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Category Archives: Transhuman News
Hookworm genome could help
Posted: January 21, 2014 at 1:43 am
Scientists say they have unravelled the genome of the hookworm, paving the way for better remedies against the disease-causing parasite that infects about 700 million people.
An international team of researchers identified genes that help the hookworm invade its host, evade the body's immune defences, and feed undisturbed on human blood for up to a decade.
'Our findings provide information on molecules that are essential for the worm's survival, therefore making them potential candidates for development of therapeutics to combat hookworm infections,' said study co-author Makedonka Mitreva of the Washington University School of Medicine.
The hookworm Necator americanus is the predominant soil-dwelling human parasite.
Adult worms feed on blood in the small intestine, causing iron deficiency, malnutrition, stunting in children, and pregnancy complications.
They infect mainly people in disadvantaged communities in tropical and subtropical regions.
The life cycle starts with the hatching of eggs in the stool of infected people, which hatch as larvae in soil, and reinfect humans by skin penetration, according to the study published in Nature Genetics.
Adult worms of about one centimetre long can drink 30 microlitres (a millionth of a litre) of blood per day, and survive in its human host for 10 years.
A female worm can lay up to 10,000 eggs per day.
'New methods to control hookworm disease are urgently needed,' said the authors.
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Hookworm genome could help
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Where’s the Compassion? Reflections on Human Privilege
Posted: at 1:43 am
In the last Carletonian of fall term, Anna Schmiel 17 wrote an op-ed titled Wheres the Tofu?: Reflections on Food Privilege. As the person with whom she had a conversation, I would like to reaffirm my message and address some of the problematic statements she made in the article.
I do not intend to suggest that every person in the world can and should go vegan right now. Rather, I believe that people should consume animal products as little as possible. Given the widespread availability of nutritious, affordable vegan food and many peoples (including subsistence farmers) reliance on crops, most people can and should go vegan. However, corporations, our families, and even our government tell us that consuming other species dead flesh, milk, and eggs is good and healthy. To be blunt, theyre incorrect. Countless reputable reports, studies, and books prove and extrapolate on this. Books such as the China Study, one of the most significant works published on human nutrition and longevity, detail how humans are physiologically ill-equipped to be omnivores. Meanwhile, studies such as the United Nations Environment Programmes Assessing the Environmental Impacts of Consumption and Production demonstrate how animal agriculture, particularly via factory farms and commercial fishing, wreaks havoc on the environment and global food security. So, given my space constraint, I will instead discuss the most ignored but most significant privilege in the food system: human privilege. As Anna correctly points out, food privileges exist between people across geography and wealth. But human privilege also prevails. We not only unnecessarily abuse and kill billions of non-human animals on factory, family, and fish farms, but we have the gall to suggest that their sufferings are somehow less legitimate, less tragic, less real than ours. This is human privilege at work.
Anna also exercises human privilege when she suggests non-human suffering is neither actually tragic nor a real-world problem, and fighting for them is fancy- which I take to mean secondary to and less legitimate than fighting for humans. By implying that eating animals is justified if we dont put them in small cages and interact with them on a daily basis, she asserts the dominating party (humans), rather than the victimized party (non-human animals), deserves to define the morality of the domination. This is highly problematic because it permits the dominator to construct morality in such a way that serves itself.
But Anna is hardly alone in exercising her human privilege. We hold that humane slaughter is not an oxymoron when applied to a member of a species besides our own. We criminalize sexual abuse of humans, although we permit, and even subsidize, the exploitation and commodification of the female reproductive system of other animals (Egg farmers use a number of tricks, including starving hens, to boost egg production. Dairy farmers continually artificially inseminate [i.e. rape] female cows to keep them constantly lactating). We publicly fund education and protection programs for human children but we steal newborn calves from their mothers so that we may consume her milk and use the calves for future dairy, beef, or veal.
In a word, we are speciesists. While we have made strides against racism, sexism, ableism, and other forms of prejudice and discrimination, we continue to hold as fact that humans are more important than all others and can use non-humans as we please.
But we dont have to be. Just as we limited and outlawed forms of human suffering, so too can we limit and outlaw non-human animal suffering. We can achieve a world where no one has to walk fearfully into a slaughterhouse, where no mother has to cry out for her stolen baby, and where people live longer lives freer of hunger and diet-related diseases. Further, I have a hunch that if we all started to act more compassionately towards animals, that compassion would spread to the human realm, resulting in less oppression and exploitation among humans. For example, we might think twice before cutting welfare benefits, banning same-sex marriage, and failing to enact universal health care. We might not even have to worry about corporations acting greedily and grain becoming the new symbol of world hunger, as Anna suggests might happen.
We are in a state of cognitive dissonance. We all understand that animals have feelings and self-awareness and are like us in most respects. You wouldnt know it, though, judging by how we objectify (NASDAQ lists live cattle, feeder cattle, lean hogs, and milk as commodities) and otherwise abominably we treat them. But we dont have to live with this cognitive dissonance. Not only that, but I, and virtually every fellow vegan and animal rights/liberation activist I have met, have found the process of abandoning speciesism liberating. The act of choosing every day to reaffirm and live out my values has proven more refreshing than any milkshake, more appetizing than any T-bone.
The author is a member of Compassionate and Sustainable Consuming, a student group that aims to create a dialogue surrounding the ethical, social, and environmental injustices that emerge from participating in a society heavily dependent on animal exploitation. For more information, please contact robinere@, massa@, or zacke@
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Where’s the Compassion? Reflections on Human Privilege
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Mount Sinai researchers find promising new drug targets for cocaine addiction
Posted: at 1:42 am
PUBLIC RELEASE DATE:
20-Jan-2014
Contact: Laura Newman laura.newman@mountsinai.org 212-241-9200 The Mount Sinai Hospital / Mount Sinai School of Medicine
New York, NYResearchers from the Icahn School of Medicine at Mount Sinai have identified a new molecular mechanism by which cocaine alters the brain's reward circuits and causes addiction. Published online in the journal Proceedings of the National Academy of Sciences by Dr. Eric J. Nestler, MD, PhD, and colleagues, the preclinical research reveals how an abundant enzyme and synaptic gene affect a key reward circuit in the brain, changing the ways genes are expressed in the nucleus accumbens. The DNA itself does not change, but its "mark" activates or represses certain genes encoding synaptic proteins within the DNA. The marks indicate epigenetic changeschanges made by enzymesthat alter the activity of the nucleus accumbens.
In a mouse model, the research team found that chronic cocaine administration increased levels of an enzyme called PARP-1 or poly(ADP-ribosyl)ation polymerase-1. This increase in PARP-1 leads to an increase in its PAR marks at genes in the nucleus accumbens, contributing to long-term cocaine addiction. Although this is the first time PARP-1 has been linked to cocaine addiction, PARP-1 has been under investigation for cancer treatment.
"This discovery provides new leads for the development of anti-addiction medications," said the study's senior author, Eric Nestler, MD, PhD, Nash Family Professor of Neuroscience and Director of the Friedman Brain Institute, at the Icahn School of Medicine at Mount Sinai. Dr. Nestler said that the research team is using PARP to identify other proteins regulated by cocaine. PARP inhibitors may also prove valuable in changing cocaine's addictive power.
Kimberly Scobie, PhD, the lead investigator and postdoctoral fellow in Dr. Nestler's laboratory, underscored the value of implicating PARP-1 in mediating the brain's reward center. "It is striking that changing the level of PARP-1 alone is sufficient to influence the rewarding effects of cocaine," she said.
Next, the investigators used chromatin immunoprecipitation sequencing to identify which genes are altered through the epigenetic changes induced by PARP-1. One target gene whose expression changed after chronic cocaine use was sidekick-1, a cell adhesion molecule concentrated at synapses that directs synaptic connections. Sidekick-1 has not been studied to date in the brain, nor has it been studied in relation to cocaine exposure. Using viral mediated gene transfer to overexpress sidekick-1 in the nucleus accumbens, investigators saw that this overexpression alone not only increased the rewarding effects of cocaine, but it also induced changes in the morphology and synaptic connections of neurons in this brain reward region.
The research opens the door to a brand new direction for therapeutics to treat cocaine addiction. Effective drug therapies are urgently needed. National data from the US National Institute of Drug Abuse reveal that nearly 1.4 million Americans meet criteria for dependence or abuse of cocaine.
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Mount Sinai researchers find promising new drug targets for cocaine addiction
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Fight in Taco Bell: Politically incorrect views and potentially dangerous rhetoric Blog #1 – Video
Posted: at 1:42 am
Fight in Taco Bell: Politically incorrect views and potentially dangerous rhetoric Blog #1
Here are my thoughts on this video of this man and woman fighting in Taco Bell. Link Below http://www.worldstarhiphop.com/videos/video.php?v=wshhf43vha083f82...
By: Miller David
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Fight in Taco Bell: Politically incorrect views and potentially dangerous rhetoric Blog #1 - Video
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The strange hate for ‘Lone Survivor’
Posted: at 1:42 am
The movie Lone Survivor didnt get any Oscar nominations, but perhaps it shouldve been nominated for Most Unlikely Politically Incorrect Picture of the Year.
Its based on the true story of a mission in Afghanistan that goes disastrously wrong. A four-man team of Navy SEALs hunting down a Taliban commander is stumbled upon by a couple of goatherds in the mountains of Kunar province. Deciding to let them go, even though it will compromise them, the SEALs are subsequently outnumbered in a fierce firefight. Three are killed, and a Chinook helicopter attempting to relieve them is downed, killing another 16 Americans. The only survivor is a SEAL named Marcus Luttrell, who is played by Mark Wahlberg and wrote a book about the mission.
None of this is remotely controversial material. How could anyone be offended by a movie about a Navy SEAL fighting with everything he has to save himself and his buddies and improbably surviving an epic ordeal? Yet the brickbats have been flying from the snotty left: Propaganda. Simplistic. Racist.
Lone Survivor has run up against part of the culture that cant stand the most straightforward depictions of American heroism and the warrior ethic.
A reviewer in The Atlantic worries that movies like Lone Survivor resemble multimillion-dollar recruitment videos tools of military indoctrination geared toward the young and the impressionable.
Theres no doubt that the SEALs are portrayed as noble and heroic, for good reason: They were. But if this is a recruitment film, it isnt of the sign up and see the world variety. The implicit message is that if you become a SEAL, you, too, can be faced with excruciating life-and-death decisions in hostile territory. You, too, can fight a battle while falling down a mountain. You, too, can get shot up and killed.
A writer in Salon complains that the targeted Taliban commander is presented as a terrible guy, and we dont learn enough about the Taliban fighters attacking the SEALs, or as he calls them, some dudes from an Afghan village about whom we know nothing. Yes, if only we knew whether or not the Taliban commander, Ahmad Shah, had a troubled upbringing, that would change everything.
Perhaps the Taliban version of the movie could present fuller, more sympathetic portraits of its fighters seeking to plunge their country into renewed medieval darkness if, that is, the Taliban believed in movies.
In perhaps the most preposterous critique, a critic in LA Weekly says the attitude of the SEALs in the movie is Brown people bad, American people good. What a stupid smear. The proximate cause of the impossible situation of the SEALs is precisely their decision to let a few unarmed brown people go. Besides, not all brown people in the film are bad. Some of them are awe-inspiringly merciful and brave. Of course, the main thrust of the Talibans war is against other brown people, whom they intimidate and kill in their quest to dominate.
It is certainly true that Lone Survivor is not Fellini. What it lacks in dialogue, it makes up for in explosions and gunfire. It is about as subtle as an RPG round. But it captures something important: the otherworldly fearlessness and grit of our best fighters.
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The strange hate for ‘Lone Survivor’
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Transformation Nation (The Politically Incorrect Work-Out) – Video
Posted: at 1:42 am
Transformation Nation (The Politically Incorrect Work-Out)
I DO NOT OWN ANY OF THE MUSIC IN THIS VIDEO. don #39;t call the number in this video, it #39;s a joke guys. thanks for watching!
By: Kelsey Thomas
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Transformation Nation (The Politically Incorrect Work-Out) - Video
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Internet censorship bill sparks violent clashes in Istanbul – Video
Posted: at 1:42 am
Internet censorship bill sparks violent clashes in Istanbul
Anti-government protesters and police clashed in Istanbul on Saturday during demonstrations against the government #39;s new internet policy. Protesters converge...
By: RuptlyTV
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Internet censorship bill sparks violent clashes in Istanbul - Video
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Path of Exile – Unnecessary Censorship – Video
Posted: at 1:42 am
Path of Exile - Unnecessary Censorship
WARNING: this video is meant to be fun, please enjoy with care. Also excuse my 5yo laptop quality recording. Reddit thread: http://en.reddit.com/r/pathofexil...
By: NightingaleChant
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Path of Exile - Unnecessary Censorship - Video
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Clashes in Turkey as internet censorship protests turn violent – Video
Posted: at 1:42 am
Clashes in Turkey as internet censorship protests turn violent
Riot police in Istanbul used water canon as crowds demonstrated against a draft bill that would... euronews, the most watched news channel in Europe Subscrib...
By: euronews (in English)
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Clashes in Turkey as internet censorship protests turn violent - Video
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CBS Ends 6 Month Censorship of IRS Scandal to Tell Viewers FBI Won’t File Charges – Video
Posted: at 1:42 am
CBS Ends 6 Month Censorship of IRS Scandal to Tell Viewers FBI Won #39;t File Charges
CBS Ends 6 Month Censorship of IRS Scandal to Tell Viewers FBI Won #39;t File Charges Air date - January 2014.
By: Mcbogsters
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CBS Ends 6 Month Censorship of IRS Scandal to Tell Viewers FBI Won't File Charges - Video
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