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Category Archives: Transhuman News

National Museum of Natural History genome exhibition unlocks 21st-century science of life

Posted: June 17, 2013 at 7:47 pm

WASHINGTON, DC.- The Smithsonians National Museum of Natural History, in partnership with the National Human Genome Research Institute of the National Institutes of Health, opened Genome: Unlocking Lifes Code June 14a multimedia exhibition that explores how the genomic revolution is influencing peoples lives and the extraordinary impact it is having on science, medicine and nature.

The exhibition looks at the complexities of the genomethe complete set of genetic or hereditary material of a living organismand chronicles the remarkable breakthroughs that have taken place since the completion of the Human Genome Project 10 years ago. With cutting-edge interactives, 3-D models, custom animation and engaging videos of real-life stories, the exhibition examines both the benefits and the challenges that genomics presents to modern society.

Genome: Unlocking Lifes Code is on view at the National Museum of Natural History through Sept. 1, 2014, when it will begin a tour of venues throughout North America.

Genomic research is a vital tool for exploring the mysteries of the natural world, and it is an important part of Smithsonian science, said Kirk Johnson, the Sant Director of the National Museum of Natural History.

Genome: Unlocking Lifes Code will help our visitors understand how genomics is transforming what we know about ourselves and how we make important life decisions.

Genome: Unlocking Lifes Code celebrates the anniversaries of two landmark scientific discoveries: the 10th anniversary of the Human Genome Projects first completely sequenced human genome and the 60th anniversary of James Watson and Francis Cricks discovery of DNAs double helix structure.

This exhibition reflects a remarkably productive collaboration between two scientific icons of the U.S. governmentthe Smithsonian Institution and the National Institutes of Health, said Dr. Eric D. Green, director of the National Human Genome Research Institute, one of the 27 institutes and centers that make up NIH in Bethesda. Our ability to share the science of genomics with the more than 7 million annual visitors to the National Museum of Natural History is profoundly exciting for the broader genomics research community.

When visitors enter the 4,400-square-foot exhibition they will be immersed in an interactive environment that communicates the pervasiveness of genomic science and provides new ways of looking at themselvesas individuals, as members of a family and a species, and as part of the diversity of all life.

Genome: Unlocking Lifes Code is organized around four themed areas, offering visitors personalized and interactive experiences that examine what a genome is (The Genome Within Us), how it is related to medicine and health (Your Genome, Your Health), how it connects them to all of life (Connections: Natural World and Genomic Journey) and how it is a part of their own personal story (Genome Zone):

The Genome Within UsAt the center of the exhibition, museumgoers will explore how the genome is a part of their own bodies. They will discover what a genome is, where it is located in the human body (in the cell nucleus), why it matters and how it influences life, all through introductory videos produced by the History channel. Visitors will see three-dimensional models of a human genome and watch historic interviews with Human Genome Project researchers. They can also participate in a media interactive that explores the ethical, legal and social implications of advancing DNA sequencing technologies and submit their responses on an interactive station and find out how their views compare with those of other visitors. An electronic news-ticker display will provide an ongoing stream of recent developments in genomics.

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Genome project spurs boom for life science

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The $14.5 billion U.S. investment in the Human Genome Project, completed a decade ago, has paid off more than 60-fold in new jobs, drugs and a rapidly expanding genetics industry, an analysis has found.

The endeavor to map human DNA in its entirety created $966 billion in economic impact and $59 billion in federal tax revenue, according to the study released last week by United for Medical Research and Battelle, two research advocacy groups.

Dozens of companies have started with the knowledge gained from the project, leading to new diagnostic tests and development of medicines that can be matched with gene variants linked to disease. The project triggered a new era in the life sciences, with new oncology drugs and screenings among the early developments in the field, said Greg Lucier, chief executive officer of Life Technologies.

Up until that time, the pharmaceutical industry was able to have major impact on human health through blockbuster drugs that in retrospect were relatively simple, he said in a telephone interview. The ushering in of the genomic era was the beginning of truly reducing science to engineering, in terms of the understanding of life.

Life Technologies also provided funding for the study. The Carlsbad, Calif.-based maker of gene-sequencing machines agreed to be bought by Thermo Fisher Scientific for $13.6 billion last April. Other companies that provide sequencing services or equipment include Illumina and Oxford Nanopore Technologies. The Human Genome Project also spurred consumer-focused genetics companies such as 23andMe that let people find out what diseases they might be at risk for or where their ancestry lies.

Although it took almost $15 billion and more than a decade for the government-funded DNA effort to fully sequence a human genome for the first time, companies can now sequence a whole genome for about $1,000 and do it in a day.

The Human Genome Project was the starting point of that magnificent, incredible effort, Lucier said.

The market for gene tests may expand to $25 billion from $5 billion within a decade as more doctors use a patients genetic makeup to tailor treatments, according to a report last year from UnitedHealth Group Inc., the largest U.S. health insurer.

This report illustrates the vital role that key federal research funding plays in growing the U.S. economy, creating new industries and innovative technologies and producing the diagnostics and treatments that can save lives, Carrie Wolinetz, president of United for Medical Research, said in a statement.

Some of biggest innovations have been in the field of oncology. The actress Angelina Jolie recently became the new face of breast cancer, after announcing that shed had a double-mastectomy upon discovering that she carried a gene that predicts about a 60 percent chance of developing the disease.

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Eczema and Allergies – What Your Doc Doesn’t Know… – Video

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Eczema and Allergies - What Your Doc Doesn #39;t Know...
Get rid of your eczema forever: http://www.thetruthabouteczema.com/ Hey guys, Wilding here, I wanted to shoot this quick video about allergies today and the ...

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Caroline Duke no longer suffers from psoriasis I The McDougall Program – Video

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Caroline Duke no longer suffers from psoriasis I The McDougall Program
http://go2.sixpackshortcuts.com/SHPm What you do eat on an intermittent fasting diet plan is of less significance. It #39;s more about reducing your calorie inta...

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Cellceutix Reports Kevetrin(TM) Dosing Increases and Prurisol(TM) Anti-Psoriasis Drug Stability Tests Underway

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BEVERLY, MA--(Marketwired - Jun 17, 2013) - Cellceutix Corporation (OTCBB: CTIX) (the "Company"), a clinical stage biopharmaceutical company focused on discovering small molecule drugs to treat unmet medical conditions, including drug-resistant cancers and autoimmune diseases, announces today that the pharmaceutical tablets for the Company's clinical trial of Prurisol as a new drug candidate for the treatment of psoriasis have been formulated by Dr. Reddy's Laboratories and are currently undergoing stability testing.The stability testing is scheduled to be completed in about 45 days.

"We have been advised that stability testing began approximately two weeks ago and that the Prurisol tablets will be shipped to the clinical site in Europe before the end of the 60-day stability research in preparation for the commencement of the clinical trial," commented Leo Ehrlich, Chief Executive Officer at Cellceutix."We are enthusiastic about reaching another milestone for our company with the start of second clinical trial. We are very optimistic about the potential for Prurisol to reproduce the laboratory results showing the drug to effectively eliminate all signs of psoriasis."

Cellceutix also wishes to inform shareholders that it has recently conducted discussions with the University of Bologna regarding Kevetrin, the Company's novel anti-cancer drug currently in clinical trials at Dana-Farber Cancer Center and Beth Israel Deaconess Medical Center, for the planned clinical trial as a new drug candidate for Acute Myelogenous Leukemia, or AML.All regulatory submissions have been made and the hospital is awaiting Kevetrin reaching its Maximum Tolerated Dose in the trials at Dana-Farber before commencing their trial.

"We are taking a different approach to realize some of the benefits of conducting the clinical trials of both Prurisol and Kevetrin in Europe," said Dr. Krishna Menon, Chief Scientific Officer at Cellceutix."It is a similar strategy that companies like Clovis Oncology employ to follow European protocol to target a broader, yet more specific, patient population.Through a promising pipeline and efficient development model, Clovis has built an impressive valuation.In our current trials at Dana-Farber, the protocol requires that we only treat Stage IV cancer patients, which presents its own set of unique challenges that can slow research.The good news is we are likely more than half way there in terms of the trial, and we are still increasing dosage. We are very pleased with the results to date especially considering the lower doses to date.With reference to the planned University of Bolognatrial, by utilizing protocol where a 'measurable stage' of the disease is not required for the patient, i.e., we are not limiting the trial to Stage IV patients, this should allow the trial to go much faster, and hopefully get that perfect 'poster.'"

About Kevetrin

As a completely new class of chemistry in medicine, Kevetrin has significant potential to be a major breakthrough in the treatment of solid tumors. Mechanism of action studies showed Kevetrin's unique ability to affect both wild and mutant types of p53 (often referred to as the "Guardian Angel Gene" or the "Guardian Angel of the Human Genome") and that Kevetrin strongly induced apoptosis (cell death), characterized by activation of Caspase 3 and cleavage of PARP. Activation of p53 also induced apoptosis by inducing the expression of p53 target gene PUMA. p53 is an important tumor suppressor that acts to restrict proliferation by inducing cell cycle checkpoints, apoptosis, or cellular senescence.

In more than 50 percent of all human carcinomas, p53 is limited in its anti-tumor activities by mutations in the protein itself. Currently, there are greater than 10 million people with tumors that contain inactivated p53, while a similar number have tumors in which the p53 pathway is partially abrogated by inactivation of other signaling components. This has left cancer researchers with the grand challenge of searching for therapies that could restore the protein's protective function, which Kevetrin appears to be doing the majority of the time.

Further information on the clinical trial, titled "A Phase 1, Open-Label, Dose-Escalation, Safety, Pharmacokinetic and Pharmacodynamic Study of Kevetrin (Thioureidobutyronitrile) Administered Intravenously, in Patients With Advanced Solid Tumors," is available at: http://clinicaltrials.gov/ct2/show/NCT01664000?term=cellceutix&rank=1

About Cellceutix

Headquartered in Beverly, Massachusetts, Cellceutix is a publicly traded company under the symbol "CTIX". It is an emerging bio-pharmaceutical company focused on the development of its pipeline of compounds targeting areas of unmet medical need. Our flagship compound, Kevetrin, is an anti-cancer drug which has demonstrated the ability in pre-clinical studies to regulate the p53 pathway and attack cancers which have proven resistant to today's cancer therapies (drug-resistant cancers). Cellceutix also owns the rights to seven other drug compounds, including KM-133, which is in development for psoriasis, and KM-391 for the treatment of the core symptoms of autism. More information is available on the Cellceutix web site at http://www.cellceutix.com.

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Cellceutix Reports Kevetrin(TM) Dosing Increases and Prurisol(TM) Anti-Psoriasis Drug Stability Tests Underway

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Final Warning Censorship – Video

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Final Warning Censorship
Comparing to the last year Ukraine gave up 10 positions in the World Freedom of Speech Index. And now we are on the 126- th place between Algeria and Hondura...

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Ron Paul: I’m Worried that Edward Snowden Will Be Killed by a Drone Strike – Video

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Ron Paul: I #39;m Worried that Edward Snowden Will Be Killed by a Drone Strike
Fox Business Network. Aired June 11, 2013.

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Ron Paul: I’m Worried That Snowden May Be Killed By Drone Strike – Video

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Ron Paul: I #39;m Worried That Snowden May Be Killed By Drone Strike
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Ron Paul Edward Snowden May Be Target Of U S Drone Strike – Video

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Ron Paul Edward Snowden May Be Target Of U S Drone Strike
WASHINGTON -- Former Rep. Ron Paul (R-Texas) warned Tuesday that the U.S. government may use a drone missile to kill Edward Snowden, who recently leaked clas...

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September 6, 1984: Ron Paul Warns of Surveillance State – Don’t Ever Say We Weren’t Warned. – Video

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September 6, 1984: Ron Paul Warns of Surveillance State - Don #39;t Ever Say We Weren #39;t Warned.
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