Category Archives: Transhuman News

The proposal of a double-helical structure for DNA over 60 years ago provided an eminently satisfying explanation for the heritability of genetic information. But why is DNA, and not RNA, now the dominant biological information store? We argue that, in addition to its coding function, the ability of DNA, unlike RNA, to adopt a B-DNA structure confers advantages both for information accessibility and for packaging. The information encoded by DNA is both digital - the precise base specifying, for example, amino acid sequences - and analogue. The latter determines the sequence-dependent physicochemical properties of DNA, for example, its stiffness and susceptibility to strand separation. Most importantly, DNA chirality enables the formation of supercoiling under torsional stress. We review recent evidence suggesting that DNA supercoiling, particularly that generated by DNA translocases, is a major driver of gene regulation and patterns of chromosomal gene organization, and in its guise as a promoter of DNA packaging enables DNA to act as an energy store to facilitate the passage of translocating enzymes such as RNA polymerase.

Keywords: A-DNA; B-DNA; DNA as an energy store; DNA backbone conformation; DNA elasticity; DNA information; DNA structure; DNA topology; alternative DNA structures; genome organisation.

Continued here:
DNA structure and function - PubMed

A flurry of false information spurred from a recent Tweet by the CDC about PCR test samples and genomic sequencing.

COLUMBUS, Ohio You've heard a lot of talk about genomic sequencing: It's the process used in labs to detect variants of COVID-19 from PCR test samples.

Some social media users falsely claim it's also used to collect samples of your DNA.

Lindsey Mills takes the claim to the experts to verify why thats not true.

The CDC is using PCR COVID test samples to collect your DNA.

Heres what we found:

This is the Tweet from the CDC that sparked a flurry of false information in a thread.

It says: "Remember that #COVID19 nose swab test you took? What happened to the swab? If it was processed with a PCR test, there's a 10% chance that it ended up in a lab for genomic sequencing analysis."

Representative Marjorie Taylor Greene retweeted it and wrote: "Did the @CDCgov get permission from people to take their DNA???" And there are replies like this: Do you have signed consent forms for every single DNA sample?"

One day after the original Tweet -- the CDC followed up with another to clarify.It says in part the "CDC and our partners conduct genomic sequencing analysis of the VIRUS that causes COVID-19."

"Our cells contain DNA, not RNA, you could do genetic sequencing on DNA or RNA but in the context of genetic sequencing, on a COVID test, it's genetic sequencing only for RNA of the virus, and not the person's DNA, explained Dr. Gastaldo.

We can verify: the claim that the CDC is collecting your DNA from PCR COVID test samples is false.

"This is an RNA virus, not the DNA virus. And that's what a PCR test does, it detects a piece of the RNA," Dr. Gastaldo said.

Have something you'd like us to verify? Send us an email to verify@10TV.com.

Read more from the original source:
No, the CDC is not collecting your DNA from PCR test samples - 10TV

disease-risk-and-health-dna-test-market

Glob Market Reports offers an overarching research and analysis-based study on, Global Disease Risk and Health DNA Test Market Report, History and Forecast 2016-2028, Breakdown Data by Companies, Key Regions, Types and Application. This report offers an insightful take on the drivers and restraints present in the market. Disease Risk and Health DNA Test data reports also provide a 5 year pre-historic and forecast for the sector and include data on socio-economic data of global. Key stakeholders can consider statistics, tables & figures mentioned in this report for strategic planning which lead to success of the organization. It sheds light on strategic production, revenue, and consumption trends for players to improve sales and growth in the global Disease Risk and Health DNA Test Market.

Some of the key manufacturers operating in this market include: 23andMe, MyHeritage, LabCorp, Myriad Genetics, Ancestry.com, Quest Diagnostics, Gene By Gene, DNA Diagnostics Center, Invitae, IntelliGenetics, Ambry Genetics, Living DNA, EasyDNA, Pathway Genomics, Centrillion Technology, Xcode, Color Genomics, Anglia DNA Services, African Ancestry, Canadian DNA Services, DNA Family Check, Alpha Biolaboratories, Test Me DNA, 23 Mofang, Genetic Health, DNA Services of America, Shuwen Health Sciences, Mapmygenome, Full Genomes and More

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Here, it focuses on the recent developments, sales, market value, production, gross margin, and other significant factors of the business of the major players operating in the global Disease Risk and Health DNA Test Market. Players can use the accurate market facts and figures and statistical studies provided in the report to understand the current and future growth of the global Disease Risk and Health DNA Test market.

Our Research Analyst implemented a Free PDF Sample Report copy as per your Research Requirement, also including impact analysisofCOVID-19 on Disease Risk and Health DNA Test Market Size

Disease Risk and Health DNA Test market competitive landscape offers data information and details by companies. Its provides a complete analysis and precise statistics on revenue by the major players participants for the period 2022-2028. The report also illustrates minute details in the Disease Risk and Health DNA Test market governing micro and macroeconomic factors that seem to have a dominant and long-term impact, directing the course of popular trends in the global Disease Risk and Health DNA Test market.

Market split by Type, can be divided into: Celiac Disease Parkinson Disease Alzheimer Disease OtherMarket split by Application, can be divided into: Online Test Offline Test

Regions Covered in the Global Disease Risk and Health DNA Test Market:1. South America Disease Risk and Health DNA Test Market Covers Colombia, Brazil, and Argentina.2. North America Disease Risk and Health DNA Test Market Covers Canada, United States, and Mexico.3. Europe Disease Risk and Health DNA Test Market Covers UK, France, Italy, Germany, and Russia.4. The Middle East and Africa Disease Risk and Health DNA Test Market Covers UAE, Saudi Arabia, Egypt, Nigeria, and South Africa.5. Asia Pacific Disease Risk and Health DNA Test Market Covers Korea, Japan, China, Southeast Asia, and India.Years Considered to Estimate the Market Size:History Year: 2015-2022Base Year: 2022Estimated Year: 2022Forecast Year: 2022-2028

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Key highlights of the Disease Risk and Health DNA Test Market report: Growth rate Renumeration prediction Consumption graph Market concentration ratio Secondary industry competitors Competitive structure Major restraints Market drivers Regional bifurcation Competitive hierarchy Current market tendencies Market concentration analysisCustomization of the Report: Glob Market Reports provides customization of reports as per your need. This report can be personalized to meet your requirements. Get in touch with our sales team, who will guarantee you to get a report that suits your necessities.

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Disease Risk and Health DNA Test Market Will Reflect Significant Growth Prospects of US$ Mn during 2022-2028 with Major Key Player: 23andMe,...

After more than a decade studying artificial intelligence, Webb shifted her sights to the links between biology and technology, generally described as synthetic biology, in part because she observed Big Tech companies becoming deeply invested in it. She and geneticist Andrew Hessel are coauthors of a new book, The Genesis Machine: Our Quest to Rewrite Life in the Age of Synthetic Biology. It does an admirable job of staying clear of both hype and fearmongering, and I wanted to ask Webb why she sees such a wide range of possible outcomes. Our conversation has been condensed and edited.

Some people are customizing their diets based on what they learn from DNA tests. Is the biological age already upon us?

For around three decades, weve been making progress on the technologies that are shaping the biological age. I think we entered it officially when the first in vitro fertilization treatment was completed successfully in 1978.

You can sequence your full genome now for less than the cost of a pair of Nike Air Jordans. However, a good question is what would compel somebody to give up their DNA to help them figure out what food to eat or when to drink what. DNA-based nutrition analysis can be entertaining, like horoscope-based science. Still, you shouldnt make any life choices based on it.

How are you defining synthetic biology in the book?

The bare-bones definition is: Synthetic biology is the application of science to improve or, in some cases, redesign life to have new or better purposes. Its a field of science that combines engineering, computer science, biology, and design.

I want to put a footnote here and say this is not about designer babies.

Do you mean synthetic biology is not only about designer babies?

Yes. I think anytime we talk about genome editing or reprogramming life, people immediately leap to designer babies. But synthetic biology is about making different types of improvements to different types of living organisms.

This includes creating new life.

Theres research being done on minimum viable genomes to understand how the different components work and why. Another field is trying to clone or re-create the DNA of animals that are extinct.

I take it youre talking about resurrecting animals like the woolly mammoth. Do you think its possible?

Lots of genomes are being decoded. George Church, a preeminent geneticist, is working on a version of the woolly mammoth. A couple of days ago some scientists figured out the genome of the numbat, a relative of the extinct Tasmanian tiger. Sequencing technology has gotten better, and we have DNA samples. And so were able to clone genomes, and this potentially could lead to resurrecting species.

The goal isnt to create a zoo filled with formerly extinct animals. Its mostly an effort to increase biodiversity, which has been plummeting, and possibly find new opportunities to deal with climate change. Part of this woolly mammoth project is about rewilding the very northern reaches of the planet, where enormous animals used to stomp around and compact the permafrost layer, which helps to keep greenhouse gases from escaping it.

Can changing the environment be risky?

Engineering biology raises questions about unpredictability. In some limited cases, there are on and off switches that can be coded into genomes. But it can be much more challenging to program an off switch for a complex organism in the wild than for a cell in a lab. Introducing something new into the environment may have downstream impacts that we didnt consider initially.

Many people are understandably worried about engineered viruses. Are there any circumstances where we should root for scientists to create new virus genomes?

The best way to think of a virus is that a virus is just a container for code. In a way, its like a USB stick: Its a container that can carry code thats malicious, benign, or great. Right now, we are dealing with a deadly pathogenic virus. But theres research underway looking at engineering viruses to fight particular types of cancer and other viruses. If we can confront deadly pathogens more precisely at a code level, what does that potentially give us? More control and better options. Right now, theres no precise way to mitigate a lot of the challenging viruses or cancers.

How can gene editing meet the challenges of global warming and food scarcity?

I think this is probably a little bit further off. Lets start with carbon dioxide. We have too much of it right now. But what if there was a way to engineer a leaf that could suck up 10 times more CO2 than, lets say, the average existing leaf, and it created organic fertilizer that doesnt cause any problems with our topsoil?

Or think about externalities that we cant control at the moment, like extreme weather events that put our food production and water supply in jeopardy. We might be able to use some of this technology to engineer better plants, like corn. I grew up outside of Chicago, where corn takes up a ton of space, and a cornstalk only has three to four ears of corn growing on it. What if we could engineer corn to be three feet taller, have 20 or 30 ears of corn, and require the same resources as our current cornstalks? Then we can do that type of farming in a fraction of the amount of space potentially indoors in a giant warehouse where you could control the temperature, humidity, and the amount of water. If you have that level of control, you dont need to use pesticides with chemicals that people are concerned about.

How can a diverse world reach a shared understanding of what the limits of synthetic biology should be?

One way to do that is to make sure more voices are a part of the conversation. One of the issues that we highlight in the book is that many of the editorial boards of core scientific journals are fairly homogenous. For various reasons, we also dont see enough people of color represented in the existing genetic databases. If were trying to optimize the future for everyone, we need more diversity and must involve more people in the conversation earlier on.

What if bad actors get their hands on powerful gene-editing technologies that are cheap and easy to use?

During the World Economic Forum, a collective of people near Davos picked up detritus, like forks and napkins, and claimed to have scraped off the DNA of global leaders, including Angela Merkel and Donald Trump. They said they would auction it to the highest bidder. Were at a point where DNA can be scraped off discarded items and used to try to piece together some form of a genome. Doing so would be problematic. After all, its illegal to pluck a hair off of somebodys head to try to scrape their DNA from it. But in the future, if a bad actor works hard enough, its plausible they could use DNA to invent an ailment intended for just one person.

Given all the possibilities, I completely understand why Emmanuel Macron recently refused a nasal swab when visiting Vladimir Putin in Russia.

Evan Selinger is a professor of philosophy at the Rochester Institute of Technology and an affiliate scholar at Northeastern Universitys Center for Law, Innovation, and Creativity. Follow him on Twitter @evanselinger.

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Bring back the woolly mammoth? Steal DNA? The prospects and pitfalls of rewriting life. - The Boston Globe

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A burglar was snared by police after leaving DNA on a rock used to smash his way into one property and a fingerprint on a window at another.

Ian Masters, aged 33, broke his way into a house in Church Lane, Southampton, on November 13 last year, by prising open a bathroom window.

Portsmouth Crown Court heard Masters smashed a kitchen door using a brick, before smearing cheese across the kitchen and stealing a Nintendo Switch, bank letters, and a laptop.

Read more: Tributes and flowers left in Alton at Storm Eunice crash scene that killed 23-year-old father

The items were not recovered.

But Hampshire Constabulary were able to link Masters to the crime after finding a fingerprint he left on the bathroom window.

Then, on December 16, a house in Brook Way, Romsey, was broken into while the occupants were out.

A glass pane on a kitchen door was smashed with a rock to gain entry.

A credit card, two debit cards, 45 worth of Icelandic currency, 30 in cash, two mobile phones and three gold rings, including a wedding ring were taken.

Again, the items were never recovered.

The owner later received a text from his bank to say the credit card was used six times to buy items worth 135.80, with one declined transaction of 21.

Police later discovered DNA left on the rock matched Masters while CCTV footage showed a man matching his description using the credit card.

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He was arrested days later on December 23 before being further arrested and charged in January.

Masters, who was serving at HMP Lewes when he appeared in court, has now been jailed for two years after pleading guilty to two counts of burglary and fraud by false representation.

Police Staff Investigator Sarah Stewart from Hampshire Constabulary, said: "Your home is somewhere you should feel safe which is why dwelling burglaries can be so traumatic for those affected, beyond the impact of the belongings that are stolen.

This sentence shows we will use all the tools at our disposal, including forensics, to bring offenders to justice and I hope it reassures our communities that we take burglary very seriously.

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Burglar snared after leaving DNA on a rock used to smash into Romsey home - Hampshire Live