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IT can be heartbreaking to watch your little one battle eczema.

The skin condition causes itchiness, redness and inflammation, which can be uncomfortable and sometimes sore for the sufferer.

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There are seven types of eczema.

Atopic eczema - the most common type - is when the skin is unable to retain moisture. It becomes dry which makes the skin more likely to react to irritants.

Contact dermatitis is when bouts of eczema are caused by a specific substance, sometimes causing a reaction days later.

One in every five children is affected by eczema at some stage, according to the British Skin Foundation.

There is no cure for the condition, but sometimes people grow out of it or have long periods without it.

People live with the skin condition by using treatments and learning what triggers their flare-ups.

But Dr Derrick Phillips, Consultant Dermatologist and British Skin Foundation spokesperson, said: "It is not always possible to identify triggers for eczema.

"Parents should focus on reducing the risk of flares by addressing the skin barrier impairment with regular application of moisturisers and use of bath emollients. Any suspected triggers should be discussed with your doctor.

"Parents should see their doctors if the symptoms (itch, redness, soreness) do not improve with moisturisers, emollients and bath emollients; or there are signs of infection."

Over the years, research has been able to pinpoint common reasons why eczema flares up.

The Centre of Evidence-based Dermatology, University of Nottingham, outlined these in a 2009 paper by reviewing studies, including one which followed 60 children with the condition.

This information is likely to be useful to families and may lead to the ability to reduce disease flares in the future, they said.

It found the following were triggers in eczema, generally:

Shampoo and other detergents like shower gel, hand soap and washing-up liquid contain dozens of chemicals.

These were found to increase how much eczema bothered children day-to-day as well how much they scratched.

Interestingly, researchers said the effect of shampoo was exacerbated by the cold weather.

This was likely due to imparired skin barrier function, they said.

When the skin barrier is weaker in the cold weather - due to water loss - there is more opportunity for soaps to enter the skin and cause irritation.

There are plenty of washing alternatives for the shower or bath that are more gentle to eczema sufferers - but the best thing to do is avoid them as much as possible.

Mums have raved about Childs Farm as eczema-friendly shower and shampoo products for easy bath times with kids.

The fur of an animal - and all the mites, dust and plant pollens they carry (dander) - is a common trigger for eczema.

The study found that eczema on the hands was particularly sensitive to pets.

Its thought that some people have a dilated hypersensitive reaction to dander which causes an allergic response. This can result in an eczema flare.

While this may be more common with other peoples pets, you can reduce the risks of your own pet causing irritation by vacuuming often, getting hardwood floors and keeping your pet well-groomed.

Some studies show that kids who grow up with a pet are less likely to get eczema when theyre older. The evidence is clearer for dogs than cats.

Dust mites are an environmental irritant linked with eczema in the same category as pollen or pollution.

These tiny bugs live in the carpets, sofas, blankets and other furnishings. They are so small you cant see them.

The dust mites dont bite, but they excrete a substance that can irritate the skin.

Unfortunately there is only one way to help fix this - clean more often!

Reducing humidity in the home can also help as house dust mites thrive in humid conditions.

To help stop the scratch-cycle, try giving your child a product that relieves the itch without breaking the skin, such as a Cosi Care Scratch Star or Attack Roller.

How to cope with winter flare-ups

Dr Derrick Phillips, Consultant Dermatologist and British Skin Foundation spokesperson, said: "Winter flares are largely driven by the reduction in household humidity caused by central heating."

The risk of flares can be reduced by:

Not sitting close to radiators

Wearing layers and reducing the heating

Use of humidifiers

Warm instead of baths/showers

Moisturising immediately after baths/showers

Nylon is a kind of material used to make clothing.

When directly next to eczema, it was found in the research to worsen symptoms, particularly on the trunk and limbs.

Nylon is one of many synthetic or man-made materials that are considered problematic for people with eczema.

These types of materials can cause overheating or sweating which can set off the dreaded itch feeling.

Meanwhile wool, which is a natural material, was found to be irritating for the limbs.

Wool can feel rough on the skin which is a nightmare for people with already sensitive, itchy skin. Some people also have an allergy to wool.

Experts always recommend people with eczema wear cotton as much as possible because it allows the skin to breathe.

Bamboo and silk are other preferred choices.

Sweating, either from hot and sunny weather or exercise, can irritate eczema, researchers say.

Sweat is the bodys natural response to the body heating up. As it evaporates, it cools the surface of the skin.

However, the sodium (salt) in sweat can dehydrate the skin of people with eczema and sometimes make it sting.

This can make summer and exercising with the condition difficult, but there are a number of ways to prevent an outbreak.

Drink plenty of fluids, wipe sweat away, try and keep cool with a fan and moisturise before and after exercise.

Kids love swimming.

But the study found it not only makes eczema more bothersome and itchy, but worsens the symptoms to the point parents seek more treatment for their child.

Some children may react to the chemicals, such as chlorine, in the pool - called irritant contact dermatitis.

Meanwhile, dryness of the skin after swimming is likely to occur if the pH of the pool water is raised, the National Eczema Society warns.

Avoiding swimming when eczema is bad is the simple solution.

But even when the skin is in a good phase, keep habits such as applying emollient cream (which is thicker than a moisturiser) around half an hour before swimming to act as a barrier against the water.

Combination of factors

The research team said that a combination of any three factors was likely to exacerbate symptoms even more.

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We know that not sleeping well and feeling stressed can give us dark circles under our eyes.

But if you are getting your forty winks, feeling calm and you still have eyebags, there could be another reason.

Eyebags could be caused by something other sleep issues or stress levels, an expert has explained.

An optometrist has revealed your diet might be why your eyes dont look and feel as sharp as they could.

Roshni Patel said: Salt encourages fluid retention in the body and can result in fluid build-up under the eyes.

A reduction in salt intake may assist with reducing puffiness.

For those that struggle with anaemia, eating iron-rich foods may also help to reduce symptoms as they allow the increase of oxygen to reach the tissues in your body and avoid the appearance of dark circles.

So if you find you are often waking up with dark puffy eyebags, try tweaking your diet.

Instead of having salty crisps as an evening snack, swap to lentil chips.

And if you have salty evening meals it might be best to change well-seasoned potatoes and veg to plan ones, or iron-rich substitutes like spinach or edamame.

The expert from Lenstore added there are other reasons why you might struggle with dark circles under your eyes.

She said: Bags under the eyes are commonly associated with a lack of sleep, and appear as mild swelling or puffiness under the eyes, primarily as a result of fluid accumulation.

They are predominantly a cosmetic concern and rarely ever are a sign of a serious medical condition.

Though the most recognisable and familiar is a lack of sleep, eye bags can result from a wide variety of different causes.

Fluid retention can become more of a problem as we age. The skin under the eyelid becomes thinner and can result in puffy eyes.

This can be especially more noticeable in the morning and can be prominent after having a salty meal, which causes greater fluid retention in the body.

Pollen, dust and pet allergies are a common reason why people suffer with puffy eye bags.

If you are not sure which is causing it, you can get an appointment with your GP who may refer you to an allergy clinic.

This will help determine the cause and hopefully reduce your exposure to the allergen.

Smoking can contribute towards puffy eyebags as the nicotine found in cigarettes disrupts sleep patterns.

This does not only lead to tiredness but also a build up on fluids as your body has not had a chance to fully rest and restore.

Smoking also breaks down skins elasticity and collagen production reduces which can cause the skin to look puffy or sag.

Unfortunately for some, puffy under eyes is not to do with their outside environment but is a hereditary condition.

Autoimmune conditions are also known to cause puffy under eyes.

If you do have a family history of puffy under eye bags, people do find cold compresses in the morning or before you go out can reduce the appearance temporarily.

Much like when we burn, our bodies are defending our skin from further damage.

If your eyes are suffering from too much sun exposure, then the natural response is inflammatory this is your bodys way of trying to protect your eyes.

Sun damage and excess heat commonly cause swelling and puffiness.

For those living with eczema, the winter air can make puffy eyes considerably worse this is due to the dry air.

Atopic dermatitis can occur, causing irritation around the eyes and eyelid, this can lead to puffiness as the skins natural defence mechanism is to protect your eyes.

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Im an eye expert and heres the real reason for your dark bags - New York Post

The most common skin complaints are eczema and acne - and over half use products in their routine despite knowing they could be damaging

Image: James Wasserman/Barcroft Media/Getty Images)

Brits go through an average of eight different skincare products in their quest to combat their skin issues, according to a study.

A poll of 2,000 adults found less than 20 percent have found the perfect routine for their skin type, although nine in ten know it's important to help maintain it.

And one in ten have tried 16 or more different bottles, lotions and potions to get themselves looking their best.

Nearly half (45 percent) choose products that have been proven effective by clinical research, and 38 percent look for those that are made with natural ingredients.

Nadav Shraibom, scientific founder and celebrity skin consultant at Medovie, which commissioned the research, said: Finding the perfect skincare routine, especially for those with chronic skin conditions such as eczema and psoriasis, can be a long road especially when youre unsure as to what your issue may be.

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While trying different products may help you find your perfect routine, this can actually be doing more harm than good and could be damaging your skin barrier, causing more irritation and inflammation.

Remember, the perfect skin routine involves the three Ps patience, persistence and prevention.

If your skin condition is triggered by stress and anxiety, this can then turn into a painful and vicious cycle so its best to try and maintain your skin health to help alleviate some of the symptoms.

The research found three-quarters have had a formal diagnosis of a skin complaint, such as eczema or psoriasis with an average of a four-and-a-half month wait to find out what it was.

And 29 percent found themselves waiting over six months to have their skin condition diagnosed.

Unsurprisingly, six in ten wish theyd been able to get their diagnosis sooner, with the most common complaints being eczema (54 percent), acne (32 percent) and psoriasis (31 percent).

Just under half (47 percent) admit to scratching their skin, and one in three have used a scrub that was too harsh.

Three in ten have over-cleansed, and a further 30 percent admit to skipping their moisturiser all of which can cause further irritation to inflamed and irritated skin.

Due to the length of time it takes to get a formal diagnosis, six in ten lived to regret these choices even though 49 percent knew full well what they were doing may be damaging.

As a result, 21 percent have missed a social engagement due to having a bad skin day, and 20 percent booked a specialist appointment soon after.

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The study, commissioned via OnePoll, also found 51 percent of respondents find knowing which products to trust hinders their quest for the perfect skincare routine.

Nadav Shraibom, for Medovie, added: Having a skin condition doesnt just have an impact on a persons skin, but can affect their everyday lives, as well as their mental health.

There is so much information available that it can be hard for many to discern what are the facts and what are the myths in relation to their skin.

Therefore, I would always advise that you seek the opinion of a specialist to help formally diagnose your condition theres no need to be embarrassed, weve seen it all.

They will then be able to recommend the best products for you to use to help treat your skin condition.

Through our innovative 3HX formula, we have managed to help people treat skin concerns, both externally and from within, and make long-lasting, effective change and help reduce the anguish many face with their skin conditions.

TOP 15 THINGS PEOPLE WITH SKIN CONDITIONS HAVE DONE ON A BAD SKIN DAY:

Continued here:
Brits typically go through eight different skincare products in bid to tackle skin issues - Mirror.co.uk

Picture this: You've just indulged in a long, relaxing shower, only when it comes time to towel off afterward, you find that your skin didn't enjoy the experience as much as you did. Splotchy, red, irritated patches of skin crop up on various parts of your body, and you wonder how you could be having this reaction when the only things you've come in contact with are water and soap. There could be a few culprits behind these common post-shower skin reactions. Perhaps it's a sign of dry skin or the results of using a dull razor blade. Rashes can also stem from skin conditions like irritant contact dermatitis, when the skin becomes red or sore from an irritating substance. POPSUGAR consulted dermatologists to help figure out what exactly causes rashes that occur in the shower, and what's the best way to treat them.

Rashes that develop in the shower can be a sign of extremely dry skin. "Xerosis cutis, which is dry skin, is one of the most prominent causes for development of a rash after taking a shower," board-certified dermatologist Michele Green, MD, told POPSUGAR. "This is because a high water temperature can strip the skin of the natural oils that keep it healthy and moisturized, causing it to become itchy."

If the temperature of the water is too hot, that can also cause a skin rash. "If a rash develops after taking a shower due to the temperature of the water being too high, it is common to experience symptoms such as redness, swelling, itching, flaking, or even peeling," Dr. Green explained.

Shaving habits are another culprit. "Using old razor blades and shaving can cause folliculitis the inflammation of hair follicles," board-certified dermatologist Marina Peredo, MD, FAAD, told POPSUGAR. "If the blade is dull, it will irritate the skin."

Preexisting skin conditions can also play a role in rashes that appear post-shower. "Irritant contact dermatitis can cause the skin to become dry from taking hot showers," Dr. Peredo said. This skin disorder in particular can become aggravated during a shower routine. "The combination of hot water, fragrant soaps, and skin that isn't moisturized can make skin red, dry, and cracked."

Both Dr. Peredo and Dr. Green agree that cholinergic urticaria can also cause a rash after showering. "Cholinergic urticaria is caused by nerve fibers in the sweat glands," Dr. Peredo said. "If you take a hot shower, your body temperature goes up, which can create hives."

The soap you use and the temperature of the shower itself can also make rashes appear for those who have eczema. "Eczema can be triggered by substances that come in contact with the skin, such as soaps, cosmetics, clothing, detergents, jewelry, or sweat," Dr. Green said. "Someone who struggles with eczema may experience a flare after taking a hot shower."

Changing the temperature of your shower is a great place to start when trying to avoid rashes. "Keep the temperature of the water on the cooler side to help keep away any unwanted itching, redness, or discomfort," Dr. Green said. A warmer shower is also much better for those with skin conditions. "Taking shorter, cooler showers are good for irritant contact dermatitis and cholinergic urticaria," Dr. Peredo advised.

Keeping skin hydrated is another simple fix. "If your skin is dry, it's important to use a rich moisturizer that can strengthen the natural barrier of your skin," Dr. Green said. Dr. Peredo suggests moisturizing skin while it's still wet, so the lotion or oil gets a better chance to absorb properly. For those with extremely dry skin, it's best to consult with your dermatologist about a more personalized treatment plan. "In extreme cases of dry skin, your dermatologist can prescribe topical steroid creams like hydrocortisone cream to reduce redness and inflammation," Dr. Green said. "Oral antihistamines like Benadryl, Zyrtec, or Claritin may also be needed to help alleviate any pruritic symptoms associated with your dry skin."

Soothe symptoms of a shower rash by cooling your skin down. "Using a humidifier and a cold-water compress can help soothe symptoms of the rash that appear after taking a hot shower," Dr. Green suggested.

Creating regular habits for more hydrated, moisturized skin will reduce dryness and lessen the chance of developing a rash after the shower. "Apply a soothing, unscented body lotion to skin twice a day to keep skin well moisturized and prevent irritation," Dr. Green said. "If you have dry skin, be sure to stay hydrated and drink plenty of water throughout the day in order to maintain healthy and moisturized skin."

Swapping out body soap, shampoo, and skin-care products might also prevent shower rashes. "Stick to gentle soaps that don't have a fragrance to ensure that your rash is not an allergic reaction to an ingredient in your hygiene products," Dr. Green advised. "Skip using skin-care products that contain potentially irritating ingredients like alpha hydroxy acids (AHAs), beta hydroxy acids (BHAs), retinols, or retinoids. These ingredients are designed to increase the rate of skin-cell turnover and can be a cause for dry skin."

If rashes are developing after you shave in the shower, it could be time for a new razor. "Replace dull razor blades with new ones to help prevent folliculitis," Dr. Peredo said.

It's also important to be mindful of how you dry off after the shower. "Instead of rubbing your skin with a towel to dry after showering, gently pat the skin with a towel to prevent irritation," Dr. Green suggested.

See more here:
Do You Get a Rash After Showering? Here's Why, and How to Make It Stop - POPSUGAR

A comprehensive analysis on the probiotic cosmetics market by Future Market Insights (FMI) provides in-depth insights into governing factors elevating the demand in the market. It discloses opportunities that will favor the market growth in various segments on the basis of product type, consumer orientation, end use, price range, packaging, and sales channel over the next 10-years.

DUBAI, UAE, Nov. 23, 2021 /PRNewswire/ -- As per a study by FMI, the global probiotic cosmetics market is projected to total US$ 594.7 Mn in 2031. In response to the growing emphasis on self-grooming, skincare, and appearance among men across the world, the market is estimated to expand at a CAGR of 6.9% over the forecast period 2021-2031, in comparison to the 5.2% CAGR registered in the past half-decade.

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Request a report sample to gain comprehensive insights at https://www.futuremarketinsights.com/reports/sample/rep-gb-14177

Rising awareness regarding the benefits of microbiomes in cosmetic and skincare products such as anti-aging, skin lightening, and efficient moisturizing is facilitating the growth in the market. Thus, increasing significance of maintaining a healthy skincare ritual among men and women alike owing to the increasing social media penetration is expected to spur the sales of probiotic cosmetics by more than 2X through 2031.

Citing this trend, a number of cosmetic companies are aiming at launching novel products that are probiotic in nature. For instance, AIME skincare, a leading skincare brand, announced expanding its portfolio by launching its probiotic-based skincare range The Simple Skin. It consists of probiotic cleansers, serums, and creams for all types of skin. A multiplicity of such product launches is expected to propel the demand for probiotic cosmetics, enabling the market register a year-on-year growth of 6.1% in 2021.

On the basis of product type, the facial care product segment is anticipated to outpace other products available in the market, accounting for more than 41% of the overall sales in 2021. Increasing demand for serums, masks, cream, and others for skincare and targeting specific skin concerns is favoring the growth in the market.

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"Rising popularity of cosmetics among millennial men and increasing adoption of probiotic skincare products for the treatment of dermatological concerns such as eczema, chronic inflammation, ichthyosis, and acne are expected to accelerate the growth in the market," says a FMI analyst.

Key Takeaways from Probiotic Cosmetics Market Study

The market in the U.S. is projected to register the fastest growth in North America, expanding at a CAGR of 3.8% over the assessment period.

The U.K. is expected to hold lead in the Europe market, accounting for more than 30.7% of the regional sales through 2021.

India is anticipated to hold the dominant share in the South Asia & Pacific market, accounting for over 30.6% of the value share in the region in 2021.

As per the price range, the premium (above US$60) segment is forecast to lead the market, surging at a robust CAGR of 8.7% between 2021 and 2031.

Key Drivers

Introduction of specialized cosmetics and skincare e-commerce platforms such as Nykaa, and the availability of a variety of products at tempting discounts across these platforms are spurring the sales of probiotic cosmetics in the online retailing segment.

Rising customer inclination towards the adoption of high-quality skincare and cosmetic products with minimal to no side effects is propelling the demand for probiotic cosmetics in the premium segment.

View TOC and Report Preview@ https://www.futuremarketinsights.com/reports/probiotic-cosmetics-market

Key Restraints

Stringent regulatory approval and cost-intensive certification process for novel cosmetics and personal care products are posing a challenge to market growth.

Use of cost-effective chemicals and moderate-quality ingredients in the production of economic range probiotic cosmetics is hindering the sales in the economy (below US$30) segment, as consumers are extensively looking for high quality and natural products.

Competitive Landscape

As per FMI, the leading players in the global market are anticipated to account for nearly 15% to 25% of the total market share through 2021.

Key companies are emphasizing on intensive research and development (R&D) activities for launching innovative products and services in the market. Some of the manufacturers are aiming at entering into a collaboration with spas, online beauty retailers, and other organizations to strengthen their footprint. For instance,

In 2019, Eminence Organic Skin Care, a natural cosmetic manufacturer, announced launching a stonecrop body products collection which includes body oil, body cream, body scrub, and others. The products are organic, natural, and biodynamic professional skincare in nature.

In September 2021, LAC2Biome S.r.l, a microbiome health startup based in Italy, announced introducing a new facial serum with a white label skincare blend, which contains hyaluronic acids and live probiotics. The new product launch will assist the company to expand its portfolio in probiotic cosmetics.

Some of the key players operating in the market profiled by FMI are:

L'Oreal SA

Procter & Gamble

Unilever Plc

Arbonne International LLC

KORRES SA

L'OCCITANE

Johnson & Johnson Consumer Inc

Amway

Andalou

Aurelia London.

BIOMILK Skincare

Columbia SkinCare.

EMINENCE ORGANIC SKIN CARE

LaFlore Probiotic Skincare

ESSE SKINCARE

Marie Veronique.

ESTE LAUDER COMPANIES

For any Queries Linked with the Report, Ask an Analyst@ https://www.futuremarketinsights.com/ask-question/rep-gb-14177

More Valuable Insights on Probiotic Cosmetics Market

The latest report by FMI provides a detailed analysis of the global probiotic cosmetics market, providing credible insights into key factor driving the market through 2021 and beyond. The study also disclosed growth projections on in probiotic cosmetics market with detailed segmentation:

By Product Type:

Facial Care products

Hair Care products

Make-up products

Body Care products

By Consumer Orientation:

By End-Use:

Individual

Professional Services

By Price Range:

By Packaging:

Tubes

Bottles

Jars

Pumps and Dispensers

Others

By Sales Channel:

By Region:

Key Questions Covered in the Report

The report offers insight into probiotic cosmetics market demand outlook for the forecast period 2021-2031

The market study also highlights projected sales growth for probiotic cosmetics market between 2021 and 2031

Probiotic cosmetics market survey identifies key growth drivers, restraints, and other forces impacting prevailing trends and evaluation of current market size and forecast and technological advancements within the industry

Probiotic cosmetics market share analysis, covering key companies within the industry and coverage of strategies such as mergers & acquisitions, joint ventures, collaborations or partnerships, and others

Explore FMI's Extensive Coverage on the Consumer Product Domain

Colour Cosmetics Market: the global market for colour cosmetics is presently valued at nearly US$ 50 Bn, and is anticipated to exhibit growth at 4.8% CAGR, surpassing US$ 79 Bn by 2026-end

Mobile Phone Accessories Market: FMI in its latest study has forecast the Mobile Phone Accessories Market to rise at a CAGR of ~6.7% between 2021 and 2031

Online Clothing Rental Market: According to FMI's analysis, Online Clothing Rental sales would grow at an 11.0% CAGR between 2021 and 2031.

About Future Market Insights (FMI)

Future Market Insights (FMI) is a leading provider of market intelligence and consulting services, serving clients in over 150 countries. FMI is headquartered in Dubai, and has delivery centers in the UK, U.S., and India. FMI's latest market research reports and industry analysis help businesses navigate challenges and make critical decisions with confidence and clarity amidst breakneck competition. Our customized and syndicated market research reports deliver actionable insights that drive sustainable growth. A team of expert-led analysts at FMI continuously tracks emerging trends and events in a broad range of industries to ensure that our clients prepare for the evolving needs of their consumers.

Contact:

Future Market Insights,1602-6 Jumeirah Bay X2 Tower,Plot No: JLT-PH2-X2A,Jumeirah Lakes Towers, Dubai,United Arab EmiratesFor Sales Enquiries: sales@futuremarketinsights.com For Media Enquiries: press@futuremarketinsights.com Website: https://www.futuremarketinsights.com/ Report: https://www.futuremarketinsights.com/reports/probiotic-cosmetics-market Press Release Source: https://www.futuremarketinsights.com/press-release/probiotic-cosmetics-market

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SOURCE Future Market Insights

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Probiotic Cosmetics Market is projected to total US$ 594.7 Mn By 2031, as the Demand for Facial Care Products Increases: FMI - Yahoo Finance

The link between inflammation and the risk of cancer is much studied currently. Inflammation originally evolved as the bodys response to various pathogens (such as viruses, bacteria, and parasites). A recent study carried out at Tampere University in Finland discovered that the expression of an allergy-related receptor chain for proinflammatory IL-13 cytokine (IL-13Ra1) protects against experimental skin cancer.

The key soluble transmitters of inflammation are a group of glycoproteins secreted by inflammatory cells called cytokines. In allergic diseases such as allergic asthma, atopic eczema and allergic rhinitis, the symptoms arise from what is known as the type 2 inflammatory response (type 2 inflammation). One of the key cytokines in type 2 inflammation is interleukin-13 (IL-13), which causes, among other things, bronchoconstriction, and increased mucus secretion in allergic asthma.

The basic finding of a recently published study is that the expression of the IL-13 receptor associated with allergic inflammation protects against experimental skin cancer; the tumors formed earlier and were more abundant in the absence of IL-13Ra1 than in its presence. Mice were used as experimental animals in the study. Murine T cells show little expression of the IL-13 receptor and, somewhat surprisingly, the study found that IL-13 receptor deficiency led to an increase in the number of immune-suppressing regulatory T cells during the development of skin cancer.

According to the researchers, this fits well with the idea that excessive regulatory T-cell activity, by inhibiting the immune response against tumour cells, may provide space for cancer to develop. While the exact mechanism remains unclear, it is clear that when the IL-13 receptor expression on the cell surface is absent during the development of cancer, the number of regulatory T cells increases, and the immune response is suppressed (skewed). This then may leave space for cancer cells to grow and form tumours.

The researchers also shed new light on the relationship between inflammation and cancer.

We made the interesting observation that IL-13 receptor deficiency leads to aberrant neovascularization in skin tumours. The abnormal accumulation of inflammatory cells after IL-13Ra1 deficiency strongly suggests that there is a chronic oxygen deficiency in the tumours associated with this abnormal new blood vessel formation. This potentially drives the formation of cancer, says ProfessorTero Jrvinen.

This is an interesting finding because cellular signalling via the IL-13 receptor has been considered a very specific allergy-related phenomenon. Our discovery that IL-13 signalling pathway might also potentially be very centrally involved in the regulation of cellular oxygen supply remains to be studied but might in some ways change our thinking about the role of immune defence in the fight against cancer. It would be straightforward to think that it is the IL-13 receptor that regulates the bodys immune defence (inflammatory response) against cancer, Jrvinen adds.

However, it is possible that the IL-13 receptor regulates tumour neovascularization and that the immune response is a secondary response to the lack of oxygen that develops in the tumour, Academy of Finland Research FellowIlkka Junttilacontinues.

Junttila and Jrvinen will therefore continue to investigate the current finding at the molecular level.

It is easy to see two new lines of research opening up in the wake of this finding: both the basic immunological effect of immune response on cancer development and the molecule-level role of IL-13Ra1 in it, and on the other hand the effect of the IL-13 receptor on neovascularization, Jrvinen and Junttila say.Reference:Salomaa T, Pemmari T, Mtt J, et al. IL-13R1 suppresses tumor progression in two-stage skin carcinogenesis model by regulating regulatory T cells. J Invest Dermatol. 2021;0(0). doi:10.1016/j.jid.2021.11.013

This article has been republished from the following materials. Note: material may have been edited for length and content. For further information, please contact the cited source.

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Exploring the Link Between Inflammation and Skin Cancer Risk - Technology Networks