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This Native American Tribe Wants Federal Recognition. A New DNA Analysis Could Bolster Its Case – Smithsonian Magazine
Posted: April 20, 2022 at 10:05 am
Archaeologists and members of the Muwekma Ohlone Tribe worked together on the project, which revealed the longstanding genetic roots of the region's Native peoples. Courtesy of Far Western Anthropological Research Group
For decades, a misperception that the San Francisco Bay Areas Muwekma Ohlone Tribe was extinct barred its living members from receiving federal recognition.
Soon, however, that might change. As Celina Tebor reports for USA Today, a new DNA analysis shows a genetic through line between 2,000-year-old skeletons found in California and modern-day Muwekma Ohlone people.
The research, published in Proceedings of the National Academy of Sciences, flies in the face of more than a century of misconceptions about the tribe and its peoples long history.
The study reaffirms the Muwekma Ohlones deep-time ties to the area, providing evidence that disagrees with linguistic and archaeological reconstructions positing that the Ohlone are late migrants to the region, write the authors in the paper.
Members of the tribe, scholars and the public are hailing the work as a chance to correct the recordand perhaps open up opportunities for the tribe to regain federal recognition, which allows tribes to qualify for federal funds and grants and be acknowledged as independent and sovereign. In the early 20th century, the tribe was on a federal list of recognized tribes, but was removed in 1927.
The tribes history mirrors that of other Native Californians. After more than 10,000 years in the area, Native people were forced to submit to colonization and Christian indoctrinationfirst by the Spaniards, who arrived in 1776, and then, beginning in the 19th century, by settlers from the growing United States.
As a result, the Ohlone and other Native groups lost significant numbers to disease and forced labor. Before European contact, at least 300,000 Native people who spoke 135 distinct dialects lived in what is now California, per the Library of Congress. By 1848, that number had been halved. Just 25 years later, in 1873, only 30,000 remained. Now, USA Today reports, there are just 500 members of the Muwekma Ohlone Tribe.
The Ohlone people once lived on about 4.3 million acres in the Bay Area. But federal negligence and anthropologist A.L. Kroebers 1925 assessment that Native Californians were extinct for all practical purposes caused the federal government to first strip the Muwekma Ohlone of their land, then deny them federal recognition, writes Les W. Field, a cultural anthropologist who collaborates with the Muwekma Ohlone, in the Wicazo Sa Review.
Even though Kroeber recanted his erroneous statement in the 1950s, the lasting damage from his diagnosis meant the very much not-extinct members of the Muwekma Ohlone Tribe never regained federal recognition, according to the New York Times Sabrina Imbler.
The new research could change that. It arose after the 2014 selection of a site for a San Francisco Public Utilities Commission educational facility. The area likely contained human remains, triggering a California policy that requires developers to contact the most likely descendants of people buried in Native American sites before digging or building. When officials contacted the Muwekma Ohlone Tribe, its members requested a study of two settlement areasSi Tupentak (Place of the Water Round House Site) and Rummey Ta Kuuwi Tiprectak (Place of the Stream of the Lagoon Site).
Experts from Stanford University, the University of Illinois Urbana-Champaign, cultural resources consulting firm Far Western Anthropological Research Group and other institutions led the research.
But members of the Muwekma Ohlone Tribe were involved in every aspect of the study, from the initiative to pursue the project to the selection of research questions, in archaeological excavation and ancient genomics involving sites in their historical lands, and in present-day genomic analysis with current tribal members, according to the study. Tribal members even helped exhume the bodies.
Researchers and tribe members alike commented on the unique nature of the collaboration.
When youre a student doing the work, its not common to have this kind of direct connection to the people who are the data that youre working with, says lead author Alissa Severson, a doctoral student at Stanford University at the time of the research, in a statement. We got to have that dialogue, where we could discuss what were doing and what we found, and how that makes sense with their history. I felt very lucky to be working on this project. It felt like what we should be doing.
Jennifer A. Raff, a paleogeneticist at the University of Kansas who was not involved in the study, describes the work as fascinating.
If other tribes are interested in using genetics to investigate histories, they may be encouraged by the fact that some researchers are doing this work in a careful way, Raff tells Science magazines Andrew Curry.
The team analyzed the DNA of 12 individuals buried between 300 and 1,900 years ago, then compared the genomes to those of a variety of Indigenous Americans. They found genetic continuity between all 12 individuals studied and eight modern-day Muwekma Ohlone Tribe members.
It was surprising to find this level of continuity given the many disruptions the Ohlone people experienced during Spanish occupation, such as forced relocations and admixture with other tribes forcibly displaced by the Spanish, co-author Noah Rosenberg, a population geneticist at Stanford, tells the New York Times.
Tribe members hope the new evidence of the Muwekma Ohlone Tribes longstanding connection to the landand their ancestorswill spur politicians to finally recognize the tribe. According to an official tribal website, Muwekma Ohlone families started the reapplication process in the early 1980s and officially petitioned the U.S. government for recognition in 1995. Despite filing a lawsuit against the Bureau of Indian Affairs, the tribe is still not recognized by the U.S. government.
Co-author Alan Leventhal, a tribal ethnohistorian and archaeologist who works with the Muwekma Ohlone Tribe, tells USA Today hes hopeful this new research will help cut through some of the bureaucratic red tape thats been delaying the tribes petition.
Privately, this further validates the tribe, he says. Now, as politicians are reading, they're noticing. And now we'll be lending support for the tribe's reaffirmation.
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This Native American Tribe Wants Federal Recognition. A New DNA Analysis Could Bolster Its Case - Smithsonian Magazine
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‘DNA doesn’t lie:’ After more than 50 years, sons of former Bison great Paul Hatchett finally united – INFORUM
Posted: at 10:05 am
FARGO Nobody knows for sure why the baby was left on the doorsteps of the Church of Ascension on North Bryant Avenue in Minneapolis in 1967, other than perhaps the mother was active in that Catholic church and had a sense of comfort that things would work out. Thats where the life of Jonathan Wright began.
He was adopted by two loving parents the father a publisher of three small newspapers in the Twin Cities but both passed away around 20 years ago. Wright always wondered about his biological parents but didnt want to pursue it for fear it would hurt his adoptive parents.
I didnt want to have them feel that I didnt want their love, he said.
After they died, at some point, he revisited the thought. He and his wife, Elva, were living in Ontario, Calif., when Jonathan saw a news segment aired Fridays on KTLA-TV in Los Angeles called Finding Family, where anchor Chris Schauble, who was adopted, talks about an organization that specializes in finding biological parents.
Thought turned to conversations on the topic with Elva. It would require an investment with an ancestry organization and in this case the Los Angeles firm of BirthParentFinder.com.
Elva gave her blessing but also gave Jonathan the following advice: You never know what youre going to find.
It could be Pandoras box, Jonathan said.
Jonathan teaches English and video in Guam, a United States territory located almost a half a world away in the western Pacific Ocean. One thing about modern science: distance doesnt matter.
Jonathan contracted with BirthParentFinder.com last October. Through DNA, in January, the news was quite startling.
Jonathan Wright found out he has a full brother, Jimmie Lee Bishop, living in the Twin Cities. He found out he has a half brother, Thomas Moede, living in Georgia. Both Moede and Bishop previously took DNA tests.
Furthermore, the DNA system identified the father of all three boys. He was former North Dakota State All-American running back Paul Hatchett.
Well it was just confounding, Bishop said. It was like, wow. But you see it all the time, you see these stories and I never imagined I would have one of these stories too with a long-lost brother I never knew about.
Hatchett was a star at Minneapolis Central High School. NCAA rules prohibited freshmen from playing back then but from 1967-69 he ran for 2,309 yards, a Bison career record that stood until the mid-1980s.
He held 15 school rushing and scoring records at one time including single-season marks of 1,213 yards and 17 touchdowns in 1968. His 41 touchdowns in that three-year period was another career record.
It was the beginning of NDSU football dominance that is alive and well at the Division I FCS level. The Bison were 29-1 with national titles in 1968 and 1969. They were second in the national wire service poll in 1967.
But Hatchett left NDSU after the 1969 season and was never heard from again in Fargo, perhaps disappointed the NFL didnt come calling. Wright would someday like to see old film footage of his biological father, if it exists. His initial online research into Hatchett took him to a small college All-American list.
I grew up a Pittsburgh Steelers fan and to see his name next to Terry Bradshaw (Louisiana Tech) was pretty cool, he said.
The question for both brothers, however, is why? Why did their mother leave Jonathan on the church doorstep? Its not a subject for conversation and, with the mother having health issues, may never be known.
There was no such thing as a safe haven law, a stipulation that allows a parent to surrender an infant without facing prosecution for abandonment.
Back in that time period, there was no sanctuary where you could drop off a child at a hospital, fire station or police station with no questions asked, said Jay Rosenzweig, the founder and CEO of BirthParentFinder.com.
Wright thinks there was more of a plan to it. He appreciates his adoptive parents, saying they did a better job than perhaps his real mother could because of a lack of resources. Bishop, who remains in touch with his mom, has heard little by little of a few clues.
She was telling stories of how she was feeling at the time, he said. She was saying at one time she didnt want to interfere with Pauls football career. And it kind of started making a little more sense, she was trying not to hinder him from going on and playing football because he loved it so much.
Whatever the case, the brothers plan on getting together in person for the first time in July in the Twin Cities. It promises to be an emotional union of siblings.
There is no sugar coating it for the boys: their father had off-the-field issues. For whatever reason, he never got a shot at pro football. There were run-ins with law enforcement in Fargo, a demon that would follow him until he died of natural causes in 2013 at the age of 64 in Savannah, Ga. Childhood friend Gregory Washington, who spoke to Hatchett a year before he died, said Hatchett had regrets that things didnt go a different way.
Wright learned of his fathers past from online links that Bishop sent him.
It was surprising, kind of bittersweet, he said. It was really stunning to hear. Im thinking he was one phone call or bad decision away from an incredible career in the NFL. I tell my students: do today what others wont so tomorrow you can do what others can. We talk about how a decision you make today can impact your career.
Bishop takes a more personal approach. He and his mother lived in north Minneapolis, but seeing her son running the streets more to her liking, they moved to the north suburb of Coon Rapids.
He had a few conversations with Hatchett over the years, like the one time as a young boy both were walking through a gym and somebody asked Hatchett if he still had it.
He took a basketball and dunked it, Bishop said. He was super strong and muscular. He kind of seemed like a superhero.
Hatchett was 5-foot-9 and at NDSU was listed at 195 pounds.
NDSU Athletics photo
Bishop was around 13 years old the last time he saw him. He was about 18 the last time they spoke on the phone.
I started drinking and was not on a very good path, Bishop said. He was like, I think I can help you out. I was like, Im grown and I dont need your help. I felt bad about that later on.
Later on, these days, Bishop is back in school at Metropolitan State in the Twin Cities working on a bachelors degree. At night he works with a local theater, a passion that may lead him and Jonathan to write a screenplay or play on their life story.
He has most of his classes done to go into addiction counseling but isnt sure he wants to continue to pursue it. But if he did, what would he theoretically tell his father?
Just to talk about things Ive learned, to open up those things inside, Bishop said. The secrets that keep us sick. Figure out the reasons why? When its all by itself deep inside, everything seems scary in the dark when youre all alone. When you bring it out and deal with other people, its easier to come back. The more people on your team, the more you dont feel so alone and isolated.
All involved agree Hatchett must have felt alone and isolated. There were signs of positivity, like telling a Forum reporter in 1969 he wanted to get into social work. He worked with underprivileged kids at the Sabathani Community Center in Minneapolis.
Wright thinks his biological father had a Dr. Jekyll Mr. Hyde-type of personality.
He was well-loved during the day, friends speak highly of him, he said. But at night time this character came out. Why did he go down that road? Guess well never know.
What the brothers do know is theyre thankful theyve found each other.
I cant say enough about that, Wright said. It provides closure because its something Ive always wondered about growing up.
They Zoom call each other. Its not easy with Wright being in Guam and the time zone change, but they try to connect every Sunday at 7 a.m. for Wright, which is Saturday in the Twin Cities for Bishop.
Bishop says the best comfort for him is knowing Jonathan grew up with a good life and continues to succeed. It was some upbringing; he was one of six kids Hardy and Elizabeth adopted from different backgrounds while living in Mendota Heights, Minn.
Jonathans sister, Beverly, discovered her grandfather was a chief on the Pine Ridge Reservation in South Dakota. Jonathans brother Mark is of Lakota descent who died of a gunshot wound in 1980 on the Pine Ridge Reservation.
His sister, Tamara, retired after working for the city of St. Paul for 36 years and is a cancer survivor. His oldest brother, Donald, was born partially blind and with facial paralysis.
When the adoption agency asked my parents what kind of children they wanted, Jonathan said, they responded the ones that need the most help.
The only help Jonathan, Jimmie Lee and Thomas need now is finding time to connect. When Jonathan and Jimmie Lee first talked, they noticed right away both like to joke and have fun.
We both seem really similar personality-wise, Bishop said. Hes a talker. One of the first things he said is youll have to excuse my sense of humor and Im like, thats not going to be a problem. Hell say something smart and Ill say something witty and our mother would do that, too. That is really amazing to me. The DNA doesnt lie.
Submitted photo
And neither do the photos. When Bishop showed photos of him and Jonathan to a third party Hatchett was Black and their mother is Caucasian the response was that can be your own twin. The noses are different but the facial structure is very similar.
The mother was 21 years old at the time Wright was born. Perhaps football was already in his blood. He knew every running back and every quarterback on every NFL team. He played the sport in high school but not beyond.
Bishop never really got into sports, but baseball was his favorite. He said a high school football coach wouldnt let him try out.
The bond of the brothers, however, is not about football. Its about, well, being brothers. Finally after all these years.
Submitted photo
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'DNA doesn't lie:' After more than 50 years, sons of former Bison great Paul Hatchett finally united - INFORUM
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Scientists hope to broadcast DNA and Earths location for curious aliens – The Guardian
Posted: at 10:05 am
Even if the aliens are short, dour and sexually obsessed, the late cosmologist Carl Sagan once mused, if theyre here, I want to know about them.
Driven by the same mindset, a Nasa-led team of international scientists has developed a new message that it proposes to beam across the galaxy in the hope of making first contact with intelligent extraterrestrials.
The interstellar missive, known as the Beacon in the Galaxy, opens with simple principles for communication, some basic concepts in maths and physics, the constituents of DNA, and closes with information about humans, the Earth, and a return address should any distant recipients be minded to reply.
The group of researchers, headed by Dr Jonathan Jiang at Nasas Jet Propulsion Laboratory in California, says that with technical upgrades the binary message could be broadcast into the heart of the Milky Way by the Seti Institutes Allen Telescope Array in California and the 500-metre Aperture Spherical Radio Telescope in China.
In a preliminary paper, which has not been peer reviewed, the scientists recommend sending the message to a dense ring of stars near the centre of the Milky Way a region deemed most promising for life to have emerged. Humanity has, we contend, a compelling story to share and the desire to know of others and now has the means to do so, the scientists write.
The message, if it ever leaves Earth, would not be the first. The Beacon in the Galaxy is loosely based on the Arecibo message sent in 1974 from an observatory of the same name in Puerto Rico. That targeted a cluster of stars about 25,000 light years away, so it will not arrive any time soon. Since then, a host of messages have been beamed into the heavens including an advert for Doritos and an invitation, written in Klingon, to a Klingon Opera in The Hague.
Such attempts at interstellar communication are not straightforward. The odds of an intelligent civilisation intercepting a message may be extremely low, and even if contact were made, establishing a fruitful conversation could prove frustrating when a response can take tens of thousands of years. Aliens may not even understand the signal: as a test run for the Arecibo message, Frank Drake, its designer, posted the missive to some scientific colleagues, including a number of Nobel laureates. None of them understood it.
There are other concerns, too. More than a decade ago, Prof Stephen Hawking warned that humans should refrain from sending messages into space in case they attract the wrong sort of attention. If aliens visit us, the outcome would be much as when Columbus landed in America, which didnt turn out well for the Native Americans, he told a Discovery channel documentary.
But Dr Jiang and his colleagues argue that an alien species capable of communication across the cosmos may well have learned the value of peace and collaboration, and humanity could have much to learn from them. We believe the advancements of science that can be achieved in pursuit of this task, if communication were to be established, would vastly outweigh the concerns, they write.
Dr Anders Sandberg, a senior research fellow at the Future of Humanity Institute at the University of Oxford, said: My view is that the overall risk and benefit of sending messages are both small; it is better and safer for us to move out into space and hopefully, eventually, find neighbours when we are both adult species.
But he said it was worthwhile to think over how we may communicate with aliens. I think it is something we should regard as training for learning to coordinate better as a species, he added.
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Scientists hope to broadcast DNA and Earths location for curious aliens - The Guardian
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Embattled DNA expert worked on some of Southern Californias most high-profile murder cases – The Mercury News
Posted: at 10:05 am
In the 1990s, the dawn of DNA analysis in Orange County, forensic scientist Mary Hong was the queen of the cold case.
Arriving at the Orange County Crime Lab in 1985 with her bachelor of science degree in criminalistics from Michigan State University Hong became a forensic star in latex gloves.
She led the way in solving stagnant, high-profile murder cases at the lab, the first local law enforcement DNA laboratory in the western United States. By 2005, she had testified more than 100 times in DNA cases.
The high point of her career: Hong linked four unsolved rape-murders in Orange County to killings in Northern California, helping to identify one of the worst serial killers in state history. Her work eventually aided in the capture of Golden State Killer Joseph DeAngelo, who would later plead guilty to 13 murders and dozens of rapes in the 1970s and 80s.
In 1996, Hong submitted Orange County samples to the states fledgling DNA database and solved six murders right off the bat, according to the late author Michelle McNamara.
McNamara prominently featured Hong in the book Ill Be Gone in The Dark, about the hunt for the Golden State Killer. Hong also has appeared in the television shows Unsolved Mysteries, Cold Case Files and Dateline.
Assigned in 1997 to a team formed to concentrate on old murders, Hong was, in the words of one top public defender, Orange Countys cold case closer.
She was a pioneer in the most advanced forms of DNA testing and analyzed the blood evidence that proved a dead woman found in an Arizona freezer was actually killed in Orange County. That finding meant that defendant John Famalaro should be tried in Santa Ana, not Arizona. Famalaro was given the death penalty in 1997 for the slaying of 23-year-old Denise Huber.
Crime writers described the lab-coated Hong as methodical and intrepid, having a scientists dispassion. In one case, a prosecutor speaking to the jury likened the work done by Hong and the crime lab to Galileo and Copernicus.
But now, Hongs reputation as a scientist and leader among California forensic experts she is the former president of the statewide association of criminalists is under attack.
Hong, who left Orange County five years ago to run a lab for the California Department of Justice, faces allegations that she cooked the books in one recent murder case that unraveled midtrial. The case also has brought renewed attention to two other murder cases in which she was accused by the defense of tailoring her analyses to benefit the prosecution.
She uses the science to come to a preconceived answer, charged Assistant Public Defender Chuck Hasse. She cooked the books.
In response, Orange County District Attorney Todd Spitzer has launched a probe into local cases new and old in which Hong testified or provided forensic opinions. And the Los Angeles County District Attorneys Office is considering a potential review of at least five cases in which she worked on behalf of the agency.
Hong did not respond to an email seeking comment.
At issue in the most recent Orange County case, involving a decades-old murder of a young Buena Park woman, is whether Hong deliberately tweaked DNA evidence in favor of the prosecution and then backed away from that analysis when it came time to testify in a second trial. Or was it just a matter of interpretation in a complicated field?
The answer lies in a forensic world that is not always black and white, but often gray.
The data is the data, but the interpretation of the data can be skewed by the person interpreting it, said Tiffany Roy, a former DNA lab worker, lawyer and forensics expert from West Palm Beach, Florida. The lawyers think DNA is black and white and they dont know how gray DNA can be.
Scott Sanders, assistant Orange County public defender, has been sparring for more than 13 years with the local Crime Lab, which is operated by the Sheriffs Department.
For nearly two decades Hong was the Crime Labs cold case closer and she clearly relished that role, which is the problem, Sanders said. The Crime Lab should not see itself as a loyal member of the prosecution team. A functioning crime lab must serve as a check on those who want to manipulate science for the sake of a conviction. When thats not the case, scientists become the most dangerous players in the criminal justice system.
As president of the California Association of Criminalists, Hong warned in the groups newsletter in 2009 that forensic scientists need to be vigilant in protecting the integrity of their work.
We need to examine and analyze evidence without compromising its integrity, she wrote. We are required to have an in-depth understanding of the scientific processes that we utilize and be able to relay the significance of the results (and) we must ensure that the methods we use are validated and proper controls are in place to guarantee the results are accurate.
But Hongs integrity is under assault in the case against Daniel McDermott, accused of the rape and murder of an 18-year-old Buena Park woman in 1988. The case languished until 2009, when Hong conducted an analysis of DNA found on the victims right wrist.
After McDermott was arrested in 2012, Hong reinterpreted the data by removing genetic markers found in the first analysis. Those deleted markers would have shown McDermott was not a match or that the sample was, at least, inconclusive, said his defense attorney, Hasse.
Hong testified in 2016 that McDermotts DNA was a match for the sample found on the victims arm. But the trial ended in a hung jury.
When it came time for a new trial this month, Hong told prosecutors she could not repeat her testimony on the DNA from the wrist. Without that testimony, the D.A. was forced to offer McDermott a plea bargain that allowed him to be immediately released with nine years time served. McDermott had been facing life in prison without parole.
Suzanna Ryan, a forensics expert hired by the McDermott defense, said Hong should never have reinterpreted her original analysis. Furthermore, Hong failed to get a second opinion on her reinterpretation, a violation of industry standards.
I do believe it was done deliberately, Ryan said.
She added, however, it is the only time she found evidence of cooking the data in the dozen or so analyses she reviewed by Hong.
I dont like what she did in this case, (but) I dont think she is consistently changing data, Ryan said.
Roy, the Florida expert, is not sure Hong did anything intentionally wrong in the McDermott case. I dont see anything that looks nefarious, said Roy, who is not involved in the case.
At the request of the Southern California News Group, Roy reviewed a forensic report done by the defense as well as a recording of Hong explaining to prosecutors why she was having trouble with her earlier testimony.
Roy said there was indeed a scientific basis for Hongs deletion of the genetic markers but barely.
Hong appeared to be operating on the fringe in disregarding the several markers that could have helped McDermott, labeling them as noise. Those markers could easily have been interpreted the other way, Roy said. She said Hong should have erred on the side of caution and included the markers, but was overly aggressive and may have succumbed to a bias for law enforcement.
Roy acknowledged forensic scientists often are pressured to overstep to give police and prosecutors what they want.
Analysts are faced with this every day. The pressure is high to operate on the fringe, Roy said. These analysts are pressured to have the answers.
In essence, scientists often want to be good teammates with law enforcement, she said. Its called confirmation bias.
They want to feel like they are helping the good guy, Roy said. You can see patterns that dont exist, its in the human mind. It happens more than people realize.
These prosecutors and defense need to stay away from these scientists and let the science speak for itself.
Sometimes when forensics experts on the witness stand go beyond what the analysis shows, no one in the courtroom knows enough to check them, Roy said. Defense attorneys dont always retain their own forensics experts, especially when the client is poor or indigent.
(Analysts) often know no one is checking on them, Roy said. There are a lot of overstatements. Theres a lot of pressure on these experts to fit into the prosecutors story.
In the McDermott case, prosecutors didnt talk to Hong for the second trial until the eve of her planned testimony. Hong said, in her recorded interview, she could not be sure the DNA standards had not changed since 2012, when she compared McDermotts DNA to the wrist swab from the victim.
I think Im over-thinking this, she said.
Hong told prosecutors she did not believe she had tailored her analysis to deliberately include McDermott. She said she didnt purposely disregard the disputed markers as noise to incriminate McDermott. She just didnt believe they were DNA, Hong told prosecutors.
She also said in their interview that she had tried earlier to set up a meeting with the prosecution team, but nothing was ever scheduled.
Even before the McDermott case collapsed, Hong was under fire for her contradictory testimony in two cases hinging on the age of semen found on the female murder victims. Both are Anaheim cold cases from the mid-1980s that were solved in the late 2000s.
In 1985 long before an arrest was made former Orange County criminalist Daniel Gammie concluded that semen found in murder victim Bridgett Lamon had not been deposited around the time of death, meaning she probably was not killed by the donor.
About 20 years later, the semen was tied to Lynn Dean Johnson, who was charged in the killing. Called to the witness stand, Gammie recanted his earlier analysis, saying the science had changed. He now believed the semen could have been deposited near the time of death, which would incriminate Johnson. Gammies then-supervisor, Hong, also testified to the same.
Despite the flip-flop, the Crime Lab never went back to review old convictions won using the antiquated science.
Months later, Hong wound up before the same judge to testify in another cold case with similar sperm evidence. This time she testified the semen could not have been deposited near the time of death, attorneys said.
Her analysis in that case allowed prosecutors to clear the victims boyfriend, whose semen was found in the victims underwear, and focus on suspect Wendell Lemond. Lemond was convicted and sentenced to 25 years to life.
Sanders, one of Johnsons attorneys, said he used Hong and Gammies flip-flop to avoid the death penalty for his client. Lemonds conviction is under appeal.
Attorneys in the two murder cases did not know about the contradictory testimony until years after the trials when they found out by happenstance.
Orange County lab officials have said the semen samples studied by Hong in the Lemond and Johnson cases were different enough to warrant her conflicting testimony.
In her 2009 newsletter message, Hong speaks about the hardships faced by forensic scientists and the need to make the most of whatever evidence has been collected.
Sanders responded that making the most isnt always good.
Mary Hong certainly lived by these words. Now the question is whether our criminal justice system cares.
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Embattled DNA expert worked on some of Southern Californias most high-profile murder cases - The Mercury News
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The Worldwide DNA Sequencing Industry is Expected to Reach $52.2 Billion by 2031 – PR Newswire
Posted: at 10:05 am
DUBLIN, April 19, 2022 /PRNewswire/ -- The "Worldwide DNA Sequencing Industry to 2031: Trend Forecast and Growth Opportunity" report has been added to ResearchAndMarkets.com's offering.
The global DNA sequencing market will reach $52,278.1 million by 2031, growing by 15.4% annually over 2021-2031, driven by the significant technological advancements, the growth of large-scale sequencing initiatives and support by major governmental funding agencies, the rise in the prevalence of chronic diseases, and the rising applications of DNA sequencing for animal & plant reproduction.
This report is based on a comprehensive research of the entire global DNA sequencing market and all its sub-segments through extensively detailed classifications. Profound analysis and assessment are generated from premium primary and secondary information sources with inputs derived from industry professionals across the value chain. The report is based on studies on 2018-2021 and provides forecast from 2022 till 2031 with 2021 as the base year.
In-depth qualitative analyses include identification and investigation of the following aspects:
The trend and outlook of global market is forecast in optimistic, balanced, and conservative view by taking into account of COVID-19. The balanced (most likely) projection is used to quantify global DNA sequencing market in every aspect of the classification from perspectives of Offering, Sequencing Type, Technology, Application, End User, and Region.
Based on Offering, the global market is segmented into the following sub-markets with annual revenue ($mn) for 2021-2031 included in each section.
Based on Sequencing Type, the global market is segmented into the following sub-markets with annual revenue ($mn) for 2021-2031 included in each section.
By Technology, the global market is segmented into the following sub-markets with annual revenue ($mn) for 2021-2031 included in each section.
By Application, the global market is segmented into the following sub-markets with annual revenue ($mn) for 2021-2031 included in each section.
By End User, the global market is segmented into the following sub-markets with annual revenue ($mn) for 2021-2031 included in each section.
Geographically, the following regions together with the listed national/local markets are fully investigated:
For each aforementioned region and country, detailed analysis and data for annual revenue ($mn) are available for 2021-2031. The breakdown of all regional markets by country and split of key national markets by Offering, Sequencing Type and End User over the forecast years are also included.
The report also covers current competitive scenario and the predicted trend; and profiles key vendors including market leaders and important emerging players.
Selected Key Players:
Key Topics Covered:
1 Introduction
2 Market Overview and Dynamics2.1 Market Size and Forecast2.1.1 Impact of COVID-19 on World Economy2.1.2 Impact of COVID-19 on the Market2.2 Major Growth Drivers2.3 Market Restraints and Challenges2.4 Emerging Opportunities and Market Trends2.5 Porter's Five Forces Analysis
3 Segmentation of Global Market by Offering3.1 Market Overview by Offering3.2 Instruments3.3 Consumables3.4 Sequencing Services
4 Segmentation of Global Market by Sequencing Type4.1 Market Overview by Sequencing Type4.2 Sanger Sequencing4.3 Next Generation Sequencing4.4 Other Sequencing Types
5 Segmentation of Global Market by Technology5.1 Market Overview by Technology5.2 Sequencing by Synthesis5.3 Ion Semiconductor Sequencing5.4 Chain Termination Sequencing5.5 Pyrosequencing5.6 Sequencing by Ligation (SBL)5.7 Single-Molecule Real-Time Sequencing (SMRT)5.8 Nanopore Sequencing5.9 Other Technologies
6 Segmentation of Global Market by Application6.1 Market Overview by Application6.2 Biomarker Discovery6.3 Diagnostics6.4 Personalized Medicine6.5 Reproductive Health6.6 Forensics6.7 Other Applications
7 Segmentation of Global Market by End User7.1 Market Overview by End User7.2 Academics and Research Organizations7.3 Pharmaceutical and Biotechnology Companies7.4 Hospitals & Clinics7.5 Other End Users
8 Segmentation of Global Market by Region8.1 Geographic Market Overview 2021-20318.2 North America Market 2021-2031 by Country8.2.1 Overview of North America Market8.2.2 U.S.8.2.3 Canada8.2.4 Mexico8.3 European Market 2021-2031 by Country8.3.1 Overview of European Market8.3.2 Germany8.3.3 U.K.8.3.4 France8.3.5 Spain8.3.6 Italy8.3.7 Russia8.3.8 Rest of European Market8.4 Asia-Pacific Market 2021-2031 by Country8.4.1 Overview of Asia-Pacific Market8.4.2 Japan8.4.3 China8.4.4 Australia8.4.5 India8.4.6 South Korea8.4.7 Rest of APAC Region8.5 South America Market 2021-2031 by Country8.5.1 Argentina8.5.2 Brazil8.5.3 Chile8.5.4 Rest of South America Market8.6 MEA Market 2021-2031 by Country8.6.1 UAE8.6.2 Saudi Arabia8.6.3 South Africa8.6.4 Other National Markets
9 Competitive Landscape9.1 Overview of Key Vendors9.2 New Product Launch, Partnership, Investment, and M&A9.3 Company Profiles
For more information about this report visit https://www.researchandmarkets.com/r/h151us
Research and MarketsLaura Wood, Senior Manager[emailprotected]
For E.S.T Office Hours Call +1-917-300-0470For U.S./CAN Toll Free Call +1-800-526-8630For GMT Office Hours Call +353-1-416-8900
U.S. Fax: 646-607-1907Fax (outside U.S.): +353-1-481-1716
SOURCE Research and Markets
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Preventive aerobic training preserves sympathovagal function and improves DNA repair capacity of peripheral blood mononuclear cells in rats with…
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Edwardson, D. W. et al. Role of drug metabolism in the cytotoxicity and clinical efficacy of anthracyclines. Curr. Drug Metab. 16, 412426. https://doi.org/10.2174/1389200216888150915112039 (2015).
CAS Article Google Scholar
Abdel-Qadir, H. et al. A population-based study of cardiovascular mortality following early-stage breast cancer. JAMA Cardiol. 2, 8893. https://doi.org/10.1001/jamacardio.2016.3841 (2017).
Article Google Scholar
Hamo, C. E. & Bloom, M. W. Getting to the heart of the matter: An overview of cardiac toxicity related to cancer therapy. Clin. Med. Insights Cardiol. 9, 4751. https://doi.org/10.4137/cmc.S19704 (2015).
CAS Article Google Scholar
Koutsoukis, A. et al. Cardio-oncology: A focus on cardiotoxicity. Eur. Cardiol. 13, 6469. https://doi.org/10.15420/ecr.2017:17:2 (2018).
Article Google Scholar
Cai, F. et al. Anthracycline-induced cardiotoxicity in the chemotherapy treatment of breast cancer: Preventive strategies and treatment. Mol. Clin. Oncol. 11, 1523. https://doi.org/10.3892/mco.2019.1854 (2019).
CAS Article Google Scholar
Kang, Y. & Scherrer-Crosbie, M. Echocardiography imaging of cardiotoxicity. Cardiol. Clin. 37, 419427. https://doi.org/10.1016/j.ccl.2019.07.006 (2019).
Article Google Scholar
Lipshultz, S. E. et al. Long-term cardiovascular toxicity in children, adolescents, and young adults who receive cancer therapy: Pathophysiology, course, monitoring, management, prevention, and research directions: A scientific statement from the American Heart Association. Circulation 128, 19271995. https://doi.org/10.1161/CIR.0b013e3182a88099 (2013).
Article Google Scholar
Michel, L. et al. Troponins and brain natriuretic peptides for the prediction of cardiotoxicity in cancer patients: A meta-analysis. Eur. J. Heart Fail. 22, 350361. https://doi.org/10.1002/ejhf.1631 (2020).
CAS Article Google Scholar
Lipshultz, S. E. et al. Chronic progressive cardiac dysfunction years after doxorubicin therapy for childhood acute lymphoblastic leukemia. J. Clin. Oncol. 23, 26292636. https://doi.org/10.1200/jco.2005.12.121 (2005).
CAS Article Google Scholar
Lakoski, S. G., Jones, L. W., Krone, R. J., Stein, P. K. & Scott, J. M. Autonomic dysfunction in early breast cancer: Incidence, clinical importance, and underlying mechanisms. Am. Heart J. 170, 231241. https://doi.org/10.1016/j.ahj.2015.05.014 (2015).
Article Google Scholar
Arab, C. et al. Heart rate variability measure in breast cancer patients and survivors: A systematic review. Psychoneuroendocrinology 68, 5768. https://doi.org/10.1016/j.psyneuen.2016.02.018 (2016).
Article Google Scholar
Lonar-Turukalo, T. et al. Heart rate dynamics in doxorubicin-induced cardiomyopathy. Physiol. Meas. 36, 727739. https://doi.org/10.1088/0967-3334/36/4/727 (2015).
Article Google Scholar
Merlet, N. et al. Increased beta2-adrenoceptors in doxorubicin-induced cardiomyopathy in rat. PLoS ONE 8, e64711. https://doi.org/10.1371/journal.pone.0064711 (2013).
ADS CAS Article Google Scholar
Xu, X. L. et al. Effects of carvedilol on M2 receptors and cholinesterase-positive nerves in adriamycin-induced rat failing heart. Autonomic Neurosci. Basic Clin. 130, 616. https://doi.org/10.1016/j.autneu.2006.04.005 (2006).
CAS Article Google Scholar
Koba, S. Angiotensin II, oxidative stress, and sympathetic nervous system hyperactivity in heart failure. Yonago Acta Med. 61, 103109. https://doi.org/10.33160/yam.2018.06.002 (2018).
CAS Article Google Scholar
Rabelo, E. et al. Baroreflex sensitivity and oxidative stress in adriamycin-induced heart failure. 38, 576-580. https://doi.org/10.1161/hy09t1.096185 (2001).
McTiernan, A. et al. Physical activity in cancer prevention and survival: A systematic review. Med. Sci. Sports Exerc. 51, 12521261. https://doi.org/10.1249/MSS.0000000000001937 (2019).
Article Google Scholar
Ghignatti, P. V. C., Nogueira, L. J., Lehnen, A. M. & Leguisamo, N. M. Cardioprotective effects of exercise training on doxorubicin-induced cardiomyopathy: A systematic review with meta-analysis of preclinical studies. Sci. Rep. 11, 6330. https://doi.org/10.1038/s41598-021-83877-8 (2021).
CAS Article Google Scholar
Grssler, B., Thielmann, B., Bckelmann, I. & Hkelmann, A. Effects of different training interventions on heart rate variability and cardiovascular health and risk factors in young and middle-aged adults: A systematic review. 12. https://doi.org/10.3389/fphys.2021.657274 (2021).
Bhati, P., Singla, D. & Hussain, D. M. Resistance training and modulation of cardiac autonomic control in animal models: A systematic review. Compar. Exercise Physiol. https://doi.org/10.3920/CEP180033 (2018).
Article Google Scholar
Feitosa, L. A. S. et al. Resistance training improves cardiac function and cardiovascular autonomic control in doxorubicin-induced cardiotoxicity. Cardiovasc. Toxicol. 21, 365374. https://doi.org/10.1007/s12012-020-09627-w (2021).
CAS Article Google Scholar
Vargas-Ortiz, K., Prez-Vzquez, V. & Macas-Cervantes, M. H. Exercise and sirtuins: A way to mitochondrial health in skeletal muscle. Int. J. Mol. Sci. https://doi.org/10.3390/ijms20112717 (2019).
Article Google Scholar
Mei, Z. et al. Sirtuins in metabolism, DNA repair and cancer. J. Exp. Clin. Cancer Res. CR 35, 182. https://doi.org/10.1186/s13046-016-0461-5 (2016).
CAS Article Google Scholar
Onn, L. et al. SIRT6 is a DNA double-strand break sensor. Elife https://doi.org/10.7554/eLife.51636 (2020).
Article Google Scholar
Meng, F. et al. Synergy between SIRT1 and SIRT6 helps recognize DNA breaks and potentiates the DNA damage response and repair in humans and mice. Elife https://doi.org/10.7554/eLife.55828 (2020).
Article Google Scholar
Cash, S. W. et al. Recent physical activity in relation to DNA damage and repair using the comet assay. J. Phys. Act. Health 11, 770776. https://doi.org/10.1123/jpah.2012-0278 (2014).
Article Google Scholar
Zhang, D. Y. & Anderson, A. S. The sympathetic nervous system and heart failure. Cardiol. Clin. 32, 33vii. https://doi.org/10.1016/j.ccl.2013.09.010 (2014).
Article Google Scholar
Floras, J. S. & Ponikowski, P. The sympathetic/parasympathetic imbalance in heart failure with reduced ejection fraction. Eur. Heart J. 36, 19741982b. https://doi.org/10.1093/eurheartj/ehv087 (2015).
CAS Article Google Scholar
Ferreira, M. J. & Zanesco, A. Heart rate variability as important approach for assessment autonomic modulation. J. Motriz Revista de Educao Fsica. 22, 38 (2016).
Article Google Scholar
Moguilevski, V., Oliver, J. & McGrath, B. P. Sympathetic regulation in rabbits with heart failure: Experience using power spectral analysis of heart rate variability. Clin. Exp. Pharmacol. Physiol. 22, 475477. https://doi.org/10.1111/j.1440-1681.1995.tb02049.x (1995).
CAS Article Google Scholar
Curigliano, G. et al. Management of cardiac disease in cancer patients throughout oncological treatment: ESMO consensus recommendations. Ann. Oncol. 31, 171190. https://doi.org/10.1016/j.annonc.2019.10.023 (2020).
CAS Article Google Scholar
Strongman, H. et al. Medium and long-term risks of specific cardiovascular diseases in survivors of 20 adult cancers: A population-based cohort study using multiple linked UK electronic health records databases. Lancet 394, 10411054. https://doi.org/10.1016/S0140-6736(19)31674-5 (2019).
Article Google Scholar
Zamorano, J. L. et al. 2016 ESC Position Paper on cancer treatments and cardiovascular toxicity developed under the auspices of the ESC Committee for Practice Guidelines: The Task Force for cancer treatments and cardiovascular toxicity of the European Society of Cardiology (ESC). Eur. Heart J. 37, 27682801. https://doi.org/10.1093/eurheartj/ehw211 (2016).
Article Google Scholar
Krzesiak, A., Delpech, N., Sebille, S., Cognard, C. & Chatelier, A. Structural, contractile and electrophysiological adaptations of cardiomyocytes to chronic exercise. Adv. Exp. Med. Biol. 999, 7590. https://doi.org/10.1007/978-981-10-4307-9_5 (2017).
CAS Article Google Scholar
Schaun, M. I. et al. Preventive physical training partially preserves heart function and improves cardiac antioxidant responses in rats after myocardial infarction preventive physical training and myocardial infarction in rats. Int. J. Sport Nutr. Exerc. Metab. 27, 197203. https://doi.org/10.1123/ijsnem.2016-0300 (2017).
CAS Article Google Scholar
Penna, C., Alloatti, G. & Crisafulli, A. Mechanisms involved in cardioprotection induced by physical exercise. Antioxid. Redox Signal. 32, 11151134. https://doi.org/10.1089/ars.2019.8009 (2020).
CAS Article Google Scholar
Liu, J.-L., Kulakofsky, J. & Zucker, I. H. Exercise training enhances baroreflex control of heart rate by a vagal mechanism in rabbits with heart failure. 92, 2403-2408. https://doi.org/10.1152/japplphysiol.00039.2002 (2002).
Hojman, P., Gehl, J., Christensen, J. F. & Pedersen, B. K. Molecular mechanisms linking exercise to cancer prevention and treatment. Cell Metab. 27, 1021. https://doi.org/10.1016/j.cmet.2017.09.015 (2018).
CAS Article Google Scholar
Squires, R. W., Shultz, A. M. & Herrmann, J. Exercise training and cardiovascular health in cancer patients. Curr. Oncol. Rep. 20, 2727. https://doi.org/10.1007/s11912-018-0681-2 (2018).
Article Google Scholar
Gebruers, N. et al. The effect of training interventions on physical performance, quality of life, and fatigue in patients receiving breast cancer treatment: A systematic review. Support Care Cancer 27, 109122. https://doi.org/10.1007/s00520-018-4490-9 (2019).
Article Google Scholar
Ormel, H. L. et al. Predictors of adherence to exercise interventions during and after cancer treatment: A systematic review. Psychooncology 27, 713724. https://doi.org/10.1002/pon.4612 (2018).
CAS Article Google Scholar
Witlox, L. et al. Attendance and compliance with an exercise program during localized breast cancer treatment in a randomized controlled trial: The PACT study. PLoS ONE 14, e0215517. https://doi.org/10.1371/journal.pone.0215517 (2019).
Article Google Scholar
ODPHP, O. o. D. P. a. H. P. Physical Activity Guidelines. (2018).
Bredahl, E. C., Pfannenstiel, K. B., Quinn, C. J., Hayward, R. & Hydock, D. S. Effects of exercise on doxorubicin-induced skeletal muscle dysfunction. Med. Sci. Sports Exerc. 48, 14681473. https://doi.org/10.1249/mss.0000000000000926 (2016).
CAS Article Google Scholar
Murphy, K. T. The pathogenesis and treatment of cardiac atrophy in cancer cachexia. Am. J. Physiol. Heart Circ. Physiol. 310, H466-477. https://doi.org/10.1152/ajpheart.00720.2015 (2016).
Article Google Scholar
Watson, R. D., Gibbs, C. R. & Lip, G. Y. ABC of heart failure. Clinical features and complications. BMJ 320, 236239. https://doi.org/10.1136/bmj.320.7229.236 (2000).
CAS Article Google Scholar
Chen, J. J., Wu, P.-T., Middlekauff, H. R. & Nguyen, K.-L. Aerobic exercise in anthracycline-induced cardiotoxicity: A systematic review of current evidence and future directions. Am. J. Physiol. Heart Circ. Physiol. 312, H213H222. https://doi.org/10.1152/ajpheart.00646.2016 (2017).
Article Google Scholar
Jordan, J. H. et al. Left ventricular mass change after anthracycline chemotherapy. Circ. Heart Fail. 11, e004560. https://doi.org/10.1161/circheartfailure.117.004560 (2018).
CAS Article Google Scholar
Ferreira de Souza, T. et al. Anthracycline therapy is associated with cardiomyocyte atrophy and preclinical manifestations of heart disease. JACC. Cardiovasc. Imaging 11, 10451055. https://doi.org/10.1016/j.jcmg.2018.05.012 (2018).
Article Google Scholar
Tham, E. B. et al. Diffuse myocardial fibrosis by T1-mapping in children with subclinical anthracycline cardiotoxicity: Relationship to exercise capacity, cumulative dose and remodeling. J. Cardiovasc. Magn. Reson. 15, 4848. https://doi.org/10.1186/1532-429X-15-48 (2013).
Article Google Scholar
Schttler, D., Clauss, S., Weckbach, L. T. & Brunner, S. Molecular mechanisms of cardiac remodeling and regeneration in physical exercise. Cells 8, 1128. https://doi.org/10.3390/cells8101128 (2019).
CAS Article Google Scholar
Sturgeon, K. et al. Concomitant low-dose doxorubicin treatment and exercise. Am. J. Physiol. Regul. Integr. Comp. Physiol. 307, R685-692. https://doi.org/10.1152/ajpregu.00082.2014 (2014).
CAS Article Google Scholar
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DNA Exclusive: Analysis of Yogi govt`s guidelines on religious processions and loudspeakers – Zee News
Posted: at 10:05 am
Amid incidents of violence during festivals in some states, Uttar Pradesh Chief Minister Yogi Adityanath has directed that no religious procession should be taken out without permission and that usage of loudspeakers should not cause inconvenience to others.
Zee News Editor-In-Chief Sudhir Chaudhary on Tuesday made an analysis of these new guidelines issued by the Yogi government.
As per the new guidelines, at religious places where loudspeakers are already being used, it will be mandatory to ensure that the noise of the loudspeaker does not go beyond the premises of that religious place. That is, if there is azaan on a loudspeaker in a mosque or aarti is performed on a loudspeaker in a temple, then the sound of azaan and aarti should not go outside the temple or the mosque premises.
Moreover, the use of loudspeakers will not be allowed at all at new religious places in the state. The government has said that the use of loudspeakers at such religious places will be considered an offense by law.
"Although mics can be used, make sure the sound does not come out of any premises. Other people should not face any problem," he said, adding that no permission should be given to install loudspeakers at new sites.
Also, no religious processions will be allowed on the roads from now on. If the police finds that a road is blocked due to any religious procession, then the police will be free to take immediate action against the organisers.
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DNA Exclusive: Analysis of Yogi govt`s guidelines on religious processions and loudspeakers - Zee News
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Scientists Are Finding Ways to Reverse Ageing. Is It Worth It? – The Swaddle
Posted: April 17, 2022 at 11:55 pm
The short answer to this existential question, according to researchers, is that the science of anti-ageing is worth it. The wisdom seems to be that we must strive to expand the human lifespan, and thereby expand progress and unbridled scientific innovation.
This idea witnessed a breakthrough last week, when scientists were able to turn the clock back 30 years for human skin cells without losing any function. Published in eLife, the study enlisted regenerative technologies for their work. A process that induces stem cells turns normal cells into stem cells or cells that dont have a unique identity and can be turned into any kind of cell. While research hasnt yet caught up sufficiently with the latter half of the equation, the new method in the current research shows another way.
Instead of waiting for the 50 days it usually takes to turn a normal cell into a stem cell, researchers at theBabraham Institutes Epigenetics research center waited only 13 days until the signs of ageing were lost and cells temporarily lost identity. They then kept the cells under normal conditions and waited for them to regain their functionality as skin cells miraculously, it worked. Our results represent a big step forward in our understanding of cell reprogrammingThe fact that we also saw a reverse of ageing indicators in genes associated with diseases is particularly promising for the future of this work, Diljeet Gill, author of the study, said.
Importantly, the cells didnt just look younger, they also functioned like they were much younger. In essence, the cells were reprogrammed to behave as if they were much younger. This can help in regenerative medicine, whose functionality can range from healing wounds to Alzheimers treatment, according to the researchers.
This isnt the first time research has been devoted to the question of anti-ageing. Fuelled by the all too human anxiety of death and decrepitude, science has always searched for the elusive fountain of youth now potentially found in the form of stem cells.
But there is an understudied side to it all: who benefits from ageing slower, or halting ageing completely?
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What if People No Longer Want To Live Forever?
If literature and fiction are anything to go by, immortality is usually the quest of the villainous. And just as art imitates life, in the real world the funding for much anti-ageing research can be traced directly back to the worlds foremost billionaires.
its about ensuring old age is enjoyed and not endured. Who wants to extend lifespan if all that means is another 30 years of ill health? This is about increasing healthspan, not lifespan, Janet Lord, from the Institute for Inflammation and Ageing at the University of Birmingham told The Guardian. Lord is one of several pioneering researchers to have become interested in Altos: the richest Silicon-valley startup youve never heard of. Also a part of Altos? Wolf Reik, Gills supervisor and leading epigenetics researcher.
A nexus of big tech, government, and science seem to be at the helm of the race to extend the finish line, ad infinitum. The Methuselah Foundation is another such startup, backed by Peter Thiel another billionaire who is hell-bent on anti-ageing tech. Their mission is to make 90 the new 50 by 2030, and they work on similar regenerative technologies. Unity Biotechnology, another Silicon-valley startup aims to flush out senescent cells or a build-up of damaged cells that cause inflammation in the body. This method could potentially eliminate diseases associated with old age, according to the company that draws its reserves from funding from Jeff Bezos and Peter Thiel.
To be sure, many of these companies have some compelling research; and the science itself is almost too good to be true. But while this may be the case, the idea is deeply troubling for how it individualizes medicine and ageing to a factor of optimizing the health of only those who can afford it. For everyone else, the usual stressors and imminent threats of the modern world threaten to cut their lives short at every turn: poverty, hunger, violence, and ecological collapse.
Moreover, the blind pursuit of this science overlooks systemic factors in age-related disease. We can be healthy only when the entire community is also healthy, wrote Rupa Marya and Raj Patel in Inflamed: Deep Medicine and the Anatomy of Injustice. Marya and Patel argue that our bodies suffer from inflammation as a result of an onslaught of the injustices of the world: colonialism, capitalism, and environmental destruction that actively harms ecosystems. The key to living longer, then, may not be completely hidden in our cells but in our surroundings.
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Scientists Are Finding Ways to Reverse Ageing. Is It Worth It? - The Swaddle
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Investigating a book of the dead in ‘The Unwritten Book’ – The Boston Globe
Posted: at 11:55 pm
Author of the brilliant short story collection The Dark Dark (2017) and the wonderfully odd and moving novel Mr. Splitfoot (2016), Samantha Hunt is one of our most interesting and bold writers. Now she has published her first work of nonfiction, The Unwritten Book. Its a characteristically wild effort that defies genre distinctions, flits from the profound to the mundane with fierce intelligence and searching restlessness, and at its best, delves deep into the recesses of the human heart with courageous abandon.
Hunts fiction has always been obsessed with ghosts and haunting, darkness and the uncanny; in this newspaper, I once referred to Hunt as an aficionado of the liminal. The Unwritten Book is if anything even more consumed with the transitional, with mortality and immortality, the spectral and the mysterious, than her fiction has been. Because this time, its personal. The Unwritten Book is Hunts idiosyncratic version of a grief memoir, an alternately crazed and cool musing on grief, literature, and her late fathers identity as both a man and an aspiring writer.
The Unwritten Book referred to in the title isnt actually unwritten, just unfinished; its a partially complete manuscript by her father that she finds in his desk only days after he dies at 71 of lung and colon cancer. But the phrase also refers to paths snuffed out, experiences aborted, stories never shared. There was much more he should have seen in life, Hunt laments. She is unhinged by her fathers dying, distraught by the loss of stories he hadnt yet told her.
The books subtitle is An Investigation, and Hunt appears as a kind of gothic Nancy Drew, a daughter/detective trying to interrogate her dead dad. The dead leave clues, she writes, and life is a puzzle of trying to read and understand these mysterious hints before the game is over. Hunt astutely parses her fathers words even as she refuses to reduce them to simple explanations, deftly teases out the relationships between his fiction and his life while allowing for mystery to remain, annotates and elaborates and expatiates with charm, wit, and an insistence on her fathers fundamental unknowability.
Intermittently, and covering somewhat less than half of The Unwritten Books total pages, Hunt presents two texts side by side: the chapters of her fathers book on the right, her annotations of these pages on the left. Printing her annotations in tiny font was a mistake not only because it strains the eyes but also because it diminishes Hunts insightful, hilarious, eloquent words in relation to the relatively hackneyed prose of her father. With typical Hunt humor, she acknowledges that her fathers book may not entrance us: Apologies if this is boring you, she says. Hunt herself never bores us; her fathers book unfortunately does.
But in the annotations and the chapters or sections without her fathers book, other vibrant characters emerge: Hunts daughters, with whom she shares a passion for the boy band One Direction, her editor, her long-suffering mother, her husband, and her five siblings, a gang of Hunts who saved each other as they navigated their fathers alcoholism, detectives, alert to the slightest changes in scent, demeanor, and language.
Hunts mind is capacious and supple; her musings cover everything from the films of Werner Herzog and Tobe Hooper to the fiction of W.G. Sebald, William Faulkner, and Toni Morrison to the music of Nick Cave, Gillian Welch, and Patti Smith. Watching her link wildly disparate topics is part of the fun. Referring to her mothers drawerful of nail polishes beside a toy turtle beside a pink pillow beside an expired jar of my dads cancer drugs beside a golden statuette of the Virgin, Hunt declares: I make it make sense. I plot these points and create a chalk line around the ghost, all thats missing. But at times, this book could have benefited from a clearer chalk line; some readers will feel lost, confused by its jumble of styles, approaches, and stories.
At one point, Hunt wonders: perhaps this is a self-help book Im writing, a wellness manual that urges us to live closer to our dead. If this is the case, it is literature that emerges as the best medicine and reading as the most salubrious activity. Reading and books have always enabled Hunt to commune with the dead, connect across boundaries of space and time with other voices, transcend human limitation and loss. I carry each book Ive ever read with me, just as I carry my dead those things that arent really there, those things that shape everything I am, she insists. In books we can find our ways back to the worlds we thought were lost, the world of childhood, the world of the dead. The Unwritten Book ponders and enacts this art of losing with an intoxicating blend of humor and pathos.
THE UNWRITTEN BOOK: An Investigation
By Samantha Hunt
FSG, 384 pages, $28
Priscilla Gilman is a former professor of English literature at Yale University and Vassar College and the author of The Anti-Romantic Child: A Memoir of Unexpected Joy.
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Investigating a book of the dead in 'The Unwritten Book' - The Boston Globe
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The Elusive Politics of Elon Musk – The New York Times
Posted: at 11:54 pm
Mr. Musk has objected when politicians have tried to characterize his views as in sync with their own, insisting that he would rather leave politics to others, despite ample evidence on Twitter to the contrary. When Mr. Abbott last year defended a strict anti-abortion law that made the procedure virtually illegal in Texas by citing Mr. Musks support Elon consistently tells me that he likes the social policies in the state of Texas, the governor said Mr. Musk pushed back.
In general, I believe government should rarely impose its will upon the people, and, when doing so, should aspire to maximize their cumulative happiness, he responded on Twitter. That said, I would prefer to stay out of politics.
If thats the case, he often cant seem to help himself. He heckles political figures who have taken a position he disagrees with or who have seemingly slighted him. Mr. Musks response to Senator Elizabeth Warren after she said that he should pay more in income taxes was, Please dont call the manager on me, Senator Karen.
After one of Mr. Musks Twitter fans pointed out that President Biden had not congratulated SpaceX for the successful completion of a private spaceflight last fall, Mr. Musk hit back with a jab reminiscent of Mr. Trumps derisive nickname Sleepy Joe.
Hes still sleeping, he replied. Several days later, he criticized the Biden administration as not the friendliest and accused it of being controlled by labor unions. These comments came just a few weeks after his insistence that he preferred to stay out of politics.
Few issues have raised his ire as much as the coronavirus restrictions, which impeded Teslas manufacturing operations in California and nudged him closer to his decision last year to move the companys headquarters to Texas. That move, however, was very much symbolic since Tesla still has its main manufacturing plant in the San Francisco Bay Area suburb of Fremont, Calif., and a large office in Palo Alto.
Over the course of the pandemic, Mr. Musks outbursts flared dramatically as he lashed out at state and local governments over stay-at-home orders. He initially defied local regulations that shut down his Tesla factory in Fremont. He described the lockdowns as forcibly imprisoning people in their homes and posted a libertarian-tinged rallying cry to Twitter: FREE AMERICA NOW. He threatened to sue Alameda County for the shutdowns before relenting.
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The Elusive Politics of Elon Musk - The New York Times
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