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Category Archives: Transhuman News
What DNA Actually Looks Like
Posted: November 30, 2012 at 5:44 pm
Scientists have developed a new method of imaging the building blocks of life. It involves an electron microscope and a bed of nails.
DNA, we are taught early on, is colorful. The building block of life is not just a whirligig-like twist, its purines and pyrimidines neatly paired and labeled; it is also an explosion of primary reds and blues and greens and yellows, the As and the Gs and the Cs and the Ts linked together to create a kind of modified, twisted rainbow.
Of course, that rendering takes artistic license. Watson and Crick determined DNA's structure[pdf, but a highly awesome one] based on a combination of sophisticated guesswork and, crucially, x-ray crystallography -- and that remains a workable, and powerful, technique for visualizing DNA strands. But crystallography creates its own kind of rendering: It's a technology whose imaging power relies on diffracted light. When we look at those now-iconic images of the double helix, the fuzzy X inside the fuzzy O, we're not seeing the DNA itself so much as we're seeing x-rays deflected from its atoms.
Which makes the image below pretty amazing. Though it is significantly less colorful than textbook DNA, and a tad less tidy than the double helix-demonstrating images produced by x-ray crystallography, it is, in certain ways, much more realistic. It isn't a rendering; it's a direct image of DNA, captured through an electron microscope. Yes. YES.
Computer renderings and actual images of a DNA molecule, as seen through an electron microscope (Enzo di Fabrizio via New Scientist)
The image showsa single thread of double-stranded DNAsuspended on a bed of nanoscopic silicon pillars. It wascreated by Enzo di Fabrizio and a team at Italy's University of Genoa, which developed a new technique ("an experimental breakthrough," they call it) for the purpose. The team, New Scientist reports, found a way to snag strands of DNA out of a dilute solution by, essentially, dehydrating them. They developed a pattern of extremely water-repellent, silicon nanopillars -- pillars that would cause moisture to evaporate quickly and leave behind strands of DNA as threads. And then, at the base of their "nanopillar bed," the team drilled tiny (very, very tiny) holes. And through those holes, they shone beams of electrons, which allowed them to capture relatively high-resolution images of the DNA thread.
And here's an even-closer-up view of the strand itself, its base pairs fuzzily evident in the magnification.
The team justpublished the details of this imaging technique in the journal Nanoletters. And the new system represents a significant step forward for nanobiology and all the fields connected to it, giving scientists a new way to understand DNA. Particularly when it comes to its structure -- the stuff beyond the double helix. "Direct imaging becomes important," the paper notes, "when the knowledge at few/single molecule level is requested and where the diffraction does not allow to get structural and functional information." The technique, New Scientist points out, will help researchers to understand more precisely how proteins, RNA, and other biomolecules interact with DNA.
Which is exciting. But even for those of us who are not researchers, the new approach gives us a whole new way to do something else: to see where we came from.
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What DNA Actually Looks Like
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Applied DNA Sciences Announces Industry Contracts for SigNature(R) DNA Marking of Electronics
Posted: at 5:43 pm
STONY BROOK, NY--(Marketwire - Nov 29, 2012) - Applied DNA Sciences, Inc. ( OTCBB : APDN ), (Twitter: @APDN), a provider of DNA-based anti-counterfeiting technology and product authentication solutions, announced today that it has signed multiple contracts in support of the mandate by the Defense Logistics Agency for use of APDN's SigNature DNA marking and authentication technology.
These electronics companies have or will receive SigNature DNA and essential materials and services from APDN for DNA marking during or after manufacture.These steps will qualify them as SigNature DNA-compliant.
For manufacturers, a SigNature DNA Authenticity Mark as applied in production, certifies authenticity in an absolute, transparent and verifiable manner.For distributors and others, a SigNature DNA Provenance Mark establishes traceability to the point of the mark, assuring the entire supply chain that the part can be tracked to a supplier.
The contracts will enable electronics companies to fulfill the DLA mandate, announced on August 7 in a clause in Defense Logistics Acquisition Directive (DLAD) 52.211-9074, and expanded on November 7 with a provision atDLAD 52.211-9008. This mandate specifically requires SigNature DNA marking for procurements of items falling within Federal Supply Class 5962, Electronic Microcircuits. The requirement applies only to procurements made by DLA.
The developing list of participating defense contractors will enable the military electronics supply chain to move toward compliance with the anti-counterfeiting language in Section 818 of the National Defense Authorization Act for Fiscal Year 2012 (Section 818).A major deadline for Section 818, which imposes strict requirements for control of counterfeits, is due to be reached very soon. In a press announcement released on October 31, DLA pointed to the connection between the mandate and the coming implementation of NDAA Section 818:
The new requirement also facilitates the goals of Congress to protect DoD's supply chains and national cybersecurity, which Congress outlined in the 2012 National Defense Authorization Act. This requires DoD, as well as industry, to develop counterfeit item detection and prevention measures for electronic items.
In the same press announcement, DLA stressed the "broad implications" of its DNA marking mandate, stretching beyond electronics, saying:
DLA is initially targeting microelectronics, but the technology is used with other commodities commercially and has broad implications for other DLA products and equipment at risk for counterfeiting.
APDN suggested that electronics companies check with suppliers to find whether they have joined the list of companies which are SigNature DNA-compliant.
Janice Meraglia, Vice President, Military and Government Programs for Applied DNA Sciences, said, "DLA, in its efforts to provide support to our war fighters, has worked for years to develop new technology and processes to mitigate counterfeit risk.We are pleased to see these efforts materialized in the electronics industry, something which will benefit industry and national security."
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Applied DNA Sciences Announces Industry Contracts for SigNature(R) DNA Marking of Electronics
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DNA 'LEGOs' Build a Mini Space Shuttle
Posted: at 5:43 pm
A tiny space shuttle made out of DNA "LEGO bricks" shows how scientists could someday build new technologies on the smallest scales.
Single DNA strands became "LEGO bricks" that could assemble together by themselves into 102 individual 3D shapes. Harvard researchers manipulated the DNA coding of the bricks so that they could form solid shapes such as the tiny shuttle, honeycomb structures, and even "written" features on a solid base such as numbers and letters of the English alphabet.
"Once we know how to compile the correct code of complex shapes and add it to the synthetic DNA strands, everything else is simple and natural," said Yonggang Ke, a chemist at Harvard University. "Those DNA strands are like smart LEGO bricks that know exactly where to go by themselves."
DNA bricks offer a powerful new tool for building structures in the tiniest detail, according to Ke and his colleagues in their study detailed in the Nov. 29 online edition of the journal Science. The work could lead to tiny medical devices for delivering drugs inside the human body or next-generation computer circuits.
But the DNA nanotechnology breakthrough also touches upon one of science's greatest mysteries how life on Earth assembled itself from a jumble of molecules in the primordial ooze. A DNA strand's width is about 1 nanometer (1 billionth of a meter) far smaller than a human hair's width of 60,000 nanometers.
Replicating life's miracle
The idea of DNA bricks that can assemble into shapes on their own seems fantastical for humans used to building things step-by-step. But it's just a hint of what nature does all the time through self-assembly, Ke said.
"All life forms on earth are self-assembled, in an environment of an enormous amount of small molecules and macromolecules, such as DNA, RNA and proteins much, much messier than our small DNA "soup" in a test tube," Ke told TechNewsDaily.
The Harvard lab of Peng Yin, senior author on the new study, had used DNA to build 2D shapes. The 3D breakthrough relied upon the bricks each consisting of a single DNA strand with 32 nucleotides DNA's building block molecules that can bind to as many as four neighboring bricks.
Two bricks connect to one another at a 90-degree angle to form a 3D shape, similar to connecting a pair of two-stud LEGO bricks. Researchers designed the 3D shapes they wanted by manipulating the coded "recipe" of how DNA's base pair molecules bind to one another. [New DNA Computer Stores 1 Bit of Data]
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Transposons and the dynamic genome – Video
Posted: at 5:43 pm
Transposons and the dynamic genome
Transposons and the dynamic genome Transposons were instrumental in our evolution contributing to our fitness more then all other traditional mutations. As transposons (TEs) emerge into our collective consciousness, they become more and more significant. They constitute 50% of our genome, and continually move around. Hitherto we were told that genome is static and nearly frozen. Keeping its image from generation to generation. New studies reveal a dynamic and vibrant genome. When facing stress TEs are turning over, some are born others disrupted. All are dispersed by transposases. I regard stress induced TE changes and gene mutations are protective measures to keep a living entity alive. This newly acquired insight is inherited by its progeny. The most famous fusion protein is BCR-ABL, which was created in a CML stem cell stressed by a virus. Medicine states, that BCR-ABL is a random error mutation which causes leukemia. I maintain that BCR-ABL was created by TE activation to slow leukemia progression. Without this protective protein, patient might have succumbed to stress like in acute leukemia.From:Gershom Zajicek M.D,Views:1 0ratingsTime:16:52More inScience Technology
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The Sea and Cake "A Mere" – Pandora Whiteboard Sessions – Video
Posted: at 5:43 pm
The Sea and Cake "A Mere" - Pandora Whiteboard Sessions
The Sea and Cake perform "A Mere" for Pandora Whiteboard Sessions 11.8.12 Pandora Oakland HQ Over the years the Pandora office has had the great pleasure of receiving visits from many of these talented musicians and comedians. Some are well-established artists in town for a major show, others are in the middle of a grassroots tour, hitting coffee houses and small clubs up and down the West Coast. Sometimes we just meet up to show them around the office and learn about their careers, other times our employees are treated to a short performance. We also take the opportunity to show them the Music Genome Project and walk them through an analysis of their music, along with some data on their audience on Pandora. It #39;s been fun to see their reaction when they learn which songs are the most "thumbed up" or how large their audience is, and what areas around the country are particularly enthusiastic for their sound. This performances take place in front of a giant whiteboard in a common area of the Pandora Oakland office. On the day of the show one of the Pandora designers creates a unique drawing to represent each artist on the white board, which becomes the backdrop for the performance. The Whiteboard Sessions are unique because the daytime office environment calls for a different kind of performance than what people normally see at concerts. These sessions are mostly acoustic and there is a lot of interaction with the crowd. And there #39;s lots of improvising too - recycling bins ...From:pandoraViews:22 1ratingsTime:04:37More inMusic
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The Sea and Cake "A Mere" - Pandora Whiteboard Sessions - Video
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inFocus: Eric Banks – Video
Posted: at 5:43 pm
inFocus: Eric Banks
Eric Banks is a computational biologist at the Broad Institute. But for Eric and his team members, problem solving doesn #39;t begin in front of a computer. Instead, they begin by talking to each other and to people outside of the analysis group, walking around, drawing on whiteboards, and generally brainstorming and asking questions. Then it #39;s time to start prototyping - trying out a solution on a small scale to see if it improves the quality of the results. The process is iterative, and Banks and his team keep tinkering, examining, and circling back to try new solutions. Learn more about how Banks became interested in the field of computational biology in general and the Broad Institute in particular in this video profile. Learn more about Banks #39;s research and about working at the Broad Institute: -Program in Medical and Population Genetics (www.broadinstitute.org -Genome Analysis Toolkit (www.broadinstitute.org -Careers at the Broad Institute (www.broadinstitute.orgFrom:broadinstituteViews:4 0ratingsTime:03:06More inScience Technology
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inFocus: Eric Banks - Video
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World’s First Proven Anti-Aging Serum is Here (Spanish) – Video
Posted: at 5:43 pm
World #39;s First Proven Anti-Aging Serum is Here (Spanish)
For more information, please go to our official website: http://www.dniusa.com Join us on Facebook! http Get the latest update via Twitter! twitter.com The world #39;s first clinically proven anti-aging serum is here. Watch this video to find out about the scientific discovery known as DNP - the main ingredient in our breakthrough new anti-aging serum, Nevaline. The scientists at DermaCareNeuroScienceInstitute have discovered this early baby stage regulatory peptide for skin health. Its efficiency is clinically proven. The human genome and genes expression have been used to verify the specific potency of this signal peptide. In our clinical and scientific studies the topical application of Nevaline works immediately on cellular level. By reintroducing this master regulator peptide to your skin via Nevaline, your signs of aging may naturally regress and you will once again retain the youthful, smooth look. Sounds too good to be true? Watch the video to find out about the science behind it.From:dnifoyViews:5 0ratingsTime:02:54More inPeople Blogs
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World's First Proven Anti-Aging Serum is Here (Spanish) - Video
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Coming in 2013 | BURZYNSKI: CANCER IS SERIOUS BUSINESS, CHAPTER 2 | A Modern Story – Video
Posted: at 5:43 pm
Coming in 2013 | BURZYNSKI: CANCER IS SERIOUS BUSINESS, CHAPTER 2 | A Modern Story
Picking up where the first highly acclaimed internationally award winning documentary left off, "Burzynski: Cancer is Serious Business, Chapter 2" tells the story of the status of clinical testing of Antineoplastons sanctioned by the Food Drug Administration mdash;as well as a modern story of patients being treated today at the Burzynski Clinic in Houston, Texas. For many patients being treated by the Burzynski Clinic today mdash;their advanced cancer itself runs secondary to the constant barrage of skepticism coming not only from their local oncologists mdash;who simply do not understand Burzynski #39;s therapy mdash;but also their own friends and family who feel they are not making the correct treatment decisions mdash;even though mainstream oncology has already left them for dead. As this story unfolds, the audience will witness a real-time change of hearts and minds from many outside doctors and families mdash;right before their eyes. Since the mapping of the Cancer Genome, Burzynski has pioneered an expansion of his therapy that he calls, "Personalized Gene-Targeted Cancer Therapy", where each patient #39;s Genomic Cancer Atlas is mapped, and a treatment regimen is personally tailored for each individual patient mdash;vs. the conveyor belt, "one size fits all" approach that current oncology adheres to. Due to the slow-moving bureaucratic obstacles of Antineoplastons by the FDA, this new expanded direction has allowed more patients who are denied access to Antineoplastons by the FDA to benefit from Burzynski #39;s ...From:BurzynskiMovieViews:61 5ratingsTime:05:10More inScience Technology
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Coming in 2013 | BURZYNSKI: CANCER IS SERIOUS BUSINESS, CHAPTER 2 | A Modern Story - Video
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Genome with Todd Hazelrigg – Video
Posted: at 5:43 pm
Genome with Todd Hazelrigg
Todd Hazelrigg jams with Genome at On The Rox in Kankakee, ILFrom:THaze87Views:1 0ratingsTime:04:08More inMusic
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Genome with Todd Hazelrigg - Video
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11/25/12 – Ok, Khaleesi? – Genome – PBX – HK416 – Video
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11/25/12 - Ok, Khaleesi? - Genome - PBX - HK416
Nothing special except more team cohesion with Genome and Saint. We got the boat pretty quick and almost uncontested. Question for everyone. Do you want use to do something special? A live stream where you can ask us questions? Or do you want any one of us to do a review of any gun in particular?From:IllestAirsoftViews:1 0ratingsTime:11:18More inEntertainment
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11/25/12 - Ok, Khaleesi? - Genome - PBX - HK416 - Video
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