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Category Archives: Transhuman News
From the journals: JLR – American Society for Biochemistry and Molecular Biology
Posted: November 21, 2021 at 9:11 pm
How psoriasis changes skin lipids. It doesnt take guts to secrete PCSK9. Anchoring NOD2 on the plasma membrane. Read about papers on these topics recently published in the Journal of Lipid Research.
Unsplash
Psoriasis sends skin cell production into overdrive, causing buildup and sheddingof dead skin cells.
Psoriasis is an inflammatory disease affecting the outer layer of the skin, or epidermis, which serves as a critical barrier against infection, chemicals and loss of nutrients and water. Psoriasis compromises skin barrier function and causes epidermal skin cells to proliferate, forming raised plaques and scales on the skin.
While skin lipids fatty acids, ceramides and cholesterol are essential for maintaining a healthy epidermis, researchers do not yet know the exact composition of skin lipids in healthy and disease states. As the epidermal skin barrier is formed, ceramides must be oxidized by lipoxygenase enzymes, or LOXs. Mutations of these LOX enzymes disrupt the skin barrier so that the skin loses water and becomes dry, red and scaly. Despite this, researchers have not fully characterized the products of LOX oxidation of ceramides and their roles in maintaining the skin barrier.
Victoria J. Tyrrell and colleagues at Cardiff University used new mass spectrometrybased methods to characterize the LOX pathway ceramides present in the human epidermis and determine how these lipids change in psoriasis. Their results, published in the Journal of Lipid Research, demonstrate that substrates of the LOX ceramide pathway are elevated in psoriatic patient skin, even in the absence of plaque, whereas oxidized ceramide products are reduced. They also found that psoriatic lesions had more oxidized free fatty acids than nonlesion or healthy skin, but the implications of this are unknown. In psoriasis, many genes were upregulated in the LOX ceramide oxidation pathway, which is required to form the epidermal barrier, possibly as an attempt to repair barrier function. Using network analyses, they identified a potential master regulator of these genes as the zinc finger transcription factor ZIC1.
While ZIC1 stimulates proliferation of some tumor cells, it had not been associated previously with skin cell proliferation during psoriasis. The authors state that ZIC1 is a potential new drug target for psoriasis.
Too much low-density lipoprotein, or LDL, cholesterol clogs the arteries so they can no longer pump enough blood. This can cause a heart attack or stroke. LDL cholesterol is cleared out of the bloodstream by the liver LDL receptor unless the receptor has been degraded.
The latest cholesterol-lowering drugs prevent LDL receptor degradation. These drugs target proprotein convertase subtilisin/kexin 9, or PCSK9, a protein that escorts the LDL receptor along the path to degradation. PCSK9 is highly expressed by the liver and intestines, but only the liver is known to secrete PCSK9 into the bloodstream where it controls liver LDL receptor expression. Researchers are debating whether the intestines secrete PCSK9.
In a study in the Journal of Lipid Research, Franois Moreau, Aurlie Thdrez and colleagues at the University of Nantes report that human intestinal explants and mature human intestinal Caco2 cells do not secrete PCSK9. In mice lacking liver PCSK9, they detected no PCSK9 in the portal vein a conduit between the intestines and liver ruling out the possibility that it transports intestinally secreted PCSK9 to the liver LDL receptors. This study emphasizes the role of PCSK9 secreted by the liver in regulating cholesterol homeostasis.
Crohns disease causes chronic inflammation of the digestive tract. Possible triggers include changes in the gut microbiome and genetic factors. One of the strongest risk factors for Crohns disease is mutation of an immune system protein called nucleotide-binding and oligomerization domain protein 2, or NOD2.
Within a cell, NOD2 senses peptidoglycans the basic unit of the bacterial cell wall that bacteria shed during infection. Then, NOD2 activates the host immune response, which requires its attachment to the cell membrane. Two cysteine residues on NOD2 can be linked to the fatty acid palmitate, thus anchoring it to the membrane.
In a new Images in Lipid Research publication in the Journal of Lipid Research providing further evidence for a study published in the journal Science in 2019, Charneal Dixon and Gregory Fairn at the University of Toronto show how they performed metabolic labeling experiments in HCT116 human colon cancer cells and showed that wild-type NOD2, but not a double cysteine mutant, was labeled with a palmitate mimetic. Additionally, the double cysteine mutant failed to reach the cell membrane. Knowing these cysteine residues are linked to palmitate, the researchers inferred that the surface of NOD2 interacts with the cell membrane. Defects in NOD2 membrane recruitment, which is critical for its ability to sense and respond to bacterial pathogens, are associated with inflammatory disorders, including Crohns disease.
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From the journals: JLR - American Society for Biochemistry and Molecular Biology
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Police called on Cree family trying to access care for baby in distress in northern Quebec – CBC.ca
Posted: November 19, 2021 at 5:48 pm
Members of a Cree family in northern Quebec saythey were in shock after police were called to a local medical clinicwherethey were trying to get help for a baby in distress in the middle of the night.
"I was shaking uncontrollably.I couldn't sleep. I couldn't eat," said the baby's mom, Jade Mukash, who lives in the fly-in Cree community of Whapmagoostui, Que., about 1,200 kilometre north of Montreal.
Eleven-month-old Slashhas eczema and was showing signs of an infection that he'd received antibiotics for before. Early Tuesday morning, after he'd been lethargic for two days, the family noticed Slash'sfeet and lips were blue, Mukash said.
At around 1 a.m., Mukash, 22, called the local medical clinic,run by the Cree Board of Health and Social Services of James Bay. Its staff includes Cree health care workers and many non-Indigenous nurses and doctors who often fly in on a rotating basis.
After initially refusing to see the boy, the nurse on duty eventually agreed over the phone that theycouldbring him in,Mukashsaid. But tensions escalated, and at one point during the phone call, the nurse said she felt "unsafe" and threatened to call police, Mukash said.
Mukash, along with her partner, Slash's father, and other family members brought the baby to the clinic. There were two nurses on duty, but no doctor, she said.
Mukash said tensions were still high at the clinicas she insisted during the consultation with the nurse that her son see a doctor who could prescribe antibiotics that had worked in the past. She saidnobody in her family at any point threatened or yelled atany of the clinic staff.
The nurse mentioned police again when the family was at the clinic, this time saying the doctor advised staff to call them, Mukashsaid. Police from two different jurisdictionsarrived, and the family left.
"I just keep reliving the fear of being forcibly removed from the clinic, just for trying to get antibiotics for my baby," said Mukash.
About 12 hours later, she returned to the clinic, where a doctor prescribed antibiotics for Slash, she said.
She said the experience has made her lose faith in the local clinic and believes her family was subjected to inadequate care and discrimination. She said one thing that made her suspect the family was being discriminated against wasthat clinic staff told them calling Cree police on a Cree family would be a conflict of interest.
"I knew there was discrimination at this point," she said.
Whapmagoostuiis located beside the Inuit community of Kuujjuarapik, and police from both forces were called to the clinic, Mukash said.
A spokesperson at the Cree Board of Health and Social Services of James Bay said the situation that occurred Tuesday isunder investigation and declined to comment further for now.
CBC called both police services and the director of operations at Whapmagoostui clinicto ask about the situation but had not heard back by the time of publication.
Mukash said the family has been besidethemselves with worry over the baby, who has been struggling withchronic diarrhea, low iron levels and suspected allergies in addition to eczema.
She said they have seen five different doctors at the Whapmagoostui clinic, but none wouldsend the family south to see a specialist, something the Cree health board does routinely. In 2018, there were 21,000 Cree patient visits to places such as Val d'Or, Chibougamau and Montreal to see medical specialists.
CreeHealth did sendMukash and Slashto see apediatrician in the Cree community ofChisasibi, Que., three weeks ago, after Mukash filed a complaint with the board over the challenges they'd experienced with Slash's health care, but there was still no referral to see a specialist.
Mukashhasnow filed another official complaint with the Cree health board about the Tuesday morning interaction, duringwhich police were called, she said.
The Mukash family had been raising money to get themselves to a pediatrician in Montreal when they learned they would finally be allowed onto a medical charter Thursday. They left forMontreal atnoon.
This is not the Mukash family's first challenge accessing care for a child with severe eczema.
Jade Mukash's seven-year-old sister, Legend,hashad a severe outbreak of eczema for many months, according to Natasia Mukash, Legend and Jade's mom.
"She started a small patch on her face, and then it spread to her whole face, her neck and her arms, and then her hands and her fingers," said NatasiaMukash. Most recently, itspread to her eyelids and ears.
It got to the point where Legend was unable to move and attend school, her mom said.
"No matter how many times we would call the clinic to ask for help we would just be told, 'Oh, it's just eczema. It's just eczema'," said NatasiaMukash.
She said the Cree health board should share more information with parents about traditional medicines.
"[Cree health board officials]don't seem to talk about it, and we need to," said NatasiaMukash.
After several painful months, the family finally found its way to local elders who taught them how to use and prepare traditional treatments with bear grease, tamarack and Labradortea leaves, she said.
Asked about this concern, aCree health boardspokesperson said on the guidance of Nishiiyuua council of elders within theboardit is careful about what it shares online aboutCree traditional medicines and that it'sbest to be guided by a knowledgeable healer. The health board does, however, have information about some traditional medicines on its website.
But NatasiaMukash saidthe boardneeds to do more, because not everyone has access toknowledge keepers. She alsosaidLegendis doing much better since they started with themedicine and followed advice from elders to eat a more traditional diet.
"It's such a simple thing ... to see your child singing and dancing and jumping," said Natasia Mukash. "But just to see her doing that is the most amazing thing to me."
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‘Eczema makes my face fall apart and people stare at me but I’m tired of hiding’ – Daily Star
Posted: at 5:48 pm
A woman has taken to social media to share the realities of living with painful eczema all over her face.
Elise Loubatieres-Phan Ngoc has spent the majority of her life trying to hide her flaky and cracked skin.
But now aged 32, Elise has finally accepted her appearance and is showing other eczema sufferers that they're not alone.
The full-time content creator from London told the Daily Star: "I get stared at when I go out, I feel so self-conscious. I'm so glad for masks because I can actually hide some of it but my eyes get quite swollen and crusty and the same with my hairline.
"It's reached the point now where I just don't care. So I go out and I'll have flaky arms and if anyone asks anything I'll just tell them it's an autoimmune disease."
While Elise takes the time to share the details of her skin condition with her followers online, she explained that it isn't her job to educate people when she's out in public.
Now she isn't letting the stares bother her and embracing the skin she is in.
"I've just been fed up with hiding away. I'm 32 and in the last two years I've become more comfortable but I spent 30 years of my life hiding and I'm sick of it," she explained.
Elise was born with eczema, which is a common condition that causes patches of skin that are itchy, inflamed or have a rash-like appearance.
People have differing levels of eczema, with Elise's being so bad she is often in pain.
She goes through various flare-ups, with the current one having gone on for three months so far.
"This three-month flare-up has caused depression. For me, the mental toll of eczema is more intense than the physical," the influencer shared.
"My doctor wants to put me on antidepressants and that's fully due to this flare up and people don't realise that. It's relentless."
Elise explained that change in weather is also a trigger, which is why going into autumn and winter is especially hard.
Stress is also a major factor, as is diet, which is why Elise tries to avoid eating gluten and dairy.
Elise has spent her whole life dealing with her painful skin and sometimes it feels neverending.
"Physically I'm in pain most of the time if I haven't lathered my skin in ointments or creams," she said.
"If I don't put cream on my ear it cracks open and bleeds and then I'm at risk of infection. It's extremely uncomfortable and then I'm very self-conscious so I don't go out a lot when I'm like this.
"People don't understand the mental side of it, people think it's just a bit of dry skin but it's not, it's all-encompassing.
"My life has been completely taken over by this in the last few months, I can't work because I need my face but my face is falling apart."
Elise explained that she had been on various atopical steroid creams for 30 years but decided in 2020 to stop using them completely.
She said that this is because she found out that they're meant to only be a short term solution.
"After 30 years of using them I've got scarring and I've got thin skin. The inner crease of the arm where you get eczema when I tan that does not tan," the 32-year-old said.
"That will just be a patch of bleached skin, which is from overusing steroids for many many years."
Elise said that this is because she didn't know any better, she was just listening to the advice of her GP.
After extensive research, she decided in September last year to stop using steroid creams completely.
"I said to myself I cannot keep going through this cycle of it getting better than it getting worse," Elise said.
"I went through atopical steroid withdrawal last year and that was intense. It can be worse than eczema itself."
Elise wants to spread awareness about the realities of what living with eczema can be like.
For some, the skin condition can be completely life-altering.
"I've had a lot of people tell me they've had to take time off because of their skin," she said.
"People try and make you feel better by saying 'it doesn't look that bad' but it diminishes the experience of what you're going through.
"I can't even wear makeup, I just want to wear a bit of makeup and I can't do that. It sounds silly but that's a massive part of my life, trying on makeup is part of my job."
Elise started posting videos on TikTok about her experience with eczema three weeks ago and her account has been skyrocketing ever since.
She has been bombarded with messages from young people who are facing the same issues, and Elise said she is happy to be a role model for them.
The influencer added: "The number of messages I have received from teenagers in the last week or so has been incredible, they've been saying things like 'Thanks so much, I look like this and I used to be embarrassed to go to school.'
"All of the comments are like 'I've never seen someone with skin like mine.' Social media has been great at connecting people who are going through the same thing, it's like a support group."
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Braum’s an Affair of the Heart show to open Friday – kjrh.com
Posted: at 5:48 pm
TULSA, Okla. The Braums an Affair of the Heart event is back this weekend.
Vendors spent the day setting up at the Tulsa County Fairgrounds. This show is celebrating 26 years but it wont be as large as it normally is.
An Affair of the Heart is a show full of artists, craftsmen, boutiques, and other small businesses.
Its not your grandmother's craft show. It is a shopping marketplace offering all various categories of an item, Kristin Ware, Braums an Affair of the Heart show promoter said.
Due to pandemic hardships, event organizers say it will be smaller, but the 520 vendors wont be as limited by COVID protocols.
The 2020 shows were much smaller and much harder," said Ware. "We were lucky that we still got to have those with a lot of contingencies: spacing, masking, that type of thing. We were really able to get away from that this year.
Even though it's a little smaller, theres still a variety of items to shop for.
Jamie Crouch, owner of Solid Rock Soap Company, uses this event to get face-to-face with her customers.
We get the opportunities at these in-person events, now that these are opening back up, to get to meet the individuals and hear their story," Crouch said. "We get to hear about their little ones that maybe have eczema or psoriasis and how our soaps and lotions have helped or how we can help them. Its great for that human connection which I think is so important.
Plus, with the holidays coming, its a great way to get ahead on gift shopping.
Weve got custom gift sets. We can do it right here in the booth at these shows. You can come through and pick what you like. We have pre-done gift sets, Crouch said.
No matter what you are shopping for, the goal is to encourage everyone to shop locally and support small businesses.
This is how our business continues to grow and thrive," Crouch said. "So when you shop small youre really impacting those business owners' lives.
Tickets for an Affair of the Heart can be bought online or at the door.
The show opens Friday morning at 9 a.m. and runs through Sunday evening.
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Meyer, Isaac: Is Information in DNA Abstract? – Discovery Institute
Posted: at 5:37 pm
Image credit: Brian Gage.
The American Scientific Affiliation is an association of Christian scientists who are not on the whole supportive of scientific arguments for intelligent design. Physicist Randy Isaac, the ASAs executive director emeritus, wrote acritical reviewfor the ASAs journal of our recent bookThe Mystery of Lifes Origin: The Continuing Controversy, and he conducted a quite interestingonline discussion on the subject. He spotlighted Walter Bradley (co-author of the original book,The Mystery of Lifes Origin) in the conversation, as well as philosopher of science Stephen Meyer and physicist Brian Miller who both contributed chapters to the substantially updated edition, to which I wrote the introduction.
I found Dr. Isaacs criticism to be idiosyncratic. His central contention turns upon the question of whether the information stored in DNA is abstract in nature.
The information is not encoded in an abstract code but in a code embodied in a biomolecular system. It is indeed a true code, but it can function only in its physical embodiment and not in a symbolic form. As humans, we represent and model this information symbolically, but its specificity can be determined only in nature in its physical form. No intelligence is required.
Its not abstract, he says, because the arbitrary code only functions if the organism survives and can reproduce. The origin of life therefore does not give scientific evidence of design, which would only be afforded if the code were abstract. While affirming creation and the existence of an intelligent designer, Isaac concludes that Origin-of-life research offers no compelling apologetic either for or against a Creator.
This is odd because as Dr. Meyer answers, other abstract codes such as the English language can have very real survival functions. For example, if you cry out Fire! in a burning building, and because of that people in the building are able to make their way out in an orderly manner and thereby survive, this does not undercut the obvious fact that the word fire is an instance of abstract linguistic coding. Nothing about the four letters f, i, r, and e has any physical connection at all with a state of combustion.
The observation about DNA is not peculiar to ID proponents, says Meyer. Instead, it
goes back to the sequence hypothesis of [Francis] Crick in 1957, 1958 where he realized that the nucleotide bases in DNA are functioning just like alphabetic characters in a written language or digital characters in a section of machine code, which is to say that they are not conveying information in virtue of their physical properties or their chemical properties but rather theyre conveying information in virtue of their precise arrangement in accord with an abstract symbol convention.
This seems pretty clear. In any event, it was gracious of Dr. Isaac to invite Meyer, Miller, and Bradley on to answer his critique. There is no little dramatic tension, in fact, as the conversation starts out very genially but becomes politely contentious about 43 minutes in. Its good to see important ideas tested by thoughtful critics. The exchange is worth watching in full.
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Science solved this. Sheriff says DNA led to arrest in 88-year-old Lennon womans cold case murder – mlive.com
Posted: at 5:37 pm
LENNON, MI -- DNA evidence placed the man who has been charged in the 1997 death of 88-year-old Mary Prieur at the scene of the crime, according to Genesee County law enforcement officials.
Michael Bur, 41, of Lennon has been charged with single counts of felony murder, first-degree criminal sexual conduct and kidnapping in the death of Prieur.
Genesee County Sheriff Chris Swanson announced the charges Thursday, Nov. 11.
At a Wednesday, Nov. 17 news conference, he offered some additional details on the case.
He said testing of biological material led to Burs arrest.
Related: Suspect arrested in 1997 cold case murder of 88-year-old Lennon woman
Prieurs body was found around 2 p.m. Feb. 27, 1997, in the area of Lennon Road and M-13.
Her brother-in-law called police around noon that day after finding the door to Prieurs residence ajar and the dog inside, but no signs of Prieur, according to Flint Journal records.
Michigan State Police canine teams taking part in training in the area responded to the scene. A trooper and K-9 officer spotted her body, wrapped in a blanket, roughly two hours after her disappearance was first reported.
An autopsy revealed Prieur had been suffocated and beaten in the head.
Over the years, billboards have gone up and door hangers placed on homes in the community, as well as police finding DNA that confirmed Prieur was sexually assaulted prior to her death.
One billboard featuring a photo of Prieur read Do you know who killed me!
Signs didnt solve this, but science solved this, Swanson said Wednesday.
Swanson was assigned Prieurs case in 2002 when he was a captain at the sheriffs office.
Investigators collected and stored biological material at the time of Prieurs death, Swanson said. Over the years technology advanced and eventually was able to match that material with Burs DNA and place him at the scene of the crime.
Biological material collected is a 1 in 1.9 octillion match for Bur, Swanson said.
Thats 26 zeros for that guy, Swanson said, pointing at a mugshot of Bur.
Genesee County Prosecutor David Leyton said it is important to remember a suspect is innocent until proven guilty in the court of law.
I think its a proper statement for me to tell you that we have that DNA evidence, Leyton said. We have evidence that I am convinced comes from the victim, comes from the accused, match up and, in fact, we will be able to present that in a courtroom.
The prosecutor noted foundational evidence is also needed to prove the evidence was taken and tested appropriately.
I believe we have probable cause and beyond a reasonable doubt that we can get there, he said.
Drag marks from the home down to the creek where the victim was found can also be used as evidence, Leyton said. A witness gave a statement a few years ago as well and is still available to testify today.
That is the evidence that was presented to me that I feel, within the bounds of ethics, that I can share with you today that led me to write my name on this warrant, charging this man with these heinous crimes. Well do the rest of our talking in court.
Ultimately, officials want closure for Prieurs family, Leyton said.
Swanson and Leyton thanked Michigan State Police Crime Lab investigators.
These folks are key players in the criminal justice system, Leyton said.
Technological advances helped get investigators to the point where charges could be filed in this case, MSP Lt. Kimberly Vetter said.
Vetter thanked the multiple departments involved in the investigation.
Co-operations between departments is critical to the success of all of us, she said.
Prieur was known as a staple in the Lennon community who was often seen walking her dog Pookie while on the way to grab some food at a local bar, according to prior reporting.
She was a regular attendee at multiple churches including St. Marys in Swartz Creek and St. Robert in Flushing.
Related: Murder of 88-year-old Lennon woman remains unsolved 21 years later
Community members rallied after Prieurs murder, putting together a $20,000 reward for information leading to an arrest and conviction of the responsible person or persons.
The money was eventually returned to those who donated after no arrest took place within a few months time.
A native of Czechoslovakia, Prieur came to the United States when she was eight years old, according to Journal records.
Prieur opened the candy business Sweet Maries after adding onto the house at Chippewa and Louisa streets in Flint she shared with her husband James.
James Prieur told The Flint Journal for a March 1997 story that his wife learned to make candy in Owosso, where she was a student at St. Pauls until dropping out in eighth grade to help put her sister and brother through school.
She was just the sweetest, kindest lady, said Gloria Schram, Prieurs neighbor, in a February 2012 Flint Journal story.
Bur is being held in the Genesee County Jail without bond. He is scheduled to appear Nov. 24 for a probable cause conference Nov. 24 in front of Genesee District Court Judge William H. Crawford.
Read more on MLive:
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When will I feel safe enough to go to a doctors office? Sexual assault victims speak out at sentencing of former chiropractor
Drug-free breast milk led to ruling Michigan womans death a homicide, medical examiner says
Suspect arrested in 1997 cold case murder of 88-year-old Lennon woman
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Science solved this. Sheriff says DNA led to arrest in 88-year-old Lennon womans cold case murder - mlive.com
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How Authorities Managed to ID Tiger Lady’ Found in NJ as Pa. Teen After 30 Years – NBC New York
Posted: at 5:37 pm
What to Know
Authorities used DNA to finally identify the body of a 1991 homicide victim in New Jersey known by her tattoo as Tiger Lady. However, how she died and her killer remain unknown.
Warren County Prosecutor James Pfeiffer on Friday announced the victim is Wendy Louise Baker of Coatesville, Pennsylvania.
She was 16 years old when her body was found off Interstate 80 in Knowlton Township near the Pennsylvania border on Oct. 26, 1991. Her death was ruled a homicide, but investigators were never able to determine how she died. There were no gunshot wounds or significant trauma.
She became known as the Tiger Lady because of a tiger tattoo on her left calf.
The prosecutor says DNA extracted from her bones in 2020 helped authorities update her profile and to explore geneological databases. That led police in July 2021 to one of her uncles in Pennsylvania, who identified his missing niece.
Her mother died in 1999 and her father died in 2015. The prosecutor said she was raised by her stepmother until she was 15 years old.
DNA obtained from the Pennsylvania State Police confirmed Bruce Baker was her father.
Pfeiffer has made it a priority to use DNA technology to help solve cold case homicides since he took office last year.
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How Authorities Managed to ID Tiger Lady' Found in NJ as Pa. Teen After 30 Years - NBC New York
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DNA: Top News of the Day | November 19, 2021 – DNA India
Posted: at 5:37 pm
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Here's a roundup of top stories from the world of politics, business, sports, and entertainment, which grabbed the spotlight and trended the most on various social media platforms on November 19 (Friday).
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DNA: Top News of the Day | November 19, 2021 - DNA India
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Tony Spring on Bloomingdale’s DNA and the Holiday Outlook – WWD
Posted: at 5:37 pm
After posting strong second and third quarters, Bloomingdales, like its sister division Macys, is anticipating the same for the fourth quarter.
We had a great third quarter. We had a great second quarter and we plan on having a good fourth quarter, said Tony Spring, chairman and chief executive officer of Bloomingdales, in an interview Thursday following the unveiling of the retailers holiday windows and in-store performances by Bebe Rexha, the Broadway Sinfonietta, and the Broadway Inspirational Voices Choir.
Discussing the character of holiday shopping, past and present, Spring said, If 2019 was all in person and 2020 was remote, 2021 is a hybrid and that may be the best of both worldsPeople feel its time to get out a little bit. More people feel like they want to shop in stores.
I wouldnt begin to quote traffic. We dont have enough traffic counters in stores to give an accurate picture, but the stores are certainly busier week-over-week. And you are beginning to see a bit of tourism. Its been happening since the beginning of the month, both domestic and international, since the federal government said beginning Nov. 8 it was OK for international travelers to come into the U.S. provided they were vaccinated, Spring added.
One thing we learned during the pandemic is that life is short. Why not enjoy it? Thats why you are seeing this conspicuous consumption right now, Spring said. Looking at people entering our stores, you see the happiness on their faces. People feel this is a perfect time to shop, particularly after theyve opened their closets and in many cases havent much liked whats there, Spring said.
To a greater extent, they are willing to pay full price. There isnt as much sale or clearance, Spring said. The benefit, if you want to call it that, of the pandemic has been leaner inventories and I dont think thats something we are going to back away from. Customers appetite for things is at regular price and she is happy about that. The increased consumer demand, the willingness to buy at full price and leaner inventories, all that is the power of the current environment, said Spring.
I think its always better to chase [merchandise] than to load up. We dont want to have excess. We are in the business at the upper end of creating a little bit of scarcity around special product. That doesnt mean not having enough for the customer or not having options.
Spring suggested that this season, perhaps more so than recent past ones, could also see greater self-purchasing. You know the best holiday seasons are always buy one for you, two for me. So hopefully people are buying for themselves and buying for others. Its going to be a good holiday season.
Last quarter, Bloomingdales comparable sales were up 38.5 percent compared to the third quarter of 2020, and up 11.2 percent compared to the third quarter of 2019.Results were driven by strong sales of luxury handbags, fine jewelry, home, mens shoes and contemporary apparel.
There was an outperformance in Q3 against 2019 largely driven by growth in bloomingdales.com, though Spring also called out activations in stores to encourage in-person shopping. There are 12 different activations here in the flagship and its also done selectively around the country, at Bloomingdales 32 other full-line stores.
The biggest experience that will be at 59th Street over the course of the fourth quarter that you will see is a fragrance fair. It will be in all of our stores. We will bring in an engraver to make the bottles personal, or a florist who helps you find the perfect note for the person you love.
Just for the holiday season, the flagship has set up a Klarna-sponsored custom wrap station and Santaland for photos with Santa; celebrity and designer holiday table settings being auctioned to support Design Industries Foundation Fighting AIDS; Ralph Laurens Polo shop has been transformed into an Italian ski chalet serving hot chocolate, and theres a Coravin pop-up wine bar the first in the U.S. demonstrating wine and Champagne preservation systems. Online, Bloomingdales has a series of virtual events on holiday entertaining and holiday dressing.
Being more experiential for the holidays requires more manpower. We are certainly hiring, said Spring. We usually hire through the beginning of December, and then we will cut off holiday hiring and resume full-time hiring. Its a competitive labor market.
Bloomingdales 59th Streets six holiday windows along Lexington Avenue are whimsical, imaginative, colorful and in sync with the stores Give Happy holiday campaign. Theres a nostalgic nod with modern twists in each, like the T-Rex dinosaur wearing headphones, riding a skateboard and draped in mini-dinosaur ornaments like a Christmas tree. Or the window thats a take on a music box, with a spinning ballerina emerging from a seashell draped in sparkle and shine and activated by a lock and key. A third window is a little more down to earth, celebrating all things crochet on the walls and floor and on mannequins snuggled together in a crochet loveseat.
Of a more permanent basis, Were about to open a new mens floor in December having had success on the womens shoe floor. We know mens shoes needs to be a destination. It was always just a component of our mens sportswear offering and we want to have a destination just for mens footwear. It celebrates big brands and showcases Bloomingdales curation.
It reflects a stepped-up emphasis on growing the shoe business. Bloomingdales recently launched shoe shops for Bottega Veneta, Balenciaga, Saint Laurent, Alexander McQueen and Valentino. Coming up in early 2022 are Versace shops for ready-to-wear, shoes and handbags.
Over the last couple of years, you see more designer content. We carry more designer brands today than we have in the past. But we are best when we go from offering the best in opening prices to the best in the designer industry, said Spring.
Bloomingdales assortment will broaden when Macys Inc. launches a marketplace, which is expected to happen in the second half of 2020 for the Macys and Bloomingdales divisions, as reported. Asked what new categories Bloomingdales could get into, Spring replied. It will be a curated marketplace. Details to follow.
Springs message is that Bloomingdales is on a roll not only because of the consumer mind-set. Its in large part due to Bloomingdales doing what its always done offer a fun, energetic environment for shopping; breadth and flexibility in assortment; playing on the power of suggestion, i.e. providing gift lists and stylists with shopping ideas, and having a cross-generational appeal.
Asked in what categories Bloomingdales put more of its holiday open-to-buy, Spring responded, The weight is in the variety. One of the advantages of a retailer like Bloomingdales is in the flexibility of our assortment, so thats both from home to fragrance to cashmere to Ugg and to the price points, be it designer diamonds, Louis Vuitton and Gucci, to Aqua, Bloomingdales private brand and opening price contemporary collection. As a destination, Bloomingdales has become more of a compelling marketplace. You can buy for more people here, for the love of your life, for your daughters teacher, your neighbor, your cousin, your aunt. There are just lots of fun items. The marketing and merchandise team did a great job in terms of creating curated ideas and gift lists for our customers, whether it was themed for people who just got married or still havent got married or for the person who has everything.
He believes theres an energy at Bloomingdales, which is lacking in other retailers. Im not saying we are Disney World. But I think there is a curation of merchandise, a curation of eventing, a curation of visual animation. I cant tell you the number of people who tell me Bloomingdales is more fun, that there is more energy in the store. Where does energy come from? Its the people, the music, the visual animation. You see a diversity of customers. You see young people. Mature people. Different ethnicities. The brand is a draw for lots of customers.
He hopes Bloomingdales nascent specialty concept, Bloomies, has a draw with its own type of merchandising and curation. The first and only Bloomies, a 22,000-square-foot site in the Mosaic District lifestyle center in Fairfax, Va., opened at the end of last August. It sells a highly curated assortment of contemporary and luxury brands and gifts for the home. Its a chance to introduce ourselves to the community with a new shopping option, said Spring.
Asked if other Bloomies are planned, he answered, It did get off to a good start. We will take it one day at a time. You dont get ahead of yourself. Its about finding the right locations.
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Alanis Morissette, All Too Well, and the DNA of the Eff-You Anthem – The Ringer
Posted: at 5:37 pm
[Ed. note: On Thursday, Ringer Films will debut the second documentary in its Music Box series on HBO: Jagged, which looks at Alanis Morissettes career and rise to fame in the mid-90s.]
On Friday, the most lacerating and lavishly acclaimed singer-songwriter of her generation released a bonkers 10-minute version of her best and most lacerating song. And you were tossing me the car keys / Fuck the patriarchy keychain on the ground, sings Taylor Swift, with her patented, elegant wistfulness that can cut through steel, on All Too Well (10 Minute Version) (Taylors Version), a supersized reimagining of the deep-cut highlight of her immaculate 2012 album Red. Those are the first lines that deviate from the original, and the thrill of Swift dropping yet another f-bomb is undeniable, but the true genius of this song in any form is subtler, and sadder, and can be roughly summarized thus: You seem very well. Things look peaceful. Im not quite as well. I thought you should know.
All Too Well, at any length, is a delicate and devastating post-breakup killshot nonpareil, and for dedicated Taylorologists, it is the richest text imaginable. The affable-doofus actor widely assumed to have inspired the song, who no doubt had a lovely weekend. The dazzling accumulation of lyrical detail: the scarf, the refrigerator light, the performatively sipped coffee, the autumn leaves falling like pieces into place. The delightful patriarchy-fucking scheme (Red is the second album Swifts rerecorded so shell own the masters) at this projects core. (Also, shes currently selling a a F*ck the Patriarchy keychain for $20; living well is the best revenge, but monetizing your exs disingenuousness is a close second.) If youre vain enough, this song can be about anyone, anything. Its heartbreaking, its furious, its uproariously mean. But these are the new lines Im stuck on now:
And I was thinking on the drive downAny time nowHes gonna say its loveYou never called it what it wasTill we were dead and gone and buried
You never called it what it was. The tabloid prurience and gossamer savagery of All Too Well are crucial, but what makes the song an all-timer is an honesty so relentless it feels like empathyif not toward him, now, then at least toward them, then. Call it what it was. Thats it. Thats all she wanted from him. And if Swift, now, has to drag the guy on Saturday Night Live for 10 minutes straight to call it what it was back then, thats what shell do, not so much to make him feel worse as to make herself feel better.
Swift learned that lesson, in part, from Alanis Morissette, who is for sure the most lacerating singer-songwriter of her own generation and could always use more lavish acclaim. I was not writing to punish, Morissette says deep into Alison Klaymans new documentary Jagged, which premieres Thursday on HBO as part of Ringer Films Music Box series. I was writing to express and get it out of my body because I didnt want to get sick.
Morissette is talking, of course, about her 1995 thunderbolt breakthrough album, Jagged Little Pill, which sold more than 15 million copies in the United States alone and reigns as the second-best-selling solo album by a female artist in world history (behind Shania Twains Come on Over). She is talking, more specifically, about that song, You Oughta Know, the lewd, profane, electrifying, mystery-celeb-eviscerating nuclear bomb that a quarter century later remains as radiantly angry, as viciously detailed, and above all else as extremely funny as it did the first time you heard it. When I launched a podcast about 90s songs in late 2020, I couldnt think of a better song to start with. I must have heard You Oughta Know 3,000 times in my life at least, but I still laughed out loud at the line but youre still alive when I listened to it again yesterday. The Jagged documentary (which Morissette herself has criticized) is careful to celebrate the cleansing fury of You Oughta Know and a handful of other more combative moments on Jagged Little Pillvarious music-biz shitheads are righteously clowned on Right Through Youbut the movie also wants to reject the long-standing reduction of Morissette to a mere Angry White Female, as her first Rolling Stone cover put it.
Theres a kindnessits like this velvet kindness, is how Morissette describes her circa-1995 self as the movie closes. No matter how pissed off she is. Its like, theres mercy in it. Theres empathy in it. Theres hope even when the song is hopeless. Theres a little drag of everythings gonna be OK. No matter how horrible it gets.
It is a profound compliment to You Oughta Know, truly, if it still crosses your mind whenever you hear another colossal Fuck Youtype pop song. Keliss Caught Out There. Pinks So What. Kelly Clarksons Since U Been Gone. Beyoncs Dont Hurt Yourself. Lily Allens Fuck You. Hell, CeeLos Fuck You. Hell, Rina Sawayamas STFU! Lucy Dacuss Night Shift or Brando. And of course, Taylor Swifts mighty All Too Well. (And Dear John. And Better Than Revenge. And Picture to Burn. And Mean. She calls it what it is a lot.) But dont forget that all of those songs are also hilarious, and arguably the best of them carry trace amounts of empathy, of grudging affection, of velvet kindness. Bet you rue the day you kissed a writer in the dark, seethes Lorde on her 2017 album Melodrama, which cemented her as another master of the form. But what the best Fuck You songs supply, in addition to all that infectious seethe-along rage, is just a tiny sliver of light.
And all I really want is some patience, sings Alanis Morisette on the first chorus of Jagged Little Pills first song. A way to calm the angry voice. It is easy to miss that this record is primarily the work of a mistreated but phenomenally talented singer-songwriterrelocated to L.A. and teamed up with producer/co-writer Glen Ballard after a tumultuous and scarring run as an Ottawa-born teen pop starcalming herself down. The angrier she sounds, the more powerful and centered she becomes. The album touches on what she is not (Perfect), and what she hopes to be (Forgiven), and what shell definitely never be (Not the Doctor). But Jagged Little Pills best moments are anthemic and empowering while deftly avoiding the zillions of clichs the word empowering implies, even then and especially now. The first verse of Hand in My Pocket makes Morissette sound immortal by reveling in her vulnerability and, by extension, yours:
Im broke, but Im happyIm poor, but Im kindIm short, but Im healthy, yeahIm high, but Im groundedIm sane, but Im overwhelmedIm lost, but Im hopeful, baby
Its the line Im sane but Im overwhelmed that jumped out at me today, the 2,000th time Ive heard this one. (My previous listen, it was Im short but Im healthy.) Jagged the movie underscores what Jagged Little Pill the album is happy to remind you of, anyplace, anytime: The greatness of You Oughta Know notwithstandingand I hate to bug you in the middle of dinner is one of the funniest line deliveries in pop historyit took all 12 tracks, working in glorious spiritual unison, to make this record the colossus it became. (Even in the mid-90s, one song wasnt gonna sell 10-million-plus copies of an album no matter how great it was.) So: Head Over Feet for the lovers, the legitimately heartening You Learn if youre in crisis, and the tender waltz Mary Jane if youre hoping more killer lines will suddenly jump out at you (I hear youre losing weight again, Mary Jane / Do you ever wonder who youre losing it for?). It is certainly remarkable that Ironic, dismissed at the time as a lesser single with some linguistic issues, is now the albums most-played song on Spotify: That Its like rain on your wedding day is a broad, melodramatic image doesnt keep it from being a great one.
It is inevitableand an eternal testament to Morissette herselfthat youll hear her, at random, in other songs by other people until the sun finally swallows us all. (The best Alanis Morissette album released in the past five years, with much respect to 2020s Such Pretty Forks in the Road, is the Chicks Gaslighter. Start with Tights on My Boat if youre impatient.) And so it was for me, 48 hours ago, blown away by a superior (and twice as long) version of what was already my favorite Taylor Swift song. By all means, revel in the surgical viciousness of All Too Well (10 Minute Version): The lines And I was never good at telling jokes, but the punch line goes / Ill get older, but your lovers stay my age certainly jump out at you. But the song, and the songwriter, and the Fuck You Song pantheon overall, is so much more than the Fuck You part. Never forget the kindness, or the velvet. Taylor learned that a long time ago, and long before that, Alanis taught us all.
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Alanis Morissette, All Too Well, and the DNA of the Eff-You Anthem - The Ringer
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