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Category Archives: Transhuman News

Gene Study Yields New Clues to Breast Cancer

Posted: September 30, 2012 at 6:13 pm

SUNDAY, Sept. 23 (HealthDay News) -- A comprehensive look at the genetic blueprint of breast cancer has revealed new insights into the disease -- including the discovery that certain breast and ovarian tumors may be closely related.

Basal-like breast tumors -- one of the most deadly subtypes of breast cancer -- are genetically more similar to ovarian cancer than to other breast cancers, the new research found.

In this study, the scientists used six different technologies to analyze 348 tumors from women with breast cancer. They looked for defects in DNA, RNA and proteins in the tumors.

They confirmed the existence of four main subtypes of breast cancer -- luminol A, luminal B, HER2 and basal-like -- and found unique genetic and molecular signatures within each of the subtypes.

The findings add to growing evidence suggesting that tumors should be catalogued and treated based on the genes that are disrupted rather than their location in the body, the researchers said.

"With this study, we're one giant step closer to understanding the genetic origins of the four major subtypes of breast cancer," study co-leader Dr. Matthew Ellis, chair of medical oncology at Washington University School of Medicine in St. Louis, said in a university news release.

One oncologist said the findings on breast cancer's diversity echo her own experience in treating patients.

"The diversity of breast cancer is instinctual to a practicing breast surgeon who has seen women with breast cancer, presumably the same stage, have differing outcomes with respect to recurrence and survival," said Dr. Donna-Marie Manasseh, director of breast surgery at the Maimonides Breast Cancer Center in New York City. "This research validates what we have suspected."

According to Ellis, the new study suggests that most basal-like breast tumors and ovarian tumors have similar genetic origins and potentially could be treated with the same drugs.

Basal-like tumors account for about 10 percent of all breast cancers and disproportionately affect younger and black women in the United States. Basal-like tumors include most triple-negative breast tumors, which are often aggressive and do not respond to therapies that target hormone receptors or to standard chemotherapies.

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Gene Study Yields New Clues to Breast Cancer

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Researchers discover gene that causes deafness

Posted: at 6:13 pm

Public release date: 30-Sep-2012 [ | E-mail | Share ]

Contact: Katie Pence katie.pence@uc.edu 513-558-4561 University of Cincinnati Academic Health Center

CINCINNATIResearchers at the University of Cincinnati (UC) and Cincinnati Children's Hospital Medical Center have found a new genetic mutation responsible for deafness and hearing loss associated with Usher syndrome type 1.

These findings, published in the Sept. 30 advance online edition of the journal Nature Genetics, could help researchers develop new therapeutic targets for those at risk for this syndrome.

Partners in the study included the National Institute on Deafness and other Communication Disorders (NIDCD), Baylor College of Medicine and the University of Kentucky.

Usher syndrome is a genetic defect that causes deafness, night-blindness and a loss of peripheral vision through the progressive degeneration of the retina.

"In this study, researchers were able to pinpoint the gene which caused deafness in Usher syndrome type 1 as well as deafness that is not associated with the syndrome through the genetic analysis of 57 humans from Pakistan and Turkey," says Zubair Ahmed, PhD, assistant professor of ophthalmology who conducts research at Cincinnati Children's and is the lead investigator on this study.

Ahmed says that a protein, called CIB2, which binds to calcium within a cell, is associated with deafness in Usher syndrome type 1 and non-syndromic hearing loss.

"To date, mutations affecting CIB2 are the most common and prevalent genetic cause of non-syndromic hearing loss in Pakistan," he says. "However, we have also found another mutation of the protein that contributes to deafness in Turkish populations.

"In animal models, CIB2 is found in the mechanosensory stereocilia of the inner earhair cells, which respond to fluid motion and allow hearing and balance, and in retinal photoreceptor cells, which convert light into electrical signals in the eye, making it possible to see," says Saima Riazuddin, PhD, assistant professor in UC's department of otolaryngology who conducts research at Cincinnati Children's and is co-lead investigator on the study.

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Researchers discover gene that causes deafness

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Colon Cancer Gene Database May Assist Research Efforts

Posted: at 6:13 pm

WEDNESDAY, Sept. 26 (HealthDay News) -- A colorectal gene database will help further research into the disease, a new study suggests.

The CRCgene database gathers all genetic association studies on colorectal cancer. It allows researchers to accurately interpret the risk factors of the disease and provides insight into the direction of further research, according to Julian Little, with the department of epidemiology and community medicine at the University of Ottawa, and colleagues.

To determine the genetic factors associated with colorectal cancer, they analyzed data from all published genetic association studies on colorectal cancer.

The researchers identified 16 independent gene variants with the strongest links to colorectal cancer, among 23 variants, a number lower than expected. Unfortunately, the researchers say, this reduces the feasibility of combining variants as a profile in a prediction tool to identity people who are at increased risk for colorectal cancer and who should be screened for the disease.

Even so, the analysis "provides a resource for mining available data and puts into context the sample sizes required for the identification of true associations," the researchers wrote in the Sept. 27 issue of the Journal of the National Cancer Institute.

About 950,000 new cases of colorectal cancer are diagnosed each year, according to a journal news release. Risk factors for the disease include age, diet, lifestyle and possibly genetics.

-- Robert Preidt

Copyright 2012 HealthDay. All rights reserved.

SOURCE: Journal of the National Cancer Institute, news release, Sept. 27, 2012

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Colon Cancer Gene Database May Assist Research Efforts

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National banned book week sheds light on censorship

Posted: at 6:12 pm

When it comes to censorship, librarians sit at ground zero.

"Librarians are on the front line in protecting our freedom to read," said Trisha Noack, supervisor of public relations for the Peoria Public Library.

Almost every day in the U.S. someone challenges a book and asks that it be removed from the shelf of a public or school library.

"They don't want you to read anything from 'Harry Potter' to 'Captain Underpants,' " said Noack. "People are still trying to keep you from reading 'To Kill a Mockingbird' - it gets challenged every year. If everyone backed down, there would be nothing on the shelves to read."

To draw attention to the issue, libraries all over the country will be participating in the American Library Association's Banned Book Week Sept. 30 through Oct. 6.

"It's a freedom we enjoy. You have to protect it," said Noack.

Books are not challenged often in Peoria. In the nine years Noack has been working at the library she has seen only onechallenge.

"The last challenge we had was to 'It's Perfectly Normal' by Robie Harris," said Noack. Meant for ages 10 and up, the book, whose full title is "It's Perfectly Normal: Changing Bodies, Growing Up, Sex, and Sexual Health," describes puberty and human sexuality in a light, kid-friendly way.

"People seemed to object to the drawings, which are line drawings and somewhat humorous at times," Noack said. "They also objected to the practices described as 'perfectly normal.' "

The challenge was instigated by a national group protesting the book all over the country, Noack said.

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National banned book week sheds light on censorship

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Internet censorship up, report says

Posted: at 6:12 pm

HONG KONG (CNN)

Draconian laws, brutal attacks against bloggers and politically motivated surveillance are among the biggest threats to Internet freedom emerging in the last two years, according to a new report from free speech advocates, Freedom House.

"Freedom on the Net 2012: A Global Assessment of Internet and Digital Media," looked at barriers to access, limits on content, and violations of user rights in 47 countries across the globe. Estonia was rated as having the greatest degree of Internet freedom, while Iran, Cuba and China were viewed as the most restrictive.

While social media was key in the uprising in Egypt, censorship there continues apace, says Freedom House, a U.S.-based independent watchdog organization.

Although online activism is increasing, the report said authoritarian regimes were employing a wider and increasingly sophisticated arsenal of countermeasures.

According to Freedom House, China has the world's largest population of Internet users, yet the authorities operate the most sophisticated system of censorship. Its "great firewall" has become notorious for literally shutting down Internet "chatter" it views as sensitive. Earlier this year, censors blocked related search terms to prevent the public from obtaining news on prominent human rights activist Chen Guangcheng, who caused a diplomatic storm when he escaped house arrest to seek refuge in the U.S. Embassy in Beijing.

Major web portals and social networking sites, though not state-owned, have had to comply with strict government censorship rules -- or risk being shut down. After launching a campaign to clean up "rampant online rumors," Chinese authorities in March ordered the country's leading micro-blogging sites -- including Sina Weibo -- to disable their comment function for three days. In China, bloggers are also required to register their real names -- though it's not clear how many have complied with the rules.

"It's a typical response by officials and quite a successful strategy in making it extremely difficult to spread information beyond some small circles of activists," Jeremy Goldkorn, a leading commentator on China's social media, told CNN at the time.

Freedom House claims Beijing's influence as an "incubator for sophisticated restrictions" has not gone unnoticed, with governments such as Belarus, Uzbekistan, and Iran using China as a model for their own Internet controls.

Unrest across the Middle East prompted increased censorship, arrests, and violence against bloggers as authoritarian regimes look to quell calls for reform. Social media was widely accepted to have played a key role in popular uprisings in Egypt and Tunisia. Fearing a similar "revolution" in Saudi Arabia, the authorities there took immediate steps to respond to what they regarded as a national security threat.

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Internet censorship up, report says

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Internet Censorship on the Up, Report Says

Posted: at 6:12 pm

HONG KONG (CNN) -- Draconian laws, brutal attacks against bloggers and politically motivated surveillance are among the biggest threats to Internet freedom emerging in the last two years, according to a new report from free speech advocates, Freedom House.

"Freedom on the Net 2012: A Global Assessment of Internet and Digital Media," looked at barriers to access, limits on content, and violations of user rights in 47 countries across the globe. Estonia was rated as having the greatest degree of Internet freedom, while Iran, Cuba and China were viewed as the most restrictive.

While social media was key in the uprising in Egypt, censorship there continues apace, says Freedom House, a U.S.-based independent watchdog organization.

Although online activism is increasing, the report said authoritarian regimes were employing a wider and increasingly sophisticated arsenal of countermeasures.

Read the full report

According to Freedom House, China has the world's largest population of Internet users, yet the authorities operate the most sophisticated system of censorship. Its "great firewall" has become notorious for literally shutting down Internet "chatter" it views as sensitive. Earlier this year, censors blocked related search terms to prevent the public from obtaining news on prominent human rights activist Chen Guangcheng, who caused a diplomatic storm when he escaped house arrest to seek refuge in the U.S. Embassy in Beijing.

Major web portals and social networking sites, though not state-owned, have had to comply with strict government censorship rules -- or risk being shut down. After launching a campaign to clean up "rampant online rumors," Chinese authorities in March ordered the country's leading micro-blogging sites -- including Sina Weibo -- to disable their comment function for three days. In China, bloggers are also required to register their real names -- though it's not clear how many have complied with the rules.

"It's a typical response by officials and quite a successful strategy in making it extremely difficult to spread information beyond some small circles of activists," Jeremy Goldkorn, a leading commentator on China's social media, told CNN at the time.

Freedom House claims Beijing's influence as an "incubator for sophisticated restrictions" has not gone unnoticed, with governments such as Belarus, Uzbekistan, and Iran using China as a model for their own Internet controls.

Unrest across the Middle East prompted increased censorship, arrests, and violence against bloggers as authoritarian regimes look to quell calls for reform. Social media was widely accepted to have played a key role in popular uprisings in Egypt and Tunisia. Fearing a similar "revolution" in Saudi Arabia, the authorities there took immediate steps to respond to what they regarded as a national security threat.

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Internet Censorship on the Up, Report Says

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Big Brother still watching: Internet censorship up, report says

Posted: at 6:12 pm

iStockPhoto / RapidEye

Draconian laws, brutal attacks against bloggers and politically motivated surveillance are among the biggest threats to Internet freedom emerging in the last two years, according to a new report from free speech advocates, Freedom House.

"Freedom on the Net 2012: A Global Assessment of Internet and Digital Media," looked at barriers to access, limits on content, and violations of user rights in 47 countries across the globe. Estonia was rated as having the greatest degree of Internet freedom, while Iran, Cuba and China were viewed as the most restrictive.

While social media was key in the uprising in Egypt, censorship there continues apace, says Freedom House, a U.S.-based independent watchdog organization.

Although online activism is increasing, the report said authoritarian regimes were employing a wider and increasingly sophisticated arsenal of countermeasures.

According to Freedom House, China has the world's largest population of Internet users, yet the authorities operate the most sophisticated system of censorship. Its "great firewall" has become notorious for literally shutting down Internet "chatter" it views as sensitive. Earlier this year, censors blocked related search terms to prevent the public from obtaining news on prominent human rights activist Chen Guangcheng, who caused a diplomatic storm when he escaped house arrest to seek refuge in the U.S. Embassy in Beijing.

Major web portals and social networking sites, though not state-owned, have had to comply with strict government censorship rules -- or risk being shut down. After launching a campaign to clean up "rampant online rumors," Chinese authorities in March ordered the country's leading micro-blogging sites -- including Sina Weibo -- to disable their comment function for three days. In China, bloggers are also required to register their real names -- though it's not clear how many have complied with the rules.

"It's a typical response by officials and quite a successful strategy in making it extremely difficult to spread information beyond some small circles of activists," Jeremy Goldkorn, a leading commentator on China's social media, told CNN at the time.

Freedom House claims Beijing's influence as an "incubator for sophisticated restrictions" has not gone unnoticed, with governments such as Belarus, Uzbekistan, and Iran using China as a model for their own Internet controls.

Unrest across the Middle East prompted increased censorship, arrests, and violence against bloggers as authoritarian regimes look to quell calls for reform. Social media was widely accepted to have played a key role in popular uprisings in Egypt and Tunisia. Fearing a similar "revolution" in Saudi Arabia, the authorities there took immediate steps to respond to what they regarded as a national security threat.

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Big Brother still watching: Internet censorship up, report says

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Big Brother still watching: Internet censorship is up, report says

Posted: at 6:12 pm

Chinese censors blocked information on the blind activist at the center of a diplomatic storm this year.

STORY HIGHLIGHTS

Hong Kong (CNN) -- Draconian laws, brutal attacks against bloggers and politically motivated surveillance are among the biggest threats to Internet freedom emerging in the last two years, according to a new report from free speech advocates, Freedom House.

"Freedom on the Net 2012: A Global Assessment of Internet and Digital Media," looked at barriers to access, limits on content, and violations of user rights in 47 countries across the globe. Estonia was rated as having the greatest degree of Internet freedom, while Iran, Cuba and China were viewed as the most restrictive.

While social media was key in the uprising in Egypt, censorship there continues apace, says Freedom House, a U.S.-based independent watchdog organization.

Although online activism is increasing, the report said authoritarian regimes were employing a wider and increasingly sophisticated arsenal of countermeasures.

Read more: The full report

According to Freedom House, China has the world's largest population of Internet users, yet the authorities operate the most sophisticated system of censorship. Its "great firewall" has become notorious for literally shutting down Internet "chatter" it views as sensitive. Earlier this year, censors blocked related search terms to prevent the public from obtaining news on prominent human rights activist Chen Guangcheng, who caused a diplomatic storm when he escaped house arrest to seek refuge in the U.S. Embassy in Beijing.

Read more: News on blind activist's escape

Major web portals and social networking sites, though not state-owned, have had to comply with strict government censorship rules -- or risk being shut down. After launching a campaign to clean up "rampant online rumors," Chinese authorities in March ordered the country's leading micro-blogging sites -- including Sina Weibo -- to disable their comment function for three days. In China, bloggers are also required to register their real names -- though it's not clear how many have complied with the rules.

Excerpt from:
Big Brother still watching: Internet censorship is up, report says

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Big Brother still watching: Internet censorship on the up, report says

Posted: at 6:12 pm

Chinese censors blocked information on the blind activist at the center of a diplomatic storm this year.

STORY HIGHLIGHTS

Hong Kong (CNN) -- Draconian laws, brutal attacks against bloggers and politically motivated surveillance are among the biggest threats to Internet freedom emerging in the last two years, according to a new report from free speech advocates, Freedom House.

"Freedom on the Net 2012: A Global Assessment of Internet and Digital Media," looked at barriers to access, limits on content, and violations of user rights in 47 countries across the globe. Estonia was rated as having the greatest degree of Internet freedom, while Iran, Cuba and China were viewed as the most restrictive.

While social media was key in the uprising in Egypt, censorship there continues apace, says Freedom House, a U.S.-based independent watchdog organization.

Although online activism is increasing, the report said authoritarian regimes were employing a wider and increasingly sophisticated arsenal of countermeasures.

Read more: The full report

According to Freedom House, China has the world's largest population of Internet users, yet the authorities operate the most sophisticated system of censorship. Its "great firewall" has become notorious for literally shutting down Internet "chatter" it views as sensitive. Earlier this year, censors blocked related search terms to prevent the public from obtaining news on prominent human rights activist Chen Guangcheng, who caused a diplomatic storm when he escaped house arrest to seek refuge in the U.S. Embassy in Beijing.

Read more: News on blind activist's escape

Major web portals and social networking sites, though not state-owned, have had to comply with strict government censorship rules -- or risk being shut down. After launching a campaign to clean up "rampant online rumors," Chinese authorities in March ordered the country's leading micro-blogging sites -- including Sina Weibo -- to disable their comment function for three days. In China, bloggers are also required to register their real names -- though it's not clear how many have complied with the rules.

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Big Brother still watching: Internet censorship on the up, report says

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WILD CARD – RON PAUL STILL IN RACE REVOLUTION ON – – Video

Posted: at 6:12 pm

27-09-2012 21:15 Request a Write-in ballot - Vote Ron Paul The Ron Paul Revolution is On Visit:

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WILD CARD - RON PAUL STILL IN RACE REVOLUTION ON - - Video

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