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Category Archives: Transhuman News

Scientists Discover 125 Million Year Old Dinosaur DNA, Are We Getting a Real Jurassic Park? – MovieWeb

Posted: November 9, 2021 at 2:21 pm

"Your scientists were so preoccupied with whether or not they could, they didn't stop to think if they should." The words of Ian Malcolm in Jurassic Park as he tries to explain his worries about a theme park inhabited with dozens of prehistoric creatures that would happily feast on the tourists. Now apparently, his words should be resonating with a team of scientists in the Chinese Academy of Scientists, who have published a paper claiming to have found fully intact dinosaur DNA in a fossil aged around 125 million years old. Hold on to your butts.

The paper, which can be viewed online, claims that the DNA was discovered on the cartilage of a Caudipteryx fossil, a dinosaur that lived in the Cretaceous era and was around the size of a peacock. The findings say that the cartilage was extracted from the femur and treated with a chemical solution that is intended to illuminate different structures of cells within the subject. The results of this have brought out a number of elements that indicate the presence of intact DNA strands.

While this will get some people excited at the prospect of Jurassic Park becoming a reality - because everyone wants the chance to be chased by a Tyrannosaur - other scientists are not quite as eager to believe the findings just yet. According to Chemistry World, a number of counter suggests say that the technique used in these tests is not a conclusive process and are too imprecise to make any kind of world-breaking announcement about the findings.

However, Alida Bailleul, corresponding author of the study, said in a press release, "We are obviously interested in fossilized cell nuclei, because this is where most of the DNA should be if DNA was preserved. So, we have good preliminary data, very exciting data, but we are just starting to understand cellular biochemistry in very old fossils. At this point, we need to work more."

What should be noted, is that the discovery of partial dinosaur DNA is not a new thing and organic material has been found in 75 million-year-old fossils previously but The Imperial College London, and by the same research scientists at the Chinese Academy of Scientists. Whether the DNA is partial or complete, even Bailleul acknowledged that the current discovery is a starting point for their research, but it is very unlikely that we would even make it to a position of being able to clone dinosaurs from this in the way John Hammond's team did in Jurassic Park, and on the whole, having now seen where that is heading in Jurassic World: Dominion, it is probably for the best.

The final movie in the Jurassic World trilogy finds dinosaurs once again walking the world freely, seemingly being given the same "they have rights" badge as every other living creature on Earth, but not really willing to stop and think before they chomp down on anyone that moves. The film unveiled its opening sequence in IMAX cinemas earlier this year, but we are still awaiting a full trailer for the movie, which fans are hoping will give a first look at original cast members Sam Neill, Laura Dern and Jeff Goldblum back in the thick of the action, trying to save the world from being taken back to the prehistoric age for good.

Jurassic World: Dominion is set to be released in movie theaters on June 10th, 2022. You can find out more about the dinosaur DNA at Nature.com.

Topics: Jurassic Park, Jurassic World

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New DNA testing could clear men convicted of murdering a Tonawanda mother in 1993 – WIVB.com – News 4

Posted: at 2:21 pm

BUFFALO, N.Y. (WIVB) Two men are hoping that new DNA testing will be enough to vacate their convictions for the 1993 murder of Deborah Meindl in her City of Tonawanda home.

It was February of 1993 when a young mother was stabbed and strangled in her home in the City of Tonawanda. Two men were sentenced to murder. Brian Scott Lorenz is still in prison for it, and James Pugh, who was paroled in 2019, maintained his innocence from the start.

I know nothing of this crime. I know nothing about the husband I dont know this family and Im not a murderer, said Pugh at his sentencing in may of 1994.

On Wednesday, Pugh was in State Supreme Court where his attorneys are asking a judge to vacate the murder conviction based on improved DNA testing which excludes any traces of Pugh or Lorenz at the murder scene.

The one and only thing the jury heard about DNA is that blood under Mrs. Meindls fingernails was her own blood, said Ilaan Mazzel, the attorney representing Lorenz. So there was no meaningful DNA produced at all at trial.

MORE | David Sweat moved to fourth different prison since 2015 escape

The attorneys are taking it even further by claiming they have evidence that the real killer is Richard Matt, who was convicted of murdering his boss, escaped from prison in Dannemora in 2015 and was shot to death while on the run.

Maazel said Mattlived a few blocks away from the victim and was also a very close frond of a lead investigator in the case. Its shocking that the lead investigator in the case was investigating a case where his very good friend Richard Matt was a suspect.

But in court Wednesday, prosecutor Colleen Curtin Gabel said the new DNA evidence also excludes Richard Matt from being at the murder scene. Its now up to Judge Christopher Burns to decide whether or not to vacate the convictions based on the updated DNA testing.

MORE | Dead prison escapee Richard Matt had WNY ties

Scotts been in prison for 28 years and three months, for 10,319 days we think every single day he remains in prison for this crime he didnt commit is a terrible injustice.

District Attorney John Flynn would not discuss many elements of the case, but released a statement Wednesday morning dismissing assertions by Maazel that the District Attorney was attempting to block the new evidence.

Read the rest of Flynns statement below:

Any assertion that the two prosecutors initially assigned to investigate this matter were removed from the case or reassigned because I did not agree with their findings is not true. I, along with my entire senior leadership team, several of my senior bureau chiefs and most experienced trial attorneys, disagreed with their conclusions due to a lack of any credible evidence. Both attorneys did not accept my decision with the professionalism expected of career prosecutors. Ultimately, I made the decision to remove both prosecutors from the case.

While I cannot comment further on personnel matters, I can confirm that both prosecutors were later reassigned after I made the decision to remove them from the case. One prosecutor was relieved of his Bureau Chief position. He continues to work as an Assistant District Attorney in the Appeals Bureau. The other prosecutor was not demoted, but reassigned from the Appeals Bureau to the offices Felony Trials Bureau.

It is incumbent on defense counsel to submit new, credible evidence that establishes that these defendants did not commit this murder in order to vacate their conviction or re-open the criminal case. Without any new, credible evidence, I will continue to oppose this motion.

I anticipate that all issues raised in this matter will be litigated in the course of the proceedings that will include submissions by both parties and in arguments before the Court. Our office cannot comment further on this matter as the 440 motion is pending.

Matt is known for his 2015 escape from Clinton Correctional Facility in Dannemora, alongside David Sweat.

Weeks after his escape, Matt was shot dead by law enforcement officers. But Sweat was later captured and taken back into custody.

Before their escape, Sweat and Matt were behind bars for murder, and the case of Matt was connected to western New York.

Matt was an Erie County native. More than two decades ago, he was convicted of killing and dismembering North Tonawanda businessman William Rickerson.

Eventually, he ended up spending time in a Mexican prison in relation to a separate homicide.

Evan Anstey is an Associated Press Award and Emmy-nominated digital producer who has been part of theNews 4team since 2015.See more of his work hereandfollow him on Twitter.

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New Publication in CELL Implicates a Rare Form of DNA Driving Antimicrobial Resistance in Bacterial Biofilms – Business Wire

Posted: at 2:21 pm

COLUMBUS, Ohio--(BUSINESS WIRE)--Clarametyx Biosciences Inc., (Clarametyx) a preclinical stage biotechnology company developing targeted, immune-enabling biologic therapies to counter serious infections associated with biofilms, today announced the publication of a new study in the prestigious journal CELL providing critical new insights about the components within bacterial biofilms that drive resistance to current medicines.

Bacterial biofilms are communities of bacteria embedded within a protective matrix that are associated with nearly 80 percent of bacterial infections. Because biofilms contribute to persistent infections, inflammation, and resistance to therapeutic interventions, there is a pressing need for novel strategies to combat this bacterial defense mechanism. Prior research has demonstrated that an extracellular DNA (eDNA) network stabilized by DNABII proteins are required for the structural integrity of biofilms across many bacterial pathogens. While enzymes that digest DNA can prevent biofilm formation, these enzymes are ineffective against biofilms that have fully formed.

This research initiative aimed to understand the development and maturation of the biofilm to elucidate its resistance to the innate immune system. A series of studies indicated that the biofilm structure is not built on the typical B-form of DNA, but instead relies on the rare Z-form of eDNA, which accumulates as biofilms mature and provides structural integrity to the biofilms matrix. Importantly, the assessments found Z-DNA to be the primary structural form of eDNA within mature biofilms across a range of bacterial pathogens, including Escherichia coli, Klebsiella pneumoniae, and nontypeable Haemophilus influenzae, each of which contribute significant patient burden today. These findings suggest that the development of therapeutic agents designed to drive biofilm eDNA back into its native B-form could enhance the prevention or clinical resolution of biofilm-mediated diseases.

This seminal publication answers a critical piece of the biofilm puzzle by articulating the central role of Z-DNA in the pathogenesis of the biofilm and its resistance to immune intervention, said Steven Goodman, Ph.D., study author, Director of the Oral GI Microbiology Research Affinity Group in the Center for Microbial Pathogenesis at the Abigail Wexner Research Institute (AWRI) at Nationwide Childrens Hospital and co-chair of the Clarametyx scientific advisory board. This improved understanding of the key contributors to biofilm development and defense will transform research efforts to overcome the mature biofilm and prevent its development.

The publication of our research in the globally renowned CELL journal validates the significance of this finding to the research community trying to solve the challenge of persistent bacterial infections and antimicrobial resistance, said Lauren Bakaletz, Ph.D., study author, Director of the Center for Microbial Pathogenesis and Vice President of Basic Sciences for AWRI and co-chair of the Clarametyx scientific advisory board. That the Z-form is the primarily form of eDNA found in mature biofilms provides a vital insight into how we approach the biofilm. If we know what to target, we can efficiently dismantle the eDNA structure, rendering the bacteria much more vulnerable to immune or antibiotic intervention and resolving infections more efficiently to improve patient outcomes while also reducing the risk of antibiotic resistance.

A more sophisticated understanding of the role of the molecular components that strengthen the biofilm and protect the bacteria is critical in our design of novel therapeutics and vaccines that could benefit many people who contract a wide range of severe bacterial infections, said Charles McOsker, Ph.D., co-founder and Chief Scientific Officer of Clarametyx. This invaluable research not only reinforces the central scientific strategy we are pursuing at Clarametyx but also informs the ongoing development of our CMTX-101 novel anti-biofilm antibody therapy that could transform the treatment of bacterial infections by disrupting both newly-formed and mature biofilms.

About Clarametyx Biosciences

Clarametyx Biosciences is combating the formidable challenge of persistent and recalcitrant infections through an innovative technology platform targeting the biofilmbacteria embedded in a protective matrixto enable a more effective immune response or antibiotic intervention. The Columbus, Ohio-based company is building a dynamic pipeline of immune-enabling therapies and vaccines for life-threatening bacterial infections associated with biofilms. Its lead candidate, CMTX-101, is a humanized monoclonal antibody in preclinical development for hospital-acquired pneumonia. For more information, visit us on the web or on LinkedIn.

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Katie Britt talks China, illegal immigration in Scottsboro campaign stop – ‘We have to have leaders that will hold them accountable’ – Yellowhammer…

Posted: at 2:08 pm

SCOTTSBORO U.S. Senate candidate Katie Britt on Monday took her campaign to rural Jackson County where she outlined her key priorities in addressing national security issues.

In her return to the states Mountain Lakes region, Britt spoke to a number of issues facing the country which she has made an integral part of her candidacy. Among these were cancel culture, education, election integrity, broadband expansion, agriculture, economic growth and others.

In matters of importance relating to national security, Britt honed in on the threat posed to the United States by way of illegal immigration and the communist regime of China.

The first-time candidate outlined statistics regarding the growing number of border encounters the nation was experiencing under the Biden administration. Britt then advocated for the return to Trump-era border security policies to curb the rising tide of illegal aliens overwhelming border enforcement personnel.

[W]e must seal and secure our border we have to, declared Britt. We have to put back Remain in Mexico and public charge. Folks, and its not just about national security, which I hope you know is of paramount importance, because they are catching about 41 criminals 3,677 pounds of drugs [per day]. It is also about ending the humanitarian crisis that is happening there every single day.

She added, As they traffic more men, women and children they found just under 15,000 children unaccompanied at the border last month Folks, we have to seal and secure our border. China is sending enough fentanyl to Mexico thats coming across our border that they said could kill every single American four times over. So no matter which way you look at it, we gotta build the wall, build it tall, and secure the border.

Britt went on to sound the alarm over the intensified aggression China had displayed against the United States, saying the communist nation was undermining us at every single turn.

From the origins of the virus, to stealing our intellectual property, to undermining the American worker We saw it first hand with regards to the intellectual property. So they steal about $600 billion of intellectual property a year, which is about two and a half times our annual GDP here in the state of Alabama, she advised.

Britt touched on Chinas recent launch of a hypersonic nuclear-capable rocket in low-space orbit which circled the globe until nearly reaching its intended target.

And the sad thing is, we dont even know about all of it. When we saw that hypersonic weapon that they tested, it came 12 miles from hitting its target. The worst thing about that was that was our technology that we didnt know they have. We have to have leaders that will hold them accountable, realize theyre ten steps ahead, not only catch up but leave them in the dust, she proclaimed.

Dylan Smith is a staff writer for Yellowhammer News. You can follow him on Twitter @DylanSmithAL

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North Yorkshire author educating children about the impact plastic is having on the planet – Free Radio

Posted: at 2:08 pm

Children's book Save Us tells the story of a sea turtle trapped in plastic who needs help from humans to be set free

A North Yorkshire author's inspiring the next generation to become more environmentally friendly through her new book.

Save Us is a tale about a seal, whale and sea turtle that addresses the problem of plastic causing problems in our oceans, but things take a turn when the turtle becomes trapped in plastic who needs help from humans to be set free.

It's hoped the book will help young people to understand what can happen if plastics aren't recycled properly and the damage it can cause to the planet.

Author Christina Gabbitas, said:

"Sienna Seal and Wahilda Whale rescue Thierry Sea Turtle out of a plastic bag that's floating in the ocean but they realise that his feet are also bound in plastic and they can't set him free so they need human intervention. So it's educating the children that the oceans need our help, they need human intervention to stop this crisis.

"I thought if we can educate children from a young age to look after our planet and environment then we've got a better fighting chance. The children are always really engaged with it and really switched on to what is happening in their world.

"It's just getting that message across, because you can never underestimate the power of storytelling. It's evident they really care about the environment and in some cases more than the adult generation.

"Whilst Thierry is rescued out of this dreadful plastic, I make it clear that it isn't always like that. So the story has a happy ending but there are messages in there that we need to do all we can to help."

Christina goes into schools across the county educating children through her books and gets them to create a wrap poem as a way to make sure they understand the subject matter.

The inspiration for writing this story came from when Christina watched BBC Blue Planet 2 with David Attenborough and she was shocked at how dangerous it had become.

It's predicted plastic pollution is set to treble in a decade unless action is taken to deal with the problem.

Hear all the latest news from across the UK on the hour, every hour, on Greatest Hits Radio on DAB, at greatesthitsradio.co.uk, and on the Greatest Hits Radio app.

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Jackson, Merrill Score Maine Amateur Wins – Standardbred Canada

Posted: at 2:08 pm

Published: November 7, 2021 3:56 pm ET

Up-and-coming horseman Dakota Jackson made a bold, three-wide move down the backside with his own Rockaholic to win the $4,500 Maine Amateur Driving Club (MADC) race on Saturday (Nov. 6) at Cumberland.

Tipping to the outside past the three-eighths marker, Jackson was dead last going to the half and pushed three-deep through that good Southern Maine air to look the leaders in the eye around the final turn. As the pacers turned for home, Jackson urged the 11-year-old son of Rocknroll Hanover to the front and emerged victorious with a length and a quarter advantage in 1:59.2.

Rockaholic is owned, trained and driven by Dakota Jackson, giving the 23-year-old reinsman his fourth career driving victory, and his first at Cumberland.

Eager to continue at the First Tracks facility, Jackson stated, I claimed [Rockaholic] during Windsor Fair week and plan on having a horse to drive in the amateur races every week.

Colorful Speech (post seven, Zach Vickerson) also rallied from behind to finish second. Three-year-old colt A Sweet Bidda Luck (post two, Scott McKenzie) set the tempo and hung on for third.

Rockaholic (post four) paid $12.80 to win, and coupled with Colorful Speech, the exacta paid $104.40.

In the second MADC split, group B, series heavyweight Benson Merrill steered Zampara to a perfect wire-to-wire score from post four, picking up his seventh victory of the season. The seven-year-old son of American Ideal was the wagering favourite and let no horse pass him, winning by a neck in 1:58.2 for owners Mo Coo Inc and Jonathan Klee Racing.

Dancin Hill (Alex Richardson) finished second and Baywood Shadow (Derek Howes) was third.

Also trained by Merrill, Zampara paid $2.60 to win.

As always, the Maine Amateur Driving Club is proudly sponsored by the good folks at Blue Seal Feeds of the Windham and North Yarmouth locations. Swag bucket trophies of stable supplies were presented by Aimee Nichols, the amiable territory manager for Blue Seal and Kent Feeds.

In the feature trot of the day, a $5,500 conditioned event, favourite Bend In The River (post five) did not disappoint his backers as driver Nick Graffam sat a perfect two-hole trip and shook loose at the head of the stretch to draw off and win by five lengths in 1:57.3.

Owned and trained by Stanley Whittemore, the eight-year-old son of Southfork picked up his seventh win of the season and first victory since a two-race win streak at the Fryeburg Fair.

High-stepping Bruizn (post six, Andy Harrington) finished second and local favourite Cherry Crown Jewel (post one, Matt Athearn) was third.

Bend In The River paid $3.20 to win the 27th race of his career.

For the on-track fans, the Trackside Pub hosted a special benefit for Futures for Standardbreds. Round Up donations and raffles took place during the races, with t-shirt giveaways tossed by winning drivers throughout the card. Founded in 2014, Futures For Standardbreds is a Southern Maine-based nonprofit, tax-exempt 501(c)3 organization that has helped retrain and rehome dozens of Standardbreds when their racing careers are over. This event was held in collaboration with Blue Seal Feeds and First Tracks Cumberland, both of which help support Standardbred aftercare programs.

Racing continues at First Tracks Cumberland for its Winter Festival extended pari-mutuel meeting featuring back-to-back cards on Tuesday and Wednesday (Nov. 9 and 10) and continues weekly through December 31, 2021.

(With files from First Tracks Cumberland)

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Oraimo Freepods 3 Review: These are the ones to get – Dignited

Posted: at 2:08 pm

Full disclaimer, I havent been all that into TWS. I mean, I know that this is the way of the industry today but the anti-establishment in me has always been reluctant to hop onto the wireless audio train. Maybe I have been in denial or I am an aging dinosaur but I have always sworn by wired earphones.

But when my trusty, beloved Pace Mzooka earphones met their untimely death courtesy of a door handle, it was time to hop onto the hype train and go for true wireless earbuds. A quick consult with my colleagues revealed that everyone had their own preference but the Anker Soundcore Life P2 Review were my go-to.

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As fate would have it, Oraimo announced their Freepods 3 just a couple of weeks ago and I thought, Oraimo is one of my favorite Africa-focused brands and I have heard good things about the previous Freepods 2 Pro so, why not get the Freepods 3? Well, today I just took procession of my Freepods 3, and heres my experience. Spoiler; these things are the real deal!

The unboxing experience is pretty unique and clearly, Oraimo put a lot of thought into this. For just a pair of TWS, the box is a little bulky but opening it reveals why this is so. You might actually want to keep this box.

In the box, you get the following:

The pairing process is pretty seamless. Just open the case and once you see the LED on the earbuds, open your phone and go to the Bluetooth settings. Locate the Oraimo Freepods 3 and tap to pair.

The Freepods 3 do support AAC codecs. AAC is one of the most popular codec after MP3 and employs a complex lossy compression method and is the most common audio format on the internet. More on that in our explainer for Bluetooth codecs.

To say that I was blown away by the audio out of these little guys is an understatement. I loved my wired earphones and they had some serious punch in the sound. But no earphones I have owned come close to the kind of sound from the Freepods 3.

The bass is punchy but isnt overbearing. Oftentimes, I have had to install an EQ app to tweak the music from my phone just how Id like it but with these Freepods, I dont really need to. The sound is balanced out of the box with the highs and mids coming through clearly in almost all volume levels except when youre like, maxing it out.

Oraimo makes some bold claims over the battery life on these bad boys. In my week or so of usage, I wasnt able to kill them in one sitting which involves several hours of music streaming while connected to the PC.

Oraimo quotes 8 hours per charge for the Freepods and an additional 28 hours from the charging case and I am inclined to believe that. Besides, 8 hours of charge is more than enough for even the longest Zoom meetings.

Basically, there is no reason to worry about the battery life on these buds.

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The FreePods 3 come with touch-sensitive areas on both earbuds. Tapping on these allows you to perform various functions as follows.

I am still trying to figure out the touchpoints of these Freepods, maybe because I am new to these touch controls, or maybe they arent as sensitive as they probably should be but I am still having some trouble about a week in.

Perhaps one of the most hyped aspects of this product is the Environmental Noise cancellation Technology. This is supposed to isolate your voice from a noisy place and have users on the other end of meetings and calls hear you more clearly.

In my testing, these buds offered decent voice isolation but nothing too dramatic. I didnt get to use the previous generation but I suppose these should be better than the previous gen due to this feature.

One thing is for sure though, these are no match for any Noise canceling earbuds in the market today.

One nifty feature that I love about these buds is the replaceable ear tips. The packaging also offers you two extra pairs of these silicon tips, presumably for users who need a different fit but if were being honest, many will just use these as replacements for when they lose the default ones.

So, awareness mode is the mode when you use the Freepods 3 without the tips. This allows ambient sound to get through to your ears hence awareness mode. Bass mode is when you have the silicon tips attached. These should provide a seal and result in deeper bassBass mode!

I legit struggle to find bad things to report about these Freepods 3, mostly coz my expectations have been exceeded, especially for the price. But these arent perfect.

The Freepods 3 have a default tune that is a little heavy on the bass. This is fine for most casual users but might not be ideal for audiophiles. And unfortunately, theres no way of changing this. Itd be nice to have a companion app, but for the price, this is nitpicking.

The Freepods 3 have been available in the market for about a month now and you can find them in your nearest accessory store. You can also get them from Oraimos official online store.

The Freepods 3 should run you a cool KES 3,300 ($30) but could go as high as KES 4,000 owing to the current demand and ongoing shortage of supply.

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PSG-Backed Signaturit and Ivnosys Join Forces with Universign – Marketscreener.com

Posted: at 2:08 pm

Combination of Signaturit, Ivnosys and Universign aims to create a leading European provider of digital signature, digital transaction management and trust services

PSG, a leading growth equity firm focused on partnering with middle-market software and technology-enabled service companies, today announced that it has agreed to acquire a majority stake in Universign, a leading provider of SaaS-based electronic signature solutions. Universign will join Signaturit and Ivnosys to offer one of the widest catalogues of digital transaction management and trust services in Europe.

Headquartered in France, Universign was founded in 2001 and has evolved into a leading e-signature, e-seal and timestamping software solutions provider, serving more than 9,000 clients. Universign has built longstanding relationships with large corporates and expanded towards the SMB segment. As one of the sectors pioneers and a qualified trust service provider under the eIDAS regulation, Universign provides high levels of compliance and security coupled with modern and scalable technology through dashboard and API-led products. The Universign operations will continue to be led by Founder and CEO Julien Stern, who will join the senior management team and remain Head of France, becoming a shareholder of the combined group.

Julien Stern, Founder and CEO of Universign, said: In our view, weve built our business on two key principles: simplicity and compliance. This investment is a testament to our vision, our team and our commitment to providing clients with a solution they can trust. We look forward to working with our new colleagues at Signaturit and Ivnosys, as we believe our combined product suite and expanded European footprint will allow us to accelerate our growth and better serve our clients throughout the region.

Sergio Ruiz and Jaime Castello, co-CEOs of Signaturit and Ivnosys, said: Were thrilled to welcome Universign to the Signaturit and Ivnosys group and believe we can create with them a digital signature leader in Europe. Julien and his talented team have built a leading software solution that shares our aim to deliver the safest and most secure solutions in the industry. Together, we aim not only to scale our full platform, but to continue to innovate and expand our breadth of products.

As part of this combination, the company has appointed Bertrand Sciard as the new Chairman of the Board.

Bertrand Sciard, new Chairman of the Board of the combined group, said: I feel privileged to take on this role at such an exciting time for the company. The last 18 months have demonstrated an accelerated need for fully compliant, digital solutions in accordance with the European eIDAS regulation. We believe the addition of the Universign platform to Signaturit and Ivnosys will enable us to continue providing the same digitisation solutions to existing customers, and build on that to expand the product suite and quality of services to create a whole greater than the sum of its parts. I look forward to supporting the combined group as it continues to build onto its current offering.

The acquisition follows the recent combination of PSG-backed Signaturit and Ivnosys in April 2021. The combined platform aims to provide a complete suite of trust services and digital transaction management software to corporates, small-medium enterprises and individuals in Europe. Through fit-for-purpose solutions, dashboard-led products and API-led deployments, the combined business today serves roughly 236,000 clients across the region.

About PSGPSG is a growth equity firm that partners with middle-market software and technology-enabled services companies to help them navigate transformational growth, capitalize on strategic opportunities and build strong teams. Having backed more than 80 companies and facilitated over 325 add-on acquisitions, PSG brings extensive investment experience, deep expertise in software and technology and a firm commitment to collaborating with management teams. Founded in 2014, PSG operates out of offices in Boston, Kansas City and London. To learn more about PSG, visit http://www.psgequity.com.

About UniversignUniversign is an eIDAS Qualified Trust Service Provider that offers a SaaS platform for electronic signature, seal and timestamp services. It aims to ensure electronic transactions are legally recognised and comply with European regulations. Founded in 2001, Universign serves over 9,000 clients across various sectors including Insurance, Banking, Industry and Energy, Services as well as the Public sector. Each year, over 24 million signatures are processed on the Universign platform.

For more information on Universign, please visit http://www.universign.com/en/

About SignaturitSignaturit is a Qualified Trust Service Provider that offers innovative cloud-based solutions in the field of Electronic Signatures (eSignatures), Certified Registered Delivery (eDelivery), and Electronic Identification (eID) to digitise transactions between companies and individuals, securely and with legal compliance. Founded in 2013, the company serves over 5,000 customers in more than 40 countries and has completed over 38 million signatures on its platform. Signaturits Trust Services seeks to optimise the signature process by enabling customers to reduce paper consumption, improve their billing and hiring processes and provide their teams with a tool that helps them to streamline their administrative tasks related to document signing. For more information on Signaturit, please visit http://www.signaturit.com/en

About IvnosysIvnosys, founded in 2013 in Valencia, develops customizable solutions and services that enable the digitalization of processes in corporates, SMEs, and individuals. Ivnosys product suite includes a market-leading platform for the centralized management of digital identities (certificates), electronic signatures, and notifications. Serving approx. 225,000 clients, Ivnosys provides its solutions both on-cloud and on-premise, seeking to provide strong legal guarantees as a Qualified Trusted Service Provider. Please visit http://www.ivnosys.com for more information.

View source version on businesswire.com: https://www.businesswire.com/news/home/20211107005128/en/

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Biological anthropology – Wikipedia

Posted: at 1:56 pm

Branch of anthropology that studies the physical development of the human species

Biological anthropology, also known as physical anthropology, is a scientific discipline concerned with the biological and behavioral aspects of human beings, their extinct hominin ancestors, and related non-human primates, particularly from an evolutionary perspective.[1] This subfield of anthropology systematically studies human beings from a biological perspective.

As a subfield of anthropology, biological anthropology itself is further divided into several branches. All branches are united in their common orientation and/or application of evolutionary theory to understanding human biology and behavior.

Biological Anthropology looks different today than it did even twenty years ago. The name is even relatively new, having been 'physical anthropology' for over a century, with some practitioners still applying that term.[2] Biological anthropologists look back to the work of Charles Darwin as a major foundation for what they do today. However, if one traces the intellectual genealogy and the culture back to physical anthropology's beginningsgoing further back than the existence of much of what we know now as the hominin fossil recordthen history focuses in on the field's interest in human biological variation. Some editors, see below, have rooted the field even deeper than formal science.

Attempts to study and classify human beings as living organisms date back to ancient Greece. The Greek philosopher Plato (c. 428c. 347 BC) placed humans on the scala naturae, which included all things, from inanimate objects at the bottom to deities at the top.[3] This became the main system through which scholars thought about nature for the next roughly 2,000 years.[3] Plato's student Aristotle (c. 384322 BC) observed in his History of Animals that human beings are the only animals to walk upright[3] and argued, in line with his teleological view of nature, that humans have buttocks and no tails in order to give them a cushy place to sit when they are tired of standing.[3] He explained regional variations in human features as the result of different climates.[3] He also wrote about physiognomy, an idea derived from writings in the Hippocratic Corpus.[3] Scientific physical anthropology began in the 17th to 18th centuries with the study of racial classification (Georgius Hornius, Franois Bernier, Carl Linnaeus, Johann Friedrich Blumenbach).[4]

The first prominent physical anthropologist, the German physician Johann Friedrich Blumenbach (17521840) of Gttingen, amassed a large collection of human skulls (Decas craniorum, published during 17901828), from which he argued for the division of humankind into five major races (termed Caucasian, Mongolian, Aethiopian, Malayan and American).[5] In the 19th century, French physical anthropologists, led by Paul Broca (1824-1880), focused on craniometry[6] while the German tradition, led by Rudolf Virchow (18211902), emphasized the influence of environment and disease upon the human body.[7]

In the 1830s and 1840s, physical anthropology was prominent in the debate about slavery, with the scientific, monogenist works of the British abolitionist James Cowles Prichard (17861848) opposing[8] those of the American polygenist Samuel George Morton (17991851).[9]

In the late 19th century, German-American anthropologist Franz Boas (1858-1942) strongly impacted biological anthropology by emphasizing the influence of culture and experience on the human form. His research showed that head shape was malleable to environmental and nutritional factors rather than a stable "racial" trait.[10] However, scientific racism still persisted in biological anthropology, with prominent figures such as Earnest Hooton and Ale Hrdlika promoting theories of racial superiority[11] and a European origin of modern humans.[12]

In 1951 Sherwood Washburn, a former student of Hooton, introduced a "new physical anthropology."[13] He changed the focus from racial typology to concentrate upon the study of human evolution, moving away from classification towards evolutionary process. Anthropology expanded to include paleoanthropology and primatology.[14] The 20th century also saw the modern synthesis in biology: the reconciling of Charles Darwins theory of evolution and Gregor Mendels research on heredity. Advances in the understanding of the molecular structure of DNA and the development of chronological dating methods opened doors to understanding human variation, both past and present, more accurately and in much greater detail.

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A Brief Guide to Genomics – National Human Genome Research …

Posted: at 1:56 pm

Virtually every human ailment has some basis in our genes. Until recently, doctors were able to take the study of genes, or genetics, into consideration only in cases of birth defects and a limited set of other diseases. These were conditions, such as sickle cell anemia, which have very simple, predictable inheritance patterns because each is caused by a change in a single gene.

With the vast trove of data about human DNA generated by the Human Genome Project and other genomic research, scientists and clinicians have more powerful tools to study the role that multiple genetic factors acting together and with the environment play in much more complex diseases. These diseases, such as cancer, diabetes, and cardiovascular disease constitute the majority of health problems in the United States. Genome-based research is already enabling medical researchers to develop improved diagnostics, more effective therapeutic strategies, evidence-based approaches for demonstrating clinical efficacy, and better decision-making tools for patients and providers. Ultimately, it appears inevitable that treatments will be tailored to a patient's particular genomic makeup. Thus, the role of genetics in health care is starting to change profoundly and the first examples of the era of genomic medicine are upon us.

It is important to realize, however, that it often takes considerable time, effort, and funding to move discoveries from the scientific laboratory into the medical clinic. Most new drugs based on genome-based research are estimated to be at least 10 to 15 years away, though recent genome-driven efforts in lipid-lowering therapy have considerably shortened that interval. According to biotechnology experts, it usually takes more than a decade for a company to conduct the kinds of clinical studies needed to receive approval from the Food and Drug Administration.

Screening and diagnostic tests, however, are here. Rapid progress is also being made in the emerging field of pharmacogenomics, which involves using information about a patient's genetic make-up to better tailor drug therapy to their individual needs.

Clearly, genetics remains just one of several factors that contribute to people's risk of developing most common diseases. Diet, lifestyle, and environmental exposures also come into play for many conditions, including many types of cancer. Still, a deeper understanding of genetics will shed light on more than just hereditary risks by revealing the basic components of cells and, ultimately, explaining how all the various elements work together to affect the human body in both health and disease.

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