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First variant of concern evolved to evade immune system – EurekAlert
Posted: December 23, 2021 at 10:11 pm
The Alpha variant of SARS-CoV-2the first variant of concernevolved mutations that allowed it to more efficiently suppress the immune systems early response to infection, according to a new study led by scientists at the University of California, San Franciscos Quantitative Biosciences Institute (QBI) and University College London.
The researchers have discovered that the variant has ramped up production of a protein that it uses to stifle infected cells immune-stimulating signals. The mutations responsible for this change likely help the Alpha variant evade immune detection and accelerates its transmission, and importantly similar mutations exist in Omicron. The findings are reported in the December 23rd issue of Nature.
The team, led by senior authors Nevan Krogan, Ph,D, of the University of California, San Francisco and Claire Jolly, PhD,and Greg Towers, PhD, of University College, London, found that Alphas enhanced infectivity arose from mutations outside of spike, the proteins that have attracted much of scientists attention since the start of the pandemic. Spike, which the virus uses to enter the cells of its host, is critical to infection and is the target of all available Covid-19 vaccines. But it is just one of many tools that the virus uses to manipulate its host.
While scientists have closely monitored mutations in the spike region of new variantsOmicron has over 30Krogan emphasized that changes in other regions might also have important impact.
The mutations in spike allow the virus to get into cells more effectively. But what about after the virus gets into cells? There may be other mutations that allow it to replicate more, said Krogan, who also leads UCSFs Quantitative Biosciences Institute (QBI) and its Coronavirus Research Group (QCRG).
After it was first detected in the United Kingdom in late 2020, Alpha spread rapidly around the world, suggesting it was significantly more transmissible than the original virus.
But experiments in Towers lab indicated that the new variant replicated no faster than its predecessor. Seeking an explanation, the QCRG set out to learn if the new variant interacted differently with the cells it infected.
The team, which also included researchers at the Massachusetts Institute of Technology (MIT), European Molecular Biology Laboratory (EMBL) and the Icahn School of Medicine at Mount Sinai, compared the variants impact on host cells to that of virus isolated early in the pandemic.
To do so, postdoctoral scholar Mehdi Bouhaddou, PhD, QBI senior scientist Lorena Zuliani-Alvarez, PhD, both co-lead authors on the study, measured the activity of each gene and monitored protein levels in lab-grown cells infected by the virus. They also surveyed the phosphorylation status of the proteinsan analysis that detects chemical modifications that can temporarily adjust proteins function.
Using this data to compare the response to infection with Alpha and the original virus, the researchers found that many of the significant differences involved the innate immune response, the bodys first line of defense against pathogens. Many of the genes involved in rallying this defense were barely activated in the presence of the SARS-CoV-2 Alpha variant.
In addition, the team discovered that the Alpha-infected cells contained large amounts of three viral proteins know to help the virus evade the bodys immune response. Further experiments showed that one of them, called Orf9b, accomplishes that task by latching on to a protein that switches on immune-stimulating genes.
The findings suggest it may be possible to help the immune system fight SARS-CoV-2 by developing drugs that block this interaction and a potential strategy for doing so.
Alpha has since been outpaced by newer variants whose mutations spur even more aggressive transmission. The virus will keep evolving and adapting to the host, and every time it will adapt better and better, said Zuliani-Alvarez. That's why Omicron has 53 mutations.
Both the Delta and Omicron appear to be cousins of Alpha, each having mutations in two of the three regions the team studied, suggesting they may have similar effects on the innate immune system.
The findings demonstrate the value of understanding the full scope of changes shaping the behavior of viral variants. Studying the variants of concern gives us ideas about how SARS-CoV-2 evolves, said Bouhaddou. Now we have a sense of the proteins that are mutating most frequently, and the biological consequences of those mutations. I think this helps us prepare for what might come next.
Link to study:https://www.nature.com/articles/s41586-021-04352-y
About UCSF:The University of California, San Francisco (UCSF) is exclusively focused on the health sciences and is dedicated to promoting health worldwide through advanced biomedical research, graduate-level education in the life sciences and health professions, and excellence in patient care.UCSF Health, whichserves as UCSFs primary academic medical center, includestop-ranked specialty hospitalsandother clinical programs,and has affiliations throughout the Bay Area.UCSF School of Medicine also has a regional campus in Fresno. Learn more atucsf.edu or see ourFact Sheet.
About QBI: The Quantitative Biosciences Institute (QBI) fosters collaborations across the biomedical and the physical sciences, seeking quantitative methods to address pressing problems in biology and biomedicine. Motivated by problems of human disease, QBI is committed to investigating fundamental biological mechanisms, because ultimately solutions to many diseases have been revealed by unexpected discoveries in the basic sciences. Learn more atqbi.ucsf.edu.
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Experimental study
Cells
Evolution of enhanced innate immune evasion by SARS-CoV-2
23-Dec-2021
Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.
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First variant of concern evolved to evade immune system - EurekAlert
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Double vaccinated and still infected with Omicron? Heres how long you should isolate – The Indian Express
Posted: at 10:11 pm
Amid the surge in Omicron cases, one of the commonly asked questions is how long should an infected patient quarantine, especially if they are double-vaccinated.
As per World Health Organization (WHO), the overall threat posed by the variant of concern largely depends on three key aspects its transmissibility, how well the vaccines and prior SARS-CoV-2 infection protect against it, and how virulent the variant is as compared to other variants.
Dr Abhishek Subhash, Consultant Internal Medicine at Bhatia Hospital said that in India, currently, the isolation period for Omicron patients is 14 days. In the US, it is 10 days for vaccinated patients, and five days after taking the booster shots.
In the US, where the Holiday season is in progress, there is a recommendation to reduce the 10-day quarantine, as per White House medical adviser Anthony Fauci.
Thats certainly an important consideration which is being discussed right now, said Fauci, director of the National Institute of Allergy and Infectious Diseases, reported CNN. This will help asymptomatic people return to work or school, the proper precautions, as per Fauci.
While breakthrough infections are rising among the fully vaccinated population, the symptoms are milder, experts point out. As a result of extensive vaccination drives, the severity of the disease is milder and has shown good response to conventional medications that we use for Covid 19, said Dr Gopi Krishna Yedlapati, consultant interventional pulmonologist, Yashoda Hospitals, Hyderabad.
Countries can and must prevent the spread of Omicron with proven health and social measures. Our focus must continue to be to protect the least protected and those at high risk, said Dr Poonam Khetrapal Singh, Regional Director, WHO South-East Asia Region.
How is Omicron detected?
As per Indias Ministry of Home and Family Affairs (MoHFW), the most accepted and commonly used method of diagnostic for SARS-CoV2 variant is the RT-PCR method. This method detects specific genes in the virus, such as Spike (S), Enveloped (E) and Nucleocapsid (N) etc to confirm the presence of virus.
However, in case of Omicron, as the S gene is heavily mutated, some of the primers may lead to results indicating absence of the S gene (called as S gene drop out). This particular S gene drop out along with the detection of other viral genes could be used a diagnostic feature of Omicron. However, for final confirmation of the omicron variant genomic sequencing is required, reads the Ministrys statement.
Treatment
The treatment protocols are similar in both delta and omicron, that is isolation for 14 days and strict monitoring of the infection and proper check-up with the pulmonologist, stated Dr Yedlapati.
Even if it does cause less severe disease, the sheer number of cases could once again overwhelm health systems. Hence, as per WHO, health care capacity including ICU beds, oxygen availability, adequate health care staff and surge capacity need to be reviewed and strengthened at all levels.
How to prevent it?
The precautions and steps to be taken remain same as before. As per MoHFW, it is essential to mask yourself properly, take both doses of vaccines (if not yet vaccinated), maintain social distancing and maintain good ventilation.
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Find Answers in Your DNA (Sponsored) – WebMD
Posted: at 10:08 pm
Do you have questions about your health? Your DNA may hold the answers. Your bodys genetic code that makes you unique also tells an important story about where you come from and where youre going. Consider it your own internal crystal ball, holding the clues to how youll develop.
Your DNA truly tells a story. It can show you what part of the world your ancestors came from, connecting you to communities across the world. It can help you understand why your hair is curly or straight, or why your eyes are brown or blue. It can reveal fun facts like whether you have an affinity for cilantro or whats unique about your ear wax. And, perhaps most critical, it can contain clues to why certain health conditions might run in your family.
With all of these exciting possibilities, its no wonder that DNA testing especially at-home DNA kits to learn about ancestry has been so popular in recent years. In fact, a 2019 study found that more than 26 million people had taken an at-home, mail-in DNA ancestry test offered by a handful of companies that swiftly came on the market. But did you know theres also an opportunity to test your DNA, uncover answers about your ancestry, reveal fun facts about your tastes and unique attributes, learn about your potential health risks, and help researchers uncover patterns about health that may transform the future of personalized medicine all at no cost to you?
That opportunity is available to anyone age 18 and older in the United States, simply by participating in The All of Us Research Program. A historic initiative by the National Institutes of Health (NIH) to engage one million or more people from communities across the country in medical research that aims to change the face of health care as we know it. All of Us is building one of the largest, most diverse databases to inform thousands of studies on a variety of health conditions. By involving participants from all demographics, including many who have historically been underrepresented in medical research, All of Us aims to change health care from the one-size-fits-all approach it often is today to a more individualized approach for tomorrow.
How? One way is through DNA. In addition to answering a wide range of surveys with questions about your health, your family history, the environment you live in participants also have the benefit of sharing biosamples, such as blood, urine and saliva, to help researchers uncover the answers only your DNA can provide. Doing so not only provides you the participant with valuable information about your own personal health and family history, but it also creates infinitely valuable opportunities for medical researchers to know the risk factors for certain diseases and figure out which treatments work best for people of different backgrounds.
But All of Us can only achieve this mission if it involves, you guessed it, All of Us. If you have questions about your health and your familys ancestral history, the next step to find the answers may be by joining the hundreds of thousands of people across the United States already aiding All of Us researchers in their mission to revolutionize precision medicine. A healthier future for all of us begins by taking an in-depth look at your ancestral past; your DNA may hold the key. Unlock the door to a healthy future today. Learn more at the All of Us website.
All of Us is a service mark of the U.S. Department of Health and Human Services. 2021
WebMD does not endorse any specific product, service, or treatment.
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Find Answers in Your DNA (Sponsored) - WebMD
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There are thousands of unidentified remains. Meet the volunteer organization trying to identify them – 12news.com KPNX
Posted: at 10:08 pm
The DNA Doe Project is a group of dozens of volunteers using DNA and family trees to identify the unidentifiable.
PHOENIX There are an estimated 40,000 unidentified human remains in the United States.
That's 40,000 people who have no names and no closure for families missing their loved ones.
They had a life, they had a story," said Carrien Binder, a genetic genealogist with the DNA Doe Project. They deserve to have their name back.
The project began in 2017. It's made up of 40 to 60 unpaid volunteers trying to figure out who these people are.
Our goal is to identify Jane and John Doe's using genetic genealogy, Binder said.
The idea is to get a DNA sample from the "Doe" and then compare it with publicly sourced DNA databases like GenBank. The project then looks for relatives and begins forming a family tree.
We can use really distance matches like fifth cousins, third cousins, and fourth cousins to build up family trees and make an identification, Binder said.
The project works in groups trying to puzzle together a tree. Sometimes identifications come together quickly. There is a DNA hit that is a close relative. Other times the puzzle can take years, looking for that missing branch to help identify a John or Jane Doe.
"This is my main hobby. I dont watch a lot of Netflix. I dont have a lot of time for other things. But it is really fulfilling and satisfying and it scratches that mystery-solving itch." Binder said.
In the last few months, The DNA Doe Project identified two previously unidentified people: A woman found in downtown Phoenix in 2017 and a murder victim found on baseline road in 1983.
A lot of people assume if someone is a John or Jane Doe, no one is looking for them. And I have found that is never true.
In four years, the project has identified more than 70John and Jane Doe's. Binder said at least a third of those identifications happened in the last year.
"They deserve to be recognized as a whole person, with a family with hobbies," Binder said, "I think we can give them a part of that when we restore their name"
If you want to help the program you can always donate.
Also if you do have DNA results from at-home DNA tests like 23andMe and ancestry type groups, you can share them with a publicly sourced site to give them more potential matches.
Catch up on the latest news and stories on the 12 News YouTube channel. Subscribe today.
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There are thousands of unidentified remains. Meet the volunteer organization trying to identify them - 12news.com KPNX
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Woolly mammoths and humans coexisted in North America much longer than experts thought – Livescience.com
Posted: at 10:08 pm
Woolly mammoths may have survived in North America thousands of years longer than scientists previously thought, vials of Alaskan permafrost reveal.
The hairy beasts might have persisted in what is now the Yukon, in Canada, until around 5,000 years ago 5,000 years longer than experts previously estimated, a new study suggests. That conclusion comes from snippets of mammoth DNA that were found in vials of frozen dirt that had been stored and forgotten in a laboratory freezer for a decade.
Related: Mammoth resurrection: 11 hurdles to bringing back an ice age beast
"Organisms are constantly shedding cells throughout their life," said study lead author Tyler Murchie, a postdoctoral researcher in the Department of Anthropology at McMaster University in Ontario. For instance, He explained thata person sheds roughly 40,000 skin cells per hour, on average, meaning we are constantly ejecting bits of our DNA into our surroundings.
That's also true of other life-forms; nonhuman animals, plants, fungi, and microbes are constantly leaving microscopic breadcrumb trails everywhere. Most of this genetic detritus doesn't linger in the environment, though. Soon after being discarded, the vast majority of the DNA bits are consumed by microbes, Murchie said. The fraction of the shed DNA that does remain might bind to a small bit of mineral sediment and be preserved. Though only a tiny proportion of what was initially shed remains centuries later, it can nevertheless provide a window into a vanished world teeming with strange creatures.
"In a tiny fleck of dirt," Murchie told Live Science, "is DNA from full ecosystems."
Murchie analyzed soil samples taken from permafrost in the central Yukon. Many of the samples dated to the Pleistocene-Holocene transition (14,000-11,000 years ago), a period marked by rapidly changingclimatic conditions in which many large mammals such as saber-toothedicats, mammoths and mastodons vanished from the fossil record.
The DNA fragments in Murchie's samples were small often no larger than 50 letters, or base pairs. However, on average, he was able to isolate roughly 2 million DNA fragments per sample. By analyzing DNA from soil samples of known ages, he indirectly observed the evolution of ancient ecosystems over this turbulent period.
The main advantage to studying ancient DNA is that researchers can observe organisms that tended not to fossilize well. "An animal has only one body," said Murchie, and the odds of it fossilizing are not that great. On top of that, you have to find it. But that same animal constantly ejected innumerable amounts of DNA into the environment throughout its lifetime.
The soil samples which span a period of time from 30,000 years ago to 5,000 years ago revealed that mammoths and horses likely persisted in this Arctic environment much longer than previously thought. Mammoths and horses were in steep decline by the Pleistocene-Holocene transition, the DNA data suggest, but they didn't disappear all at once due to changes in climate or overhunting.
An earlier study, published in October in the journal Nature, suggested that some mammoths survived on isolated islands away from human contact until 4,000 years ago. However, the new study is the first to determine that small populations of mammoths coexisted with humans on the mainland of North America well into the Holocene, as recently as 5,000 years ago.
. Megafauna extinctions from this era have largely been blamed on one of two explanations: human paleo-hunters or climate catastrophe, said lead author Hendrik Poinar, an evolutionary geneticist and director of the McMaster Ancient DNA Centre.
However, the new study "changes the focus away from this two-pitted debate that has plagued [paleontology] for so long," Poinar said.
The team's research provides evidence that the extinction of North American megafauna is much more nuanced, he said. There's no doubt that the animals were under pressure from both human hunters and a rapidly changing climate. The question is, "how much were they hunted and whether or not that was truly the tipping point," Poinar told Live Science.
Analyzing ancient DNA from dirt has the potential to tell us a lot about ancient life; Poinar and Murchie said Arctic permafrost is ideal for these types of ancient DNA studies because freezing preserves ancient DNA very well. But that might not be possible forever: As ice in the Arctic melts due to rapid increases in temperature, "we're going to lose a lot of that life history data," Murchie said. "It's just going to fall away before anyone gets a chance to study it."
This study was published Dec. 8 in the journal Nature Communications.
Originally published on Live Science.
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Gift Someone The Ability to Unlock Their DNA This Holiday With InsideTracker – Men’s Journal
Posted: at 10:08 pm
Mens Journal aims to feature only the best products and services. We update when possible, but deals expire and prices can change. If you buy something via one of our links, we may earn a commission.Questions? Reach us at shop@mensjournal.com.
The ultimate gift is the gift of healthfor you and for your friends and family. But your body is a complex machine, and fine-tuning your health is not as straightforward as, say, fine-tuning your car. It can be pretty overwhelming. Luckily, optimizing your health isnt an independent journey. And personalized guidance on understanding whats best for your body can come with a dedicated support system. Enter InsideTracker.
Founded in 2009 by top scientists at MIT, Harvard, and Tufts in the fields of aging, genetics, and biology, InsideTracker is a truly personalized nutrition and performance system. You can choose from several, customizable plans that analyze data from your blood, DNA, wearable fitness devices (like Garmin and FitBit, and lifestyle to deliver a science-backed Action Plan to help guide you toward optimal health.
By taking a deeper look inside, you can see objective metrics that tell the story of your health and uncover advanced physiological analysis into how your body is performing. Most people are accustomed to occasional, generic blood work that may come at the request of your doctor, but for seeking a more comprehensive view of your health, InsideTracker provides personalized plans that go well beyond a traditional blood test.
Several InsideTracker plans include a blood draw. InsideTracker makes this process simple and streamlined. Most customers book an appointment at one of the 2,000 Quest Diagnostics testing sites across the US. Or you can also get tested right from your home by scheduling an appointment with a certified phlebotomist (just click include mobile blood draw at checkout). Additionally, you can upload your blood data from a previous test for even more convenience.
After your blood is tested, youll be prompted to complete a questionnaire asking about your lifestyle habits. Be as specific as possible, because InsideTracker takes all those factors into consideration when providing you with recommendations.
Lastly, you will select the health goal that matters most to youlike heart health, endurance, strength & power, or immunity to name a few.Based on the analysis of your test results and questionnaire, InsideTrackers proprietary algorithm creates a highly personalized Action Planprioritizing food, supplement, and exercise recommendations that align most with your selected goal. Youll gain access to the science behind why these are the best actions for your personal well-being.
With InsideTracker, your path to optimal health becomes measurable, trackable, and manageable. Once you have your test results, the InsideTracker app will become your central place to access your data, see your analysis, and actively track your progress. And with routine testing (recommended every 3-6 months) you can see exactly how the changes youve made are impacting your internal biomarkers.
There are several plans to choose from, depending on the level of analysis you are looking to receive. Check out the options below to find one that fits with your health and wellness goals. . And right now, you can save 25% on your order when you use code INSIDETWENTYFIVE at checkout!
With InsideTracker, youll have everything you need to add years to your lifeand life to your years.
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Gift Someone The Ability to Unlock Their DNA This Holiday With InsideTracker - Men's Journal
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DNA Special: COVID-19 changed everything but politics – DNA India
Posted: at 10:08 pm
Due to the increasing cases of COVID-19 in most cities of India, you will neither be able to celebrate Christmas with your friends nor will you be able to have a New Year party. Christmas and New Year's party has been banned in many big cities of the country including Delhi. Even in weddings, you can no longer invite more than 200 guests. But if you are holding a political rally, you can also invite 2 lakh people to that. In many places, you cannot go to a mall or a government office without taking both doses of the vaccine. But if you go to a political rally, neither you will be asked about the mask nor will you be asked for information about vaccination. If you have a big party or you want to invite thousands of people to the wedding, then declare yourself a politician and your program as an election rally. By doing this, you can invite as many people as you want.
In the last two years, COVID-19 has changed our lives. People working in offices are doing work from home, online hearings are being held in courts. Online classes are going on in schools. The customs after birth and death are also happening online. Sports like IPL and Olympics are being organized without spectators. And movies are being released on OTT instead of theatre. But there is one area where COVID-19 has not made any difference at all and that is politics. Even now, elections are being held as before, voting is also happening in the same way and the attitude of the politicians is also the same.
In the last two years, neither the elections have changed, nor the process of elections has changed nor the manner in which the politicians' rallies have changed. At present, massive campaigning is going on for the Uttar Pradesh Legislative Assembly elections. And all the parties are holding rallies by mobilizing thousands of people. But there is no restriction on these rallies. More than 40 state-level elections have been held in India in the last two years and next year's calendar is also full from the election dates.
In the year 2022, elections to the Legislative Assembly are to be held in seven states of Uttar Pradesh, Goa, Punjab, Uttarakhand, Himachal Pradesh, Gujarat and Manipur. During this time, even if the cases of coronavirus increase in these states, perhaps, the process of elections and elections will not change at all.
Unfortunately, no more than 200 guests can come in a wedding ceremony today, but in election rallies, 20,000 people can easily gather at one place. You can't party in a restaurant or pub with more than 50 people, but you can go to a crowd of thousands at an election rally. You cannot go to a shopping mall or shop without a mask and vaccination. But you can easily go to the rallies of leaders, where no one will ask you for a mask or ask for vaccination.
That is, the situation has become such that today if someone is getting married in your house and you call people in that marriage saying that they are organizing an election rally then probably the administration and governments will not take any action against you. But if you have invited more than 200 guests to the wedding or party with 50 people on Christmas then you can also be arrested under criminal sections and can also be fined up to a maximum of Rs 2 lakh.
However, we are not saying this thing only for India. Politics is the only area in the whole world that has not changed.
In the last two years, since the pandemic arrived, elections have been held in 146 countries of the world. Out of these, there are 124 countries where national and state-level elections have been held. That is, elections were held for the post of President, Prime Minister, Chief Minister and Governor and in these elections, the leaders held rallies among the crowd, Due to this, the cases of coronavirus also increased in these countries. For example, Presidential elections were held in America last year and due to these elections, there was a tremendous explosion of COVID-19. But despite this, the politics there did not change.
Elections were also held in South Korea, Mongolia, Singapore, Sri Lanka and Croatia despite increasing cases of infection. And when people died from this disease, these leaders did not even take moral responsibility for it. Rather, these leaders became silent when it came to taking responsibility.
That is, the world has told you that in COVID-19, markets can be closed for common people, marriage can also stop, jobs can also be done from home, customs of birth and death can also be changed and movies can also be released online instead of cinema halls. That is, everything can be changed and stopped for you. But nothing can stop for politics and politicians. Whether coronavirus remains or not, politics will remain the same as it was before.
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DNA Special: COVID-19 changed everything but politics - DNA India
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Burglar left DNA on porthole window he was filmed peering through – Liverpool Echo
Posted: at 10:08 pm
A hapless burglar who targeted two locations an hour apart was snared after CCTV filmed him pressing his face against a porthole window to peer inside.
Liam Lingham, 26, of Laburnum Grove, Runcorn, and an unknown accomplice first struck at The Food Group on Dalton Court in Astmoor Industrial Estate at 10.50pm on Thursday, March 11.
Kate Morley, prosecuting at Chester Crown Court today, said CCTV showed the pair approach and this defendant could be seen with his face up at a porthole window.
Forensic tests were later able to match DNA retrieved from the glass to Lingham.
READ MORE: Man stabbed to death was 'loving dad of two married to childhood sweetheart'
After searching inside a van without finding anything, the burglars forced entry to an office and made an untidy search and swiped between seven and 10 Euros from on top of a desk.
At 9am the next morning, it was discovered that the same two intruders had entered a dock office at Bridgewater Motor Club on Victoria Road at about 12.10am
The building, described as a shipping container, wasnt secured as access but the burglars forced an internal door and dragged a cabinet out of place to force it open, revealing two cash tins inside, from which they stole about 200-250 and left.
Repair costs for the club were estimated at about 200 plus labour.
After his arrest by Cheshire Police on September 20, Lingham was also charged in connection with a burglary at Halton Play Council resource centre on Mersey Road, Runcorn, on June 27 but in light of the two guilty pleas on October 19 to the other burglaries, prosecutors decided not to seek a trial in respect of the Mersey Road allegation.
Ms Morley told the court Lingham, who brought a large packed bag with him to court and whose female supporter sat weeping in the public gallery for much of the hearing, had 22 convictions for 49 offences.
These spanned dwelling burglaries, handling stolen goods offences, theft from a vehicle, taking a vehicle without consent, possession with intent to supply Class A drugs, aggravated vehicle taking, and theft.
The most recent of those was in 2018.
Judge Simon Berkson sought details of the tag Lingham has been on since September 21 as part of his deliberations.
Paul Wood, defending, said his client deserved credit for his guilty pleas and had complied with his curfew conditions.
He cited a positive pre-sentence report but acknowledged Linghams negative antecedent history.
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Mr Wood said Lingham was a father with children and has developed a positive attitude, particularly following the recent birth of a baby.
He said the public interest could be best served by a suspended sentence with conditions, and urged the court to give his client a last chance.
Judge Berkson concurred and although he accepted Lingham was a "prolific" offender, sentenced him to 12 months in prison, suspended for 18 months, with a 25-day rehabilitation activity requirement and 120 hours of unpaid work plus curfew.
He told Lingham he had a terrible record but offered him a chance to mend his ways.
Judge Berson said: Since committing that offence and being arrested you havent committed any other crime and have complied with a stringent curfew and come before the court with a positive pre-sentence report and a suggestion you can stay out of trouble.
Lingham lit a cigarette and beamed with joy after leaving court.
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Burglar left DNA on porthole window he was filmed peering through - Liverpool Echo
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As Brazil looks to the future, its president looks to Trump playbook – The Bakersfield Californian
Posted: at 10:03 pm
SAO PAOLO Inara Couto, a 54-year-old teacher here, won't shop at stores whose owners support Brazilian President Jair Bolsonaro.
She stopped speaking to some of her oldest friends for the same reason.
Her husband, Sergio, is so at odds politically with his Bolsonaro-backing, coronavirus-vaccine-refusing brother that the two mostly limit their conversations to a single topic: soccer.
Ten months before the next presidential election, Brazil is more polarized than at any point in recent memory, with political conflicts and raging culture wars souring friendships, wrecking family gatherings and spilling into the streets.
At the center is Bolsonaro, 66, a far-right nationalist who rode into office three years ago on a wave of populist anger over corruption and who now insists there are only three possibilities for his future: jail, death or reelection.
Like former President Donald Trump, whom Bolsonaro has described as his "idol," the Brazilian leader has downplayed the coronavirus, stoked racial resentments, relaxed environmental protections and rallied his supporters to the nation's capital to protest his perceived enemies in Congress and the courts.
With the help of Trump strategist Steve Bannon, he has already begun sowing doubt about electoral fraud in the event that he loses.
And as in the United States a year ago, the opposition's best hope of defeating the demagogic incumbent rests with an old stalwart of the left who is trying to kindle nostalgia for more civil and prosperous times.
Polls show Bolsonaro badly trailing former President Luiz Incio Lula da Silva, the charismatic 76-year-old democratic socialist who was jailed in 2018 for corruption but released the following year after his convictions were annulled.
Lula, as he is known, is a divisive figure in his own right, beloved by many for lifting millions out of poverty but despised by others as a symbol of Brazil's entrenched corruption.
Even if Lula wins, there are questions about whether Bolsonaro and his supporters will accept defeat and whether his tenure has done irreparable harm to the country's fragile democracy.
Bolsonaro, a former military officer, has lionized the country's former military dictatorship, vowed to defy Supreme Court rulings and has called on his supporters to arm themselves.
The rally he organized in Brasilia in September did not turn violent, as many feared. But the deterioration of political discourse is evident nearly everywhere from heated WhatsApp groups to impassioned dinner table debates.
This month, Bolsonaro supporters and members of his security detail attacked journalists who were trying to interview him. In the city of Borba, two rival politicians settled their differences with kicks and punches in an MMA-style fight.
Couto recently marched in an anti-Bolsonaro protest, holding a sign that read: "This nightmare must come to an end."
A survivor of Brazil's repressive dictatorship, which ruled from 1964 to 1985, she said life has never felt more turbulent than it does today. The country's economy is in recession, more than 600,000 people have died from the coronavirus, and she finds herself constantly bracing for conflict, whether with a stranger or a beloved member of her family.
"It's like a big collective madness," she said. "We feel like we are in some kind of dystopian novel one that is very poorly written."
It wasn't long ago that Brazilians were filled with hope.
In the 2000s, global demand for beef, soybeans and iron and Lula's broad social programs including cash payments to the poor lifted an estimated 20 million people out of poverty.
When Lula left office in 2010 after serving the maximum two consecutive presidential term limits, he had an 83% approval rating and had been dubbed by former President Barack Obama as the "most popular politician on Earth."
But shortly after Lula's protege, Dilma Rousseff, took office, commodities prices began to fall and the economy crumbled. Sprawling corruption investigations implicated politicians from across the ideological spectrum, including Rousseff and Lula.
Conservatives seized on the disappointment, impeaching Rousseff in 2016 on charges of manipulating the federal budget. During the trial, a fringe congressman drew national attention when he dedicated his impeachment vote to a Brazilian army officer who had captured and tortured Rousseff when she was a young guerrilla fighting the dictatorship.
That congressman was Bolsonaro, who won election two years later by modeling himself after Trump as a politically incorrect outsider who would "make Brazil great" by cleansing politics of corruption and cracking down on crime with an iron fist.
He called immigrants "scum," said a female political rival was so ugly she was "not worth raping" and proclaimed that he would prefer his son die than be homosexual.
But many voters were so eager for a change that they were willing to overlook such inflammatory statements.
"He goes too far sometimes, but he talks straight to the people," said Eurico Da Conceio Santos, a 49-year-old lawyer who had once supported both Lula and Rousseff but came to regret it when they were accused of corruption.
He said it is his duty as an evangelical Christian to support Bolsonaro. A conviction has helped him overlook recent accusations of corruption against two of the president's sons.
Santos spoke over the din of Christian rock playing at a church party for teenagers where he was volunteering on a recent afternoon.
The pastor at the church, Change Life Ministry, has described Bolsonaro, who furiously opposes abortion and LGBTQ rights, as "an instrument of God."
A majority of Brazil's growing population of evangelical Christians continue to support Bolsonaro, even as it has led to some intense family debates.
Some of Santos' relatives question how he can be a Christian but also support Bolsonaro policies they consider un-Christian, including calls to arm more Brazilians with guns.
His wife, Sandra Hinz Da Souza Santos, a 52-year-old accountant, shares her husband's political views but worries where it will lead the country.
"We're tearing Brazil apart," she said.
Other segments of society, including women and people with college degrees, have lost patience with the president.
The turning point for most was the coronavirus, which Bolsonaro famously dismissed as a "little flu" even as it ravaged Brazil.
In the face of the pandemic, he encouraged mass gatherings, mocked masks in a bid to achieve herd immunity and recommended unproven treatments.
His policies including his government's delay in procuring vaccines led to 300,000 deaths, more than half the total in Brazil, according to a congressional panel that recently recommended he be charged criminally with "crimes against humanity."
Other investigations into Bolsonaro including a Supreme Court probe into his false claim that COVID-19 vaccinations put people at a higher risk of contracting AIDS have also damaged his popularity.
So has the country's deepening economic crisis. With 13% of the workforce unemployed and soaring inflation, millions of people are going hungry. Public parks have been swallowed up by tent cities, with entire families living on the streets.
As he trudged through downtown So Paulo on a recent afternoon, handing out his resume to anybody who would accept it, Jos Bonfim, 56, said the hard times had made him long for the days of Lula, his candidate for next year's election.
Bonfim was laid off a year ago when the restaurant where he had flipped burgers for 13 years closed because of the coronavirus.
Under Lula, he had been able to buy a car. It's sitting at home now, unused. "I have no money for gas," he said.
There are other candidates who have sought to appeal to voters in the center, but some of them also have sullied reputations.
Srgio Moro, the judge who oversaw Lula's corruption case and who was later named Bolsonaro's justice minister, was disgraced earlier this year when leaked messages showed he had offered strategic advice to prosecutors in the Lula trial.
Another likely candidate, Ciro Gomes, had his home raided by federal police last week as part of a corruption investigation.
And so the race continues to be dominated by two candidates from the left and right who are appealing to nostalgia for very different versions of the past.
Nilton Gonalves de Oliveira, the owner of a firearms store called Top Gun, voted for Bolsonaro in 2018 because he vowed to ease gun restrictions. The president made good on his promise, in 2019 signing an order increasing the amount of ammunition a person can buy in a year and making it easier to import guns.
Oliveira said he also understood Bolsonaro's appreciation for the dictatorship. Back then, he said, there weren't furious debates about politics and racism such as the ones that have consumed his soccer team, making postgame celebrations unpleasant. The streets were safe and work was ample, he said.
"Everybody had a job," he said. "It was not so bad."
He's looking forward to voting for Bolsonaro again.
(Special correspondent Marcelo Soares in So Paulo contributed to this report.)
2021 Los Angeles Times. Visit at latimes.com. Distributed by Tribune Content Agency, LLC.
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As Brazil looks to the future, its president looks to Trump playbook - The Bakersfield Californian
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Peace On Earth Requires More Good Will | Opinion | coronadonewsca.com – Coronado Eagle and Journal
Posted: at 10:03 pm
The angels message to the shepherds announcing the good news of the birth of a Savior spoke of peace on earth toward men of good will. We could use a little more of each. Two thousand and twenty-one years later, peace is still elusive and good will even more so. Still every year at Christmas, we repeat those sentiments and hope that the season will bring new reasons for hope.
The birth of Christ brought hope to the world and as we celebrate each anniversary of that birth, we renew that hope for peace and mutual good will among people. Even during the darkest days of our Civil War and two World Wars, there are recorded instances of brief pauses in the fighting to celebrate Christmas and to pray and sing carols, sometimes across battle lines.
Each year there are words spoken about the real meaning of Christmas but they often miss the mark. Were told that Christmas is about giving, often resulting in an orgy of Christmas shopping and stress over what to give to whom. Thats great for sales and profit and no one should begrudge the revenue that merchants may require to make their entire year profitable. The three kings brought gifts to the infant Jesus but somehow today the giving of lavish gifts while others starve, lack shelter and struggle to heat their homes doesnt seem to be exactly what Christmas is all about. Think, then, about including the needy through your favorite charities on your Christmas gift list.
When asked, many answer that Christmas is mainly for children and for the annual visit of Santa Claus laden with gifts. Thats a wonderful sentiment and tradition but its certainly not what Christmas is all about. Christmas is for everyone, not just for children. But while youre planning the best Christmas ever for your kids, think about including charities that provide clothing, toys and treats for needy children on your gift list.
Christmas season is a time for church celebrations including Christmas concerts featuring the beloved classical Christmas music of the masters which has inspired worshipers for generations. The past two years, however, has seen a precipitous decline in church attendance. Covid pandemic precautions contributed to part of that but the start of the decline preceded the pandemic. For many Christians, attending church is just a twice a year event, mainly to enjoy the pomp and ceremony of Easter and Christmas celebrations, including the beautiful religious music beautifully sung and played by artists. Sadly, some churches have cut back on music programs which contributed so much to these celebrations for decades.
America was founded by Christian pilgrims who sought religious freedom and has prospered among the nations as a nation under God. Our values, traditions and culture are based on Christian-Judaic principles. For most of our history we have celebrated Christmas as a Christian holiday while extending Christmas greetings and blessings not only to other Christians but to all people of good will. We did, that is, until it became politically incorrect to do so and Merry Christmas became Happy Holidays. But Christmas refers quite specifically to the annual celebration of the birth of Jesus Christ. To Christians, it is more than just a happy winter holiday, it is a holy day. After Easter, which celebrates not the Easter bunny, but the resurrection of Christ from the dead, it is the holiest day of the year.
Good will to all men refers to an attitude of friendliness and cooperation toward all. Christians are commanded by their faith to love their fellow humans, including even their enemies. Indeed, of all the commandments, love is the greatest. Love toward one another is hardly a universal trait in the world or in our nation today. Im not optimistic that this will change much this season, but there is aways hope.
Merry Christmas to all. Try to love one another. Thats the best gift you can give anyone at any price.
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Peace On Earth Requires More Good Will | Opinion | coronadonewsca.com - Coronado Eagle and Journal
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