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Category Archives: Transhuman News
Calico cats may help scientists understand human genetics
Posted: February 19, 2014 at 7:47 pm
TUESDAY, Feb. 18, 2014 (HealthDay News) -- Cat lovers have long known that the distinctive three-toned calico patterning is almost exclusively found in female felines.
Now, the genetics behind that anomaly may help scientists understand human DNA a little better, too.
That's because calico cats may help explain so-called gene silencing -- flipping the "off switch" on genes, researchers say.
A team at the University of California, San Francisco say the unique orange-white-and-black patchwork fur on these cats is due to the silencing or inactivation of one of their two X chromosomes.
As the researchers explained, cells in female mammals have two copies of the X chromosome -- one from the mother and one from the father. Cells require only one active X chromosome, so the second one is turned off.
Calico cats have an orange-fur-color gene on one of their X chromosomes and a black-fur gene on the other. According to the UCSF team, the random silencing of one of the X chromosomes in each cell results in the calico cats' unique patchwork coat.
Scientists don't know exactly how a cell turns off a chromosome, so the researchers are trying to learn more about how different kinds of genes can be switched on or off without affecting the underlying DNA sequence.
This knowledge could lead to improved understanding, diagnosis and treatment of X-chromosome-related diseases in humans, said the researchers, who are scheduled to present their findings Tuesday at the Biophysical Society's annual meeting in San Francisco.
"Uncovering how only one X chromosome is inactivated will help explain the whole process of 'epigenetic control,' meaning the way changes in gene activity can be inherited without changing the DNA code," Elizabeth Smith, a postdoctoral fellow in the anatomy department at UCSF, said in an American Institute of Physics news release.
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Calico cats may help scientists understand human genetics
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AC4 Multiplayer – AA vs DNA – Video
Posted: at 7:47 pm
AC4 Multiplayer - AA vs DNA
Intro von: http://youtube.com/user/paulhyotoko07 Song: Awolnation - Sail (Unlimited Gravity Remix) DNA http://www.youtube.com/channel/UCt8vowK8rFypqp8Ra1oG1F...
By: DerRechteWinkel
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AC4 Multiplayer - AA vs DNA - Video
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Cris, Corina si dna Iuliana…de pe aplay (18.02.2014) – Video
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Cris, Corina si dna Iuliana...de pe aplay (18.02.2014)
by Iustina Andreea.
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Cris, Corina si dna Iuliana...de pe aplay (18.02.2014) - Video
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THE CORRECT VIEWS (2/18/2014) – Wash Nuked?, Bible DNA, PETA Kills, NSA Death, Pizza Guns, Ohio Dumb – Video
Posted: at 7:47 pm
THE CORRECT VIEWS (2/18/2014) - Wash Nuked?, Bible DNA, PETA Kills, NSA Death, Pizza Guns, Ohio Dumb
Greetings Unsettled Souls, #39;Tis Sam I Be Di Gangi of The Media Speaks (www.themediaspeaks.com) and who would guess that Washington state is finding a cl...
By: TheCorrectViews
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THE CORRECT VIEWS (2/18/2014) - Wash Nuked?, Bible DNA, PETA Kills, NSA Death, Pizza Guns, Ohio Dumb - Video
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roblox digimon master how to dna charge :P – Video
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roblox digimon master how to dna charge 😛
today we are teacghing u how to dna charge with the help of my friend spikehead297 :P.
By: Raphael Parker
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roblox digimon master how to dna charge 😛 - Video
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22watt video better than DNA 20, Use the latest SX220 chip – Video
Posted: at 7:47 pm
22watt video better than DNA 20, Use the latest SX220 chip
Green Leaf G new technology, latest SX220 technology for the 220watt mod; price is very competitive. Manufature Email: denny@pioneer4you.com Skype:chan.pione...
By: Chris Zhang
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22watt video better than DNA 20, Use the latest SX220 chip - Video
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Filling Gaps in the Spinach Genome with SMRT Sequencing – Video
Posted: at 7:46 pm
Filling Gaps in the Spinach Genome with SMRT Sequencing
Allen Van Deynze from UC Davis presents the genome sequencing and assembly project for spinach, an organism of 980 Mbp. Results indicate a high-accuracy asse...
By: PacificBiosciences
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Filling Gaps in the Spinach Genome with SMRT Sequencing - Video
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Whole Genome Analysis, STAT
Posted: at 7:46 pm
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Newswise Although the time and cost of sequencing an entire human genome has plummeted, analyzing the resulting three billion base pairs of genetic information from a single genome can take many months.
In the journal Bioinformatics, however, a University of Chicago-based teamworking with Beagle, one of the worlds fastest supercomputers devoted to life sciencesreports that genome analysis can be radically accelerated. This computer, based at Argonne National Laboratory, is able to analyze 240 full genomes in about two days.
This is a resource that can change patient management and, over time, add depth to our understanding of the genetic causes of risk and disease, said study author Elizabeth McNally, MD, PhD, the A. J. Carlson Professor of Medicine and Human Genetics and director of the Cardiovascular Genetics Clinic at the University of Chicago Medicine.
The supercomputer can process many genomes simultaneously rather than one at a time, said first author Megan Puckelwartz, a graduate student in McNallys laboratory. It converts whole genome sequencing, which has primarily been used as a research tool, into something that is immediately valuable for patient care.
Because the genome is so vast, those involved in clinical genetics have turned to exome sequencing, which focuses on the two percent or less of the genome that codes for proteins. This approach is often useful. An estimated 85 percent of disease-causing mutations are located in coding regions. But the rest, about 15 percent of clinically significant mutations, come from non-coding regions, once referred to as junk DNA but now known to serve important functions. If not for the tremendous data-processing challenges of analysis, whole genome sequencing would be the method of choice.
To test the system, McNallys team used raw sequencing data from 61 human genomes and analyzed that data on Beagle. They used publicly available software packages and one quarter of the computers total capacity. They found that shifting to the supercomputer environment improved accuracy and dramatically accelerated speed.
Improving analysis through both speed and accuracy reduces the price per genome, McNally said. With this approach, the price for analyzing an entire genome is less than the cost of the looking at just a fraction of genome. New technology promises to bring the costs of sequencing down to around $1,000 per genome. Our goal is get the cost of analysis down into that range.
This work vividly demonstrates the benefits of dedicating a powerful supercomputer resource to biomedical research, said co-author Ian Foster, director of the Computation Institute and Arthur Holly Compton Distinguished Service Professor of Computer Science. The methods developed here will be instrumental in relieving the data analysis bottleneck that researchers face as genetic sequencing grows cheaper and faster.
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Whole Genome Analysis, STAT
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Suffering From Eczema and Dry Itchy Skin? Get Rid of Them by Eliminating Internal Toxins! – Video
Posted: at 7:46 pm
Suffering From Eczema and Dry Itchy Skin? Get Rid of Them by Eliminating Internal Toxins!
Learn How To Get Rid Of Eczema FOREVER | Link Here: CLICK: http://www.VanishEczema.net The need to know how to get rid of eczema often arises for those peopl...
By: Elena Cupova
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Suffering From Eczema and Dry Itchy Skin? Get Rid of Them by Eliminating Internal Toxins! - Video
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Eczema Diet – A Curing Eczema Juice – Video
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Eczema Diet - A Curing Eczema Juice
Learn How To Get Rid Of Eczema FOREVER | Link Here: Click: http://www.VanishEczema.net The need to know how to get rid of eczema often arises for those peopl...
By: Nemanja Supic
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Eczema Diet - A Curing Eczema Juice - Video
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