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Category Archives: Transhuman News
WATCH: Libby Emmons and Matt Walsh find hope for humanity in space exploration on Timcast IRL – The Post Millennial
Posted: April 15, 2022 at 12:56 pm
The Post Millennials editor-in-chief on Tim Pool's Timcast IRL defended the liberation of exploring the stars in the face of the crushing qualms of reality that have kept mankind on Earth.
Pool's daily show was shooting live in Nashville this week, where Pool hosted luminaries from The Daily Wire, including Matt Walsh, who was also in favor of humanity's exploration of the stars.
It was amidst the more difficult subjects on Tuesday night like Gibsons Bakery at Oberlin college, controversy surrounding the anti-grooming law in Florida, and the recently unfolding Brooklyn subway shooting tragedy in New York that the group managed to fit in the subject of space exploration.
Pool focused on the realist aspects of space exploration, as in highlighting the entropy problem of energy. But that didnt turn him off from the extraterrestrial conversation overall.
Elijah Schafer of the You Are Here podcast responded with skepticism to Emmons and her appeal to the optimism of adventure that exploring space would present to humanity. Tim backed Libbys point up with a touch of realism by alluding to the ambitions of SpaceXs Elon Musk when it came to colonizing Mars.
But Schafer doubled down on his doubts about human nature going wrong.
"I want to make this point about the colonization. Is sometimes I think that humans, we have this big man syndrome where I agree with the exploration, and my wife was really having a difficult time we have been watching like cave accidents. And she's like, 'why are people going into caves?' And I and this is where I would concede your point. I said, Dude exploration, and this idea of of pushing the boundaries as part of the human spirit that God gave us.'"
"But going into space is sort of a taxpayer funded burden. that I feel in many ways. I mean, the privatization of it, what's happening now is still very interesting as we're moving in that. But overall, it's been very costly. I've always wondered, those resources, and that movement with going to Mars almost seems like a distraction" Schafer said
Emmons argued that the problems of space exploration solve themselves when it comes to the potential rewards and discoveries that are possible in the pursuit.
Walsh of The Daily Wire made the pragmatic decision of ordaining that the societal focus on space exploration would solve the general depression and pessimism experienced in modern day culture.
Walsh said the best approach is from a fun mindset rather than realistic doom and gloom.
In the alternative media slate of content that Tim Pools enterprise is promoting, one of these ventures includes the usage of livestreaming chickens 24 hours a day, 7 days a week.
This so-called "Chicken City" joint is said to be seriously considered enough that Pool is aiming to advertise it during Tucker Carlsons primetime show on Fox News.
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Global Psoriasis Treatment Market To Be Driven By Robust Research And Development (R&D) For The Development Of An Effective Treatment Method In The…
Posted: at 12:29 pm
The new report by Expert Market Research titled, Global Psoriasis Treatment Market Report and Forecast 2021-2026, gives an in-depth analysis of the globalpsoriasis treatment market, assessing the market based on its segments like drug classes, types, routes of administration, distribution channels, andmajor regions. The report tracks the latest trends in the industry and studies their impact on the overall market. It also assesses the market dynamics, covering the key demand and price indicators, along withanalyzingthe market based on the SWOT and Porters Five Forces models.
Request a free sample copy in PDF or view the report summary@https://www.expertmarketresearch.com/reports/psoriasis-treatment-market/requestsample
The key highlights of the report include:
Market Overview (2016-2026)
The global market for psoriasis treatment is being driven by the rising incidences of psoriasis making it a critical global issue, hence augmenting the demand for an effective treatment. According to the World Health Organisation, the reported prevalence of psoriasis in countries range from between 0.09% to 11.4%. Thus, robust investments towards the development of advanced treatment to control the spread of psoriasis disease is aiding the market growth of psoriasis treatment.
Industry Definition and Segmentation
Psoriasis refers to a common inflammatory condition in which skin cells build up and form scales and itchy, dry patches. Treatment such as topical ointments, light therapy, and medication aims to remote scales and stop the robust growth of skin cells.
Explore the full report with the table of contents@https://www.expertmarketresearch.com/reports/psoriasis-treatment-market
On the basis of drug class, the market can be divided into:
Based on type, the market can be categorised into:
The market, based on administration, can be segmented into:
On the basis of distribution channel, the market can be classified into:
The regional markets for the product include:
Market Trends
The growth in the global market for psoriasistreatmentis being driven by the unawareness regarding the origin of the disease. As a result, robust research and development (R&D) about the cause, potential effects, and effective treatments is expected to have a significant influence over the growth of the market. In addition to this, favourable government measures such as reimbursement schemes, subsidised treatments, and other thoughtful measures are also expected to boost the market growth. A combination of topical and systematic therapies to reduce the effects of psoriasis in a lifelong treatment, aimed at remission, is thus driving the growth of the market.
Latest News on Global Psoriasis Treatment Market@https://www.expertmarketresearch.com/pressrelease/global-psoriasis-treatment-market
Key Market Players
The major players in the market are AbbVie Inc., Novartis AG, Johnson and Johnson Services, Inc., Pfizer Inc., and Merc and Co., Inc., among others. The report covers the market shares, capacities, plant turnarounds, expansions, investments and mergers and acquisitions, among other latest developments of these market players.
About Us:
Expert Market Research is a leading business intelligence firm, providing custom and syndicated market reports along with consultancy services for our clients. We serve a wide client base ranging from Fortune 1000 companies to small and medium enterprises. Our reports cover over 100 industries across established and emerging markets researched by our skilled analysts who track the latest economic, demographic, trade and market data globally.
At Expert Market Research, we tailor our approach according to our clients needs and preferences, providing them with valuable, actionable and up-to-date insights into the market, thus, helping them realize their optimum growth potential. We offer market intelligence across a range of industry verticals which include Pharmaceuticals, Food and Beverage, Technology, Retail, Chemical and Materials, Energy and Mining, Packaging and Agriculture.
Media Contact
Company Name: EMR Inc.Contact Person: Eliana Grace, Business ConsultantEmail: sales@expertmarketresearch.comToll Free Number: US +1-415-325-5166 | UK +44-702-402-5790Address: 30 North Gould Street, Sheridan, WY 82801, USACity: SheridanState: WyomingCountry: United StatesWebsite: https://www.expertmarketresearch.com
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*We at Expert Market Research always thrive to give you the latest information. The numbers in the article are only indicative and may be different from the actual report.
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Thirty Madison launches Facet, aims to offer the most comprehensive clinical skin health platform – PR Newswire
Posted: at 12:29 pm
"With Facet, Thirty Madison will fundamentally shift how we approach skin health by actually looking through a medical lens to solve medical skin concerns, versus focusing on what often feels like these unachievable beauty standards. People need medical solutions to properly treat their skin it's the body's largest organ," said Facet Medical Director Dr. Peter Young, board-certified dermatologist. "For patients with conditions like psoriasis or eczema, every product they use plays an important role in managing their condition from their daily face wash and moisturizer to an oral treatment or an injectable and finding the right mix of treatments is critical to achieving healthy skin."
Facet will treat eczema, psoriasis, acne, rosacea, dandruff, melasma, and anti-aging. Thirty Madison's care model will offer Facet patients specialty-level care, personalized treatment, and ongoing condition management. The unique care model, paired with clinically backed treatments across a breadth of conditions, ensures patients can access their treatment right at home, whenever they need it. Treatments include prescription topicals, custom prescription formulas, prescription orals and biologics, and/or non-prescription options. Facet is Thirty Madison's first offering to provide systemic treatments and lab testing on a case-by-case basis for patients with severe psoriasis or atopic dermatitis.
"Conditions like eczema, psoriasis, and rosacea often go untreated and even for those who do receive a diagnosis, people still feel like it's a battle to manage these conditions long-term. You're left to figure it out on your own," said Rajani Rao, General Manager for Facet. "Patients deserve an empathetic, thoughtful approach led by medical experts who can offer them the holistic care plans they need to feel confident again. We've built that experience with Facet, and made it accessible, personalized, and genuinely supportive."
More consumers are looking to telehealth for their skin concerns. The average wait time to receive an in-person dermatology appointment is 32 days. During the pandemic, telehealth for dermatology usage skyrocketed by 188% from 2019 to 2022. Of U.S. consumers who accelerated their digital health/wellness engagements during the pandemic, 80% say they will continue engagements post-COVID.
Facet is the latest offering from Thirty Madison, the healthcare company whose care model powers Keeps, Cove, Evens, Picnic, and Nurx, focused on supporting patients living with chronic conditions. Thirty Madison closed its merger with Nurx last month, forming the largest and most innovative virtual care company.
About Thirty MadisonThirty Madison is the premier healthcare company for people living with chronic conditions. Thirty Madison's unique care model delivers accessible, affordable care, and superior outcomes for hundreds of thousands of patients. This specialized care model is powered by the company's proprietary platform: the technology, services, and physical infrastructure needed to provide high-quality care to an increasing number of patients. With Keeps, Evens, Cove, Picnic, Nurx, and Facet, Thirty Madison offers an extensible solution that best serves patients across the vast spectrum of chronic conditions. Learn more at ThirtyMadison.com.
SOURCE Thirty Madison
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Thirty Madison launches Facet, aims to offer the most comprehensive clinical skin health platform - PR Newswire
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David Cronenbergs Crimes of the Future trailer shows return to sci-fi body horror – Polygon
Posted: at 12:27 pm
It always sounded as if David Cronenbergs Crimes of the Future would be a return to the veteran directors preoccupation with body horror, transhumanism, and weird, organic sci-fi and the films first trailer proves this very much to be the case.
Featuring strange, fleshy technologies, body parts sewn shut or relocated to unfamiliar places, and scenes that confuse sex with surgery as well as what appears to be a shot of someone eating a waste paper basket Crimes of the Future is very recognizable as the work of the man who made such unsettling explorations of the human-machine interface as Videodrome, The Fly, Dead Ringers, Crash, and Existenz in the 1970s, 80s and 90s.
Crimes of the Future, which will be released in theaters in June, reunites Cronenberg with Viggo Mortensen, star of his much more grounded (but also excellent) 2000s crime thrillers A History of Violence and Eastern Promises. Mortensen plays a near-future performance artist who publicly showcases the metamorphosis of his organs, assisted by his partner (La Seydoux). Kristen Stewart plays an investigator from the National Organ Registry who looks into the couple, and uncovers a plan to use their fame to shed light on the next phase of human evolution. (You can get a very slightly better sense of this plot from the French version of the trailer below.)
In a statement, Cronenberg said, Crimes of the Future is a meditation on human evolution. Specifically the ways in which we have had to take control of the process because we have created such powerful environments that did not exist previously. [...] At this critical junction in human history, one wonders can the human body evolve to solve problems we have created? Can the human body evolve a process to digest plastics and artificial materials not only as part of a solution to the climate crisis, but also, to grow, thrive, and survive?
Crimes of the Future comes after a fairly long hiatus for the 79-year-old Cronenberg, whose last film was 2014s Maps to the Stars. In 2020, his son Brandon Cronenberg released Possessor, a horror film that seemed strongly influenced by the elder Cronenbergs work.
It was also revealed that Crimes of the Future will premiere at the prestigious Cannes Film Festival in May in the main competition. The winner of last years top prize at Cannes, Titane, also owed a clear debt to Cronenberg, so it seems the Canadian elder statesman of horror is making his comeback at a time when his twisted visions are in fashion.
Also premiering at Cannes will be Top Gun: Maverick; Baz Luhrmanns Elvis biopic; a new crime thriller from Oldboy director Park Chan-wook; a French remake of the cult Japanese zombie film One Cut of the Dead; a new film by Mad Max director George Miller; the directorial debut of Squid Game star Lee Jung-jae, and much more. Looks like a great festival.
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David Cronenbergs Crimes of the Future trailer shows return to sci-fi body horror - Polygon
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How the generation that refuses to grow old and feel pain invented assisted suicide News Release India – News Release India
Posted: at 12:27 pm
The news about actor Alain Delons decision for assisted suicide is a disturbing call for reflection. I never liked getting old, the actor said on one occasion. At 86 years old, the right to leave calmly would make provoked death the most logical and natural thing to do, in the Frenchmans opinion, which is far from being considered a terminal patient. The youngest sons recent statements, denying that his father intends to end his own life and asking that he be allowed to live in peace, seem to reinforce the thesis that a nostalgia for the spotlight has motivated the farewell atmosphere. . In any case, Delon reminded us of the urgency of thinking about what Albert Camus defined as the only truly serious philosophical problem: judging whether or not life is worth living.
The rejection With aging, the obsession with eternal youth and permanent happiness seem to be creating a generation of adults without emotional maturity, who confuse whims with rights and have an aversion to duties. This is evidenced by the Argentine psychologist Sergio Sinay, in his book The society that does not want to grow. A society committed to remaining a teenager lives in immediacy, in the fleetingness, in the escape from responsibilities, he says.
The alleged constant duty of happiness is the theme of the essay The Perpetual Euphoria, by French Pascal Bruckner. Happiness is no longer a chance that happens to us, a favorable moment in relation to the monotony of days, as well as unhappiness, since both are natural in human life, in the authors view. happiness a program of life and ends up feeling unhappy precisely because of that.
If the path of reflection and subjective intention does not account for the desire to reduce the burden of a self-consciousness that weighs and makes suffer, why not take the shortcut of objective intervention through technological manipulation?, provokes Eduardo Gianetti da Fonseca, in the suggestive work Felicidade. The reflection on antidepressants and drugs is easily applicable to the extreme of assisted suicide.
The promise of quality of life embedded even in the transhumanist discourse (a kind of overcoming biological limitations by technology) hides in itself an attack on the sacredness of life, points out gynecologist and obstetrician Elizabeth Kipman, audible knowledge of Personalist Bioethics. The population is absorbing this discourse of individual empowerment, without knowing the political issues that are behind it. It absorbs the idea of an earthly paradise, without realizing that it will be necessary to eliminate those who are worthless, such as the sick and the elderly. To achieve this, it is first necessary to build a social consensus, and that is what is happening, he defends.
The idea of control of the population through pleasure already appeared in the Brave New World , by Aldous Huxley, who paints a paradise without family ties, responsibilities and pain, even with the help of a drug soma to guarantee well-being free from side effects. Published in 1932, the work seems like a prophecy of the ideal of many today: The world is now stable. People are happy, they have what they want and they never want what they cannot have. They feel good, they are safe; they never get sick; they are not afraid of death; they live in the blissful ignorance of passion and old age; they are not burdened with fathers and mothers; they have no wives, no children, no mistresses for whom they can suffer violent emotions; they are conditioned in such a way that they practically cannot help but behave as they should. And if, by chance, something goes wrong, theres the soma.
With the infinite possibilities brought by technology, came proposals about new ways of dying. And although, in the Hippocratic Oath, every doctor at the end of his training utters that Even when urged, I will neither give a deadly drug nor advise it, practices such as assisted suicide and euthanasia offer help usually medical in dying. The difference is that in the first, the patient administers the lethal drug and in the second, it is the medical team. From a moral point of view, however, they are not different from common suicide, in the opinion of the oncologist and master in philosophy Franco Scariot, author of the book Ethical issues in terminal patients according to personalism (2021).
This is in fashion because the priority of the value has been inverted. Before it was clear that the value of life was superior to that of freedom, now it is reversed. But it has no logical argument, because to be free, you have to be alive. Not to mention that he shows little knowledge of the concept of freedom, since there is no full freedom, lifes contingencies are always suffered, he recalls.
Thinking life as a right or as a duty is in the x of the issue of suicide, according to Professor Jos Dias, a member of the Graduate Program in Philosophy, Masters and Doctorate at Unioeste Campus de Toledo. For the first conception, there are no major ethical problems involved in suicide, as we are not obliged to enjoy a right when it has become an unbearable burden. However, for the second conception, suicide presents serious ethical problems, because if life is considered a duty for the living, we need to put into the equation the rights of the other parties involved: family, friends, society, he ponders.
Scariot adds that, in addition to contradicting a natural tendency to fight for survival, inherent to every being, suicide is immoral as it promotes a break in relationships. Studies show that man is a social being, a being of relationships, he is not alone. Suicide not only takes the persons life, but breaks relationships with family, friends, it is a selfish act in which the person thinks of himself, not of who he is leaving, he adds.
The suicide is a definitive answer to a temporary problem, says nurse Lidiane Melo, a professor at the postgraduate course in Suicidology at the Municipal University of So Caetano do Sul, pointing out that at least ten people are impacted in each case. And it is thinking about these broken relationships that the specialists work in postvention, that is, in the assistance to those who stay. The last days of survivors bereaved by a suicide are carrying the pain of someone who saw in suicide the way out of suffering. It gives the impression that the problem is solved, but it generates infinite grief, the bereaved is never the same again, he laments.
Suicide causes an irreparable break in relationships, and it is precisely it is in human relationships that the meaning of life can be found, says Elizabeth Kipman. I remember a patient with breast cancer, who lived alone, without a partner, one child had been killed by drug trafficking and the other, whom she loved very much, was in prison for the same reason. She didnt want to have the surgery, she was aggressive, she swore a lot, she says. Everything changed when a psychologist got her son a permit from the prison to go to the hospital. It was very exciting. She discovered that she could offer what was going through him, and he promised that he would regenerate for her, he recalls.
More than physical pain, reinforces the doctor, what leads to suicide is the pain of hopelessness, of nothingness, of emptiness. The human person exists to seek a meaning beyond himself. Giving up on life because you cant stand the pain due to the inner emptiness or the lack of horizon is not realizing a meaning. It is always possible and necessary to come out of oneself to achieve some value, opines the doctor, evoking the neuropsychiatrist Viktor Frankl, father of Logotherapy.
A survivor of four concentration camps, the Austrian said that every person can discover the meaning of life in the realization of creative, existential and attitudinal values. The first ones happen when you act, build, love; the second are linked to what he receives, to love, to the beautiful; but the most properly human value is that of attitude. When someone is affected by unavoidable suffering, such as illness or the death of a person, it is properly human to take an attitude in the face of suffering, summarizes Kipman.
Scariot adds that practically all patients who ask for help to die give up when suffering is suppressed. As a society, we should fight to address suffering, not to fulfill the request for suicide with a false humanitarian justification, she argues. Thus, if from a subjective point of view it is the anguish caused by physical or emotional pain that almost always leads a person to make this decision, a large part of the voluntariness of the act is lost since there is an internal coercion, adds the doctor.
The dignity of the person, expressed in the right to a dignified and painless death, is among the main arguments of the pro- assisted suicide. Dignitas, by the way, is the name of a Swiss non-profit society that offers alternatives to die.
Legal principle of principles, which underlies all rights and ethics, human dignity is not it is related to any external condition or usefulness of the person, recalls Professor Jos Dias. In this sense, neither old age nor infirmity can hijack someones worth. His dignity (human value) goes beyond his physical, chronological or mental situation, therefore, whether child, young or old, healthy or sick, every human individual is an absolute value: it is priceless, because it cannot be replaced, it is single. Under no historical circumstances could the individual lose their dignity, as this would mean ceasing to be human, which is impossible, he reinforces.
The fundamental choice for life in limiting situations is far from religious motivations. A record holder in longevity among those diagnosed with Amyotrophic Lateral Sclerosis (ALS), physicist Stephen Hawking, who died in 2018, at 76 years old, is a good example of this. My expectations were reduced to zero when I was 21 years old. Everything since then has been a bonus, he said on one occasion.
With his muscles paralyzed by the disease, Hawking who declared himself an atheist on several occasions used a wheelchair and used a wheelchair. voice synthesizer to communicate. Ive been living with the prospect of dying early for the last 49 years. Im not afraid of death, but Im in no hurry to die. I want to do a lot before that, declared the physicist, considered one of the most brilliant minds in history.
Elizabeth Kipman recalls that Hawking himself saw in transhumanism a great disaster, a risk of dehumanize man. In this sense, she reinforces the importance of accepting death as a natural stage in the cycle of life. Its about getting ready, learning to face the things that happen to us, the disappointments, which are small deaths that life teaches us to live. However, it is completely different to act to dominate ones own life and death. Suicide is not the realization of a value, even from apparently good justifications. It is a slope of dominance, manipulation and subjection, even when it is advocated as conquered freedom, he defends.
In March, the Alain Delons eldest son told the press that the actor had asked for help to undergo assisted suicide in the near future. Delon even posted a farewell text on his Instagram account. I would like to thank everyone who has followed me over the years and given me great support. I hope that future actors can find in me an example not only in the field of work, but in everyday life between victories and defeats. The post was later deleted.
With one of the least restrictive laws in the world in this area, Switzerland where Delon lives and would plan to undergo assisted suicide, which was denied last Friday (8). ) by the actors youngest it is the destination of a strange type of tourism, in which people pay large sums to take their own lives. Without requiring the candidate to have a terminal illness, the legislation opens precedents for situations that are difficult to explain, such as that of two North American sisters, 54 and 49 years old, who disappeared in February after traveling to the country.
They would have sent messages to family and friends, who they believe they were written by other people the day before he died by assisted suicide. The two American ladies died in 11 February, the Swiss government said in a statement reproduced by the Daily Mail. Both health professionals, the sisters were healthy and had not previously expressed a desire for the procedure.
One of the best known names in this Swiss death tourism is Philip Nitschke. Known as Dr. Death, he created a suicide machine called Sarco (of sarcophagus), which gained approval for use late last year. The invention is a kind of capsule made in 3D printing, where the person dies a few minutes after the release of a gas. After that, the wrapper itself becomes a coffin.
Among the countries with laws that allow some type of assisted death are Holland, Belgium, Luxembourg, Spain, Austria, Canada, some states in the United States and Colombia.
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How the generation that refuses to grow old and feel pain invented assisted suicide News Release India - News Release India
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Watch: First Trailer for Body Horror movie ‘Crimes of the Future’ – We Got This Covered
Posted: at 12:21 pm
Iconic director David Cronenberg made his name with a series of eye-popping body horror movies. The best are The Fly, Videodrome, and Dead Ringers, though he apparently abandoned the genre in 1999 with eXistenZ. Since then, hes put out several warped crime thrillers, but now hes returned to the icky stuff with Crimes of the Future. And, judging by this debut trailer, hes back in style.
The film stars Viggo Mortensen, Kristen Stewart, and La Seydoux for what appears to be a highly sexually charged glimpse into a future heavily influenced by the works of H.R. Giger. The synopsis indicates well see mankind exploring ways to adjust their biology and physiology at will known as Accelerated Evolution Syndrome.
Mortensen will play Saul Tensor, an artist whos decided to dive headlong into the transhuman world, resulting in him beginning to grow alien-looking organs on his body. Seydoux plays his partner Caprice, who aids Tensor in performances that involve him removing his new organs, though trouble is brewing from those who think humans should stay as God made them.
Crimes of the Future is set to premiere at the Cannes Film Festival, where itll be in contention for the coveted Palm dOr award. Cannes is notable for its intense audience reactions and habit of audience members dramatically leaving the theater to express their disgust with a movie. So, how does Cronenberg think this will go down? As per World of Reel, he said
I expect walk-outs, faintings and panic attacks.
Hell yeah. Bring it on.
Crimes of the Future opens in the U.S. this June.
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Watch: First Trailer for Body Horror movie 'Crimes of the Future' - We Got This Covered
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Matthias Mann to present at the 9th Aging Research & Drug Discovery Meeting 2022 – EurekAlert
Posted: at 12:16 pm
image:The ARDD Meeting 2022 will be hosted on August 29 - September 2, 2022 view more
Credit: Insilico Medicine Hong Kong Limited
April 11, 2022 - Matthias Mann, Ph.D., will present the latest research on the topic Single cell and Deep Visual Proteomics and its applications in precision medicine at the worlds largest annual Aging Research and Drug Discovery conference (9th ARDD). Dr.Matthias Mann is the Director, Department of Proteomics and Signal Transduction at the Max Planck Institute of Biochemistry.
By merging the power of microscopy, AI and our ultra-sensitive MS-based proteomics workflow, we have developed a method that is very powerful in dissecting tissue heterogeneity at single-cell resolution - something that had not been possible at the protein level before. We expect DVP to be applicable to personalized medicine. said Matthias Mann, Ph.D., Director, Department of Proteomics and Signal Transduction at the Max Planck Institute of Biochemistry.
Matthias Mann is the Director at the Max Planck Institute for Biochemistry near Munich, and manages the proteomics program at the Novo Nordisk Foundation Center for Protein Research at the Medical School in Copenhagen. He is a pioneer and leader in mass spectrometry-based proteomics, where he has helped develop many of the foundational technologies such as electrospray, peptide sequence tags, quantitative proteomics and many more. The core interests of his groups are signal transduction, MS technological development and bioinformatics, with a main focus on clinical proteomics for better diagnosis, prognosis and biological understanding of diseases.
The conference proceedings of the ARDD are commonly published in peer-reviewed journals with the talks openly available at http://www.agingpharma.org. Please review the conference proceedings for 2019, 2020 and 2021https://www.aging-us.com/article/203859/text .
Aging is emerging as a druggable condition with multiple pharmaceuticals able to alter the pace of aging in model organisms. The ARDD brings together all levels of the field to discuss the most pressing obstacles in our attempt to find efficacious interventions and molecules to target aging. The 2022 conference is the best yet with top level speakers from around the globe. Im extremely excited to be able to meet them in person at the University of Copenhagen in late summer. said Morten Scheibye-Knudsen, MD, Ph.D., University of Copenhagen.
Aging research is growing faster than ever on both academia and industry fronts. The ARDD meeting unites experts from different fields and backgrounds, sharing with us their latest groundbreaking research and developments. Our last ARDD meeting took place both offline and online, and it was a great success. I am particularly excited that being a part of the ARDD2022 meeting will provide an amazing opportunity for young scientists presenting their own work as well as meeting the experts in the field. said Daniela Bakula, Ph.D., University of Copenhagen.
Many credible biopharmaceutical companies are now prioritized aging research for early-stage discovery or therapeutic pipeline development. It is only logical to prioritize therapeutic targets that are important in both aging and age-associated diseases. The patient benefits either way. The best place to learn about these targets is ARDD, which we organize for nine years in a row. This conference is now the largest in the field and is not to be missed, said Alex Zhavoronkov, Ph.D., founder and CEO of Insilico Medicine and Deep Longevity.
Building on the success of the ARDD conferences, the organizers developed the Longevity Medicine course series with some of the courses offered free of charge at Longevity.Degree covered in the recent Lanced Healthy Longevity paper titled Longevity medicine: upskilling the physicians of tomorrow.
About Aging Research for Drug Discovery Conference
At ARDD, leaders in the aging, longevity, and drug discovery field will describe the latest progress in the molecular, cellular and organismal basis of aging and the search for interventions. Furthermore, the meeting will include opinion leaders in AI to discuss the latest advances of this technology in the biopharmaceutical sector and how this can be applied to interventions. Notably, this year we are expanding with a workshop specifically for physicians where the leading-edge knowledge of clinical interventions for healthy longevity will be described. ARRD intends to bridge clinical, academic and commercial research and foster collaborations that will result in practical solutions to one of humanity's most challenging problems: aging. Our quest? To extend the healthy lifespan of everyone on the planet.
About Scheibye-Knudsen Lab
In the Scheibye-Knudsen lab we use in silico, in vitro and in vivo models to understand the cellular and organismal consequences of DNA damage with the aim of developing interventions. We have discovered that DNA damage leads to changes in certain metabolites and that replenishment of these molecules may alter the rate of aging in model organisms. These findings suggest that normal aging and age-associated diseases may be malleable to similar interventions. The hope is to develop interventions that will allow everyone to live healthier, happier and more productive lives.
About Deep Longevity
Deep Longevity has been acquired by Edurance RP (SEHK:0575.HK), a publicly-traded company. Deep Longevity is developing explainable artificial intelligence systems to track the rate of aging at the molecular, cellular, tissue, organ, system, physiological, and psychological levels. It is also developing systems for the emerging field of longevity medicine enabling physicians to make better decisions on the interventions that may slow down, or reverse the aging processes. Deep Longevity developed Longevity as a Service (LaaS) solution to integrate multiple deep biomarkers of aging dubbed "deep aging clocks" to provide a universal multifactorial measure of human biological age. Originally incubated by Insilico Medicine, Deep Longevity started its independent journey in 2020 after securing a round of funding from the most credible venture capitalists specializing in biotechnology, longevity, and artificial intelligence. ETP Ventures, Human Longevity and Performance Impact Venture Fund, BOLD Capital Partners, Longevity Vision Fund, LongeVC, co-founder of Oculus, Michael Antonov, and other expert AI and biotechnology investors supported the company. Deep Longevity established a research partnership with one of the most prominent longevity organizations, Human Longevity, Inc. to provide a range of aging clocks to the network of advanced physicians and researchers. https://longevity.ai/
About Endurance RP (SEHK:0575.HK)
Endurance RP is a diversified investment group based in Hong Kong currently holding various corporate and strategic investments focusing on the healthcare, wellness and life sciences sectors. The Group has a strong track record of investments and has returned approximately US$298 million to shareholders in the 21 years of financial reporting since its initial public offering. https://www.endurancerp.com/
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Matthias Mann to present at the 9th Aging Research & Drug Discovery Meeting 2022 - EurekAlert
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Life expectancy: Experts think they’ve solved mystery of why humans live to around 80 – Express
Posted: at 12:16 pm
Experts previously suggested that size was the key to longevity as smaller animals burn up energy quicker than their larger counterparts. This means they require a faster cell turnover, which causes them to decline faster. But new research from the Wellcome Sanger Institute in Cambridge suggests that the speed of genetic damage could be the key to survival.
They believe that long-living animals are able to successfully slow down their rate of DNA mutations regardless of their size.
It could explain how a five-inch long naked mole rat can outlive a giraffe.
That's because the team found that naked mole rats suffer 93 mutations a year and giraffes 99.
Meanwhile, mice experience up to 796 mutations a year which may explain why they live on average for 3.7 years.
Genetic changes, known as somatic mutations, occur naturally in cells.
Dr Alex Cagan, the first author of the study, said: To find a similar pattern of genetic changes in animals as different from one another as a mouse and a tiger was surprising.
But the most exciting aspect of the study has to be finding that lifespan is inversely proportional to the somatic mutation rate. This suggests that somatic mutations may play a role in ageing.
The team found, overall, that the longer the lifespan of a mammal, the slower the rate at which mutations occur.
READ MORE:NASA spots 'largest ever' comet racing Earthbound at 22,000mph: 'It's barrelling this way'
Dr Inigo Martincorena, the senior author of the study, said: Ageing is a complex process, the result of multiple forms of molecular damage in our cells and tissues.
Somatic mutations have been speculated to contribute to ageing since the 1950s, but studying them has remained difficult.
With the recent advances in DNA sequencing technologies, we can finally investigate the roles that somatic mutations play in ageing and in multiple diseases.
The research was published in the journal Nature.
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Life expectancy: Experts think they've solved mystery of why humans live to around 80 - Express
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How to have a longevity mindset for anti-aging technology – Fast Company
Posted: at 12:16 pm
The worlds billionaires arepouringmoney into age-reversal investments.
Last September, it came out thatJeff Bezos had invested in Altos Labs, a company pursuing biological reprogramming technology. Reprogramming is the scientific term for turning old cells young again. It was discovered in 2012 by Japanese scientist Shinya Yamanaka, who called it a potential elixir of life. The Nobel Prize in Medicine Committeeseemed to agree.
Bezosand Altosarent the only ones.
Theres Google-backedCalico Labs, also focused on longevity via reprogramming. AndLineage Cell Therapeutics, backed by BlackRock, Raffles Capital Management, Wells Fargo, and others.
Coinbase Co-founder and CEO Brian Armstrong recently invested in a company working to radically extend human healthspan using epigenetic reprogramming therapies. Altogether, the anti-aging industry isexpected to grow toover $64 billionby 2026, a 45% increase from its 2020 value ($44 billion).
So, why are billionaires like Jeff Bezos investing in age-reversal or anti-aging tech?
Because they have aLongevity Mindset.
One way to understand the Longevity Mindset is by looking at its opposite.
Most people take the aging process for granted. If theyre disciplined, healthy, and lucky, theyll get 20 or so years of youth, start declining in their 40s, and die sometime between 60 and 80.
They accept that life expectancy is 81.2 years for females and 76.4 years for malesnothing they can do, just take the lemons and make lemonade.
And who can blame them? Nearly every human institutiongovernments, the insurance industry, medicine, religionis organized around this mindset.
The anti-Longevity Mindset is: mortality is inevitable, youth is fleeting.
So, the Longevity Mindset is: mortality is avoidable, youth is extendable.
If that sounds shocking to you, youre not the only one. For years, scientists supporting a Longevity Mindset were shunned, and as a result longevity studies were tabled for fear of losing grant funding.
But medicine has evolved.
Weve entered a period ofexponential medicine: Innovations like genome sequencing, RNA transcriptomics, Wnt pathway modifiers, vaccines, CRISPR, liquid biopsies, CAR-T cells, Gene Therapy, exosomes, and stem cells are just a sampling of the technologies that the worlds billionaires are fast-tracking.
Free from the narrow paradigm of academia, these scientists earn as much as five to tentimesa top professors salary by working for Altos and others.
Ultimately,aging is a diseasea disease that many of the most powerful people on the planet believe can be slowed, stopped, even reversed.
Thats the spirit of the Longevity Mindset.
Examine and assess the six basic areas of life that everyone, whether you live on the margins or in a mansion, must negotiate.
Laying the foundation of a Longevity Mindset doesnt take any capital investment. Everyone has beliefs, a media diet, and a community. Everyone has to sleep, eat, and move around.
In the background, billionaires like Bezos are accelerating the industry, working to bring cutting-edge longevity tech to human beings.
When they do, will you be ready?
This article originally appeared in Minutes and is reprinted with permission.
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Why billionaires Mark Zuckerberg, Jeff Bezos and Peter Thiel want to live longer and Elon Musk doesn’t – CNBC
Posted: at 12:16 pm
Over the past decade, Mark Zuckerberg, Jeff Bezos and Peter Thiel have all poured money into life-prolonging and anti-aging research. Tesla and SpaceX CEO Elon Musk isn't buying in.
"I don't think we should try to have people live for a really long time," Musk recently told Insider. "It would cause asphyxiation of society because the truth is, most people don't change their mind. They just die. So if they don't die, we will be stuck with old ideas and society wouldn't advance."
That's a contrarian viewpoint, at least among Silicon Valley billionaires many of whom have a track record of investing in longevity research. So far, very few perhaps none of those investments have panned out.
In September 2021, the MIT Technology Review reported that Bezos invested an undisclosed sum of money in anti-aging start-up Altos Labs, which officially launched earlier this year. According to its website, the San Francisco-based biotech company focuses on "cellular rejuvenation programming," a theorized method of reversing disease, injury and disability.
Bezos and Thiel have also both invested in Unity Biotechnology, a South San Francisco-based company that researches "senescent cells," which stop dividing in humans as they age. The idea, according to the company's website, is to develop "transformative medicines to slow, halt, or reserve diseases of aging."
Unity Biotechnology raised more than $300 million in funding before going public in 2018. As of Monday afternoon, it has a market cap of $73.06 million, down significantly from its September 2018 peak of nearly $972 million.
Thiel is perhaps one of Silicon Valley's most well-known proponents of anti-aging research. One start-up Thiel helped fund, called Ambrosia, revisited a 1950s practice called parabiosis, which experimented with cutting open and stitching together circulatory systems in rats.
The studies didn't yield concrete conclusions, but the Monterey, California-based company still began similar trials in humans injecting blood from people under age 25 into participants aged 35 and older claiming rejuvenation effects.
"It's one of these very odd things where people had done these studies in the 1950s and then it got dropped altogether," Thiel told Insider in 2015. "I think there are a lot of these things that have been strangely underexplored."
In 2019, the U.S. Food and Drug Administration issued a warning against parabiosis. Ambrosia appears to be nonoperational today.
That hasn't stopped other tech billionaires from pursuing similar end goals. Zuckerberg and his wife, Priscilla Chan, are co-founders of The Breakthrough Prize, which annually awards $3 million to scientists who make "transformative advances toward understanding living systems and extending human life," according to its website.
"I'm most interested in questions about people," Zuckerberg said at a 2015 Facebook Q&A event. "What will enable us to live forever? How do cure all diseases? How does the brain work? How does learning work and how we can empower humans to learn a million times more?"
According to The New Yorker, Oracle co-founder Larry Ellison has donated at least $370 million to anti-aging research. Google co-founders Sergey Brin and Larry Page helped launch biotech start-up Calico, an Alphabet subsidiary that researches aging-related diseases like diabetes and Alzheimer's.
In other words, it seems that Musk the richest person in the world, with a net worth of $265.4 billion, according to Forbes stands against many of his Silicon Valley peers. "I certainly would like to maintain health for a longer period of time," Musk told Insider. "But I am not afraid of dying. I think it would come as a relief."
Bezos, Thiel, Musk, Zuckerberg, Ellison, Brin and Page did not immediately respond to CNBC Make It's request for comment.
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