Category Archives: Transhuman News

Wales, DNA Surnames (Brian Swann)
Brian Swann obtained a PhD in organic chemistry in 1971 from the University of East Anglia and then worked in and around the pharmaceutical industry until hi...

By: DNA Lectures - Who Do You Think You Are 2014

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Wales, DNA & Surnames (Brian Swann) - Video

How to make a disinformation video DNA BUDDY PART2
How to make a disinformation video. WATCH: http://www.youtube.com/watch?v=3Ye6aKvHKRI and you see the name on the screen durring the beginning? You take some...

By: SONSofLIBERTYIII

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How to make a disinformation video DNA BUDDY PART2 - Video

New Discovery DNA Molecule Transmit genetic Material

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New Discovery DNA Molecule Transmit genetic Material - Video

Drake || DNA | [Star Crossed]

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Drake || DNA | [Star Crossed] - Video

DNA test may be used to nab high rise litterbugs - 23Feb2014
SINGAPORE: The number of complaints related to high-rise littering cases has increased by 50 percent over the past four years. Some residents at Dover Cresce...

By: 154thmedia2014

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DNA test may be used to nab high rise litterbugs - 23Feb2014 - Video

DnA feat. Rio Black - Someone Else (...not real mix!)
Music: Dime (D #39;nA) - Vox/Lyrcs: Rio Black (Atomic Neon) http://www.facebook.com/theatomicneon https://www.facebook.com/pages/DnA/116301365096293 http://www.atomicneon.de.

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DnA feat. Rio Black - Someone Else (...not real mix!) - Video

DNA Science Lesson Plan
SUBSCRIBE to Youtube University Channel Learn and Enjoy: http://www.youtube.com/subscription_center?add_user=YourUniversityTube Free Lectures designed to app...

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DNA Science Lesson Plan - Video

Scottish DNA - Clans, Families, and Surnames (Alasdair Macdonald)
Alasdair is volunteer administrator for the Scottish DNA and R-L165 Projects at Family Tree DNA. He is a tutor and member of the core team leading the postgr...

By: DNA Lectures - Who Do You Think You Are 2014

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Scottish DNA - Clans, Families, and Surnames (Alasdair Macdonald) - Video

DNA MS16561642; Mammoth Spoke Wheel 16inch X 5 5inch Rear
Buy at: http://www.partspak.com/productcart/pc/viewPrd.asp?idproduct=531383 DNA MS16561642; Mammoth Spoke Wheel 16" X 5.5" Rear Motorcycle.

By: partspak 27

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DNA MS16561642; Mammoth Spoke Wheel 16inch X 5 5inch Rear - Video

Viruses such as HBV can persist by depositing their genetic information (DNA) in the cell nucleus, where the DNA is normally not degraded. This prevents antiviral drugs from eliminating these viruses. But the newly discovered mechanism could make this possible without damaging the infected cell in the liver. In the current issue of the journal Science, the scientists report that now new therapeutic possibilities are consequently opening up.

Although preventive vaccination is possible, the World Health Organization (WHO) reports that more than 240 million people around the world are currently suffering from a chronic hepatitis B infection. They face a high risk of developing liver cirrhosis or even liver cancer. In Germany alone, more than half a million people are affected. Although available antiviral medicines can control the hepatitis B virus, they cannot completely eliminate it. As a result, the HBV in the patient's liver is reactivated as soon as the treatment is discontinued.

This is due to virus DNA (cccDNA: covalently closed circular DNA) "hidden" in the cell nucleus. This virus DNA stores multiple copies of the virus in the nucleus of infected liver cells (hepatocytes) and in this way protects itself from destructive influences. The cccDNA serves as a template for the virus' own proteins and new viral genomes. An international team of scientists headed by Prof. Ulrike Protzer and Prof. Mathias Heikenwlder, Institute of Virology at the Helmholtz Zentrum Mnchen and the Technische Universitt Mnchen, has now found a way to selectively attack and eliminate the viral genetic information in the cell nucleus of the liver cells without damaging the host cell in the process.

"The degradation of viral DNA in the cell nucleus that we describe represents an important mechanism in the defense against the virus," Protzer reports. "Moreover, for the first time, the results offer the possibility to develop a treatment that can heal hepatitis B."

The scientists have discovered that in addition to interferons (the immune system's defense agents), activation of the lymphotoxin receptor in the host cell promotes certain proteins and supports their function in such a way that they chemically modulate and degrade viral cccDNA. This keeps the virus from reactivating, and also prevents the disease from breaking out again, even after the treatment has ended.

On the other hand, the proteins do not influence the genetic information of the host cell itself, which here is the liver cell. "With the activation of the lymphotoxin receptor, also combined with substances that are already available, we have a very promising new therapy concept available," Heikenwlder explains.

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The above story is based on materials provided by Helmholtz Zentrum Mnchen - German Research Center for Environmental Health. Note: Materials may be edited for content and length.

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Degradation of viral DNA in cell nucleus opening up new treatment for hepatitis B