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New Private Rocket Arrives at Virginia Launch Pad for Tests
Posted: October 2, 2012 at 7:18 am
A private rocket NASA is counting on to make robotic cargo flights to the International Space Station achieved a key milestone today (Oct. 1), as its first stage rolled out to its Virginia launchpad for the first time.
The first stage of Orbital Sciences' Antares rocket arrived today at its pad at the Mid-Atlantic Regional Spaceport (MARS), which is located at NASA's Wallops Flight Facility in eastern Virginia. The move marks the beginning of on-pad preparations for a series of important trials with Antares that will take place over the next few months, Orbital officials said.
The company aims to perform hot-fire tests of the first stage in four or five weeks, followed by Antares' first test flight about a month later. If all goes well, Antares will then launch Orbital's unmanned Cygnus capsule on a demonstration mission to the space station, officials said.
"MARS has completed construction and testing operations on its launch complex at Wallops Island, the first all-new large-scale liquid-fuel launch site to be built in the U.S. in decades," Orbital president and CEO David Thompson said in a statement.[Gallery: Orbital's Cygnus Spacecraft & Antares Rocket]
The hot-fire operation will demonstrate the readiness of Antares' first stage and launch pad fueling systems to support the upcoming flights.The test involves firing the rocket's dual AJ26 engines which will be held down on the pad for about 30 seconds, generating a combined total thrust of 680,000 pounds (308,000 kilograms), officials said.
Antares is slated to blast off on its maiden journey about a month after the hot-fire test, carring a Cygnus mass simulator whose instruments will gather data about the flight. The rocket will also carry and deploy four minuscule "picosatellites" during the mission, officials said.
Finally, Antares will carry Cygnus aloft on a demonstration mission to the orbiting lab. The capsule will autonomously rendezvous and berth with the space station, delivering about 1,210 pounds (550 kg) of supplies. On its way back down to Earth, Cygnus will carry 2,200 pounds (1,000 kg) of disposal cargo from the station, officials said.
If all goes well with these three tests, Antares and Cygnus will be ready to begin making bona fide supply runs to the space station for NASA. Virginia-based Orbital holds a $1.9 billion contract to launch eight such unmanned flights.
NASA also signed a $1.6 billion deal with California-based SpaceX, which is slated to launch the first of its 12 unmanned supply flights to the station this Sunday (Oct. 7). This past May, SpaceX's Dragon capsule aced its demonstration mission, becoming the first private vehicle ever to dock with the $100 billion orbiting complex.
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NASA Plan to Build Space Station Beyond the Moon Criticized
Posted: at 7:18 am
NASA's proposal to build a small space station at the Earth Moon Lagrange Point-2, which is where the gravity of the Earth and moon cancel out 38,000 miles from the far side of the moon, is coming under some criticism.
The EMLP-2 station proposal
According to the Orlando Sentinel, NASA officials made a presentation to the White House for a space station to be built at the EMLP-2 point using left over International Space Station modules. The station would be serviced by the Orion Multi Purpose Crew Vehicle launched by the heavy lift Space Launch System. A near term purpose for the EMLP-2 station would be for astronauts to teleoperate robotic explorers on the lunar surface, with one mission mentioned a lunar sample return. Later the station could be used as a way station and refueling depot to support deep space missions, to the asteroids and eventually to Mars.
Problems with the EMLP-2 station
The Orlando Sentinel suggests that there are two problems with the NASA proposal. First, because of the great distance the station would be from Earth, problems of resupply and even rescue in case of disaster would be more difficult than with the ISS in low Earth orbit. Also, since the station would be beyond Earth's magnetic field, radiation shielding would be a major issue.
EMLP-2 station a make work project
Paul Spudis, a planetary geologist who writes frequently on space issues, offers a critique of the near term stated purpose of the EMLP-2 station. He suggests that positioning astronauts 38,000 miles from the moon would provide little if any advantage to controllers on Earth where it comes to teleoperating robots on the lunar surface. Spudis suggests that such a station would make sense if it were part of a larger cislunar transportation infrastructure that included a fuel depot supplied, by preference, by rocket fuel refined from lunar ice known to lay in the permanently shadowed craters at the moon's north and south poles.
EMLP-2 station a plot to justify Orion/SLS
John Strickland, a space advocate and a member of the National Space Society Board of Directors, suggests in the Space Review that building what is in effect a smaller version of the ISS at an Earth Moon Lagrange Point is a scheme by NASA to justify the expense of the Orion and Space Launch System. Currently Orion/SLS have a limited number of destinations. Without a lander, astronauts cannot access the lunar surface. Without a long duration habitation module, astronauts cannot visit Earth-approaching asteroids. A station in empty space in the cislunar system is about the only place that the Orion/SLS can go.
Strickland, like Spudis, favors a space station at one of the EMLPs if it could serve as a fuel depot. But he suggests that building such a space station is pointless until reusable launch vehicles and space craft are developed to service such a facility and take advantage of its capabilities to explore further into the solar system.
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Private SpaceX Rocket Test-Fires Engines for Space Station Trip
Posted: at 7:18 am
A private rocket poised to launch its first official cargo delivery run to the International Space Station performed a major engine test this weekend, setting the stage for its planned Oct. 7 liftoff.
The Falcon 9 rocket fired up its nine Merlin engines on Saturday (Sept. 29) for just two seconds during a full dress rehearsal at Florida's Cape Canaveral Air Force Station ahead of the upcoming flight by Space Exploration Technologies (SpaceX).
"During the static fire test today, SpaceX engineers ran through all countdown processes as though it were launch day," SpaceX officials wrote in an update Saturday. "Post static fire, SpaceX will conduct a thorough review of all data, and the Dragon spacecraft will be mated to Falcon 9 in preparation for next Sunday's targeted launch."
The Falcon 9 rocket is scheduled to launch an unmanned Dragon space capsule (also built by SpaceX) on Sunday at 8:35 p.m. EDT (0035 Oct. 8 GMT). If all goes well, the spacecraft should arrive at the International Space Station on Oct. 10, where it will be grappled by a robotic arm controlled by astronauts and attached to a docking port.
The mission follows a similar demonstration flight to the station in May by SpaceX's Dragon spacecraft. But Sunday's launch will kick off the company's first official cargo flight for NASA under a $1.6 billion deal that includes 12 such missions. [Photos: SpaceX's 1st Dragon Flight to Space Station]
The Hawthorne, Calif.-based SpaceX is one of two U.S. spaceflight companies with contracts to provide robotic cargo flights to the International Space Station for NASA. The other firm, Orbital Sciences Corp., of Virginia, has a $1.9 billion contract for eight missions using its new Antares rocket and Cygnus spacecraft. The first Antares rocket rolled out to its launch pad on the Virginia coast today (Oct. 1).
With the retirement of NASA's space shuttle fleet in 2011, the space agency is relying on new privately built spacecraft to ferry American astronauts and cargo to and from low-Earth orbit. The unmanned resupply flights are the first stage of that plan, which also includes purchasing seats for U.S. astronauts on private space taxis once they become available.
SpaceX is one of several companies also seeking to launch astronauts into space for NASA. The company plans to use a crewed variant of its Dragon capsule for the job.
The upcoming Falcon 9 launch will be the fourth flight of the booster for SpaceX and the third flight of a Dragon spacecraft. The Dragon capsule made its first test flight in December 2010, which was followed by a successful round trip to the International Space Station earlier this year during SpaceX's demonstration flight in May.
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Just another GE mirage
Posted: at 7:18 am
The announcement about scientists producing GE milk will damage New Zealands brand on which our more than $10 billion a year dairy exports rely, the Green Party said today.
Today AgResearch scientists announced they have used genetic engineering (GE) technology to breed the first cow in the world that produces high protein milk that may be hypo-allergenic.
"This is just another GE mirage; another announcement from GE proponents about a potential product which we do not need and has no market," Green Party GE Steffan Browning said today.
"Its not right for these scientists to be touting their finding as a solution to milk allergies in babies as some sort of justification for the huge amount of resources that have been invested into GE research.
"We see this over and over again with GE scientists; this new product or that new product that will have apparent amazing results but it never actually meets our real needs for a safe, healthy food supply.
"The Royal Commission into GE recommended that wherever possible animals that are a common source of food should not be used for GE but that recommendation has been ignored.
"Field trials in New Zealand need to be closed down and GE research needs to be kept in the lab.
"Our export markets want safe food grown in a natural environment but the production of GE milk puts those markets at risk.
"Putting at $10 billion a year industry at risk for half a glass of milk is not something to be celebrating," said Mr Browning.
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GENETICS Journal Highlights for October 2012
Posted: at 7:17 am
Newswise Bethesda, MDOctober 1, 2012 Listed below are the selected highlights for the October 2012 issue of the Genetics Society of Americas journal, GENETICS. The October issue is available online at http://www.genetics.org/content/current. Please credit GENETICS, Vol. 192, October 2012, Copyright 2012.
Please feel free to forward to colleagues who may be interested in these articles.
ISSUE HIGHLIGHTS
Energy-dependent modulation of glucagon-like signaling in Drosophila via the AMP-activated protein kinase, pp. 457466 Jason T. Braco, Emily L. Gillespie, Gregory E. Alberto, Jay E. Brenman, and Erik C. Johnson How organisms maintain energetic homeostasis is unclear. These authors show that the actions of a known cellular sensor of energythe AMP-activated protein kinase (AMPK)cause release of a glucagon-like hormone in Drosophila. They further show that AMPK regulates secretion of adipokinetic hormone. This suggests new roles and targets for AMPK and suggests metabolic networks are organized similarly throughout Metazoa.
The relation of codon bias to tissue-specific gene expression in Arabidopsis thaliana, pp. 641649 Salvatore Camiolo, Lorenzo Farina, and Andrea Porceddu This article reports systematic differences in usage of synonymous codons in Arabidopsis thaliana genes whose expression is tissue specific. The authors propose that codon bias evolves as an adaptive response to the different abundances of tRNAs in different tissues. Integrity and function of the Saccharomyces cerevisiae spindle pole body depends on connections between the membrane proteins Ndc1, Rtn1, and Yop1, pp. 441455 Amanda K. Casey, T. Renee Dawson, Jingjing Chen, Jennifer M. Friederichs, Sue L. Jaspersen, and Susan R. Wente Budding yeast face an unusual challenge during cell division: they must segregate their chromosomes while the nuclear envelope remains intact. Consequently, mitosis begins with insertion of the duplicated spindle pole body (a.k.a. centrosome) into the nuclear envelope, a process that parallels the generation of new nuclear pore complexes. These authors report data that suggest new mechanisms for linking nuclear division and transport.
Cellular memory of acquired stress resistance in Saccharomyces cerevisiae, pp. 495505 Qiaoning Guan, Suraiya Haroon, Diego Gonzlez Bravo, Jessica L. Will, and Audrey P. Gasch Cells can retain memory of prior experiences that influence future behaviors. Here, the authors show that budding yeast retains a multifaceted memory of prior stress treatment. Cells pretreated with salt retain peroxide tolerance for several generations after removal of the initial stressor. This is due to long-lived catalase, produced during salt treatment and distributed to daughter cells. These cells also display transcriptional memory dependent on the nuclear pore subunit Nup42 that functions to promote reacquisition of stress tolerance in future stress cycles.
Genomic variation in natural populations of Drosophila melanogaster, pp. 533598 Charles H. Langley, Kristian Stevens, Charis Cardeno, Yuh Chwen G. Lee, Daniel R. Schrider, John E. Pool, Sasha A. Langley, Charlyn Suarez, Russell B. Corbett-Detig, Bryan Kolaczkowski, Shu Fang, Phillip M. Nista, Alisha K. Holloway, Andrew D. Kern, Colin N. Dewey, Yun S. Song, Matthew W. Hahn, and David J. Begun This article greatly extends studies of population genetic variation in natural populations of Drosophila melanogaster, which have played an important role in the development of evolutionary theory. The authors describe genome sequences of 43 individuals taken from two natural populations of D. melanogaster. The genetic polymorphism, divergence, and copy-number variation revealed in these data are presented at several scales, providing unprecedented insight into forces shaping genome polymorphism and divergence.
Estimating allele age and selection coefficient from time-serial data, pp. 599607 Anna-Sapfo Malaspinas, Orestis Malaspinas, Steven N. Evans, and Montgomery Slatkin The relative importance of the four fundamental processes driving evolutiongenetic drift, natural selection, migration, and mutationremains undetermined. These authors propose a new approach to estimate the selection coefficient and the allele age of time serial data. They apply their methodology to ancient sequences of a horse coat color gene and demonstrate that the causative allele existed as a rare segregating variant prior to domestication. This illuminates the debate on the relative importance of new vs. standing variation in adaptation and domestication. DNA replication origin function is promoted by H3K4 di-methylation in Saccharomyces cerevisiae, pp. 371384 Lindsay F. Rizzardi, Elizabeth S. Dorn, Brian D. Strahl, and Jeanette Gowen Cook What defines a DNA replication origin? It is becoming increasingly apparent that post-translational modifications of nucleosomes near replication origins help mark them and control their activity. The genetic analysis presented in this article implicates di-methylated histone H3 lysine 4 (stimulated by histone H2B monoubiquitination) as part of the definition of active replication origins. Since these histone modifications are highly conserved, these findings are relevant to genome organization in other eukaryotes.
Comparative oncogenomics implicates the Neurofibromin 1 gene (NF1) as a breast cancer driver, pp. 385396 Marsha D. Wallace, Adam D. Pfefferle, Lishuang Shen, Adrian J. McNairn, Ethan G. Cerami, Barbara L. Fallon, Vera D. Rinaldi, Teresa L. Southard, Charles M. Perou, and John C. Schimenti This study of a mouse model of genomic instability indicates that NF1 (Neurofibromin 1) deficiency can drive breast cancer. ~ 63,000 people in the United States annually will develop breast cancer with an NF1 deficiency. Together with evidence that NF1 depletion confers resistance of human breast cancer cells to tamoxifen, these findings suggest therapeutic strategies for patients with NF1-deleted tumors.
ABOUT GENETICS: Since 1916, GENETICS (http://www.genetics.org/) has covered high quality, original research on a range of topics bearing on inheritance, including population and evolutionary genetics, complex traits, developmental and behavioral genetics, cellular genetics, gene expression, genome integrity and transmission, and genome and systems biology. GENETICS, a peer-reviewed, peer-edited journal of the Genetics Society of America is one of the world's most cited journals in genetics and heredity.
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300th person exonerated by DNA evidence
Posted: at 7:17 am
Published: Oct. 2, 2012 at 1:56 AM
LOS ANGELES, Oct. 2 (UPI) -- A 38-year-old Louisiana man on death row became the 300th prisoner to be exonerated by DNA evidence, officials said.
"It feels good. I'm still processing it," Damon Thibodeaux told the Los Angeles Times.
Thibodeaux was convicted in 1997 and sentenced to death after confessing to the rape and murder of his 14-year-old step-cousin, Crystal Champagne, on July 19, 1996.
Thibodeaux, who said he was coerced into providing a false confession after 9 hours of interrogation, was ordered freed Friday by a Jefferson Parish judge after 16 years of incarceration.
"This is a tragic illustration of why law enforcement must record the entire interrogation of any witness or potential suspect in any investigation involving a serious crime," said Steve Kaplan, one of Thibodeaux's attorneys.
In 2007, Thibodeaux's legal team convinced Jefferson Parish District Attorney Paul Connick to take another look at the case. DNA testing indicated Crystal had not been raped and Thibodeaux was not her killer.
Of the 300 prisoners exonerated, 18 had been on death row, attorneys for the Innocence Project said.
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IntegenX Announces U.S. Launch of the RapidHIT™ 200 System – Rapid DNA Technology That Will Revolutionize the Use of …
Posted: at 7:17 am
SAN DIEGO & PLEASANTON, Calif.--(BUSINESS WIRE)--
IntegenX Inc., a leading developer of rapid human DNA identification technology, today announced the commercial availability of its RapidHIT 200 Human DNA Identification System in the U.S. at the 2012 International Association of Chiefs of Police Conference and Exposition in San Diego, California. Representatives from IntegenX are on site at the meeting to demonstrate the self-contained desktop system, which is the first commercially available rapid DNA device.
Rapid DNA analysis is a transformative technology that promises to fundamentally change the way investigations are conducted by enabling law enforcement personnel to quickly and definitively link a suspects DNA to a crime scene, or eliminate suspicion, all while the suspect is still in police custody.
The RapidHIT 200 System provides actionable intelligence by automating and accelerating the process of producing standardized DNA profiles from cheek swabs in about 90 minutes. This is compared to a process that currently takes up to eight instruments and at least a day in a specialized lab, with results typically returned to police in weeks to months.
Stevan Jovanovich, President and Chief Executive Officer of IntegenX commented: The availability of this technology now will revolutionize the use of DNA in law enforcement. We see the implementation of rapid DNA as reinforcing the partnership between crime labs and police putting more power in their hands to get DNA results faster. Law enforcement agencies have been waiting a long time for this capability. We are proud to be the first to deliver it and to say Rapid DNA is here!
Numerous international law enforcement and security agencies use DNA-based human identification to make informed decisions regarding the arrest, detention or release of suspects, as well as to analyze crime scene evidence. By integrating what was until now a multi-step, multi-system process, rapid DNA technology has the potential to accelerate and expand the use of proven DNA technologies to help the efforts of law enforcement, homeland security, and defense to create safer communities and a safer world.
One of the first police departments to place an order for the RapidHIT 200 System is Palm Bay, Florida, an organization known for its progressive use of DNA to solve high volume crimes.
We are extremely proud of what we have been able to accomplish so far using DNA, and expect the RapidHIT 200 System to greatly accelerate our efforts, said Doug Muldoon, Police Chief of Palm Bay. Based on our experience, the more we can use this ultimate identification tool in our work, the more our crime rates go down and our case closure rates go up. That is good news for creating safer communities for our citizens. Rapid DNA will enhance our methods for dealing with high volume crimes using our locally created database.
This is one of the best crime fighting tools we have seen in decades. It allows law enforcement to identify the bad guys and put them in jail. It also protects the innocent from going to jail for a crime they did not commit, added Chief Muldoon.
Dr. Jovanovich will speak along with Chief Muldoon and the Denver District Attorney, Mitch Morrissey, during a press conference today at the IACP meeting at 9:00 a.m. PT. For more information about IACP, please visit: http://www.theiacpconference.org.
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Rape DNA process 'not adequate'
Posted: at 7:17 am
1 October 2012 Last updated at 12:38 ET
Forensic procedures carried out by a private firm which wrongly linked the DNA of a man to a rape were "not adequate", a report says.
Adam Scott, from Devon, was held for a couple of months after being accused of raping a woman in Manchester.
The charges were dropped when it emerged a DNA sample had been contaminated at LGC Forensics.
Forensic Science Regulator Andrew Rennison said Mr Scott was an "innocent victim of avoidable contamination".
LGC Forensics said that it "deeply regrets the incident of contamination".
Mr Scott was charged in 23 October 2011 after a plastic tray containing a sample of his DNA was re-used in the analysis of a swab from a rape victim in Plant Hill Park, Blackley. The result of that test linked him to the crime.
The report said police investigating the rape allegations raised concerns seven weeks later because phone records suggested Mr Scott had been in Plymouth a few hours after the alleged attack.
In March this year, the government wound up the Forensic Science Service, leaving private companies and police laboratories to take on its work.
That month, news emerged of the DNA mix-up involving Adam Scott at the Teddington lab of the biggest private provider, LGC.
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Surprising differences between apples and pears
Posted: at 7:17 am
Analysis of the genome sequence of the fruit known as the gift of the gods has shown that pears have some surprising differences to apple at the DNA level.
The European pear genome - sequenced by a team of scientists at Plant & Food Research in New Zealand and the Istituto Agrario di San Michele allAdige (IASMA) in Italy - has 600 million base pairs of DNA encoding around 51,000 genes on 17 chromosomes. By comparison, apple has 25% more DNA (750 million base pairs) with 57,000 genes on the same number of chromosomes. Many of the differences between the two correspond to areas of the genome that switch genes on or off.
"In ancient Greece, pears were lauded by the poet Homer as the gift of the gods, thanks to their melting texture and the unmistakeable aromatic pear flavour," says Dr David Chagn, the leader of the project. "We hope that by sequencing the genome of the European pear, with its melting flesh and wonderful flavours, and comparing it with the genome sequence of apple and Asian pears, which tend to be crisper, we will be able to identify how flesh texture in these fruits is controlled. Ultimately, this will allow us to develop tools to speed up the breeding of new varieties of pear with novel combinations of texture and flavours."
Most surprising to the science team was that the number of genes controlling texture, which was expected to be higher in pears due to the way the flesh melts in the mouth, were the same as that of apple. However, the research showed that in pears one family of these genes in particular, known as expansins, was significantly more active.
Dr Sue Gardiner, the leader of Plant & Food Researchs Breeding Technologies Group, believes the project is one of the fastest genome sequencing projects undertaken so far, taking only two years from inception to completion.
"This genome sequence project was led by scientists at Plant & Food Research, and the hard work and strong collaboration between all the scientists involved, both in Italy and New Zealand, has meant the sequence has taken much less time to deliver than other genome sequencing projects," she says.
Apples and pears evolved from a common ancestor around 35-50 million years ago, about 20 million years after this ancestor diverged from other fruits in the same family, such as strawberries and peaches. This divergence from other members of the Rosaceae family was caused by a duplication of the genome and corresponds to an era of major evolutionary activity, thought to be a genetic survival response to an event that caused the extinction of many species, including the dinosaurs.
Dr Gardiner is presenting the findings of the research at the Rosaceous Genomics Conference at IASMA in Trento, Italy this week.
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What whales tell us about the evolution of menopause
Posted: at 7:17 am
Scientists have been hard pressed to explain why menopause happens so early in humans there's no obvious evolutionary advantage to having your reproductive system shut down decades before the rest of your body.
Most other long-lived animals keep reproducing until the end. Female turtles can lay fertile eggs at 100. Our primate relatives, too, keep pumping out young until they are near death.
Now, scientists are finding clues to our unusual life pattern in killer whales - one of the few other species in which females get decades of so-called post-reproductive life. What they found was a surprising connection between longevity of mothers and their sons.
Biologist Emma Foster of Exeter University in England said that females become fertile around 12, have a calf every 3 to 5 years, and then stop reproducing in their late 30s and early 40s. After that they can live many years, sometimes to 90 and beyond. "No other animals have such long post-reproductive lives," she said, except for pilot whales and humans.
And while there's a small difference between the sexes in human longevity, it's extreme for whales, with females living to 90 and males rarely getting past 40. Scientists have little understanding of why this would be.
In puzzling over this anthropologists have proposed what they call the grandmother hypothesis - the possibility that post-menopausal women gain an evolutionary edge by helping their existing children and grandchildren.
In Darwinian terms, after all, no matter how many offspring you have, you'll still be a dead end unless your offspring have surviving offspring.
Ultimately, according to the hypothesis, grandmotherly support could allow women to pass on more copies of their genes than by investing the same energy in continuing to have their own babies.
The other possibility is that menopause is some sort of evolutionary byproduct that can occur in long-lived animals.
Scientists have tried to test the grandmother hypothesis by studying hunter-gatherer populations - people representing the way humans lived through most of our evolutionary past. Results over the years have been mixed, but work in the last decade has supported the idea, said Foster.
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