company FTX went belly up.Rob Dietz All the money he threw was cryptocurrency which probably is now nothing, right? Asher Miller Well, but people had invested real wealth in this.Jason Bradford There's a lot of overhead in all that. Rob Dietz Well, now you wonder how much the Effective Altruists - Maybe this is good for our story if we're trying to battle this philosophy. Maybe they don't have quite as much money.Jason Bradford Maybe now they're down to 20 billion.Rob Dietz Imagine they could only have a 10th as much and they're still bazillions of dollars beyond where we are.Jason Bradford I'll just cut the number of hunter gatherers I'm going to bring in half. Okay?Asher Miller Alright. But I would say actually the sort of effective altruists community, if you want to call it that, has been following a little bit of the Powell memo playbook. We talked about this before in our last season. You know, talking about the Powell memo, for folks haven't listened to it, that basically laid out a strategy for neoliberalist advocates to basically change things on all sorts of levels of society that was affecting higher education, the media politics - Rob Dietz - The coordination of think tanks. Just basically getting the message out any way they could.Asher Miller And you actually could see that happening. I mean, I don't know, maybe there'll be expos days later about this being sort of coordinated, you know, on some level. But there's certainly been that kind of a spread of long term missed ideas. And Effective Altruism is you know, you talked about money that Musk has thrown to Bostrom. Millions of dollars going to Oxford University and these other institutions. You're saying Bankman-Fried was throwing a ton of money into the recent congressional elections and local elections. And he was specifically funding, I mean, he was funding people that are gonna basically change the rules or protect cryptocurrency from being regulated. But he was also funding actual sort of Effective Altruist longtermist candidates. There was actually one that ran here in Oregon. He was the first sort of Effective Altruism congressional candidate. He got like, you know, I think he had $11 million. I don't know how many of that came from Sam Bankman-Fried. And that guy worked briefly at Future of Humanity Institute, which is Bostrom's shop. But you have the head of the RAND Corporation, which is one of the most influential kind of think tanks, big think tanks in the country. He's a longtermlist. You've got longtermists writing reports for the United Nations. So there's a report in September 2021, called Our Common Agenda and it explicitly uses longtermist language and concepts in it. You have people in the media who have been really promoting longtermism. Good example of that is Sam Harris, who's a very famous well-known author and podcaster. He wrote the foreword to MacAskill's book, which you talked about. Jason Bradford He interviewed MacAskill quite a bit on his podcast, yeah. Asher Miller And he, you know, said to MacAskill, he said, quote, "No living philosopher has had a greater impact on his own thinking and his ethics." We could talk about the ethics of some of these guys, later, maybe, but - Rob Dietz Unbelievable money and influence and reach.Melody Allison How would you like to hang out with Asher, Rob, and Jason? Well, your chance is coming up at the 4th annual Crazy Town Hall. The town hall is our most fun event of the year, where you can ask questions, play games, get insider information on the podcast and share plenty of laughs. It's a special online event for the most dedicated Crazy Townies out there. And it's coming up on June 6, 2023 from 10:00 to 11:15am US Pacific Time. To get an invite, make a donation of any size, go to postcarbon.org/supportcrazytown. When you make a donation, we'll email you an exclusive link to join the Crazy Town hall. If we get enough donations, maybe we can finally hire some decent hosts. Join us at the Crazy Town hall on June 6, 2023. Again, to get your invitation go to post carbon.org/supportcrazytown.Jason Bradford Alright. I am really happy to talk about this species. This is one of my favorite species, Homo machinohomo. Also known as the Cyborgian.Rob Dietz Ah, this was our second one. Jason Bradford Yeah. Very different than the type specimen, Ray Kurzweil. But, you know, they both sort of believe in this transhumanism singularity type thing or the future of these high tech, you know, fusing with technology cyborgs. MacAskill is, he's not the techie guy, he's a philosophy guy. So you see how even within a species there can be great variance in form. Like imagine if you're an alien spacecraft and you're hovering over say, Albuquerque, New Mexico. Rob Dietz I used to live there. Jason Bradford Yeah. And you suck up a chihuahua and you suck up a great dane. Rob Dietz Used to see that all the time on the streets.Jason Bradford Exactly. At first you might have you might not have any clue that the same species are so different. Right? But within that detailed taxonomic work you can tease these things more.Asher Miller Which one is Kurzweil? The chihuahua or the great dane?Jason Bradford But I just want to explain a little bit about the evolution in the discussion section of my paper. I go into some detail -Rob Dietz This is where we realize that you're sad that you didn't really go the professorial route and you became a farmer. This is your chance.Jason Bradford This is my time. If any University is out there, maybe Oxford or Cambridge.Jason Bradford There's Singularity University.Rob Dietz What about the Jack Welch Institute of Management? Asher Miller So many options to choose from.Jason Bradford So many options. Anyway, you know, we have this species that we covered a lot called the double downer, right? Now what you're seeing is there's a lot of double downism in all these other species like the Cyborgians. They also kind of have double downing in them, but I consider them an offshoot of the double downer.Asher Miller Yeah, isn't double downers like an ancestor?Jason Bradford Yes. It is a paraphyletic species, probably the -Asher Miller Do they have a common ancestor?Jason Bradford - The mother species spinning off daughter species. Such as, Rocket Man, which we'll get to later in the season. The Industrial Breatharians, the Cyborgians, and Complexifixers. So these species -Rob Dietz What are we talking about here? Jason Bradford Oh, well, okay. Okay. I think you know, what you have is this sort of technology fetish that they all possess. But then these other species have particular niches. You can think if there's a species that's widespread in the lowlands, and then there's daughter species that kind of move up into the mountains and occupy different mountain tops. That's what I think is going on. But we're gonna need a lot more population genetics.Asher Miller What a beautiful world this is. What I actually think is - you remember that game PokemonGo? Jason Bradford Yeah. Asher Miller We need a PokemonGo to spot these phalse prophets. Jason Bradford I think that would be great. Asher Miller You could just like hold up your camera and be like, "Oh, what species is this dude?Rob Dietz Personally, I'd rather just go back to chihuahuas and great danes.Jason Bradford Okay, it's quite obvious by now that longtermism and all of the related TESCRAL beliefs are built on pretty insane assumptions about technological process, exponential growth, no limits to - But we've covered that before. And so we're not going to go into any detailed critique of that.Rob Dietz Yeah, but what I do want to go into a critique of is this rich versus poor, sort of this classist thing that's gotten built into the philosophy. And the easiest place to pick that apart is from one of MacAskill's colleagues, a guy named Nick Beckstead. And here's a quote I'm just gonna read you guys: "Saving lives in poor countries may have significantly smaller ripple effects than saving and improving lives in rich countries. It now seems more plausible to me that saving a life in a rich country is substantially more important than saving a life in a poor country, other things being equal. Richer countries have substantially more innovation and their workers are much more economically productive." That guy, Singer, talk about a perversion of what he was saying. It's like the opposite.Rob Dietz This is why longtermism really fucks with people's heads because it takes the Effective Altruism and says well, we have to consider trillions of people in the future. In which case, let's invest in the people now that have the most capacity to ensure that those, whatever, we can go colonize space.Rob Dietz Well that's how you get some jackass thinking let me import some of the poor people to live in Jason's bunker.Jason Bradford Exactly. We can't get rid of all the primitives or totally dismiss them because they are optionality in case - Asher Miller They are our backup. Jason Bradford They're our backup.Asher Miller They're our reboot, right? Jason Bradford They'e a reboot of civ. Asher Miller There's a generator in the garage.Jason Bradford There we go. Okay. Let's not forget about the bunkers we need with these people.Rob Dietz I'm sad again. Very sad again. But before we jump into that, can I just pat myself on the back for not making a joke after you said dark shit?Asher Miller Sure. You just had to point it out.Rob Dietz Sorry. My bad. My bad. I cant help it. It's a disease.Asher Miller We could go down a seriously dark rabbit hole like getting into some of the philosophy. Like what you just talked about Rob, like that quote that you read from Beckstead. Pretty fucking reprehensible. There's some shit here on the transhumanism front that is really to me quite disturbing. And I'll just give sort of one example of this. In a 2014 paper Bostrom - So Nick Bostrom, just to recall is another Oxford guy. I think highly influential on our guide MacAskill. He and a co-author of his name Karl Schulman proposed a process of engineering humans to achieve an IQ gain of up to 130 points by screening 10 embryos for desirable traits, selecting the best out of the 10 while destroying the other nine, of course, and then repeating the selection process 10 times over. This human would be so much more intelligent than we are that they would be an entirely new species. They would be a post-human, right?Asher Miller Yeah. And then of course, we become Cyborgians eventually right? You know, so that's just the first step.Rob Dietz Well, and that first one that they create in the lab would be like Lex Luthor. Asher Miller Right. It's just like, yeah, I mean, that is definitely like straight up eugenics stuff.Rob Dietz Continuing on this front, the whole idea of longtermism is to promote taking high risks in the now because the upside is so great in the future. And it so much outweighs the downside of taking those risks. And that's exactly how you get a Sam Bank-Fried. He's gonna go off and make as much money as he can. He sees this crypto thing going and he's like, "Yeah, I can take advantage of this and I can take some risks. And off and running. And he's like a poster child for this.Asher Miller But they use this philosophy to justify. To say that actually, this is for the greatest good.Jason Bradford Yes, 80,000 hours. Asher Miller Because we're going to make as much fucking money as we can right now and we're going to use that all for the purposes of ensuring these 80 trillion people, you know, in the future can have the best lives they can. You know, there's another infamous character, someone that that worked very closely with Sam Bankman-Fried. I think they even had a relationship of some kind named Caroline Ellison. She actually was the chief executive of Alameda research, which was like that sister company that was connected to FTX. She once wrote, this has since been deleted, but I think this is really interesting in terms of the logic here. She wrote, "Is it infinitely good to do double or nothing coin flips forever? Well, sort of, because your upside is unbounded and your downside is bounded at your entire net worth. But most people don't do this" she wrote. So basically she's saying, yeah, you know, keep doubling it. Flip the coin, try to double it. Take the risk.Rob Dietz It's like going to Vegas And playing blackjack. And when you lose, you just put twice the bet of what you lost, right? Jason Bradford Roulette. Roulette is better.Rob Dietz Or any of them, whatever. You lose, you just double it. And you keep doing it.Asher Miller But I mean, her saying okay, so the downside is you lost your initial quarter, or whatever it was, right? But the potential upside is so big. Jason Bradford But it's ridiculous. Asher Miller But she's like, people don't want to do this. And then she said, they don't really want to lose all their money. And then she wrote in parentheses, "Of course, those people are lame and not EAs,"Asher Miller Effective Altruists.Asher Miller Effective Altruists.Asher Miller "This blog endorses double or nothing coin flips and high leverage," right? So if you think about the cavalier nature of that, like, these people are lame, you know. Well, they fucking profited off of these lame people who invested in FTX. They invested all their money, and they lost it, right? Rob Dietz It's so arrogant, too. It's like, I'm enlightened and you are not.Asher Miller And you gotta wonder, is she as Cavalier these days now? I mean, all that coin flipping that they were doing with FTX and Alameda like, might put her in jail, right? Jason Bradford I mean, the probability is you're gonna lose everything if you're just coin flipping. That's what is so crazy. I mean, the odds that you actually keep doubling forever are ridiculous.Rob Dietz Matt Damon told me that crypto was the space for the bold. If you're a red blooded American . . . Asher Miller But it is interesting. You pair that mindset of like, double down, doubled down, take risks, do all this stuff. Oh, but we also have these existential risks we gotta worry about.Jason Bradford We've got our bunkers.Rob Dietz Well, you are leading into the double down doctrine. Okay? Now bear with me here. There's some circular logic here. There's some teenager style rationalization going on. I apologize to our four teenage listeners out there. No offense meant. I was a teenager once. Asher Miller Still are in some ways. Rob Dietz I didn't get through the poop jokes. I know. We're still there. But this double down doctrine, you see it among the longtermlists, the Effective Altruist, the TESCREALists. I wish I could just name all those things in a row. It rolls off the tongue. But it's really weird. They're sort of saying if we want to fix the problems that are caused by human's exploitation of the world, then we've got to exploit even more. And that way we can address all the externalities caused by our exploitation.Jason Bradford You got through it. Rob Dietz Right. I mean, that's the earn to give thing, right? It's like, make as much money as you possibly can now and then use that later.Rob Dietz Yeah. Well, and a really good example of it, there's a really good Guardian article where the author is interviewing William MacAskill. And he says that McCaskill is kind of saying, look, rather than cut back on consumption - And I should say, MacAskill, he said, we're over consuming, economic growth can't go on forever. He understands the -Jason Bradford Climate change is a problem. Blah, blah, blah. Rob Dietz Yeah, he understands the exponential math. He's like, yeah, of course if we keep growing the economy at 3% a year, eventually we - Asher Miller You say he understands it, but then he also thinks that we're going to have 80 trillion humans.Asher Miller Just keep digging. Rob Dietz Yeah. So he says all that and then this is wat he says about consumption. He says, "Rather than cut back on consumption, it's much more effective to donate to causes that are dealing with the problems created by consumption." So you know, like a doctor instead of dealing with the cause, just keep putting band-aids on top.Jason Bradford This reminds me of Woody Tasch, the Slow Money founder.Rob Dietz Yeah, those two are exactly the same. Woody Tasch and William MacAskillJason Bradford Well, he got so frustrated because he was working for the Ford Foundation, and they kept investing money in their endowment that was trashing the planet. And then they had to work on granting to fix it.Asher Miller Right. 95% gets invested in shit that makes everything worse And 5% you spend to try to fix the problem.Jason Bradford It's just not fair that 95% is winning all the time. Asher Miller That's the philanthropic model. Apparently it's the Effective Altruist's model too.Jason Bradford So this Oxford philosopher is not impressing me whatsoever. The other thing that keeps driving me crazy is this constant going into AI. They have a lot where like one of the most important jobs you can have is to invest in the safety of AI. The governance of AI. The prevention of AI from killing us all. Like, they're investing in how to protect ourselves from the AI that they need, so that we can create all these technologies, so that we can go post-human?Jason Bradford Well, they're saying, like, I'm really worried. I mean, you've got Musk saying this. All these people saying, basically, I'm really worried about AI. So we need to invest in AI. Rob Dietz Well, that's the that's the teenager part to me. It's like, I want to do this thing. I know it's dangerous. Let me find a reason why I should be able to do this thing. And it's this weird circular logic.Asher Miller I sometimes think that there's like, speaking of teenager hood, there's this desire to pursue whatever fucking instincts and impulse you have. But you also still kind of want a parent. Jason Bradford They want governance.Asher Miller They don't, but they do. Rob Dietz I wish instead of doing crypto adventures and all this crazy stuff, they were just throwing water balloons at people on the street like a regular teenager.Asher Miller That's not going to help us get to space and merge with technology in the singularity, Rob.Asher Miller Yeah, it is interesting to think about that the process of a good intention is being perverted on some level, right?Jason Bradford So I think this is a really interesting story how you start off with these well intentioned philosophies of like, Peter Singer, you know, is famous for animal liberation and being altruistic and giving and thinking about future generations. And it ends up becoming this sort of self serving, really juvenile rationalizations justifying your own work, your own sort of sense of power, and then basically relying on other wackadooley - Wackadoodlery? Like Kurzwelian wackadoodlery? To give you this reason to be doing all this just nutty stuff. And so it becomes also ironic that you have Singer who's this animal rights people and caring for other generations, and it becomes all centered around humans and our potential, and all the trillions of human lives ,and consciousness, and experience. Ah, God.Jason Bradford Yeah. I've been following the work of Sarah Pessin, who's a philosopher.Jason Bradford Another philosopher?Rob Dietz Does she have a Doctor of Philosophy in philosophy?Jason Bradford I think so.Asher Miller I'm sorry, I have to digress for a second. Do you recall watching Monty Python's Meaning of Life? Jason Bradford Oh my gosh. Oh I love that movie.Asher Miller There's a scene where this older couple is at this dinner in heaven, and they don't know what to talk about. And so the waiter gives them a topic to talk about which is philosophers. One of them was talking about like Schopenhauer and the other one, I can't remember, and the wife said, "Do all philosophers have S's in their name?" Like they are not capable of having a philosophical conversation.Rob Dietz It's reminiscent of us.Jason Bradford Well, look up Sarah. You can go to SarahPessin.com. And she has this really interesting section called Meaning Maps and Political Spiral Logics. And she talks about how in our society right now, there's all these good ideas that end up getting kind of corrupted. And she talks about this thing called the slipstream vector. So you imagine people with good intentions, and these philosophies sort of open up opportunities for someone to come in who just creates some extreme version that ends up being completely perverted. And this is happening a lot in our politics, actually. So the slipstream vector, I think. I see this happening in this movement.Rob Dietz Yeah, you just totally open the visual in my mind of pace lines in biking up. So you know like, when you're drafting behind somebody, you use like 30% less energy. Which is why in like the Tour de France, you see these huge mobs of cyclists right on each other's wheels. And yeah, so it's like, you know, there's Singer out in front, and then suddenly MacAskill and Bostrom get right on his wheel.Asher Miller So that is an interesting metaphor. I think we bring it back to William McCaskill, you could say, I don't know. I don't know the guy, but it seems like maybe that's his journey here. Which is like, it starts from a fairly innocent and maybe quite innocent or immature place, but well-intentioned. And then these things get their hooks in it. Do you know what I mean? So It's like, once you take Effective Altruism, and then you you add on this idea of not just like thinking about the long term and future generations, but you add this idea of human exceptionalism and the singularity.Jason Bradford Yes. Asher Miller And you start thinking about and you believe in this technological potential. It becomes this totally perverted thing. And then worse than that, you're talking about like, Singer in front And MacAskill and Bostrom, but then you got the guys like Sam Bankman-Fried and Elon Musk coming in. You're basically using this fucking thing, you know what I mean, to justify what they're doing. Back to that quote of like, it's better to invest in people in wealthy nations right now to do more long term good.Jason Bradford And they're completely willing to maybe push technology to the point where it kills us all off, and their backup plan is a bunker of hunter gatherers and peasants.Rob Dietz On plus side if we're sticking to the Tour de France metaphor here, Sam Bankman-Fried just got run by one of the support cars so we got that at least.Jason Bradford Okay, the insufferability index. Listeners, what is your score? We're gonna go through it here, but it's zero to 10. We've got intentions, personality, ideas, and then you get a bias. Does anyone want to go first?Asher Miller And high score of zero to three in each of those categories. Highest is is matched insufferable. Jason Bradford Yes, most insufferable. So how insufferable?Rob Dietz I'm happy to start. I think intentions for William MacAskill, I think he's getting a zero. I think he has really good intentions. From what I've read he's done some amazing projects trying to spread nets around places where mosquitoes are a problem to prevent malaria. I mean, really good altruistic instincts. Personality, I think he seems okay from what I've read. So he's getting a low score there too, as well. Ideas is where it gets a little bit iffy. For me, I think, again, earlier in our discussion I kept saying, "Well, that sounds okay." So some of the ideas are alright, it's just the way they've been perverted. So I think he's getting about a three for me. Jason Bradford Okay, pretty good.Asher Miller I'm gonna raise it by one. I'm gonna give him a one for personality. I'm not gonna go with zero because, you know, I don't really like people.Rob Dietz Yeah, there's no one.Asher Miller No one gets a zero. Rob Dietz Jason and I are twos in your book. Asher Miller My wife gets zero. If she heard this she'd be like, what are you talking about? Rob Dietz Yeah, I'm a 10, not a zero.Asher Miller The ideas, I'm gonna give him a two because it definitely goes into some wacky shit. But you know, there's some things like, you know, thinking about future generations that I agree with. But I'm gonna use my my scorers bias. I'm gonna add an extra point in there because there's some, he's kind of promoted some designer baby shit, too. You know, there's some stuff in there that's kind of dark. Yeah. I'm gonna go with a four.Jason Bradford Okay, okay. I think its really weird. I'm really disappointed in a so called Oxford philosopher. I'm no philosopher, I wouldn't consider myself a philosopher.Rob Dietz You are a Doctor of Philosophy.Jason Bradford In biology. Rob Dietz Yeah, those don't fit right.Jason Bradford Right. But I feel like he's got some such huge holes in this. Like the circularity of stuff. Like it pisses me off, right?Rob Dietz Well, you need to go to Oxford to understand this stuff.Jason Bradford Okay, anyway, I'm gonna go split the difference and add it up to a 3.5.Asher Miller Pretty low score. Jason Bradford Yeah, he got a pretty low score. Asher Miller Good job, William.Rob Dietz Let's call him up for beers.Jason Bradford He's young. He's got time to catch up. Asher Miller He's got time.George Costanza Every decision I've ever made in my entire life has been wrong. My life is the complete opposite of everything I want it to be. If every instinct you have is wrong, then the opposite would have to be right.Jason Bradford Alright, I really struggled with the do the opposite. Because I think these people so overthink it, And they just come up with stuff that just that no normal human would ever consider. I'm just like, the opposite might just be a normal frickin' human being.Asher Miller Well look, they have to come up with some ideas. They're the professors of philosophy.Jason Bradford They're living in their head and thinking of 80 trillion and like, billions of years in the future. And it just gets absolutely absurd. So just be normal. Just be a normal human being. And, also, okay, this is kind of weird, but you gotta be more present. Live more in the present. Like a goldfish. Okay? Not completely. You know, short-termism might be okay, sometimes.Asher Miller I'm gonna say we should, doing the opposite is maybe splitting the difference, right? Jason Bradford Right, right. Help balance it out. Asher Miller So it's not discounting the future. But It's also not discounting the present which is what longtermism has done. Rob Dietz Yeah, I think that's a really good point. Because if you go back to that episode we did in the hidden driver season about discounting the future, we kind of said, "Hey, stop doing that." And think about projects and things that you could do in this world that have a legacy. But kind of like with some limits on the horizon, right? We're not going to the sci-fi billions of years in the future on the other side of the wormhole.Jason Bradford And make sure that when you're doing those things, they also bring you joy in the here and now. I mean, you have to align those so you're never going to follow through.Asher Miller Yeah, so you know, maybe the whole seventh generation thing. Maybe that's a pretty good. . .Rob Dietz Yeah, in fact, there was an article on resilience.org by Christopher McDonald that was comparing the seven generations idea from the Iroquois Confederacy to this longtermism - Jason Bradford And he was excited about, oh longtermism is like seven generations.Rob Dietz Yeah, and he was like us sort of saying, "Oh, I agree. Oh, wait. Wait a second. What am I reading?" Look, I also think if okay, longtermism is a philosophy, or any of these other TESCREALs you want to pull - Never pull someone's TESCREAL, okay.Jason Bradford It might bite you.Rob Dietz But if you want to talk about philosophy, try to find a philosophy, some philosophical ideas, that can help you be present and help you be a good steward of the places you inhabit. You know, I like going old school with things like stoicism, you know, like letting go the things you can't control. I like Taoism. You know, there's a lot of go with the flow kind of ideas in there. Asher Miller Can I go with the Big Lebowskisms?Rob Dietz Perfect. Exactly. The dude abides. We can all abide. I also, on a more serious note, I think that Robin Wall Kimmerer, I think that we brought up her book, "Braiding Sweetgrass" before, and I know some of our listeners are fans of that book. What she does, it's amazing as she combines ecology, ecological science, with Indigenous philosophy. And it's a really wonderful mix, in a way, to think about the world. And as I think your goldfish example, kind of be present, where you are.Jason Bradford To be part of this world. This world and you are the same. We're one. That kind of stuff, And yeah, no, that's a beautiful book.Asher Miller And you know, honestly, I mean, we didn't get into this too much, but the human centeredness of longtermism and Effective Altruism and all the stuff - Doing the opposite of that is actually recognizing the more than human. And if we're not discounting the future lives of seven generations, let's say, of humans in front of us, what about all the other species that we share this planet with? And we've talked about this before, too, but another do the opposite is the precautionary principle rather than the double down doctrine that were these guys are pushing and were pushing on so many fronts right now. Everything seems to be fucking double down.Jason Bradford I know. I remember when I was reading West Jackson and Bob Jensen's book, they were explaining a conversation they had with each other over the phone. And Wes was like, "Bob, why isn't all this just enough? Just what we have. Why can't it just be enough?" And you wrote a book called, "Enough is Enough."Rob Dietz Yeah. My book was called, "Enough is Enough." Their book is called, "An Inconvenient Apocalypse." I bet they're selling a lot better than I am.Jason Bradford But I think that's true. I mean, can you just have a normal decent life and just consider the beauty of the world enough for you? I hope so.Rob Dietz I don't think so. I think that's a stupid idea. We instead have started a new organization.Jason Bradford Oh, we have?Rob Dietz Yeah, it's gonna counteract the Centre for Effective Altruism.Jason BradfordHow are you gonna spell it?Rob Dietz I don't know. I think we gotta go "-er" since we're here in America. We're not gonna go "-re"Asher Miller Yeah, we're American. You gotta spell it the right way, man. Rob Dietz And yeah, this center is going to be the opposite of the Centre for Effective Altruism, right? It's gonna be called the Center for Incompetent Hoarding. So, you know, listeners find it online, donate as much money as you can. It doesn't matter what you do to get that money.Asher Miller Just don't do crypto. We can't take crypto.Asher Miller Well, thanks for listening. If you made it this far, then maybe you actually liked the show.Rob Dietz Yeah, and maybe you even consider yourself a real inhabitant of Crazy Town. someone like us who we affectionately call a Crazy Townie.Jason Bradford If that's the case, then there's one very simple thing you can do to help us out. Share the podcast, or even just this episode.Asher Miller Yeah, text three people you know who you think will get a kick out of hearing from us bozos.Rob Dietz Or if you want to go away old school, then tell them about the podcast face to face.Jason Bradford Please for the love of God. If enough people listen to this podcast, maybe one day we can all escape from Crazy Town. We're just asking for three people, a little bit of sharing, we can do this.Jason Bradford If you are the effectively altruistic parent of a young human, one of your greatest potential impacts is making sure your offspring make as much money as possible. At temps for future trillions, we will place your child with one of our special clients, all of whom are in constant need of discreet services and are willing to pay unbelievable sums. With just one or two summer jobs with our agency placed with either a drug lord, human trafficker, or weapons dealer. Your kid will have a substantial endowment available for whatever lucrative business they can think of after they drop out of college. They can then leverage their wealth in the service of securing the wondrous eternal life of infinitely happy post-human sentient beings. Temps for Future Trillions, effectively justifying sociopathy today for a universe of transhuman colonization tomorrow.
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Why Warhammer 40K fans keep arguing about the Emperors terrible sons – Polygon
Posted: at 1:13 am
Primarchs, Space Marines, and a boatload of daddy issues
Warhammer 40,000 stands apart largely because of its vast scale. Billions of people are stacked in hive cities, trillions of people sign up for the Imperial Guard (and die horribly in the process), and quadrillions of humans are spread across the galaxy. Thats without mentioning the various alien races, known as xenos terrifying space bugs, ferocious orks, awe-inspiring space elves, and immortal robot skeletons.
But thats not what fan conversation tends to center on. If you check out Warhammer 40K fan spaces and content channels, youll find that much of the conversation surrounds twenty terrible boys and all the bad decisions they make. Whats up with that?
The God-Emperor of Mankind is the guy who set up the Imperium of Man, powers the lighthouse that all Imperium ships use to travel, and stops an endless horde of demons from breaking into Terra and exploding the planet. The God-Emperor sustained an ouchie 10,000 years ago that means hes confined to the chair, a carrion lord who consumes a thousand souls a day. And its all because of his terrible sons the Primarchs and their nonsense.
Image: Games Workshop
The Primarchs and their exploits started as vague myths and legends, half-remembered from a lost age. These characters existed far back in history, and had no realistic bearing on contemporary gameplay and their stories werent explicitly told. That was before Black Library, the prolific book publishing arm of Games Workshop, started putting out books about these boys. There are now dozens of books in the Horus Heresy series, detailing each Primarchs exploits.
The various authors of the Black Library pull this off by writing the Horus Heresy series like a particularly nasty WWE-style feud, or a soap opera with constant gunfights and walking tanks. Many of the Primarchs seem either ridiculous, or they just blend together into a smear of big men and space battles. Each Primarch also has their own supporting cast from their legion of Space Marines, transhuman biosoldiers built from the gene-seed of their Primarchs. Space Marines are the poster boys of the setting, and one of the most iconic parts of 40K, and each legion has their own role and function.
If youre not deep on the lore of Space Marines and Primarchs, though, this nuance can easily be lost on the reader. The Imperial Fists, Iron Hands, and Iron Warriors, for instance, each have their own niche but if youre interested in reading about the Aeldari or Necron, they all just look like Space Marine palette swaps. (Although if you are interested in the nitty-gritty, there are good resources to help break that down.)
Two of the God-Emperors sons got deleted from the record we dont know what happened to them, and well never learn, thanks to a series of memory wipes and document burning leaving eighteen boys behind to start the Great Crusade, the Emperors attempt to reunite humanity and take over the whole galaxy. Each boy has a legion of Space Marine sons, which causes a recursive spiral of bad dad/son relationships. The Emperor went into the basement to work on his projects for a couple of decades, only showing up once in a while (and making things worse in the process).
But the Primarchs can also feel over-represented in the setting. The problem is that there becomes a vicious cycle where people love Primarchs, so more Primarch books are written, which helps build a fanbase for Primarchs. If youre pursuing stories about other factions and youre not a Space Marine fan, it can be frustrating to feel like every other vast corner of the universe is drowned out by the nonsense of these big sons.
Personally, I used to fall into this camp. Im still not that into Space Marines as theyre depicted in 40K. But I have found myself being charmed, first by the memes and tidbits of knowledge I picked up about these guys did you know Fulgrim, Primarch of the Emperors Children, is a giant snake demon who had his soul stuck in a painting for a while? Or that big Bobby G of the Ultramarines once fought in space with no helmet for twelve hours, fueled by rage at brotherly betrayal? and then by delving into the actual stories depicted in print.
Image: Games Workshop
In the modern day of 40K, only two loyalist Primarchs have returned Lion ElJonson and Roboute Guilliman. Guillimans return in 2017 was a massive deal that flipped the entire setting upside down, but as time went on, he became less of a protagonist and more of a garnish on top of the nightmare pasta that is the Imperium of Man. The traitorous Primarchs make fantastic bosses and have cool tabletop models, but theyve already lost. They lost 10,000 years ago, and it means that characters like Angron are more like environmental effects than actual characters.
These characters are at risk of overwhelming the setting due to their sheer popularity, but they work best as background figures who just make things worse (or at the very least, more complicated) for everyone around them. Theyre also a reminder not to take the setting too seriously. When characters like Corvus Corax of the Raven Guard are running around, its a charming relic from the older days of 40K where everything wasnt so carefully and meticulously sanded-down to be cool. I love my garbage boys just the way they are, heresy and all.
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Gene therapy: Donor DNA may protect babies from certain disorders – Medical News Today
Posted: at 1:10 am
A novel new technique combining DNA from three different people has reportedly been used as a way to prevent the generational transmission of certain rare genetic diseases.
The process, called mitochondrial donation, uses genetic material from a mother and father and a third donor, in an attempt to drastically reduce or eliminate the exchange of mitochondrial diseases such as muscular dystrophy, hearing and vision disorders, epilepsy, heart conditions, learning disabilities, and even potentially neurodegenerative diseases.
Mitochondria are often called the powerhouses of the cell, and in the cases of mitochondrial diseases, they stop being able to power certain functions as well as they would if they were healthy. That includes the most energy-intensive cells, such as nerves and heart muscle cells.
These babies have genomes derived from their biological father and mother just like any other babies but only had their mitochondria replaced with the ones coming from the donor, said Dr. Steven Kim, a researcher in aging and cancer at the Coriell Institute of Medical Research in New Jersey and a medical content advisor at Breakout.
The practitioners did so by transferring the nucleus of the original egg (mother) to a new, unfertilized egg (donor), he explained to Medical News Today. This will theoretically eliminate the mitochondrial disorders but not without limitations since some residual mitochondria can still be present in the egg and later develop problems.
The process has been approved for use in the United Kingdom under the auspices of the countrys Human Fertilization and Embryology Authority (HFEA), which regulates fertility clinics and their operations.
Hopeful parents are eligible for this procedure only if they are at a very high risk of passing a serious mitochondrial disease onto their children, according to the authoritys website.
Mitochondrial diseases can be quite severe, Dr. Shvetha Murthy Zarek, a reproductive endocrinologist and the Medical and Practice IVF Director at Oma Fertility in St. Louis, told Medical News Today. Curative therapies for mitochondrial diseases have proven to be challenging and this technique is promising.
So far, fewer than five babies have been born using this procedure, although 32 have been approved to do so, the HFEA says.
Mitochondrial donation treatment offers families with severe inherited mitochondrial illness the possibility of a healthy child. The HFEA oversees a robust framework which ensures that mitochondrial donation is provided in a safe and ethical manner, they wrote in a statement. These are still early days for mitochondrial donation treatment and the HFEA continues to review clinical and scientific developments.
While the program is an experimental procedure, its success has raised concerns about using genetic techniques to alter babies before birth in ways outside of the scope of rare genetic diseases.
Before its widespread adoption, there will inevitably be some form of ethical scrutiny and debate in the scientific and healthcare communities, and the regulatory authorities will intervene and provide guidance in the near future, Kim said.
But in the case of this particular method, experts say the potential for it to be exploited for other means is low.
This may be seen as a form of genetic engineering, but this form of Artificial Reproductive Technology (ART) does not lead to intentional modifications in a childs physical features, Dr. Karenne Fru, a fertility specialist at Oma Fertility in Atlanta, told Medical News Today. There is limited utility for this form of ART in individuals without mitochondrial disease. As we gather more data on feasibility and long-term effects, it is possible that more couples choose to proceed with this route.
Fru said there was the potential for all genetic mitochondrial disorders to be cured in this fashion since all of a babys mitochondria are passed down through the mother.
Beyond that, she said the ethics were similar to those involved with any in vitro fertilizations involving donors.
There needs to be clear counseling and communication [to kids] about their origins in a supportive manner to avoid any crisis of identity later on, Fru said. Simply put, it took both parents and a generous, healthy donor for them to exist.
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Viewpoint: Grim consequences of Greenpeace’s war on … – Genetic Literacy Project
Posted: at 1:10 am
A genetically modified rice variety could save the lives of thousands of children. But nowGreenpeacehas prevented the sowing because of alleged health risks. Typical: The eco-activists care neither about science nor about the common good. Your agenda is completely different.
This rice could save the lives of millions of children every year, said the American news magazine Time jubilantly 23 years ago about the successful production of golden rice. Using genetic engineering, biochemists had succeeded in developing the rice variety with increased amounts of a vitamin A precursor. Hundreds of thousands of children go blind every year from vitamin A deficiency, about half of them die. Golden rice could prevent misery.
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But the project is faltering becauseGreenpeaceand other so-called environmental organizations are torpedoing the Golden Rice with lawsuits in court over alleged risks of the genetically modified seeds despite criticism from experts. A study in the journal Environment and Development Economics nine years ago came to the conclusion that delaying the use of golden rice could have cost one and a half million years of life unnecessarily even then.
[Editors note: This article was originally published in German and has been translated and edited for clarity.]
This is an excerpt. Read the original post here
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Predicting Diabetic Kidney Disease with the Use of a Novel Algorithm – Genetic Engineering & Biotechnology News
Posted: at 1:10 am
Scientists from Sanford Burnham Prebys and the Chinese University of Hong Kong say they have developed a computational approach to predict whether a person with type 2 diabetes will develop kidney disease. Their results, DNA methylation markers for kidney function and progression of diabetic kidney disease, published in Nature Communications, could help doctors prevent or better manage kidney disease in people with type 2 diabetes.
This study provides a glimpse into the powerful future of predictive diagnostics, notes co-senior author Kevin Yip, PhD, a professor and director of bioinformatics at Sanford Burnham Prebys. Our team has demonstrated that by combining clinical data with cutting-edge technology, its possible to develop computational models to help clinicians optimize the treatment of type 2 diabetes to prevent kidney disease.
Diabetes is the leading cause of kidney failure worldwide. In the U.S., 44% of cases of end-stage kidney disease and dialysis are due to diabetes. In Asia, this number is 50%.
There has been significant progress developing treatments for kidney disease in people with diabetes, adds co-senior author Ronald Ma, a professor in the department of medicine and therapeutics at the Chinese University of Hong Kong. However, it can be difficult to assess an individual patients risk for developing kidney disease based on clinical factors alone, so determining who is at greatest risk of developing diabetic kidney disease is an important clinical need.
Epigenetic markers are potential biomarkers for diabetes and related complications. Using a prospective cohort from the Hong Kong Diabetes Register, we perform two independent epigenome-wide association studies to identify methylation markers associated with baseline estimated glomerular filtration rate (eGFR) and subsequent decline in kidney function (eGFR slope), respectively, in 1,271 type 2 diabetes subjects, write the investigators.
Here we show 40 (30 previously unidentified) and eight (all previously unidentified) CpG sites individually reach epigenome-wide significance for baseline eGFR and eGFR slope, respectively. We also developed a multisite analysis method, which selects 64 and 37 CpG sites for baseline eGFR and eGFR slope, respectively. These models are validated in an independent cohort of Native Americans with type 2 diabetes. Our identified CpG sites are near genes enriched for functional roles in kidney diseases, and some show association with renal damage.
This study highlights the potential of methylation markers in risk stratification of kidney disease among type 2 diabetes individuals.
The new algorithm depends on DNA methylation, which occurs when subtle changes accumulate in our DNA. DNA methylation can encode important information about which genes are being turned on and off, and it can be easily measured through blood tests.
Our computational model can use methylation markers from a blood sample to predict both current kidney function and how the kidneys will function years in the future, which means it could be easily implemented alongside current methods for evaluating a patients risk for kidney disease, says Yip.
The researchers developed their model using detailed data from more than 1,200 patients with type 2 diabetes in the Hong Kong Diabetes Register. They also tested their model on a separate group of 326 Native Americans with type 2 diabetes, which helped ensure that their approach could predict kidney disease in different populations.
This study highlights the unique strength of the Hong Kong Diabetes Register and its huge potential to fuel further discoveries to improve our understanding of diabetes and its complications, points out says study co-author Julianna Chan, MD, a professor in the department of medicine and therapeutics at the Chinese University of Hong Kong, who established the Hong Kong Diabetes Register more than two decades ago.
The Hong Kong Diabetes Register is a scientific treasure, adds first author Kelly Yichen Li, PhD, a postdoctoral scientist at Sanford Burnham Prebys. They follow up with patients for many years, which gives us a full picture of how human health can change over decades in people with diabetes.
The researchers are currently working to further refine their model. They are also expanding the application of their approach to look at other questions about human health and diseasesuch as determining why some people with cancer dont respond well to certain treatments.
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Predicting Diabetic Kidney Disease with the Use of a Novel Algorithm - Genetic Engineering & Biotechnology News
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Quantum biology on horizon? How futuristic physics theory could … – Study Finds
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Imagine using your cellphone to control the activity of your own cells to treat injuries and disease. It sounds like something from the imagination of an overly optimistic science fiction writer. But this may one day be a possibility through the emerging field of quantum biology.
Over the past few decades, scientists have made incredible progress in understanding and manipulating biological systems at increasingly small scales, from protein folding to genetic engineering. And yet, the extent to which quantum effects influence living systems remains barely understood.
Quantum effects are phenomena that occur between atoms and molecules that cant be explained by classical physics. It has been known for more than a century that the rules of classical mechanics, like Newtons laws of motion, break down at atomic scales. Instead, tiny objects behave according to a different set of laws known as quantum mechanics.
For humans, who can only perceive the macroscopic world, or whats visible to the naked eye, quantum mechanics can seem counterintuitive and somewhat magical. Things you might not expect happen in the quantum world, like electrons tunneling through tiny energy barriers and appearing on the other side unscathed, or being in two different places at the same time in a phenomenon called superposition.
I am trained as a quantum engineer. Research in quantum mechanics is usually geared toward technology. However, and somewhat surprisingly, there is increasing evidence that nature an engineer with billions of years of practice has learned how to use quantum mechanics to function optimally. If this is indeed true, it means that our understanding of biology is radically incomplete. It also means that we could possibly control physiological processes by using the quantum properties of biological matter.
Researchers can manipulate quantum phenomena to build better technology. In fact, you already live in a quantum-powered world: from laser pointers to GPS, magnetic resonance imaging and the transistors in your computer all these technologies rely on quantum effects.
In general, quantum effects only manifest at very small length and mass scales, or when temperatures approach absolute zero. This is because quantum objects like atoms and molecules lose their quantumness when they uncontrollably interact with each other and their environment. In other words, a macroscopic collection of quantum objects is better described by the laws of classical mechanics. Everything that starts quantum dies classical. For example, an electron can be manipulated to be in two places at the same time, but it will end up in only one place after a short while exactly what would be expected classically.
In a complicated, noisy biological system, it is thus expected that most quantum effects will rapidly disappear, washed out in what the physicist Erwin Schrdinger called the warm, wet environment of the cell. To most physicists, the fact that the living world operates at elevated temperatures and in complex environments implies that biology can be adequately and fully described by classical physics: no funky barrier crossing, no being in multiple locations simultaneously.
Chemists, however, have for a long time begged to differ. Research on basic chemical reactions at room temperature unambiguously shows that processes occurring within biomolecules like proteins and genetic material are the result of quantum effects. Importantly, such nanoscopic, short-lived quantum effects are consistent with driving some macroscopic physiological processes that biologists have measured in living cells and organisms. Research suggests that quantum effects influence biological functions, including regulating enzyme activity, sensing magnetic fields, cell metabolism and electron transport in biomolecules.
The tantalizing possibility that subtle quantum effects can tweak biological processes presents both an exciting frontier and a challenge to scientists. Studying quantum mechanical effects in biology requires tools that can measure the short time scales, small length scales and subtle differences in quantum states that give rise to physiological changes all integrated within a traditional wet lab environment.
In my work, I build instruments to study and control the quantum properties of small things like electrons. In the same way that electrons have mass and charge, they also have a quantum property called spin. Spin defines how the electrons interact with a magnetic field, in the same way that charge defines how electrons interact with an electric field. The quantum experiments I have been building since graduate school, and now in my own lab, aim to apply tailored magnetic fields to change the spins of particular electrons.
Research has demonstrated that many physiological processes are influenced by weak magnetic fields. These processes include stem cell development and maturation, cell proliferation rates, genetic material repair and countless others. These physiological responses to magnetic fields are consistent with chemical reactions that depend on the spin of particular electrons within molecules. Applying a weak magnetic field to change electron spins can thus effectively control a chemical reactions final products, with important physiological consequences.
Currently, a lack of understanding of how such processes work at the nanoscale level prevents researchers from determining exactly what strength and frequency of magnetic fields cause specific chemical reactions in cells. Current cellphone, wearable and miniaturization technologies are already sufficient to produce tailored, weak magnetic fields that change physiology, both for good and for bad. The missing piece of the puzzle is, hence, a deterministic codebook of how to map quantum causes to physiological outcomes.
In the future, fine-tuning natures quantum properties could enable researchers to develop therapeutic devices that are noninvasive, remotely controlled and accessible with a mobile phone. Electromagnetic treatments could potentially be used to prevent and treat disease, such as brain tumors, as well as in biomanufacturing, such as increasing lab-grown meat production.
Quantum biology is one of the most interdisciplinary fields to ever emerge. How do you build community and train scientists to work in this area?
Since the pandemic, my lab at the University of California, Los Angeles and the University of Surreys Quantum Biology Doctoral Training Centre have organized Big Quantum Biology meetings to provide an informal weekly forum for researchers to meet and share their expertise in fields like mainstream quantum physics, biophysics, medicine, chemistry and biology.
Research with potentially transformative implications for biology, medicine and the physical sciences will require working within an equally transformative model of collaboration. Working in one unified lab would allow scientists from disciplines that take very different approaches to research to conduct experiments that meet the breadth of quantum biology from the quantum to the molecular, the cellular and the organismal.
The existence of quantum biology as a discipline implies that traditional understanding of life processes is incomplete. Further research will lead to new insights into the age-old question of what life is, how it can be controlled and how to learn with nature to build better quantum technologies.
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Quantum biology on horizon? How futuristic physics theory could ... - Study Finds
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