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Category Archives: Transhuman News

DNA Evidence Doesn't Convince Jury of Guilt in 1983 Murder

Posted: October 5, 2012 at 2:26 am

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The state's highest court has overturned a sexual assault conviction.

San Francisco prosecutors have struck out in their first try to convict William Payne of murder. But they will keep swinging.

Payne, 48, was charged with first-degree murder in the 1983 death of 41-year old Nikolaus Crumbley in January, after a "cold hit DNA" test linked him to the death, according to the San Francisco Examiner.

But despite the DNA evidence proving Payne was on the scene with Crumbley, with whom he had sex, the jury hung on charges of murder.

The San Francisco District Attorney's Offcie will push for a retrial, with opening arguments scheduled for Oct. 22, the newspaper reported.

Payne was 19 when Crumbley was found dead, face down and with his pants and underwear pulled down to his ankles, at the corner of John Shelley Drive and Mansell Street near John McClaren Park.

Payne was arrested for the crime in January. The DNA evidence proves that the pair had sex, but not that Payne killed Crumbley, the newspaper reported.

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DNA Evidence Doesn't Convince Jury of Guilt in 1983 Murder

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Security: What if all law enforcement agencies could do instant DNA analysis?

Posted: at 2:26 am

What would happen if everyone could do DNA analysis within minutes using a simple computerized box that accepted a person's cell samples on a swab and spit out the answer about a person's genetic identity automatically?

Though it sounds like the stuff of science fiction, that possibility is now within reach. And as the new capability of what's being called 'Rapid DNA' analysis takes off, law enforcement in police stations and the FBI could be using it to catch criminals without having to send DNA off to official DNA-testing labs as is done now. But it doesn't stop there. U.S. agencies could not only use this instant "DNA analysis in a box" to check the identity of someone wanting to come into the country, but easily check to see if two people who say they're related really are since DNA genetic information can provide that. And that's just what governments might do with it -- there's no reason that businesses and individuals couldn't easily be doing DNA analysis, too, in the years to come.

What if Ethernet failed?

What if Windows 8 flops?

"What science has given us is some very miraculous work in the DNA world," said Peter Verga, chief of staff for the Under Secretary of Defense for Policy at the U.S. Department of Defense, during his keynote at the Biometric Consortium Conference in Tampa recently.

After years of research encouraged by the FBI and DoD, 'Rapid DNA' analysis-in-a-box is here, proving a DNA profile can be produced automatically, with no need for professional lab training, in 90 minutes or less. Two companies, integenX and NetBio, are the manufacturers whose 'Rapid DNA' equipment is now under government evaluation at the National Institute of Standards and Technology and the U.S. Army Criminal Investigative Laboratory. More companies, including Lockheed Martin, are expected to soon follow.

Verga noted it would theoretically be possible in the future to do a DNA profile on travelers coming into Dulles Airport, for example, for security purposes. But whatever ends up happening with the new power for instant DNA analysis, it must "adhere to the rule of law" and conform to the idea that one must "do good with biometrics and avoid evil," he added.

The 'Rapid DNA' analysis is only going to get more powerful in what it can do.

Richard Selden, CEO of NetBio, describes its ANDE System as a 'Rapid DNA' box that measures 26.6''-inches by 16.5-inches' x 23.1-inches' and can take an inserted cotton swab with cell samples from someone's cheek and produces a DNA profile in 83 minutes. Ruggedized for air, truck and hand-carry, it's "stable for at least six months without refrigeration," said Selden, speaking about it at the conference. It works in "an uncontrolled environment" with "no manual processing."

To match DNA, it can connect to a remote database or do the DNA matching in a local database onboard. The technology developed by NetBio is already being expanded into next-generation device that will accept very minute samples of DNA collected from cups or virtually anywhere for a DNA profile of the individual. The box is also being expanded to do "kinship analysis," Selden pointed out.

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Security: What if all law enforcement agencies could do instant DNA analysis?

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Good News for NICU Babies: Faster DNA Testing for More Accurate Diagnoses

Posted: at 2:26 am

David Aaron Troy / Getty Images

Fifty hours. Thats how long it now takes to decode and interpret a newborn babys genome an undertaking that used to take weeks, or even months. And those two days can mean the difference between life and death for a critically ill infant.

In a paper published in the journal Science Translational Medicine, researchers led by Stephen Kingsmore, director of the Center for Pediatric Genomic Medicine at Childrens Mercy Hospital, describe a new genetic test that can rapidly screen the DNA of babies in the neonatal intensive care unit (NICU) for about 3,500 diseases known to be linked to single-gene mutations. Of these, doctors can treat about 500.

Up to a third of babies admitted to the NICU have a genetic disease. But many newborns are not diagnosed properly and may therefore miss the opportunity for a potentially life-saving therapy. Many of the symptoms of such genetic diseases are both general and shared by many different conditions, which makes them difficult to diagnose; whats more, many of the genetic conditions in question are rare, so most physicians, even NICU specialists, may not be familiar them or unable to recognize their symptoms. Currently used genetic tests are also too expensive and time-consuming to be clinically useful; because the tests can take weeks, or sometimes months, most NICU babies will have either gone home or died by the time the results are ready.

(MORE: 23andMe Wants FDA Approval for Personal DNA Testing. What Can It Reveal?)

So Kingsmore and his colleagues collaborated with Illumina, a manufacturer of gene-sequencing machines, to shorten the time it takes to both decode an entire genome and generate a clinically useful analysis of that sequencing. Thanks to recent advances in the ability to break up and re-knit DNA, the company was able to sequence the 3 billion base pairs of the genome in just 27 hours down from weeks.

But decoding a genome is only half of the challenge. Words in a book dont make sense unless they are put together in a grammatically sensible way, and similarly, DNA is meaningless unless its analyzed in the context of genes, which in turn are connected to human functions or conditions. So for two years, Kingsmores team worked on special software designed to help doctors use genetic information to make accurate diagnoses and guide ill babies to the right treatment.

The software simplifies and standardizes the often complex process of diagnosis, by allowing doctors to click on the symptoms they see in newborns; the program then puts together a list of the genes that might be most likely to be at fault. Doctors can then compare these genetic suspects to the newborns sequenced genome to see if any of the same genes are mutated; if they are, they can pinpoint a diagnosis.

(MORE: Decoding Cancer: Scientists Release 520 Tumor Genomes from Pediatric Patients)

There is a phenomenal need for more accurate and faster diagnosis in the NICU, says Kingsmore, adding that this is a setting where we know that giving treatments is one of the most effective things we can do in medicine from the cost standpoint, since these patients have 65 to 70 years of life to live out.

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Good News for NICU Babies: Faster DNA Testing for More Accurate Diagnoses

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Applied DNA Sciences to Present at SAE Event

Posted: at 2:26 am

STONY BROOK, NY--(Marketwire - Oct 4, 2012) - Applied DNA Sciences, Inc. ( OTCBB : APDN ) (Twitter: @APDN), a provider of DNA-based anti-counterfeiting technology and product authentication solutions, announced today it has been invited to present at the important SAE International 2012 Counterfeit Parts Avoidance Symposium. The Symposium will take place on Friday, Nov. 2, 2012 in Phoenix, Arizona. APDN will present an important white paper which Dr. James A. Hayward, APDN CEO and President, calls "a significant contribution to an urgent conversation and a call to action."

The speakers line-up for the Symposium includes thought leaders from throughout the industries impacted. SAE International (SAE) is a global association of more than 128,000 engineers and related technical experts in the aerospace, automotive and commercial-vehicle industries.

SAE has played a key role in the development of industry and government standards in the effort to stem counterfeits in electronics and aerospace. In 2009, the U.S. Department of Defense officially adopted SAE International's standard SAE AS5553-Counterfeit Electronic Parts; Avoidance, Detection, Mitigation, and Disposition.

SAE's G-19 Counterfeit Electronic Parts Committee continues to develop and refine the widely-followed anti-counterfeiting standards.

The Symposium takes place at a critical time in the effort against counterfeits. Electronics and aerospace continue to come to grips with new anti-counterfeiting requirements expressed in Section 818 of the National Defense Authorization Act for Fiscal 2012. Section 818 directs the Office of the Secretary of Defense to update the procurement rules and guidelines to account for the new anti-counterfeiting requirements. These updates may come in early October. The rules and guidelines are found in the Defense Federal Acquisition Regulation (DFAR) Supplement to the Federal Acquisition Regulation (FAR).

APDN technology, which uses an engineered botanical DNA marker to assure authenticity of parts, is the centerpiece of a pilot program supported by the Defense Logistics Agency, managed by the LMI consultancy. As of August 7, 2012, the technology is required by DLA for defense contractors providing microcircuits in FSC 5962 to that Agency.

Janice Meraglia, APDN Vice President for Government and Military Programs, commented: "We are honored to present at an event which includes leaders who have made a real difference in the fight against counterfeits, going back many years. We believe our technology platform is poised to become a key tool in this effort, and something which will work well with and contribute to ongoing standards initiatives."

About Applied DNA Sciences

APDN is a provider of botanical-DNA based security and authentication solutions that can help protect products, brands and intellectual property of companies, governments and consumers from theft, counterfeiting, fraud and diversion. SigNature DNA and smartDNA, our principal anti-counterfeiting and product authentication solutions that essentially cannot be copied, provide a forensic chain of evidence and can be used to prosecute perpetrators.

The statements made by APDN may be forward-looking in nature. Forward-looking statements describe APDN's future plans, projections, strategies and expectations, and are based on assumptions and involve a number of risks and uncertainties, many of which are beyond the control of APDN. Actual results could differ materially from those projected due to our short operating history, limited financial resources, limited market acceptance, market competition and various other factors detailed from time to time in APDN's SEC reports and filings, including our Annual Report on Form 10-K, filed on December 8, 2011 and our subsequent quarterly reports on Form 10-Q. APDN undertakes no obligation to update publicly any forward-looking statements to reflect new information, events or circumstances after the date hereof to reflect the occurrence of unanticipated events.

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Applied DNA Sciences to Present at SAE Event

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The Eczema Company Pledges Donation for National Eczema Awareness Month

Posted: at 2:25 am

For national eczema awareness month, The Eczema Company will donate $1 from every sale to the National Eczema Association. http://www.eczemacompany.com

(PRWEB) October 04, 2012

In support of the National Eczema Associations ongoing efforts to provide education on eczema, The Eczema Company is donating $1 from every sale to the association during Octobers national eczema awareness month. As a mother of a child with eczema, I understand the need to reach out and connect with other parents dealing with the same itchy skin. We are thrilled to support the National Eczema Association as they offer a world of resources for parents such as myself and they have an excellent network of support groups located around the country, states Jennifer Roberge, owner of The Eczema Company.

In 2012, The Eczema Company was also a proud sponsor of the National Eczema Associations Itching for a Cure Walk in Asheville, NC and Patient Conference in Atlanta, GA.

About the Eczema Company:

The Eczema Company was created for families dealing with the daily emotional and physical strains of eczema. The online store provides products to help soothe your itchy little world that include scratch protective clothing, healing jewelry, and natural, non-toxic skincare.

Jennifer Roberge The Eczema Company 877-600-7130 Email Information

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Gum disease linked to psoriasis: Taiwanese study

Posted: at 2:25 am

NEW YORK - People with chronic gum disease seem to be slightly more likely to develop the skin condition psoriasis, according to a new study.

Taiwanese researchers found that in a group of more than 230,000 people, those with gum disease were 54 percent more likely to get psoriasis over five years.

The study is among the first to investigate the link between the two conditions and doesn't necessarily mean gum disease can cause psoriasis.

"We don't know very much about what the risk factors are for chronic inflammatory diseases like psoriasis," said Dr. Joel Gelfand, a dermatologist at the University of Pennsylvania in Philadelphia, who was not involved in the new research.

"This study points in a potentially new direction for a potential risk factor thatin theorycould be modified and thus lower the risk of psoriasis in the future," he told Reuters Health. "That being said, this finding needs to be confirmed by more-rigorous, more-controlled studies to determine if the findings are real."

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Study: People with gum disease 54% more likely to develop psoriasis

Posted: at 2:25 am

Psoriasis

NEW YORK (Reuters Health) - People with chronic gum disease seem to be slightly more likely to develop the skin condition psoriasis, according to a new study.

Taiwanese researchers found that in a group of more than 230,000 people, those with gum disease were 54 percent more likely to get psoriasis over five years.

The study is among the first to investigate the link between the two conditions and doesn't necessarily mean gum disease can cause psoriasis.

"We don't know very much about what the risk factors are for chronic inflammatory diseases like psoriasis," said Dr. Joel Gelfand, a dermatologist at the University of Pennsylvania in Philadelphia, who was not involved in the new research.

"This study points in a potentially new direction for a potential risk factor that - in theory - could be modified and thus lower the risk of psoriasis in the future," he told Reuters Health. "That being said, this finding needs to be confirmed by more-rigorous, more-controlled studies to determine if the findings are real."

Psoriasis is thought to be caused by a mistaken immune reaction directed at the body's own cells, leading to inflamed patches of red, scaly skin.

It's not the first time the condition has been linked to other health problems. Earlier this year, a study of people evaluated for heart disease found 84 percent of patients with psoriasis had coronary artery disease, compared to 75 percent of patients without the skin condition. (See Reuters Health article from January 10, 2012.)

Oral health has also been tied to other conditions, with two studies from this year finding links to heart disease and dementia. (See Reuters Health articles from April 19 and 21, 2012.)

But until now only one other study had looked at the link between psoriasis and chronic periodontitis, the advanced stage of the gum disease gingivitis.

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Study: People with gum disease 54% more likely to develop psoriasis

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Gum disease linked to psoriasis: study

Posted: at 2:25 am

NEW YORK (Reuters Health) - People with chronic gum disease seem to be slightly more likely to develop the skin condition psoriasis, according to a new study.

Taiwanese researchers found that in a group of more than 230,000 people, those with gum disease were 54 percent more likely to get psoriasis over five years.

The study is among the first to investigate the link between the two conditions and doesn't necessarily mean gum disease can cause psoriasis.

"We don't know very much about what the risk factors are for chronic inflammatory diseases like psoriasis," said Dr. Joel Gelfand, a dermatologist at the University of Pennsylvania in Philadelphia, who was not involved in the new research.

"This study points in a potentially new direction for a potential risk factor that - in theory - could be modified and thus lower the risk of psoriasis in the future," he told Reuters Health. "That being said, this finding needs to be confirmed by more-rigorous, more-controlled studies to determine if the findings are real."

Psoriasis is thought to be caused by a mistaken immune reaction directed at the body's own cells, leading to inflamed patches of red, scaly skin.

It's not the first time the condition has been linked to other health problems. Earlier this year, a study of people evaluated for heart disease found 84 percent of patients with psoriasis had coronary artery disease, compared to 75 percent of patients without the skin condition. (See Reuters Health article from January 10, 2012.)

Oral health has also been tied to other conditions, with two studies from this year finding links to heart disease and dementia. (See Reuters Health articles from April 19 and 21, 2012.)

But until now only one other study had looked at the link between psoriasis and chronic periodontitis, the advanced stage of the gum disease gingivitis.

For the new research, published in the British Journal of Dermatology, Dr. Joseph J. Keller from Taipei Medical University and his colleague turned to a database of Taiwan's national health system.

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Gene diseases in newborns spotted with 2-day test

Posted: at 2:25 am

Too often, newborns die of genetic diseases before doctors even know what's to blame. Now scientists have found a way to decode those babies' DNA in just days instead of weeks, moving gene-mapping closer to routine medical care.

The idea: Combine faster gene-analyzing machinery with new computer software that, at the push of a few buttons, uses a baby's symptoms to zero in on the most suspicious mutations. The hope would be to start treatment earlier, or avoid futile care for lethal illnesses.

Wednesday's study is a tentative first step: Researchers at Children's Mercy Hospital in Kansas City, Mo., mapped the DNA of just five children, and the study wasn't done in time to help most of them.

But the hospital finds the results promising enough that by year's end, it plans to begin routine gene-mapping in its neonatal intensive care unit and may offer testing for babies elsewhere, too while further studies continue, said Dr. Stephen Kingsmore, director of the pediatric genome center at Children's Mercy.

Even if the diagnosis is a lethal disease, "the family will at least have an answer. They won't have false hope," said Kingsmore, who team reported the method in the journal Science Translational Medicine.

More than 20 per cent of infant deaths are due to a birth defect or genetic diseases, the kind caused by a problem with a single gene. While there are thousands of such diseases from Tay-Sachs to the lesser known Pompe disease, standard newborn screening tests detect only a few of them. And once a baby shows symptoms, fast diagnosis becomes crucial.

Sequencing whole genomes all of a person's DNA can help when it's not clear what gene to suspect. But so far it has been used mainly for research, in part because it takes four to six weeks to complete and is very expensive.

Wednesday, researchers reported that the new process for whole-genome sequencing can take just 50 hours half that time to perform the decoding from a drop of the baby's blood, and the rest to analyze which of the DNA variations uncovered can explain the child's condition.

That's an estimate: The study counted only the time the blood was being decoded or analyzed, not the days needed to ship the blood to Essex, England, home of a speedy new DNA decoding machine made by Illumina, Inc. or to ship back the results for Children's Mercy's computer program to analyze. Kingsmore said the hospital is awaiting arrival of its own decoder, when 50 hours should become the true start-to-finish time.

Specialists not involved with the study said it signals the long-promised usefulness of gene-mapping to real-world medicine finally is close.

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Gene diseases in newborns spotted with 2-day test

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2-day test can spot gene diseases in newborns

Posted: at 2:25 am

WASHINGTON (AP) -

Too often, newborns die of genetic diseases before doctors even know what's to blame. Now scientists have found a way to decode those babies' DNA in just days instead of weeks, moving gene-mapping closer to routine medical care.

The idea: Combine faster gene-analyzing machinery with new computer software that, at the push of a few buttons, uses a baby's symptoms to zero in on the most suspicious mutations. The hope would be to start treatment earlier, or avoid futile care for lethal illnesses.

Wednesday's study is a tentative first step: Researchers at Children's Mercy Hospital in Kansas City, Mo., mapped the DNA of just five children, and the study wasn't done in time to help most of them.

But the hospital finds the results promising enough that by year's end, it plans to begin routine gene-mapping in its neonatal intensive care unit - and may offer testing for babies elsewhere, too - while further studies continue, said Dr. Stephen Kingsmore, director of the pediatric genome center at Children's Mercy.

"For the first time, we can actually deliver genome information in time to make a difference," predicted Kingsmore, whose team reported the method in the journal Science Translational Medicine.

Even if the diagnosis is a lethal disease, "the family will at least have an answer. They won't have false hope," he added.

More than 20% of infant deaths are due to a birth defect or genetic diseases, the kind caused by a problem with a single gene. While there are thousands of such diseases - from Tay-Sachs to the lesser known Pompe disease, standard newborn screening tests detect only a few of them. And once a baby shows symptoms, fast diagnosis becomes crucial.

Sequencing whole genomes - all of a person's DNA - can help when it's not clear what gene to suspect. But so far it has been used mainly for research, in part because it takes four to six weeks to complete and is very expensive.

Wednesday, researchers reported that the new process for whole-genome sequencing can take just 50 hours - half that time to perform the decoding from a drop of the baby's blood, and the rest to analyze which of the DNA variations uncovered can explain the child's condition.

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2-day test can spot gene diseases in newborns

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