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Category Archives: Transhuman News

Rapid gene-mapping test may diagnose disease in newborns

Posted: October 5, 2012 at 2:25 am

WASHINGTONToo often, newborns die of genetic diseases before doctors even know what's to blame. Now scientists have found a way to decode those babies' DNA in just days instead of weeks, moving gene-mapping closer to routine medical care.

The idea: Combine faster gene-analyzing machinery with new computer software that, at the push of a few buttons, uses a baby's symptoms to zero in on the most suspicious mutations. The hope would be to start treatment earlier, or avoid futile care for lethal illnesses.

Wednesday's study is a tentative first step: Researchers at Children's Mercy Hospital in Kansas City, Mo., mapped the DNA of just five children, and the study wasn't done in time to help most of them.

But the hospital finds the results promising enough that by year's end, it plans to begin routine gene-mapping in its neonatal intensive care unit -- and may offer testing for babies elsewhere, too -- while further studies continue, said Dr. Stephen Kingsmore, director of the pediatric genome center at Children's Mercy.

"For the first time, we can actually deliver genome information in time to make a difference," predicted Kingsmore, whose team reported the method in the journal Science Translational Medicine.

Even if the diagnosis is a lethal disease, "the family will at least have an answer. They won't have false hope," he added.

More than 20 percent of infant deaths are due to a birth defect or genetic diseases, the kind caused by a problem with a single gene. While there are thousands of such diseases -- from Tay-Sachs to the lesser known Pompe disease, standard newborn screening tests detect only a few of them. And once a baby shows symptoms, fast diagnosis becomes crucial.

Sequencing whole genomes - all of a person's DNA - can help when it's not clear what gene to suspect. But so far it has been used mainly for research, in part because it takes four to six weeks to complete and is very expensive.

Wednesday, researchers reported that the new process for whole-genome sequencing can take just 50 hours -- half that time to perform the decoding from a drop of the baby's blood, and the rest to analyze which of the DNA variations uncovered can explain the child's condition.

That's an estimate: The study counted only the time the blood was being decoded or analyzed, not the days needed to ship the blood to Essex, England, home of a speedy new DNA decoding machine made by Illumina, Inc. -- or to ship back the results for Children's Mercy's computer program to analyze. Kingsmore said the hospital is awaiting arrival of its own decoder, when 50 hours should become the true start-to-finish time.

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Rapid gene-mapping test may diagnose disease in newborns

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Ron Paul: I Don’t Think Romney Will Have an Epiphany – Video

Posted: at 2:24 am

04-10-2012 14:30 -Please like, share, subscribe & comment! Facebook Backup YouTube channel: Email updates: 10 Ron Paul is America's leading voice for limited, constitutional government, low taxes, free markets, sound money, and a pro-America foreign policy. To spread the message, visit and promote the following websites: (grassroots website) http (Ron Paul in Congress) (discussion forum) Disclaimer This video is not-for-profit clip that is uploaded for the purpose of education, teaching, and research, which falls under fair use according to the Copyright Act of 1976 and tips the balance in favor of fair use; all intellectual content within the video remains property of its respective owners.

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Ron Paul: I Don't Think Romney Will Have an Epiphany - Video

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Q&A: Terrance Nelson and Nazanin Afshin-Jam debate his trip to Iran

Posted: at 2:24 am

Less than a month after Canada cut off diplomatic relations with Iran, former First Nations chief Terrance Nelson says he will meet with Mahmoud Ahmadinejads regime in Tehran next week as part of an exploratory mission to discuss resource development and human rights abuses in Canada.

The announcement sparked widespread condemnation and concerns about Irans intentions.

The Posts Kathryn Blaze Carlson spoke Thursday to Terrance Nelson and Iranian-born activist Nazanin Afshin-Jam, who is also wife of Defence Minister Peter MacKay, about Nelsons planned visit:

Terrance Nelson, former chief of Manitobas Roseau River First Nation, lost his bid to lead the Assembly of First Nations this summer.

Q: The Iranian regime has a brutal human rights record. Do you acknowledge that? A: The United Nations, Amnesty International, all the Jewish press and western media have always talked about that kind of stuff. The Iranian government cant do anything or not do anything without it being reported here in the west. The same cant be said of Canada; none of the so-called allied countries, like the United States, Germany, Italy, France, Britain, ever make comments much less condemn the human rights violations here in Canada.

Q: So do you acknowledge there are human rights abuses in Iran? A: Of course, but there are human rights abuses over here, too. There are 600 missing women in this country.

Q: Whats been the reaction from the First Nations community? A: The western media has influenced a lot of the First Nations people. Theres no question about that. But what the western media says is not always true. Nobody gave a damn about half-a-million children dying in Iraq in 1998 [because of economic sanctions], because gasoline was 88 cents a gallon in the United States. A lot of our people are saying, Its your choice. And as far as Im concerned, its a personal choice.

Q: What are you willing to do for the Iranian regime? A: One of the things we want to be able to do is try and humanize the Iranian people. The western media has very clearly demonized the Iranian people. We know what demonization is all about because weve been demonized in our own land.

Q: The Iranian regime has been accused of monitoring Iranian-Canadians in Canada. Some people are concerned the regime will try to get you to keep an eye on dissidents here. What do you say to that? A: We have no intentions of monitoring anybody.

Q: What do you say to concerns the regime will enlist First Nations to perpetrate violence against Canada? A: Thats a pretty big stretch. When have First Nations people ever bombed anything? The worst weve ever done is make the white man late for lunch when we do our protests in the city street. Im 59 years old. If I was going to bomb something, I would have bombed it a long time ago. Peter MacKays wife is constantly pushing the Conservative agenda and talking about human rights violations. [Iranian-Canadians] might not like the Iranian government, but does that mean they support the deaths of millions of their people [because of the economic sanctions]?

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Q&A: Terrance Nelson and Nazanin Afshin-Jam debate his trip to Iran

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Black ‘Human Zoo’ Fury Greets Berlin Art Show

Posted: at 2:24 am

A performance-art show with half- naked black people thats touring Europe has drawn protests during its visit to Berlin. Activists have termed it a human zoo.

White stage director Brett Baileys Exhibit B features museum-style installations of living models in static poses designed to highlight the troubled history of European colonialism in Africa.

Black activists demonstrated at the Kleiner Wasserspeicher, which is showing the work as part of the Foreign Affairs Festival, after acclaimed stagings in Brussels and Grahamstown, South Africa.

This is the wrong way to discuss a violent colonial history, said Sandrine Micosse-Aikins, a member of Buehnenwatch, the organization which instigated the protest.

In one piece, a black woman sits above a cooking pot, holding a skull and a shard of glass. A plaque describes how Namibian women in concentration camps had to boil and scrape clean the skulls of their menfolk so that they could be sent to Germany for scientific examination in the early 20th century.

In another display, photographs of severed black heads stuffed and skewered on metal prongs recall the work of Eugen Fischer (1874-1967), the German professor of anthropology and eugenics whose theories of racial hygiene guided the Nazis.

Below them, the heads of four living Namibian singers seem to float above plinths. They sing beautiful Herero songs about genocide, in counterpoint to the grisly displays.

Contemporary asylum seekers are on show alongside a supine representation of Angelo Soliman, an 18th-century Nigerian philosopher and confidant of Maria Theresa and Emperor Joseph I. Upon his death in 1796, Solimans body was stuffed and displayed in a glass case alongside wild animals.

An earlier version of the show, Exhibit A, opened at Viennas Festwochen in 2010 and went on to Braunschweig, Germany, and Helsinki.

On Oct. 2, a post-performance public debate took place in Berlin below the photographs of Fischers severed heads.

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Black ‘Human Zoo’ Fury Greets Berlin Art Show

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Miguel parties with panache in 'The Thrill' video

Posted: at 2:23 am

The singer Miguel. (Kai Reagan)

October 4, 2012, 1:41 p.m.

We've had our eye on the young, L.A.-based R&B futurist Miguel for a while now. But it appears that he's finally having his moment in the critical spotlight, with a best new music badge from Pitchfork for his ravishing new album, "Kaleidoscope Dreams."

In the video for his latest single, "The Thrill," Miguel hits all the high points of the rising-star life: pool parties, packed clubs and general bonhomie. (Watch the video below.)

But it's all filmed in a sleek, detached black and white that makes the revelry seem a little distant. In fact, that's a pretty good visual metaphor for Miguel's newer music from "Dreams" and his three-part series of EPs, "Art Dealer Chic." "The Thrill" pairs bone-dry electric guitars reminiscent of Fleetwood Mac with a jittery kick drum sample and a whole lot of reverb -- a spacious showcase for Miguel's pristine pipes.

His sound has all the minimal spookiness of "PBR&B" peers such as the Weeknd and AlunaGeorge, but he's toured with Usher and has major-label muscle angling to get him on big stages. Here's hoping he gets there and stays there.

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Miguel parties with panache in 'The Thrill' video

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No on Proposition 37

Posted: October 4, 2012 at 11:21 am

There's a growing gap between what grocery shoppers think they know about their food and the reality. Those tomatoes with the evenly rich red color that look ripened to perfection? They were bred to avoid showing streaks of green, a result of genetic prodding that also stole away most of their flavor. Unless the carton says otherwise, the eggs didn't come from chickens that scratched around in barnyards but rather spent their lives in cramped battery cages that offered no room to move around. There's a good chance the meat came from animals that were given antibiotics from their youngest days, both to promote growth and to prevent disease from sweeping through their crowded pens. Pesticides were almost certainly used on the fruits and vegetables. And the sweetener in the soda, or the golden corn on the cob, probably was a product of genetic engineering.

In most cases, there is no requirement to inform consumers, via labels, about the use of pesticides, hormones or antibiotics, or about the inhumane conditions in which animals are often kept. But Proposition 37 would make an exception for genetically engineered food, requiring that it be labeled before being sold in California. Although we generally endorse people's right to know what goes into their food, this initiative is problematic on a number of levels and should be rejected.

Genetic engineering tinkering with genes in a laboratory to produce desirable qualities has dominated the production of certain crops for years. Today, somewhere between 85% and 95% of the corn and soybeans grown in this country, for example, have altered genes. Often, the alteration renders the crops "Roundup ready," which means they're able to withstand the herbicide glyphosate, marketed by Monsanto under the trade name Roundup. That allows farms to spray against weeds without killing the food plants. And because corn and soy appear in so many products in the form of high-fructose corn syrup, as just one example genetically engineered ingredients are common in processed foods.

ENDORSEMENTS: The Times' recommendations for Nov. 6

Unfortunately, the initiative to require labeling of those ingredients is sloppily written. It contains language that, according to the nonpartisan Legislative Analyst's Office, could be construed by the courts to imply that processed foods could not be labeled as "natural" even if they weren't genetically engineered. Most of the burden for ensuring that foods are properly labeled would fall not on producers but on retailers, which would have to get written statements from their suppliers verifying that there were no bioengineered ingredients a paperwork mandate that could make it hard for mom-and-pop groceries to stay in business. Enforcement would largely occur through lawsuits brought by members of the public who suspect grocers of selling unlabeled food, a messy and potentially expensive way to bring about compliance.

These are all valid arguments for rejecting Proposition 37, but a more important reason is that there is no rationale for singling out genetic engineering, of all the agricultural practices listed above, as the only one for which labeling should be required. So far, there is little if any evidence that changing a plant's or animal's genes through bioengineering, rather than through selective breeding, is dangerous to the people who consume it. In fact, some foods have been engineered specifically to remove allergens from the original version. By contrast, there is obvious reason to be worried about the fact that three-fourths of the antibiotics in this country are used to fatten and prevent disease in livestock, not to treat disease in people. The rise of antibiotic-resistant bacteria from overuse of pharmaceuticals poses a real threat to public health. So why label only the bioengineered foods? Because the group that wrote Proposition 37 happened to target them. What's needed is a consistent, rational food policy, not a piecemeal approach based on individual groups' pet concerns.

That's not to belittle consumer doubts about genetically engineered foods. The nation rushed headlong into producing them with lax federal oversight, and although many studies have been conducted over the last couple of decades, a 2009 editorial in Scientific American complained that too much of the research has been controlled by the companies that create the engineered products. The solution, though, is more independent study and, if necessary, stronger federal oversight and legislation, not a label that would almost certainly raise alarm about products that haven't been shown to cause harm.

VOTER GUIDE: 2012 California Propositions

The more substantiated issue with genetically engineered foods is their effect on the environment and possibly on other crops. The over-reliance they've encouraged on a single herbicide has contributed to the emergence of Roundup-resistant weeds. The industry is now seeking federal permission to grow corn that can withstand a different, more problematic herbicide. The Obama administration should withhold permission until agribusiness comes up with a better long-term solution than creating ever-tougher weeds.

Meanwhile, the marketplace already provides ways to inform consumers about their food. Just as some meats are labeled antibiotic-free or hormone-free, and some eggs are labeled cage-free, food producers are welcome to label their foods as GE-free. The Trader Joe's grocery chain has helped market itself to concerned consumers by announcing that its private-label foods do not contain genetically engineered ingredients. Organic foods are never genetically engineered. There are no genetically engineered versions of most fruits sold in markets.

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Valley farmers fear 'modified' wording in Prop. 37

Posted: at 11:21 am

The Valley's edible crops are grown without genetic engineering, but farmers here still fear a ballot initiative aimed at labeling food that has been genetically modified, saying it could make it harder to sell their products.

Farmers are battling Proposition 37 because they say it hurts business and exposes them to possible lawsuits.

Supporters of the November California ballot measure argue that consumers have a right to know whether the food they are buying has been altered using genetic technology. Many crops grown nationwide, including corn, soybeans and canola, have been tinkered with to resist chemicals, bugs or drought.

But Valley farmers say the proposition has some unintended consequences that could increase costs and hurt their ability to sell even non-genetically engineered crops.

As part of Prop. 37, retailers will be required to label products that have genetically engineered ingredients. That means stickers or labels on many common grocery store items, including cereal, cake mixes and cookies.

But products that are exempt, including those that are not genetically engineered, need to be verified by either the wholesaler, food maker or farmer.

Growers believe that could mean more paperwork -- and potential lawsuits by consumer groups if they don't do it right.

"In addition to the substantial record-keeping that we already do, we will have to provide sworn statements proving that we do not have genetically engineered peaches," said Karri Hammerstrom, who farms 40 acres of peaches and plums in Kingsburg with her husband, Bill. "And if we don't do that, we could be sued."

Hammerstrom also is troubled by wording in Prop. 37 that could limit farmers or processors from using the word "natural" when selling products.

The proposition bans the use of the word "natural" or any variation of that in the labeling of genetically engineered foods. But the state's Legislative Analyst's Office said that the way the proposition is written, there is a possibility that the ban could apply to some processed foods regardless of whether they are genetically engineered.

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Valley farmers fear 'modified' wording in Prop. 37

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ORF Genetics to Offer endotoxin- and Animal-free FGFb and mLIF for Stem Cell Research

Posted: at 11:21 am

REYKJAVIK, Iceland, October 4, 2012 /PRNewswire/ --

ORF Genetics announced today that the company has added endotoxin- and animal-free human Fibroblast Growth Factor Basic (FGF basic) and mouse Leukemia Inhibitory Factor (mouse LIF) to its portfolio of growth factors for stem cell research.

Most growth factors applied in stem cell research today are made in E. coli bacteria, which produce endotoxins that can have adverse effect on stem cell cultures. Other manufacturers of growth factors have various methods to remove these endotoxins, but traces inevitably remain, which can lead to increased death rate of cells and other suboptimal effects in cell cultures. Other growth factors on the market today are made by animal cells. However, most stem cell researchers prefer to use growth factors of non-animal origin to exclude risks of viral contamination and the inclusion of growth factor homologs.

This has led to a market demand for alternative sources of animal-free growth factors, void of endotoxins. ORF Genetics' unique growth factors are produced in the seeds of the barley plant, which does not produce any endotoxins or other substances toxic to mammalian cells.

FGF basic and mouse LIF are key growth factors for the cultivation of their respective stem cells, i.e. FGF basic for human stem cells and mouse LIF for mouse stem cells. Each protein is used to expand the stem cells' populations before researchers make them differentiate into various cell types, such as heart, liver or neural cells.

"ORF Genetics has built a reputation for offering the first plant-made, endotoxin-free and animal-free growth factor portfolio for stem cell researchers. As we are producing these growth factors in our novel plant expression system ORFEUS, we are very happy to be able to offer these high quality growth factors at more efficient prices than market leaders," said Bjrn rvar, CEO of ORF Genetics.

ORF Genetics is a world leader of plant made growth factors and offers a portfolio of endotoxin- and animal-free growth factors for human stem cell research. The company's production takes place in a biorisk-free production system in barley, bypassing conventional bacteria and animal cell production systems. The cultivation of barley takes place in greenhouses in inert volcanic pumice, using renewable geothermal energy.

For more information please contact:

Dr. Hakon Birgisson, Director of Global Market Development Tel: +354-821-1585 email:hakon.birgisson@orfgenetics.com

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ORF Genetics to Offer endotoxin- and Animal-free FGFb and mLIF for Stem Cell Research

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DNA Scans Help Pinpoint Causes of Mental Retardation

Posted: at 11:21 am

Sequencing the genomes of 100 individuals with mental retardation with no known cause yielded genetic answers for 16 of them, a study found, suggesting the technique may help diagnose and aid in treatment.

While more than 400 genetic mutations are known to cause intellectual disability, they are responsible for less than half of the cases, said Han Brunner, a study author and head of human genetics at Radboud University Nijmegen Medical Centre in the Netherlands. The research is published today in the New England Journal of Medicine.

The study shows how gene sequencing can improve diagnosis in patients with mental disabilities, many of whom never learn the cause. Knowing the genetic origin can help patients and families understand the prognoses and may lead to specific treatment options, the authors said in the study.

Half of the children and adults with intellectual disability never have an explanation of why they are retarded -- thats a big problem, leading many parents on a quest to numerous doctors looking for answers, Brunner said in a telephone interview. This is what people call the diagnostic odyssey, and people can put that to rest, by using genetic sequencing, he said.

Researchers scanned the DNA of children with mental retardation, defined as having an IQ of less than 50, as well as their parents, and looked for differences. While all children have some mutations, few lead to intellectual disability, Brunner said. Once the culprits are known, it can help direct some therapies or dietary changes.

We had two cases where the type of mutation would suggest that you might try a treatment for a metabolic disorder, and another with epilepsy, he said.

For instance, patients with a mutation in the PDHA1 gene would benefit from a ketogenic diet, which is high in fat, and those with SCN2A mutation should avoid sodium-channel blockers to better control their epileptic episodes and improve cognitive function, according to the study.

The research, funded in part by the European Union, demonstrates how the quickening pace of gene sequencing technology may lead to wider use in the clinic to help patients, said Heather Mefford, assistant professor of pediatrics at the University of Washington in Seattle.

The technology used in the study is called exome sequencing and looks at the 1 percent of the DNA containing genes that create proteins. The researchers used equipment from Carlsbad, California-based Life Technologies Corp. (LIFE) to perform the sequencing.

Previously, you might test one or two genes. Or more recently, a panel of genes, Mefford, who wrote an accompanying editorial to the study, said in a telephone interview. That approach could take weeks or months and not lead to any answers, she said. This test allows us to look at all the genes at once.

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DNA Scans Help Pinpoint Causes of Mental Retardation

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DNA links two rapes in St. Louis County, may be more nationally

Posted: at 11:21 am

CLAYTON St. Louis County police believe a serial rapist is targeting Asian women in northwestern St. Louis County and possibly elsewhere in the country.

Detectives found DNA evidence linking the rapes of two women in separate attacks to the same man, said county Police Chief Tim Fitch. But the culprit's identity has not been determined.

Fitch said it may be significant that one victim is of Chinese descent and the other Korean.

"This is the kind of stuff that will keep us awake at night: Some stranger out there attacking innocent victims," Fitch said. "That is why it's so important to let the public know to be on guard and let us know if you have information to help us catch the guy because we also know people like this just don't stop."

The first incident took place about 1:45 a.m. April 4, 2011, at the Beau Jardine apartment complex along the 10300 block of Sannois Drive. In that case, the victim, 27, said her attacker put a blanket over her head while she was asleep in her home and sexually assaulted her. There were no signs of forced entry to the second-floor apartment, but she told police she couldn't recall whether she had locked her door.

The other attack occurred Sept. 19 and involved a woman, 18, who said she was grabbed from behind while walking on a sidewalk near Fee Fee and Bennington roads in northwestern St. Louis County. The victim told police she was walking home from a friend's house when she was taken to a grassy area about 20 feet from the sidewalk.

The locations are within five miles of each other.

"Generally speaking, serial rapists do their homework on their victims before they attack," Fitch said. "We have every reason to believe this guy isn't just driving up the road and attacking the first woman he sees."

Fitch also said similar reports going back several years have surfaced in San Diego, New York and in Maryland involving a man targeting Asian women.

"We're trying to determine if this a transient person, who is moving from city to city for a job, and see if there are links in those other cases," he said. "That makes it even more difficult to catch someone when they're mobile like that. But it could turn out that he was born and raised here as well."

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DNA links two rapes in St. Louis County, may be more nationally

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