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Genome Sequencing | SEATTLE SCIENCE CAFE – Video
Posted: December 21, 2013 at 8:43 am
Genome Sequencing | SEATTLE SCIENCE CAFE
November 2013 - Seattle Join UW #39;s Jay Shendure, M.D., Ph.D., to explore his team #39;s efforts to decipher the HeLa genome amidst controversy regarding issues of...
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The origin of flowers: DNA of storied plant provides insight into the evolution of flowering plants
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Dec. 19, 2013 The newly sequenced genome of the Amborella plant addresses Darwin's "abominable mystery" -- the question of why flowers suddenly proliferated on Earth millions of years ago. The genome sequence sheds new light on a major event in the history of life on Earth: the origin of flowering plants, including all major food crop species. On 20 December 2013, a paper by the Amborella Genome Sequencing Project that includes a full description of the analyses performed by the project, as well as implications for flowering plant research, will be published in the journal Science. The paper is among three on different research areas related to the Amborella genome that will be published in the same issue of the journal.
Amborella (Amborella trichopoda) is unique as the sole survivor of an ancient evolutionary lineage that traces back to the last common ancestor of all flowering plants. The plant is a small understory tree found only on the main island of New Caledonia in the South Pacific. An effort to decipher the Amborella genome -- led by scientists at Penn State University, the University at Buffalo, the University of Florida, the University of Georgia, and the University of California-Riverside -- is uncovering evidence for the evolutionary processes that paved the way for the amazing diversity of the more than 300,000 flowering plant species we enjoy today.
This unique heritage gives Amborella a special role in the study of flowering plants. "In the same way that the genome sequence of the platypus -- a survivor of an ancient lineage -- can help us study the evolution of all mammals, the genome sequence of Amborella can help us learn about the evolution of all flowers," said Victor Albert of the University at Buffalo.
Scientists who sequenced the Amborella genome say that it provides conclusive evidence that the ancestor of all flowering plants, including Amborella, evolved following a "genome doubling event" that occurred about 200 million years ago. Some duplicated genes were lost over time but others took on new functions, including contributions to the development of floral organs.
"Genome doubling may, therefore, offer an explanation to Darwin's "abominable mystery" -- the apparently abrupt proliferation of new species of flowering plants in fossil records dating to the Cretaceous period," said Claude dePamphilis of Penn State University. "Generations of scientists have worked to solve this puzzle," he added.
Comparative analyses of the Amborella genome are already providing scientists with a new perspective on the genetic origins of important traits in all flowering plants -- including all major food crop species. "Because of Amborella's pivotal phylogenetic position, it is an evolutionary reference genome that allows us to better understand genome changes in those flowering plants that evolved later, including genome evolution of our many crop plants -- hence, it will be essential for crop improvement," stressed Doug Soltis of the University of Florida.
As another example of the value of the Amborella genome, Joshua Der at Penn State noted "We estimate that at least 14,000 protein-coding genes existed in the last common ancestor of all flowering plants. Many of these genes are unique to flowering plants, and many are known to be important for producing the flower as well as other structures and other processes specific to flowering plants."
"This work provides the first global insight as to how flowering plants are genetically different from all other plants on Earth," Brad Barbazuk of the University of Florida said, "and it provides new clues as to how seed plants are genetically different from non-seed plants."
Jim Leebens-Mack from UGA noted that "The Amborella genome sequence facilitated reconstruction of the ancestral gene order in the 'core eudicots,' a huge group that comprises about 75 percent of all angiosperms. This group includes tomato, apple and legumes, as well as timber trees such as oak and poplar." As an evolutionary outsider to this diverse group, the Amborella genome allowed the researchers to estimate the linear order of genes in an ancestral eudicot genome and to infer lineage-specific changes that occurred over 120 million years of evolution in the core eudicot.
At the same time, Amborella seems to have acquired some unusual genomic characteristics since it split from the rest of the flowering plant tree of life. For example, DNA sequences that can change locations or multiply within the genome (transposable elements) seem to have stabilized in the Amborella genome. Most plants show evidence of recent bursts of this mobile DNA activity, "But Amborella is unique in that it does not seem to have acquired many new mobile sequences in the past several million years," stated Sue Wessler of the University of California-Riverside. "Insertion of some transposable elements can affect the expression and function of protein-coding genes, so the cessation of mobile DNA activity may have slowed the rate of evolution of both genome structure and gene function."
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Genome Analyses of Single Human Oocytes – Video
Posted: at 8:43 am
Genome Analyses of Single Human Oocytes
Jie Qiao and colleagues describe how high-throughput sequencing of oocyte polar bodies could enhance preimplantation genomic screening in IVF.
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Review: Loyce Houlton’s ‘Nutcracker’ retains its energy
Posted: at 8:43 am
Marie (Zoe Derauf) and her magical toy in "Loyce Houlton's Nutcracker Fantasy." (Courtesy photo: Jim Smith)
So pervasive are productions of "The Nutcracker" on Twin Cities stages this time of year that it's easy to forget that it was still something of a novelty when Minnesota Dance Theatre founder Loyce Houlton created her own version in 1964. While many a dance company makes the ballet an annual tradition, "Loyce Houlton's Nutcracker Fantasy" has them all beat for longevity.
And this year's version of the "Nutcracker Fantasy" still summons up a lot of magic. On opening night Friday at Minneapolis' State Theatre, the Minnesota Dance Theatre company and a few dozen guest artists and MDT trainees presented a production full of sparkle and grace. The Christmas party of the first act swirled with energy and excitement, the colorfully rendered setting bursting with color and movement.
However, the performance lost some momentum in the second act, when the choreography was often far too safe and unspectacular to match the passion that poured forth from Pyotr Tchaikovsky's score as played by a 44-piece orchestra under Philip Brunelle's direction. But things always took an elegant turn whenever Kevin Iverson appeared onstage as Godfather Drosselmayer. He's the magnetic maker of magical toys who leads young Marie (a consistently impressive Zoe Derauf) on her dreamy odyssey to a dessert-laden landscape. There, she's joined by her now human-size nutcracker, beautifully danced by Zachary Manske.
Iverson's every flowing movement was impressively synchronized with Tchaikovsky's music. Opening the ballet amid a slanted, enchanted village (a delightful design by James Guenther), Drosselmayer is soon sending human-size dolls off to a party with a sharp crack drill squad of rifle-toting soldiers, human marionettes manipulated by invisible strings, and dozens of dancers taking a shift in the spotlight.
The international assembly of dancers that entertains Marie and her prince proves a mixed bag. While Katie Deuitch and Chris Hannon offer a lovely hybrid of ballet and flamenco as the Spanish couple, neither the Arabian nor Chinese dances ask much of the performers. In some versions, these are the most thrilling dances in the ballet, but they were too simple to be satisfying. The lone excitement comes from the lithe, leaping Russians, Serena Lu giving the proceedings a needed shot of adrenaline with her twirling, tumbling performance.
The grand pas de deux of Act 2 can similarly provide an explosion of emotion with its surging strains and lovely lifts, but Houlton's choreography proved disappointingly conservative, although impeccably executed by Katie Johnson and Sam Feipel, their solos far more intriguing than their duets. But one can find plenty of outstanding ensemble work in the "Dance of the Commedia Dell'Arte" and "Waltz of the Flowers."
This production is at its best when creating a kind of three-ring circus of a ballet, something interesting always happening somewhere onstage. Such scenes feel like the ballet equivalent of a sugar rush, something of which we could use more as it winds to a close.
Rob Hubbard can be reached at rhubbard@pioneerpress.com.
Who: Minnesota Dance Theatre
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Raw cacao benefits human longevity without any negative side …
Posted: at 8:43 am
Unlike processed dark chocolate, antioxidants are preserved in raw cacao. Benefits from keeping organic chocolate unheated include; much higher levels of the famous chocolate antioxidants (oligomeric procynanidins, resveratrol and the polyphenols: catechin and epicatechin) as well as the preservation of vitamin C, phenethylamine (PEA, the feel good neurotransmitter responsible for the feeling of love!), Omega 6 fatty acids (which when heated become rancid and cause inflammation), tryptophan (a commonly deficient amino acid in those who consume a diet of mostly cooked food) and serotonin. The cool facts about chocolate in this article reveal how this fun and amazing superfood is actually healthy for you!
It turns out that all the bad things commonly attributed to non-raw chocolate bars, such as cavities, weight gain and diabetes, are actually caused by the dairy, sugar and others fillers added to the dark chocolate. Health benefits of chocolate when it is in the form of raw cacao beans, butter, nibs and/or the powder include; weight loss (because of its high chromium and coumarin content), prevention of cavities (theobromine actually kills streptococci mutans one of the strains of bacteria that cause tooth decay) and regulation of blood sugar which is beneficial for diabetes (chromium can naturally regulate blood sugar). Also raw cacao benefits the heart and the entire cardiovascular system as a whole.
Cacao is the highest whole food source of magnesium, which also happens to be the most deficient mineral in the diet of modern cultures. Magnesium relaxes muscles, improves peristalsis in the bowels and relaxes the heart and cardiovascular system. The dark chocolate antioxidants have been clinically proven to literally dissolve plaque built up in the arteries which helps in reversing heart disease and causes naturally lower blood pressure. Also, various other vitamins and minerals in raw cacao benefits the cardiovascular system. You can find organic cacao butter, cacao powder, cacao nibs, cacao beans and cacao paste at a great price, by clicking this link.
~Yang Jing, Qi, Shen, Blood ~Cooling, in excess heating ~Sweet, Astringent, Bitter ~Heart, Kidneys, Spleen
The antioxidant content of raw cacao benefits the cardiovascular and general whole body health. In processed dark chocolate, antioxidants such as epichatehins, chatechins, resveratrol and procyanidins can be present, but are in much lower levels than in unheated raw chocolate nibs as an example. Out of all the whole foods that contain antioxidants, raw chocolate is the highest in the world. It dwarfs the popular foods and beverages commonly touted as being antioxidant rich foods such as red wine, green tea and blueberries by a factor of 10x or more! There are certain herbs and spices, such as the chaga mushroom and cinnamon, which have higher levels of antioxidants in them but generally you won't be consuming enough volume of them to get as much antioxidant value from them as you would from a normal dose of raw cacao. Benefits from consuming antioxidants come when a range of different types of foods high in them are in your diet, since different coloured foods have different antioxidant compounds which target different parts of the body. The phytochemical analysis of cacao beans reveal that raw chocolate is perhaps the most chemically complex food on Earth. There are compounds yet to be discovered in this most amazing of live superfoods. Phytochemicals usually degrade in the cooking process, so the raw forms of them should be abundant in every diet for longevity.
~Anandamide (the only food that contains this neurotransmitter responsible for the feeling of "bliss") ~ N-linoleoylethanolamine (prevents the re-uptake of anandamide) ~Phenethylamine (PEA, a neurotransmitter known as the "love molecule") ~Seratonin (a neurotransmitter that acts as a "stress defense shield" by making you feel good) ~Dopamine (a neurotransmitter that boosts motivation and pleasure) ~MAO Inhibitors (prevents the re-uptake of serotonin and dopamine) ~Coumarin (has appetite suppressant, blood thinner and anti-tumor properties) ~Theobromine (controversial but actually quite beneficial for humans, see last section) ~Asparaginase (an enzyme that has anti-leukemia properties) ~Ergosterol (a precursor to vitamin D) ~Sitosterol (decreases LDL cholesterol)
The nutrient density of raw cacao benefits every function of the body. One of the many cool facts about chocolate is that it is the highest source of magnesium and chromium of any food! Magnesium is the most deficient mineral in the average human. All of the compounds found in raw cacao benefits longevity in humans.
~Vitamin A ~Vitamin B (1, 2, 3, 5 and 6) ~Vitamin C ~Vitamin E ~Magnesium ~Copper ~Calcium ~Manganese ~Zinc ~Sulphur ~Iron ~Chromium ~Phosphorus ~Omega 6 Fatty Acids ~Saturated Fats ~Amino Acids ~Carbohydrates ~Soluble Fiber (which is the type people need more of) ~Enzymes (including catalase, lipase and amylase) ~Other Beneficial Phytonutrients (such as the antioxidants already mentioned in this article)
Dr. Gabriel Cousens conducted a study on the health benefits of chocolate in February of 2008. What he discovered was that raw cacao benefits diabetics as a safe food since it raises blood sugar less than almost any other food, despite it's theobromine content! It even raises insulin sensitivity! One of the other cool facts about chocolate that he discovered was that it's not toxic to the liver (many people are falsely claiming the contrary), except when combined in large amounts with sweeteners high in fructose such as agave. This is basically the only well known clinical study done specifically on how raw cacao benefits human health.
It has been shown that raw cacao benefits a wide range of cardiovascular issues. The dark chocolate antioxidants and abundant amounts of magnesium and other phytochemicals can balance blood pressure, lower high cholesterol, scrub away arterial plaque and promote general health by reversing heart disease. (Raw) chocolate bars are known as a great remedy for many menstruation issues women can get. It is also confirmed as an aphrodisiac for both genders. What more do you want from one of the worlds top live superfoods? For more information about this amazing superfood, check out the book "Naked Chocolate" by David Wolfe and Shazzie which is packed full of information and amazing recipes!
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Atopic eczema – NHS Choices
Posted: at 8:43 am
Atopic eczema, also known as atopic dermatitis, is the most common form of eczema. It mainly affects children, but can continue into adulthood.
Eczema is a condition that causes the skin to become itchy, red, dry and cracked. It is a long-term, or chronic, condition.
Atopic eczemacommonly occurs in areas with folds of skin, such as:
Atopic eczema can vary in severity andmost people are only mildly affected. Severe symptoms include cracked, sore and bleeding skin.
People with atopic eczema usuallyhave periods when symptoms are less noticeable, as well as flare-ups when symptoms become more severe, needing additional treatment.
Read more about thesymptoms of atopic eczema.
The exact cause of atopic eczema is unknown. However, it often occurs in people whogetallergies ("atopic" means sensitivity to allergens).
Atopic eczema can run in families and often occurs alongside other conditions, such asasthma and hay fever.
Readmore information about thecauses of atopic eczema.
Atopic eczema clears up or significantly improves in many childrenas they get older. Inabout 53%of cases,atopic eczema clears up by the timea child reaches 11 years of age, and in 65% of cases it clears up by 16 years of age.
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Top 5 Powerful Home Remedies For Psoriasis – Video
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Top 5 Powerful Home Remedies For Psoriasis
Read More Remedies Here: http://www.natural-homeremedies.com/top-5-powerful-home-remedies-for-psoriasis/
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Psoriasis feedback after hijama – Video
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Psoriasis feedback after hijama
Hijama.
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Psoriasis Symptoms, Treatment, Causes, Medication Information …
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Psoriasis facts Psoriasis is a chronic inflammatory skin disease. Patients with psoriasis who are obese are predisposed to diabetes and heart disease. Psoriasis can be initiated by certain environmental triggers. A predisposition for psoriasis is inherited in genes. Psoriasis is not contagious. Psoriasis gets better and worse spontaneously and can have periodic remissions (clear skin). Psoriasis is controllable with medication. Psoriasis is currently not curable. There are many promising therapies, including newer biologic drugs. Future research for psoriasis is promising. What is psoriasis?
Psoriasis is a noncontagious skin condition that produces red papules that merge together into plaques of thickened, scaling skin. The dry flakes of skin scales are thought to result from the excessively rapid proliferation of skin cells that is triggered by abnormal lymphocytes. Psoriasis commonly affects the skin of the elbows, knees, and scalp.
Some people have such mild psoriasis (small, faint dry skin patches) that they may not even suspect that they have a medical skin condition. Others have very severe psoriasis where virtually their entire body is fully covered with thick, red, scaly skin.
Psoriasis is considered an incurable, long-term (chronic) skin condition. It has a variable course, periodically improving and worsening. It is not unusual for psoriasis to spontaneously clear for years and stay in remission. Many people note a worsening of their symptoms in the colder winter months.
Psoriasis affects all races and both sexes. Although psoriasis can be seen in people of any age, from babies to seniors, most commonly patients are first diagnosed in their early adult years. The quality of life of patients with psoriasis is often diminished because of the appearance of their skin. Recently, it has become clear that people with psoriasis are more likely to have diabetes, high blood lipids, and heart disease. There are speculations as to how this might relate to their joint and skin inflammation. Caring for psoriasis takes medical teamwork.
Medically Reviewed by a Doctor on 5/16/2013
Psoriasis - Effective Treatments Question: What kinds of treatments have been effective for your psoriasis?
Psoriasis - Symptoms Question: What symptoms and signs did you experience with psoriasis?
Scalp Psoriasis - Creams and Lotions Question: Which creams or lotions (topical medications) have helped you treat scalp psoriasis?
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Psoriasis Free For Life Review – Watch This Before You Buy – Video
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Psoriasis Free For Life Review - Watch This Before You Buy
Psoriasis Free For Life Download: http://tinyurl.com/nd6va7q.
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