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Atopic eczema causes areas of skin to become itchy, dry, cracked and sore.

There are usually periods where the symptoms improve, followed by periods where they get worse (flare-ups). Flare-ups may occur as often as 2 or 3 times a month.

Atopic eczema can occur all over the body, but is most common on the hands (especially fingers), the insides of the elbows or backs of the knees, and the face and scalp in children.

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The severity of atopic eczema can vary a lot from person to person. People with mild eczema may only have small areas of dry skin that are occasionally itchy. In more severe cases, atopic eczema can cause widespread inflamed skin all over the body and constant itching.

Inflamed skin can become red on lighter skin, and darker brown, purple or grey on darker skin. This can also be more difficult to see on darker skin.

Scratching can disrupt your sleep, make your skin bleed, and cause secondary infections. It can also make itching worse, and a cycle of itching and regular scratching may develop. This can lead to sleepless nights and difficulty concentrating at school or work.

Areas of skin affected by eczema may also turn temporarily darker or lighter after the condition has improved. This is more noticeable in people with darker skin. It's nota result ofscarring or a side effect of steroid creams, but more of a "footprint" of old inflammationand eventually skin tone returns to its normal colour.

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Atopic eczema - Symptoms - NHS

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An eczema treatment plan may have many facets, from medication to stress reduction. Some research indicates that vitamin E may also help relieve symptoms.

Eczema is a chronic, inflammatory condition that causes dry, itchy skin. Although many cases improve or resolve with time, eczema can sometimes persist for years, beginning in childhood and lasting into adulthood.

There is no cure for eczema, and the symptoms can sometimes be difficult to control with moisturizers and topical therapies. For this reason, many people turn to alternative treatment options to help control their symptoms.

Some people might try using vitamin E, but the body of research supporting its safety and effectiveness as an eczema treatment is still limited.

Read on to learn more about the rationale behind using vitamin E to help control eczema symptoms, as well as important considerations for its use in children and adults.

Experts believe that eczema results from a combination of skin barrier dysfunction and underlying inflammation.

Defects in the connections between skin cells allow microbes, chemicals, and other irritants to get deep into the skin. A heightened immune system overreacts to these invaders and releases signals that cause more inflammation in a misguided attempt to protect the body.

This inflammation causes the characteristic discoloration, swelling, and irritation associated with eczema.

Vitamin E is an antioxidant that possesses a variety of anti-inflammatory processes.

Antioxidants are substances that help clear reactive oxygen molecules that the body releases as part of the inflammatory response. Although these molecules are usually protective against microbial invaders, they can cause tissue damage if they go unchecked.

Vitamin E works by limiting the formation of reactive oxygen molecules, thereby decreasing inflammation and injury to the skin.

Several studies that researchers have carried out since the early 1990s have examined the use of vitamin E in eczema treatment, and most have seen positive results.

In an older study involving 96 people with eczema, those who took 268 milligrams (mg) of oral natural vitamin E had lower levels of certain markers of inflammation after 8 months, and many saw improvements in the condition of their skin.

In a more recent clinical trial with 70 participants, people with eczema who took 400 international units of oral vitamin E for 3 months experienced significant improvements in their eczema symptoms, including itchiness, compared with people who received a placebo treatment.

There has also been interest in using topical forms of vitamin E to treat eczema.

In a small 2016 study involving 44 people with eczema, those who used a topical skin cream that included vitamin E and other antioxidants had a faster improvement in eczema symptoms than those who used a placebo cream.

It is important to note that the majority of the studies investigating vitamin E supplementation either oral or topical in people with eczema have involved mostly adults. The efficacy and safety of vitamin E as a treatment for eczema in children are not yet clear.

According to the average daily recommended amounts, most adults and children 14 years of age or older should aim for 15 mg of vitamin E per day. Most people can reach these levels through dietary sources.

Some of the best sources of vitamin E in foods include:

However, people with eczema should be cautious when adjusting their diet, as certain foods may trigger eczema symptoms.

Vitamin E may provide a variety of health benefits, but there are certain risks to consider.

Animal models and human studies have shown that high dosages of vitamin E can cause bleeding and disrupt blood clotting. These effects may increase a persons likelihood of developing certain bleeding disorders.

For example, in a 10-year study involving nearly 15,000 adult males, vitamin E supplementation with 180 mg of synthetic vitamin E every other day increased the risk of hemorrhagic stroke by 74%.

Based on available safety data, the Office of Dietary Supplements recommends an upper limit of 1,000 mg of vitamin E per day for most adults to avoid adverse health risks.

Upper limits are lower for children, ranging from 200 mg daily for children aged 13 years to 800 mg for those aged 1418 years.

High doses of vitamin E, such as those in supplements, may also interfere with certain medications, including:

Before taking vitamin E supplements, people using these medications should talk with a healthcare professional to determine a safe dosage of vitamin E that will not affect how well their other treatments work.

Vitamin E is a potent antioxidant that provides a variety of anti-inflammatory benefits. Clinical studies suggest that oral or topical supplementation may help reduce inflammation in people with eczema and provide relief from some of the most bothersome symptoms.

Seeds, nuts, and leafy greens are excellent sources of dietary vitamin E. Before beginning oral supplements, people with eczema should talk with a healthcare professional about the potential risks and benefits. They should also seek the professionals advice on what constitutes a safe and effective dosage.

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Eczema and vitamin E: The connections - Medical News Today

Eczema and acne are totally different but they dont always seem that way. Thanks to some similar symptoms (whats up, bumpy redness!), it can sometimes be hard to tell the two conditions apart.

When dealing with either or both! of these conditions, its important to remember that they each have their own unique set of symptoms, causes, and treatments. In the words of Friends character Chandler Bing: Could they BE any less alike?! Heres how to identify eczema vs. acne.

Acne and eczema can look alike because both conditions sometimes cause inflamed, red, pimple-like bumps. But each has its own unique causes, symptoms, and treatment methods.

Eczema is a chronic condition that causes super dry, inflamed patches of skin that itch intensely. Theres no cure for eczema, and treatment is centered around managing the itch and other symptoms.

Acne, on the other hand, causes zits, whiteheads, blackheads, cysts, and clogged pores. Unlike eczema, acne symptoms thrive in oily areas, not dry ones. Acne also doesnt itch, though it can cause sensitivity or soreness.

While its possible to have both eczema and acne at once, its rare for them to appear in the exact same spot which makes targeting treatment a bit easier.

Nearly 31 million people in the U.S. live with some form of eczema, which is a skin condition characterized by dry, itchy, inflamed patches of skin.

Other common eczema symptoms include:

Eczema can appear or flare up anywhere on your body. In babies and small children, it often occurs on the face, arms, and legs. Older kids, teens, and adults will most often see symptoms on areas that rub together, like the back of the knees, back of the neck, inner elbows, or other areas with skin-to-skin contact, but it can show up anywhere and everywhere.

While the condition usually doesnt show up on your face past infancy, it can look a heck of a lot like acne when it does.

TBH, no ones sure what exactly causes eczema. Researchers think eczema may be a result of genetics, immune system issues, or allergens and other environmental triggers. Eczema isnt contagious, so you cant catch it from someone. Anyone can develop the condition, and it can flare up at any age.

Other possible causes include:

Theres no cure for eczema (major bummer), but there are ways to treat and manage its symptoms (major yay!).

Lets talk about zits, baby.

Nearly 50 million Americans deal with acne each year, and it usually starts showing up around puberty though its totally possible for it to not pop up until adulthood.

There are basically two main types of acne: inflammatory and noninflammatory. Those pesky, painful red ragers are considered inflammatory acne, while your general whiteheads, blackheads, and gunked-up pores make up the noninflammatory type.

Acne most often pops up on your face, neck, chest, back, or shoulders though it can appear anywhere (yes, even down *there*).

Acne can show up in many forms, including:

Acne is often caused by an excess of sebum, which is the oil your skin produces. Too much sebum can clog your pores and result in a breakout.

Other common acne triggers include:

Acne doesnt have to be permanent, and you can often treat it with the right (for you) skin care routine, medication, or diet and lifestyle changes.

Ready for a little show instead of tell? To help give you an even better understanding of how acne and eczema may show up differently on your skin, weve got some visual aids to share:

Sure, eczema cant be cured but that doesnt mean you cant make its symptoms more bearable. Treatment can involve doctor-prescribed options, at-home remedies, or a mix of the two.

Symptoms can be managed by:

When a flare-up does flare its important to resist the urge to itch (its hard, we know!). Keep the area clean, moisturized, and away from any triggers that may make it worse.

Every persons acne is a bit different, and the approach you take to treating it may be unique to you.

Some cases of acne are treated by developing a skin care routine that helps combat oily skin, while others may require some prescription problem-solving.

You can treat acne at home by:

Products or ingredients commonly used to treat acne include:

For more severe cases, your doctor or derm may recommend prescription products, which are stronger than what you can get at the drugstore. They may also prescribe:

Its totally possible to have both eczema and acne at the same time (*groan*).

However, theyll typically occur on different parts of your body because each shows up under very different skin conditions. Eczema loves dryness, while acne thrives in oily areas.

If they do show up on the same body part, each will often stake their claim to a specific area. For instance, you may be experiencing a breakout on your forehead and chin, but then an eczema flare-up might affect your eyelids. Or some pimples could pop up on your chest while an eczema rash develops under your boobs (yep, thats a thing).

Its very rare, however, for both acne and eczema to occur in the exact same spot at the exact same time.

When dealing with both a breakout and a flare-up, its important to continue using your usual forms of treatment for each condition. If you have any questions or concerns, talk with your doctor or dermatologist for guidance.

First things first, identify your triggers. According to the National Eczema Association, this is your golden ticket to prevention. This can be applied to both eczema and acne.

When you know your triggers, you can steer clear and *fingers crossed* hopefully keep flare-ups and breakouts at bay.

There are also other steps you can take to prevent both acne and eczema, like:

If youre having a hard time preventing either eczema or acne, talk with your doctor or dermatologist. Theyll look at your specific diagnosis and work with you to develop strategies for positive prevention.

Eczema and acne are two different skin conditions, but they can have certain overlapping symptoms like blisters or bumps. Its possible to experience both acne and eczema at the same time, but theyll usually show up on different parts of your body.

Theres no cure for eczema, but there are ways to treat and manage symptoms, including prescription creams or medications, stress reduction, and avoiding triggers. Acne is often temporary and can be treated with nonprescription skin care products or healthy habits. More severe acne cases may require support from a doc or derm, such as medicated cleansers, creams, or hormonal treatment.

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Eczema vs. Acne: How to Tell the Difference with Photos - Greatist

Articles

By Clare Maloney

Published On: Feb 25, 2022

Last Updated On: Feb 25, 2022

We all know that melatonin can help you fall asleep. But did you also know that emerging research is exploring whether melatonin may additionally help reduce your nighttime itching to help you stay asleep at night.

Melatonin is a hormone mainly produced in the pineal gland in the brain. Like other hormones, it circulates throughout the body and interacts with the immune system. This helps to coordinate the timing of immune system activity, said Dr. Anna Fishbein, associate professor of pediatrics (allergy and immunology) at Northwestern University Feinberg School of Medicine. Melatonin interacts with the immune system via multiple pathways, such as acting as an antioxidant or acting directly on immune cells via melatonin receptors. Although our bodies produce melatonin naturally, a melatonin supplement before bed can help provide a sedative effect to fall asleep faster. For people with itchy skin at night, the research shows that the benefits of melatonin may extend beyond simply falling asleep which could lead to sleeping more soundly, too.

According the March 2020 More Than Skin Deep Voice of the Patient report, a collaborative initiative within the eczema community to inform treatment research and development for atopic dermatitis (AD), sleep ranked third among the top three most problematic symptoms in responses to polling and a survey, behind itch and condition/appearance of skin.1 This comes as no surprise since sleep disturbance is reported in 47% to 80% of children with AD and in 33% to 87.1% of adults with AD.1

Id wake every few hours, bloody and in tears because I had ripped everything off in my sleep because my skin felt like it was on fire. It burned and itched and the only thing I could do for relief was to scratch and claw at it, rub it feverishly on anything I could reach, said More Than Skin Deep panelist, Briana Cox.

During sleep, our bodies cycle between four stages: one rapid eye movement (REM) cycle and three non-REM (NREM) cycles.2 Its common for many people to wake briefly between the cycles. For people with eczema, the pain, dry skin and nighttime itching from a flare is often enough to wake them up and keep them up. This is in part due to the activation of the immune system during a flare, leading to free radical production associated with decreased melatonin levels and depressed antioxidant enzyme activities.3

Temperature can also play a role. At night, our bodies naturally prepare for sleep by cooling our core temperature.4 Melatonin is secreted in a diurnal pattern, or daily cycle, with a steady increase and peak between 2:00 AM and 4:00 AM, followed by a gradual decrease.5

Circadian rhythm influences cutaneous blood flow (which determines the amount of heat lost through the skin), among other properties of skin barrier function, which is associated with greater skin permeability, histamine release and you guessed it itching.5 Since the skin barrier is most defective, or permeable, at night, this may explain why itching is usually worse at night.

Melatonin has been tested and documented to help fight free radicals in our bodies and function as a potent anti-inflammatory agent.6 This means melatonin stimulates a series of antioxidative activities within the body, which can help protect skin integrity and maintain a functional skin barrier.6 Since melatonin is a key player in kicking off these anti-inflammatory activities, this is why its thought to help reduce eczema flare symptoms that may be keeping you up at night. Melatonin helps regulate our circadian rhythm, which in turn regulates immune function. Levels of proinflammatory cytokines, such as IL-1, IL-2, TNF-, IFN-, and IL-6, are increased at night and generally promote sleep.6 The production of these specific cytokines coupled with cortisol secretion at night are thought to contribute to reducing the urge to itch and disrupting a sleep cycle.

In a 2016 study for melatonin supplementation for children with atopic dermatitis and sleep disturbance, results were evaluated using the Scoring Atopic Dermatitis (SCORAD) index. After melatonin treatment among the 48 children included in the study, the SCORAD index decreased by 9.1 compared with after placebo.7 The results concluded that melatonin supplementation is a safe and effective way to improve the sleep-onset latency and disease severity in children with atopic dermatitis.7

While more research is still needed determine melatonins proven benefits for people with eczema, it likely works better at managing active flares, as opposed to preventing flares, said Dr. Fishbein. While melatonin is generally well tried, some common side effects may include nausea, headache, dizziness, or feeling overly tired or groggy. However, long-term sleep deprivation can have more lasting negative effects on attention, performance, productivity and mood swings, in addition to being is associated with higher rates of anxiety, depression and an increased risk for other serious health issues.1

Melatonin is an over-the-counter supplement, available at most drug stores or to order online. There are many different brands and forms of melatonin, or melatonin-containing sleep aids, to choose from. Prices vary depending on quantity and brand, but the most common brands found on sites like Amazon or Walmart typically run for prices ranging between $7$12 per bottle for a 13-month supply.

Since its considered a dietary supplement, melatonin is not as strictly regulated by the FDA. Furthermore, many sleep-aid supplements often include additional natural or synthetic sleep-promoting ingredients, so its important to check the ingredient listed and look for a tried and trusted brand. You may ask your doctor or pharmacist for a recommendation based on your needs. The key is to ensure youre taking the correct dose: Melatonin is typically taken every night, about 30 minutes before bedtime with general dosing of 1 mg in infants, 2.53 mg in older children and 5 mg in adolescence/adults, said Dr. Fishbein.

While more research is still needed to determine how nightly melatonin supplements can help reduce flares, theyve proven to be helpful for many people with eczema who experience sleep disturbances. Do not be afraid to ask your [healthcare] provider for a referral to a sleep medicine expert. Good sleep is really important for physical, psychologic and immune health, said Dr. Fishbein. If you find yourself lying awake at night, unable to stop scratching, just know youre not alone. Melatonin supplements may be a game changer in improving the quality of your sleep.

SOURCES

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Get the Facts: Melatonin and Eczema - National Eczema Association

Eczema is a skin woe thats haunted me since birth. It even earned me one of my first nicknames: Alligator Legs (thanks, fam!). And while Ive come to terms with the flare-ups on my body, the itchy patch on my left eyelidcaused by a specific kind of eczema called neurodermatitishas been particularly difficult to rein in. After 15 years of a hate-hate relationship with my topical prescription, I realized that rehydrating my flaky skin and repairing my skin barrier was key to alleviating my eczema, and thats when I stumbled upon Dr. Jarts Ceramidin Liquid Toner.

Thats right, a toner. Never in a million years would I expect a toner to become the number-one product in my routine, but this isnt the alcohol-and-witch-hazel astringent I slathered on my face with reckless abandon in junior high. As explained in our guide to facial toners, the formulas of today have seen a serious glow-upnot unlike me after discovering Dr. Jarts liquid gold. Toners are now often formulated with much more hydrating ingredients such as glycerin, hyaluronic acid, and (surprise!) ceramides. They can even, like this product, feel more like a serum masquerading as a toner than anything else.

Dr. Jarts Ceramidin Liquid Toner has a liquid gel consistency that, as the name suggests, is boosted by ceramideswhich repair your skin barrier by increasing moisture retention and preventing water loss. Ceramides are helpful in maintaining the long-term health of your skin by protecting it from environmental stressors and preventing moisture loss from conditions like eczemawhich is precisely why the product is an absolute mainstay for me and my beauty routine.

After washing my face and patting it dry, I smooth the toner all over, then press it into my skin. The Liquid sinks in instantly and doesnt leave a tacky residue. I use it as a base layer, morning and night, and have found that it really delivers on its promises of restoring your skin and locking in moisture. On top of the toner, I use a serum, a moisturizer, then sunscreen. The Liquid never pills and hardly feels like its on my skin at all, except for the comforting feeling of complete and total hydration.

Over the years Ive become a Dr. Jart convert and live by the entire Ceramidin line. They may not be the cheapest ceramide-boosted products out there, but Ive had epidermis thinning, discoloration, and a leatherized appearance due to a combo of eczema and overuse of prescription steroids, and the formula not only hydrates but strengthens my skin. Perhaps best of all, it minimizes my incessant need to itch.

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Dr. Jart Ceramidin Liquid Toner Review: This Toner Is a Must If You Have Dry Skin - Glamour

A new investigation into peanut introduction guidelines in pediatric allergy care found that a training video improved pediatric clinicians knowledge of the practice.

The data was presented at theAmerican Academy of Allergy, Asthma & Immunology Annual Meeting (AAAAI) 2022 during the session, Pediatric Clinicians' Knowledge of Infant Peanut Introduction Guidelines Following iREACH Training Modules.

In 2017, the National Institute of Allergy and Infectious Diseases (NIAID) Addendum Guidelines for the Prevention of Peanut Allergy recommended early introduction of food containing peanuts to infants.

However, barrier to implementing these guidelines were attributed to insufficient knowledge on peanut introduction practices.

As such, investigators led by Ruch Gupta, MD, MPH, Northwestern University Feinberg School of Medicine, measures the effectiveness of a training video to improve upon clinicians knowledge of the guidelines.

The training video was developed as part of the Intervention to Reduce Early (Peanut) Allergy in Children or iREACH. The video was intended to increase pediatric clinicians knowledge while also lowering the incidence of peanut allergy.

Gupta and colleagues enrolled pediatric clinicians from 19 practice sites across Illinois.

The iREACH training video summarized the NIAID guidelines, a clinical decisions support tool, as well as different classifications of eczema. From there, pediatric clinicians were tasked with completing a multiple-choice survey consisting of 7 clinical scenarios designed to access guideline knowledge before and after training.

Finally, differences in the percentage of pediatric clinicians who correctly answered each item were assessed both pre- and post-survey training via McNemars test.

A total of 175 pediatric clinicians participated in the study, with 100% completing both the surveys and the training.

Prior to training, investigators observed that the percent of correct responses to each clinical scenario had ranged from 48% (prevention for infants with moderate eczema) to 87% (prevention for infants without eczema or food allergy).

However, after training the percentage of correct responses increased significantly for both scenarios (p<0.002), with knowledge on distinguishing moderate and severe eczema having increased the most after training.

Though the iREACH training video improved pediatric clinicians knowledge on the guidlelines for peanut introduction, Gupta and colleagues added that Future efforts exploring knowledge retention following use of the training video is necessary.

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Knowledge of Infant Peanut Introduction Improves Following Training Modules - MD Magazine

Arent we all constantly on the hunt for holy grail beauty products? You know, the ones that do exactly what they say theyre going to do? And sometimes even more?

Well over on TikTok, it looks like user @abigailfeehls has uncovered one. She recently posted a TikTok video sharing all the ways she uses the cult-popular CeraVe Healing Ointment, and it has nearly 450,000 likes and more than 11,800 shares.

CeraVe Healing Ointment | 2 Pack (0.35 Ounce Each), $8.69

In the video, @abigailfeehls reveals that she uses this simple yet versatile product under her eyes, on her lips and even on the eczema on her neck. It may be hard to believe, but this one product can really help a multitude of common skin conditions.

TikTok user @abigailfeehls isnt the only person who swears by CeraVes Healing Ointment. The product has legions of loyal fans on Amazon, too. The listing for the two-pack alone has more than 1,000 ratings and 4.7 out of 5 stars.

One satisfied shopper called the product a skin savior. They went on to write, Buy the bigger bottle because this stuff is worth it.

Another shopper who uses the ointment daily wrote, This stuff is amazing. Ive been putting it on my lips every night and throughout the day. No more chapped lips, and they look more full as well.

Given that this bundle of two small ointments is less than $10, you can try it out for yourself without feeling like youre spending a lot of money on a new product. Just be sure to order while theyre still in stock.

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TikTok user in awe of how well this $9 product heals eczema, soothes dry lips and smoothes under eyes - In The Know

Hydration and moisture are two distinct skin care needs. Hydrating ingredients in skin care products attract water to the outermost layer of the skin, while moisturizing ingredients lubricate the skin to prevent water from escaping.

Many products marketed as moisturizers have both moisturizing and hydrating properties. Additionally, because there is no consensus on the definition of a moisturizer among experts, some classify hydrating ingredients as moisturizers.

People may not know if they need more hydration or moisture in their skin care routine, but this is not always necessary when choosing products. The American Academy of Dermatology Association (AADA) recommends that people pick products formulated for their skin type, such as dry or oily.

Read more to learn about the differences between hydration and moisture, how to tell which ingredients a persons skin needs most, and more.

A simple way to differentiate these terms is to remember that hydration refers to water while moisture refers to oil.

Skin care products use different ingredients to either hydrate or moisturize the skin. Some ingredients, such as humectants, do both.

Humectants are ingredients that increase the skins hydration by attracting water from the environment to the skin. They also draw water from deeper layers of the skin, called the dermis, and bring it to the outermost layer of the skin, called the epidermis.

Examples of hydrating ingredients include:

In addition to being hydrating ingredients, humectants are also moisturizing. Other types of moisturizers include:

According to a 2017 study, experts have not reached a consensus on the precise definition of moisturizers. This means that when it comes to distinguishing hydrators from moisturizers, there is some gray area. As a result, people often use the terms emollient and moisturizer interchangeably.

Many products labeled as moisturizers contain hydrating ingredients in addition to moisturizing emollients and occlusives. Each type of ingredient offers different benefits, so many skin care products have a combination of all three.

Their uses are:

Among the three types of ingredients, there is some overlap in the type of skin they benefit. A dermatologist can sort this out and tell people if their skin requires more moisture, hydration, or both. These professionals can also provide suggestions for specific products that address these needs.

A small 2015 study examined how daily water intake from food and drinks affects a persons skin. Among 49 healthy females, it compared the skin characteristics of people who consumed more water and people who consumed less.

The results indicated that consuming more water made a difference in some skin characteristics but not others.

When people consumed more water, the hydration in the epidermis the outermost layer of skin increased. The authors concluded that higher water intake has a positive effect on skin physiology. Despite this finding, they did not note an optimal daily water intake amount.

However, an older study from 2010 recommended 3,000 milliliters of water per day for males and 2,200 ml for females. This equates to 101 ounces for males and 74 oz for females. Since 1 cup contains 8 oz, this means the daily recommendation is for males to drink 12 cups and for females to drink 9 cups.

Individuals may not know if they need more hydration or moisture. Additionally, few people are familiar with the many ingredients on skin care product labels.

The AADA advises choosing skin care products based on an individuals skin type. This involves looking for products that have specific formulations for the following skin types:

For aging skin, the AADA recommends choosing products that are hypoallergenic. This means they do not trigger an allergic reaction. It also advocates selecting products that are non-comedogenic or non-acnegenic, meaning they do not cause acne.

Aside from using skin care products, a person can take various steps to keep their skin hydrated and healthy. The AADA encourages people to:

If a person has dry skin, the AADA recommends they:

When people are deciding between products that provide hydration or moisture, it may help to become familiar with a few ingredients that fit into both categories.

Examples of hydrators include hyaluronic acid and glycerin, while examples of moisturizers include lanolin and mineral oil. Because remembering the multiple ingredients that fit into each category can pose a challenge, it may be easier for people to choose products formulated for their skin type, such as oily or dry.

Continued here:
Hydration vs. moisture: How to know what your skin needs - Medical News Today

Abrocitinib resulted in a recaptured response for a large proportion of patients with atopic dermatitis suffering from flares.

A team, led by Jonathan Silverberg, George Washington University, evaluated the efficacy of abrocitinib as a rescue therapy in data presented at the American Academy of Allergy, Asthma & Immunology Annual Meeting (AAAAI) 2022.

In the JADE REGIMEN trial, investigators examined the efficacy of abrocitinib-induced responses with continual, reduced dose, or withdrawal of the treatment in patients with moderate-to-severe atopic dermatitis.

The investigators selected a patient population who flared during the maintenance period to receive abrocitinib rescue treatment.

Responders to abrocitinib 200 mg, defined by the Investigators Global Assessment (IGA) 0/1 with at least a 2 grade improvement and 75% improvement in Eczema Area and Severity Index (EASI-75), were randomly assigned to either abrocitinib 200 mg, abrocitinib 100 mg, or placebo for 40 weeks.

Patients who flared during the maintenance period, defined as at least a 50% loss of week-12 EASI response and at least 2 IGA grades, were offered rescue therapy of abrocitinib 200 mg and topical corticosteroids or calcineurin inhibitors for 12 additional weeks.

The investigators evaluated responses defined as recaptured IGA, EASI, or Peak Pruritus Numerical Rating Scale (PP-NRS) as scores not worse than randomization baseline responses.

The investigators enrolled 16.2% (n = 43) of the abrocitinib 200 mg cohort, 39.2% (n = 104) of the abrocitinib 100 mg group, and 76.4% (n = 204) of the placebo arm into the rescue study following protocol-defined flares.

The results show at week 12 the proportion of patients recapturing IGA response was 35.7% (95% CI, 21.2-50.2%), 50.5% (95% CI, 40.8-60.1%), and 74.0% (95% CI, 67.8-80.1%), respectively.

For EASI response, it was 33.3% (95% CI, 19.1-47.6%), 32.0% (95% CI, 23.0-41.1%), and 57.1% (95% CI, 50.2-64.1%) and for PP-NRS response it was 28.6% (95% CI, 9.2-47.9%), 39.7% (95% CI, 27.1-52.2%), and 68.2% (95% CI, 58.5-77.9%) for the abrocitinib 200 mg, 100 mg, and placebo arms, respectively.

Rescue therapy with abrocitinib 200 mg plus topical medicated therapy recaptured response in patients who flared during the maintenance period of JADE REGIMEN, the authors wrote.

The study, Efficacy of Abrocitinib Rescue Therapy in the Phase 3 Study JADE REGIMEN, was published online by the Journal of Allergy and Clinical Immunology.

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Abrocitinib Working as a Rescue Therapy for Atopic Dermatitis - MD Magazine