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Category Archives: Transhuman News

Bit Shifter – hexadecimal Genome – Video

Posted: February 10, 2014 at 4:43 am


Bit Shifter - hexadecimal Genome
im am back again. quite a long time, but it had to be.

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Bit Shifter - hexadecimal Genome - Video

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Getting Started with Genome Mate – Video

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Getting Started with Genome Mate
The purpose of this video is to help people get started using Genome Mate. We will be covering just the basic steps to create a profile, import match data an...

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Genome editing goes hi-fi

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PUBLIC RELEASE DATE:

9-Feb-2014

Contact: Anne Holden anne.holden@gladstone.ucsf.edu 415-734-2534 Gladstone Institutes

SAN FRANCISCO, CAFebruary 9, 2014Sometimes biology is cruel. Sometimes simply a one-letter change in the human genetic code is the difference between health and a deadly disease. But even though doctors and scientists have long studied disorders caused by these tiny changes, replicating them to study in human stem cells has proven challenging. But now, scientists at the Gladstone Institutes have found a way to efficiently edit the human genome one letter at a timenot only boosting researchers' ability to model human disease, but also paving the way for therapies that cure disease by fixing these so-called 'bugs' in a patient's genetic code.

Led by Gladstone Investigator Bruce Conklin, MD, the research team describes in the latest issue of Nature Methods how they have solved one of science and medicine's most pressing problems: how to efficiently and accurately capture rare genetic mutations that cause diseaseas well as how to fix them. This pioneering technique highlights the type of out-of-the-box thinking that is often critical for scientific success.

"Advances in human genetics have led to the discovery of hundreds of genetic changes linked to disease, but until now we've lacked an efficient means of studying them," explained Dr. Conklin. "To meet this challenge, we must have the capability to engineer the human genome, one letter at a time, with tools that are efficient, robust and accurate. And the method that we outline in our study does just that."

One of the major challenges preventing researchers from efficiently generating and studying these genetic diseases is that they can exist at frequencies as low as 1%, making the task of finding and studying them labor-intensive.

"For our method to work, we needed to find a way to efficiently identify a single mutation among hundreds of normal, healthy cells," explained Gladstone Research Scientist Yuichiro Miyaoka, PhD, the paper's lead author. "So we designed a special fluorescent probe that would distinguish the mutated sequence from the original sequences. We were then able to sort through both sets of sequences and detect mutant cellseven when they made up as little one in every thousand cells. This is a level of sensitivity more than one hundred times greater than traditional methods."

The team then applied these new methods to induced pluripotent stem cells, or iPS cells. These cells, derived from the skin cells of human patients, have the same genetic makeupincluding any potential disease-causing mutationsas the patient. In this case, the research team first used a highly advanced gene-editing technique called TALENs to introduce a specific mutation into the genome. Some gene-editing techniques, while effective at modifying the genetic code, involve the use of genetic markers that then leave a 'scar' on the newly edited genome. These scars can then affect subsequent generations of cells, complicating future analysis. Athough TALENs, and other similarly advanced tools, are able to make a clean, scarless single letter edits, these edits are very rare, so that new technique from the Conklin lab is needed.

"Our method provides a novel way to capture and amplify specific mutations that are normally exceedingly rare," said Dr. Conklin. "Our high-efficiency, high-fidelity method could very well be the basis for the next phase of human genetics research."

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Genome editing goes hi-fi

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Anti-Human Trafficking Organization Unlikely Heroes Announces Year-Long Human Trafficking Awareness and Prevention …

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Los Angeles, CA (PRWEB) February 10, 2014

To coincide with the White House's announcement of January as National Slavery and Human Trafficking Prevention month, international anti-human trafficking organization Unlikely Heroes launched a human trafficking awareness and prevention campaign, including updated branding and a new website. Based in Los Angeles, Unlikely Heroes is dedicated to eradicating modern-day slavery through strategic rescues and the implementation of restoration homes and holistic rehabilitation centers. Unlikely Heroes has residential restoration homes and projects for child victims of sex slavery in The Philippines, Thailand and Mexico. Current conservative estimates say there are over 27 million people trapped in modern-day slavery worldwide. It is considered one of the fastest growing criminal industries in the world.

The new Unlikely Heroes website features in-depth updates on each of the Unlikely Heroes projects, awareness and educational information on the issue of human trafficking, words and imagery designed to inspire visitors, and a brand new crowd-funding platform to offer a way for anyone to get involved to become a hero themselves. The crowd-funding platform, referred to on the website as Campaigns, exists to create a space for anyone who wants to join the movement to end human trafficking. Users can register to host their own Campaign and use it as a way to bring awareness to the cause and raise funds in their own way birthday gift donations, church or school events, car washes, etc.

In an article released on January 30, 2014, Forbes Magazine praised the Unlikely Heroes business model and fundraising events, saying, The young & stylish crowd enjoyed the social aspect of the event, but also demonstrated their commitment to the Unlikely Heroes cause by donating over $150,000 that night. Emerging philanthropists, especially millennials, are growing accustomed to having it all in one sustainable & cause-centric organizations, entertaining social events, & creating real immediate impact. The article, titled The 'Unlikely' Social-Cause Startup Attracting Young Hollywood, emphasizes not only the effective Unlikely Heroes programs for survivor care, but also the organizations strong relationships with celebrities in the entertainment industry.

Also in the Forbes article, Founder and CEO of Unlikely Heroes Erica Greve says about her method of running Unlikely Heroes, Whether we are rescuing a girl out of a brothel, or recognizing the accomplishments of a celebrity advocate at one of our red carpet events, we do our best to protect the vulnerable and highlight the valuable.

Unlikely Heroes has also launched their viral Public Service Announcement, summarizing the global issue of human trafficking and explaining the Unlikely Heroes plan to combat it. The PSA includes interviews from several members of the Unlikely Heroes team, as well as inspirational stories of the rescues and rehabilitation taking place at the Unlikely Heroes Restoration Homes. In the video Greve reiterates, Our mission at Unlikely Heroes is to rescue, restore and rehabilitate child victims of sex slavery worldwide.

For National Slavery and Human Trafficking Prevention Month, Unlikely Heroes has intended to reach a broad spectrum of demographics through editorial articles and an ad campaign that will continue throughout the year.

In reference to the Unlikely Heroes awareness plan for 2014, Ben Decker, the Unlikely Heroes Director of Outreach and Strategic Partnerships, says, It is important that people become intimately aware of the issue of modern-day slavery. We are working intentionally to expand our awareness and prevention campaigns throughout the year not keeping them confined to January as National Slavery and Human Trafficking Prevention Month.

Through a long-standing partnership, Unlikely Heroes received a donation of two full-page PSA ads in national celebrity weekly publication, OK! Magazine, reaching millions. The ad, also designed and developed by Sharp Machine Media, reads, among other things, Every human being no matter what race, color or age, was born to be free and stay free. Time and time again, history has proven that when people join their voices together, change is inevitable. Functionally similar ads will be run throughout the year in OK! Magazine, Relevant Magazine and Solutions Magazine, as well as other partner publications.

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Best Remedy for Eczema Dry Skin Rash – Stop Scratching Now! – Video

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Best Remedy for Eczema Dry Skin Rash - Stop Scratching Now!
http://www.VanishEczema.net Eczema is a painful and irritating skin disease that can be cured if treated correctly (especially when natural eczema remedies a...

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Information of Eczema – 3 Bad Things About Milk – Video

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Information of Eczema - 3 Bad Things About Milk
http://www.VanishEczema.net Eczema is a painful and irritating skin disease that can be cured if treated correctly (especially when natural eczema remedies a...

By: Joshua Stanem

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Natural Remedy for Eczema – Aloe Vera is the Eczema Remedy – Video

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Natural Remedy for Eczema - Aloe Vera is the Eczema Remedy
http://www.VanishEczema.net Eczema is a painful and irritating skin disease that can be cured if treated correctly (especially when natural eczema remedies a...

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Eczema Cures – Hydrate With Hemp Seed Oil – Video

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Eczema Cures - Hydrate With Hemp Seed Oil
http://www.VanishEczema.net Eczema is a painful and irritating skin disease that can be cured if treated correctly (especially when natural eczema remedies a...

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Eczema Cures - Hydrate With Hemp Seed Oil - Video

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Best Eczema Treatment – Video

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Best Eczema Treatment
http://www.VanishEczema.net Eczema is a painful and irritating skin disease that can be cured if treated correctly (especially when natural eczema remedies a...

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Ayurveda Cure For Eczema – Video

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Ayurveda Cure For Eczema
http://www.VanishEczema.net Eczema is a painful and irritating skin disease that can be cured if treated correctly (especially when natural eczema remedies a...

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Ayurveda Cure For Eczema - Video

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