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Category Archives: Transhuman News

Novan to Participate in the Virtual Investor Innovation in Dermatology Spotlight Event – Yahoo Finance

Posted: April 20, 2022 at 10:26 am

Novan, Inc.

Live moderated video webcast with members of the Novan management team on Tuesday, April 26th at 2:00 PM ET

DURHAM, N.C., April 20, 2022 (GLOBE NEWSWIRE) -- Novan, Inc. (the Company or Novan) (Nasdaq: NOVN), today announced it will participate in the Virtual Investor Innovation in Dermatology Spotlight event on Tuesday, April 26, 2022, at 2:00 PM ET.

For the event, Paula Brown Stafford, President and Chief Executive Officer of Novan. will be joined by John A. Donofrio, Novans Executive Vice President and Chief Operating Officer. The event will spotlight Novans newly acquired portfolio of commercial medical dermatology products and its proprietary nitric oxide-based technology platform, NITRICIL, which has the potential to generate new, innovative treatments for multiple dermatological indications.

Novan recently announced its acquisition of EPI Health, a growing specialty dermatology company that has launched and markets innovative prescription therapies to dermatologists to improve the quality of life of patients. As a result, Novan now has a well-established product portfolio that addresses patient needs across psoriasis, rosacea, dermatosis and acne.

Novans innovative and clinically proven NITRICIL technology leverages nitric oxides (NO) naturally occurring antimicrobial and immunomodulatory effects to develop potential new therapies for unmet medical needs across multiple therapeutic areas. NITRICIL stores the gaseous NO species on large polymers, which allows nitric oxide to be applied as timed-release chemical entities. This technology allows the Company to control the level of nitric oxide storage, the rate of release, and the molecule size for targeted delivery. This targeted technology with anti-microbial and anti-inflammatory properties has the potential to address a number of skin diseases. The combined organization now has the capability to take potential treatments from bench to bedside through research and development, production, market access and commercialization to deliver therapies that meet unmet needs in dermatology and ultimately benefit patients.

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A live video webcast of the spotlight event will be available on the Events page of the Investors section of the Companys website (novan.com). A webcast replay will be available two hours following the live presentation and will be accessible for 90 days.

About Novan

Novan, Inc. is a specialty dermatology company focused on researching, developing and marketing innovative therapeutic products for skin diseases. Through our acquisition of EPI Health, we sell products for psoriasis, rosacea, dermatosis and acne. Our goal is to deliver safe and efficacious therapies where there are unmet medical needs. We are developing SB206 (berdazimer gel 10.3%) as a topical prescription gel for the treatment of viral skin infections, with a current focus on molluscum contagiosum. We have a pipeline of product candidates using our proprietary nitric oxide-based technology platform, NITRICIL, to generate new treatments for multiple indications.

Forward-Looking Statements

Any statements contained in this press release that do not describe historical facts may constitute forward-looking statements as that term is defined in the Private Securities Litigation Reform Act of 1995. These statements may be identified by words such as believe, expect, target, anticipate, may, plan, potential, will, and similar expressions, and are based on the Companys current beliefs and expectations. These forward-looking statements include, but are not limited to, statements related to the Companys pharmaceutical development of nitric oxide-releasing product candidates, such as berdazimer 10.3% gel (SB206) for molluscum contagiosum, and the potential benefits of berdazimer 10.3% gel, if approved, and the Companys ability to realize the benefits of the EPI Health acquisition, including potential synergies and the ability to commercialize the product portfolio acquired through the EPI Health acquisition. Forward-looking statements are subject to a number of risks and uncertainties that could cause actual results to differ materially from the Companys expectations, including, but not limited to, risks related to the EPI Health acquisition, including the risk that the EPI Health acquisition disrupts current plans and operations, the ability to recognize the anticipated benefits of the proposed business combination, which may be affected by, among other things, competition, the ability of management to integrate the combined companys business and operation, and the ability of the parties to retain its key employees, and costs related to the EPI Health acquisition; risks related to the regulatory approval process, which is lengthy, time-consuming and inherently unpredictable, including the risk that the FDA will not agree with the Companys approach to a potential NDA submission, that the Companys product candidates may not be approved or that additional studies may be required for approval or other delays may occur, that the Company may not have sufficient quantities of drug substance and/or drug product to support regulatory submissions and that the Company may not obtain funding sufficient to complete the regulatory or development process; the Companys limited experience as a company in obtaining regulatory approvals and commercializing pharmaceutical products; risks and uncertainties in the Companys ongoing or future product development activities and preclinical studies, which may not prove successful in demonstrating proof-of concept, or may show adverse toxicological findings, and even if successful may not necessarily predict that subsequent clinical trials will show the requisite safety and efficacy of the Companys product candidates; any operational or other disruptions as a result of the COVID-19 pandemic; the Companys ability to obtain additional funding or enter into strategic or other business relationships necessary or useful for the further development or commercialization of the Companys product candidates; the Companys reliance on arrangements with third parties to support its operations and its development, manufacturing and commercialization efforts and the risk that such parties will not successfully carry out their contractual duties or meet expected deadlines; and other risks and uncertainties described in the Companys annual report filed with the Securities and Exchange Commission on Form 10-K for the twelve months ended December 31, 2021, and in the Companys subsequent filings with the Securities and Exchange Commission. Such forward-looking statements speak only as of the date of this press release, and Novan disclaims any intent or obligation to update these forward-looking statements to reflect events or circumstances after the date of such statements, except as may be required by law.

INVESTOR AND MEDIA CONTACT:

Jenene Thomas JTC Team, LLC833-475-8247NOVN@jtcir.com

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Managing Psoriatic Arthritis at Work | Psoriatic Arthritis and Your Career – Healthgrades

Posted: at 10:26 am

When I started my first full-time job after graduating college, I was surprised at the toll my 9-to-5 took on my body. I thought I would choose a desk job and that would be it. I was wrong! The long hours, repetitive movements, and even the commute ran me ragged. In my first few months of working, life was an endless cycle of work, sleep, repeat. Fatigue and burning pain from PsA made it impossible to do much else.

Over the years, I had to learn ways to make my office job easier on my body. It took a lot of trial and error, but eventually, I figured out what worked.

Half the battle of going to work is the commute; at the end of the day, you may not have energy for much else when combined with PsA fatigue.

One positive thing the pandemic has brought is the opportunity to work from home. If it's an option, I highly recommend you take it. I've been working remotely for two years now, and it's improved my quality of life since I can preserve my limited energy by avoiding traffic.

5 Tips For People With Psoriatic Arthritis From People With Psoriatic Arthritis

Of course, there are some jobs that can't be done from home. If you have a long commute, consider carpooling or taking public transportation. My office is in the city, and I take the commuter train when I must go in. I love being able to rest, relax, and catch up on my reading while someone else takes over the driving.

Whether youre on your feet all day or sitting at a desk, wearing good-quality, comfortable shoes is a must. I get blisters easily due to joint swelling, even if I'm sitting all day. So, instead of flats or heels, I wear booties to work when I go into the office. They still look professional but are much more comfortable.

Choose shoes with soft, shock-absorbent materials if you're standing all day. PsA can often cause heel and foot tenderness, which can worsen when standing on hard surfaces. I prefer shoes with a chunky foam or cork sole, as they are excellent shock absorbers. Rubber and plastic can be heavy and too firm.

If you must wear work boots, which usually have a rubber base and steel toes, try adding inserts for cushioning. Cork, foam, and gel inserts are great choices. And bring a change of shoes for commuting.

You never know when a joint may get irritated, so I always keep my favorite arthritis supplies nearby. In my desk, I have a drawer full of my preferred pain medications like nonsteroidal anti-inflammatory drugs (NSAIDs), topical pain relievers, and disposable heat packs the type with adhesives that attach to your body. I've found them helpful to take the edge off. I also like to keep compression gloves, sleeves, and socks on hand, which help me deal with swelling and pain. They can be a lifesaver to slip on during a long day.

I've heard time and time again that motion is lotion. Moving can help keep your joints from getting too stiff and painful. I was surprised by how painful working a sedentary job can be, and I constantly have to make an effort to stretch and get up for frequent walks.

Even people working physical jobs need the opportunity to stretch. Repetitive movements and standing on your feet for too long can irritate your joints. During my past employment and vocational training, I took a moment every half hour or so to stretch, and it made a big difference in how I felt.

It's a highly personal decision to reveal your diagnosis to your employer. Some people are worried that disclosing their condition may lead to bias in the workplace. I have worried about being seen as incapable at past jobs and have chosen to keep my diagnosis private.

I can't tell you the best option for your situation. I bring it up if I know my employer can make a reasonable accommodation that helps me complete my work. The few times I've chosen to reveal my condition have often brought positive changes, such as being able to work from home more frequently or allowing me to commute during off-hours. My supervisors were happy to grant these accommodations since they helped me work more efficiently and improved my work quality. You don't know what they can offer until you start the conversation!

It's not easy to work with PsA, but it can be possible. People today have more options when it comes to making the workplace work for you. Working from home, flexible hours, and other arrangements can make a career possible. It just takes some preparation and thinking outside the box.

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What is that rash? Genetic fingerprints can help doctors diagnose and treat skin conditions more effectively – The Conversation Indonesia

Posted: at 10:26 am

Rashes can be thought of as a dysfunctional community of skin cells. Your skin harbors dozens of distinct cell types, including those that form blood vessels, nerves and the local immune system of the skin. For decades, clinicians have largely been diagnosing rashes by eye. While examining the physical appearance of a skin sample under a microscope may work for more obvious skin conditions, many rashes can be difficult to distinguish from one another.

At the molecular level, however, the differences between rashes become more clear.

Scientists have long known that molecular abnormalities in skin cells cause the redness and scaliness seen in conditions like psoriasis and eczema. While almost all the various cell types in your skin can release chemicals that worsen inflammation, which ones leads to rash formation remains a mystery and may vary from patient to patient.

But molecular testing of skin rashes isnt a common practice because of technological limitations. Using a new approach, my colleagues and I were able to analyze the genetic profiles of skin rashes and quantitatively diagnose their root causes.

Traditional genetic analyses work by averaging out the activity of thousands of genes across millions of cells.

Genetically testing tissue samples is standard practice for conditions like cancer. Clinicians collect and analyze tumor biopsies from patients to determine a particular cancers unique molecular characteristics. This genetic fingerprint helps oncologists predict whether a cancer will spread or which treatments might work best. Cancer cells lend themselves to this form of testing because they often grow into recognizable masses that make them easy to isolate and analyze.

But skin is a complex mixture of cells. Collapsing these unique cell communities into a single group may obscure genetic signatures essential to diagnosis.

Recent technological advances called single-cell RNA sequencing, however, have enabled scientists to preserve the identity of each type of cell that lives in the skin. Instead of averaging the genetic signatures across all cell types in bulk, single-cell RNA sequencing analyses allow each cell to preserve its unique characteristics.

Using this approach, my colleagues and I isolated over 158,000 immune cells from the skin samples of 31 patients. We measured the activity of about 1,000 genes from each of those cells to create detailed molecular fingerprints for each patient. By analyzing these fingerprints, we were able to pinpoint the genetic abnormalities unique to the immune cells residing in each rash type. This allowed us to quantitatively diagnose otherwise visually ambiguous rashes.

We also observed that some patients had treatment responses consistent with what we expected with our predicted diagnoses. This suggests that our concept could viably be expanded for further testing.

To make our approach available to clinicians and scientists, we developed an open source web database called RashX that contains the genetic fingerprints of different rashes. This database will allow clinicians to compare the genetic profile of their patients rashes to similar profiles in our database. A closely matching genetic fingerprint might yield clues as to what caused their patients rash and lead to potential treatment avenues.

The rapid development of drugs that target the immune system in recent years has inundated doctors with difficult treatment decisions for individual patients. For example, while certain drugs that act on the immune system are known to work well for conditions like psoriasis or eczema, many patients have atypical rashes that cant be precisely diagnosed.

An open source database like ours could help enable clinicians to profile and diagnose these rashes, providing a stepping stone to choose a suitable treatment.

Furthermore, chronic inflammatory diseases that affect organs other than the skin share similar genetic abnormalities. Lab tests that can illuminate the root causes of skin diseases can likely be expanded to many other conditions.

Our RashX project initially focused on just two very common types of rashes, psoriasis and eczema. It is unknown whether other types of rashes will have similar genetic profiles to psoriasis and eczema or instead have their own unique fingerprints. It is also unclear which parts of the fingerprint would best predict drug response.

But RashX is a living web resource that will grow more useful as more scientists collaborate and contribute new data. Our lab is also working to simplify the process of developing genetic profiles of rashes to make participating in this area of research more accessible for clinics around the world. With more data, we believe that projects like RashX will make precision testing for rashes an essential next step in diagnosis and treatment.

[Understand new developments in science, health and technology, each week. Subscribe to The Conversations science newsletter.]

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Is It Ever Worth Asking Your Doctor About a Medication You Saw on TV? – Lifehacker

Posted: at 10:26 am

Photo: Drazen Zigic (Shutterstock)

There is a uniquely American phenomenon anyone living in or visiting the states is familiar with: A commercial full of happy, smiling people appears on television. A narrator declares that a brand-name drug is changing the lives of people with, say, psoriasis. A faster voice runs down a list of potential side effects of the drug while the actors keep smiling and laughing, maybe dancing (for some reason). The narrator returns with a clear directive: Talk to your doctor today about [the medication].

The thing is, though, that talking to your doctor about medication can be kind of fraught, especially if you plop down in the exam room with a brand name you heard on TV, but no real clue what its all about. Is that how this is supposed to work? Theyre the one with years worth of education and experience, after all. Is it OK for you to suggest to them that you want medication?

It is OK, but there are no guarantees youll get the medication. That might be OK, too. Lets go over how you can talk to your doctor about medication options.

If you are having symptoms and did your own research, you might worry that a doctor will be dismissive of you if you bring up your interest in medication, since youre not, well, a doctor. To be clear, they might bedoctors are human and bias in healthcare is definitely a thingbut there is no reason you shouldnt advocate for yourself. You might not be a medical expert, but you are the expert on your own body.

Dr. Yoni Freedhoff, associate professor of family medicine at the University of Ottawa, said hes noticed patients can be cautious about suggesting to doctors that they have a medication that they think they should be on or theyd like to try. That can come from negative experiences with healthcare providers in the past or a feeling of sheepishness about coming out and saying they think they need medication.

Dr. Joseph Thomas, a hospitalist in New York, agreed that there certainly is some hesitancy at times because they dont want to come off as pushy, like theyre being demanding ... but I think if patients are curious or if they have questions, if theres something they would like to ask about being started on, then yes, absolutely bring that up.

The bottom line, Freedhoff said, is this: If a person has a desire to discuss something with their doctor, regardless of what that thing is, ideally, they should be able to have that discussion with their doctor. A doctors job is pretty straightforward. Our job is to inform people about their treatment options and the risks and ramifications of doing things and not doing things, but never to judge people on the treatment they decide for themselves.

The doctors job is to listen to your concerns and answer your questions, so you have every right to share them.

Did anyone ever tell you, God answers all our prayers, just not always with a yes? Doctors can be kind of like that (but theyre not God). They dont get to make executive decisions about your treatment andalso unlike Godthey are available for follow-up questions when they give you a no.

There will definitely be times where people will bring up medications that are not necessarily appropriate, Freedhoff said. Youre not a doctor, so you might not know that a certain medication wont work for your symptoms or isnt advisable at this point in your treatment. You might not realize you dont meet the clinical criteria for a certain prescription or your insurance wont cover it. Thats fine; youre not the doctor here, so how could you know? The doctors job in this situation is to explain all of that to you. A good doctor, Freedhoff said, would be able to explain thathopefully in a way that doesnt upset the patient.

If the doctor says you dont meet the clinical criteria, ask why not and ask about what options exist that you do qualify for. Freedhoff recommended asking what criteria are utilized in determining a medications appropriateness, for instance, and Thomas pointed out that a doctor might have insight they can share about your particular tolerances. At the heart of any visit to the clinic are your health, your body, and your life. You should feel empowered to ask as many questions as it takes until you have a solid understanding of your treatment.

Were not saying you should hop from doctor to doctor until you find someone who agrees with your self-diagnosis, but you can absolutely consult someone else, provided there are doctors in your area who are available to you.

Seeking a new doctor could be a solution to a number of problems beyond the fact that your current one isnt prescribing a certain medication. As Freedhoff said, If you have a doctor and you do not feel comfortable bringing up a discussion around medication or treatment options, that should be a sign that you need to either discuss your relationship with your doctor and discuss the fact that you dont feel comfortable, try to explore why, and get past that, or get a new doctor.

Thomas added, Ive unfortunately heard too many stories of patients kind of being dismissed by their doctors, [saying things like] Oh, thats why you shouldnt go to Dr. Google and that sort of thing. That happens, and its a thing I think myself and other folks in my profession should discourage. If people are bringing up these questions, its usually because they want to be engaged in their own health and they want to do the best they can to be better and to feel better.

See? There are doctors out there who want to talk and listen. You should feel confident in sharing the truth about your symptoms and what youre going through, no matter what treatment option you decide on. If a doctor is dismissive, wont answer your questions, or shows any signs of bias, you should always feel free to look elsewhere.

All of that being said, have reasonable expectations here. In an instance where youre being treated poorly or a doctor is being very dismissive, sure, push back and advocate for yourself, but use your judgment. If a doctor is telling you youre not a candidate for something and seems willing to have ongoing conversations about what could work for you, hear them out.

Is there bias in healthcare? No question, said Freedhoff, but there will be times a drug just doesnt work for you, and that wont be due to bias. Respecting the fact that there are clinical criteria for prescription medications is worthwhile.

Remember that, as weve established, doctors arent Godbut they do have training and insights most patients dont. Thomas pointed out, for example, that while the media raised significant awareness of monoclonal antibodies as part of a treatment for COVID-19, patients may not realize those dont work as well on the latest variants. There is a lot you can find out through your own investigations, and while you should feel empowered to bring all of that up, be open to learning new things from doctors, who have more expertise here than the average journalist or marketing person.

Its worth having these discussions because medical care, at this point, is a team effort between doctor and patient, he said. Its not the paternalistic relationship that it once was decades ago. So, it cant hurt to ask.

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Eczema Linked to Potential for Other Health Problems – Everyday Health

Posted: at 10:26 am

People with atopic dermatitis, commonly known as eczema, may find that inflammation of the skin is just one of the health conditions theyre living with.

Dermatologists have been aware of an association between eczema and other health concerns. Now, after evaluating data from numerous studies, the American Academy of Dermatology (AAD) has produced an official guideline, which was released at the beginning of the year.

The analysis, published in the Journal of the American Academy of Dermatology in January, found strong evidence tying atopic dermatitis in adults to a number of diseases and conditions, including hay fever, asthma, and food allergies; alopecia (sudden hair loss) and chronic urticaria (hives); osteoporosis; mental health disorders like depression; and skin infections.

When it comes to substance abuse disorder, ADHD (attention deficit hyperactivity disorder), and metabolic syndrome (a group of five conditions that can lead to heart disease, diabetes, stroke, and other health problems), study authors identified some evidence linking these issues to eczema.

The report also suggested a link between atopic dermatitis and various cardiovascular issues, but this association was considered to be small. Evidence supporting a link between eczema and autism spectrum disorders, heart attack, and stroke was inconclusive.

The lead author of the guideline,Dawn Davis, MD,a dermatologist at the Mayo Clinic, calls the AAD guideline groundbreaking because its the first paper of its kind to give a comprehensive review of how eczema may be related to these other physical and mental problems.

We are realizing more and more that inflammatory skin disease such as atopic dermatitis and psoriasis are not only skin conditions, but rather affect the entire person, says Dr. Davis. So we need to practice whole-person care. This guideline is created to empower patients, and to empower the medical community to help patients better address their skin needs.

For decades, dermatologists have recognized a connection between eczema and other atopic and allergic conditions. (The word atopic itself indicates an association with allergies.) MedlinePlus says that up to 60 percent of people with atopic dermatitis develop asthma or hay fever (allergic rhinitis) later in life, and up to 30 percent have food allergies.

Eczema can often signal the beginning of a progression of allergic diseases known as atopic march or allergic march. After people develop eczema, a typical pattern is for them to develop food allergies, followed by hay fever and then asthma.

This new AAD guideline found that about a quarter of adults with eczema had asthma, and they were three times more likely to have this inflammation of the airways than the general population.

The research also spotlighted evidence suggesting that asthma in children ages 7 to 11 was linked to a more persistent type of eczema. Targeted biologic therapies such as dupilumab (Dupixent) demonstrated a potential benefit for both severe atopic dermatitis and asthma.

Dupilumab has been approved for asthma and eczema because both of these diseases kind of work through the same pathway and cause inflammation, says Karan Lal, MD,the committee chair for the Society for Pediatric Dermatology. Its possible if were treating eczema with dupilumab at a very early age, we may prevent [children] from developing clinical signs of asthma.

When it comes to food allergies, researchers estimated that just over 1 in 10 individuals with eczema were likely to have this condition. While the researchers were unclear as to what the implications may be, they pointed out that patients often ask whether food allergies are a trigger for their eczema and whether they should seek out testing for food allergies.

The AAD team observed a consistent link between allergic rhinitis (hay fever) and eczema but little data showing a relationship to allergic conjunctivitis (inflammation of eye tissue) and eosinophilic esophagitis (inflammation of the esophagus).

We always suspected and knew in practice that asthma, food allergies, and other atopic diseases such as allergic rhinoconjunctivitis were more common in patients with eczema, but now we have research data to support those conclusions, says Davis.

Davis stressed that the study confirmed that certain skin diseases are more common in atopic dermatitis patients, such as alopecia areata an autoimmune disease in which the immune system attacks hair follicles, causing sudden hair loss that often results in bald patches on the head and that can affect the hair on other parts of the body as well.

The guideline presented data demonstrating a strong association between eczema and the autoimmune condition chronic urticaria (hives).

Overall, if you have eczema, youre 2.5 times more likely to have an autoimmune condition, according to the new guideline.

An analysis that pooled four studies, including 11,244 adults with eczema and 149,713 people without the condition, found that individuals with eczema faced double the odds of self-reported or clinician-diagnosed depression. In addition, researchers found that eczema patients were more likely to consider suicide, but evidence linking the condition to actual death by suicide was weak.

As to why these patients may be more apt than the general public to have mental health issues, the AAD panel believes that itching, poor sleep, and decreased quality of life overall may play an extensive role.

Although some research made a connection between substance abuse and eczema, evidence was limited about any tie between the skin condition and alcohol use or cigarette smoking.

Davis and her collaborators underscored that ADHD and autism spectrum disorders are better studied in children rather than adults, and these connections will be explored more in depth in an upcoming pediatric guideline.

Atopic disease patients have increased levels of blood proteins connected with cardiovascular risk.

Because systematic inflammation is an established risk factor for cardiovascular disease, its possible that treatments that manage inflammatory skin diseases like eczema could decrease the likelihood of heart problems, according to the guideline.

But in general, the research found only a slight link between eczema and hypertension, peripheral and coronary artery disease, congestive heart failure, and events such as myocardial infarction and cardiovascular death.

The data suggested a small association between eczema and obesity and dyslipidemia (an imbalance of lipids such as cholesterol). Still, pooled facts from eight cross-sectional studies revealed that eczema patients were 36 percent more likely to be obese and 13 percent more likely to have high cholesterol than the general population.

The guideline authors pointed out that atopic dermatitis may actually have an inverse relationship with diabetes, with some research suggesting that individuals have a lower risk of diabetes overall and type 2 diabetes specifically. Based on data analyzed in this paper, however, Davis emphasized that patients with eczema may face a greater likelihood of metabolic syndrome as a whole.

Davis and her team highlighted an investigation demonstrating an increased risk of osteoporosis among those with eczema, and a separate study showed a heightened likelihood of bone fracture. For those with severe atopic dermatitis, the possibility of fracture due to osteoporosis was even greater.

Investigators noted that more research is needed to understand the mechanisms behind this association, but some explanations suggest that chronic systemic inflammation may have a negative effect on bone metabolism, leading to increased bone loss.

The connection between eczema and staphylococcal skin infections is well known. The guideline spotlights a study from the United Kingdom indicating that herpes superinfection is twice as common among those with eczema. Other data suggested cutaneous infections, bacterial skin infections, and eczema herpeticum (a painful, blistering rash caused by the herpes simplex virus) are all more likely to occur among people with eczema.

While Golara Honari, MD, a dermatologist with Stanford Medicine, sees the value in raising awareness about eczemas link to other diseases, she believes patients and doctors need to interpret these correlations with caution.

We need to learn more about these conditions in relation to atopic disease, says Dr. Honari, using cardiovascular disease as an example. There are other common skin diseases for example, psoriasis that have really solid evidence for increased risk of cardiovascular disease, but for atopic dermatitis, that evidence is still not very solid.

Were putting together associations, but we have to be careful, because I don't think these associations necessarily lead to clinical correlations, adds Dr. Lal. Do the results in the guideline mean that for patients that come in, I have to screen all my patients for metabolic syndrome because they have a diagnosis of eczema? It doesn't really work like that.

Overall, Davis and her colleagues view the new guideline as a tool to educate and empower and not induce fear.

When we know certain diseases are interrelated, then we can work on monitoring for those diseases and screening for them, and we can work on lifestyle modification factors that can alter the risk of a disease course, she says.

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Personal Freedom: Libertarians, the Russia-Ukraine Crisis, and a Crisis of Ideology – Modern Diplomacy

Posted: at 10:09 am

Russia has ultimately collapsed foreign academic, human rights and media operations in the Russian Federation. It has crippled and ridiculed their work with civil society. Long before the start of the special military operations aimed at what is officially described as demilitarization and denazification in the post-Soviet republic, Russian authorities have been on the neck of these organizations, consistently accusing them of being biased and anti-Russian.

The battle of biased reporting (including issues relating to misinformation and disinformation and propaganda) has resulted on the shutdown of foreign media organizations, accreditation of foreign correspondents revoked over the past years. Social media including Meta platforms, Facebook and Instagram have come under scrutiny and designated as extremist organizations. It is still getting worse as the United States, European Union and Russia constantly lock horns about reporting ethics and information war.

As already known, Russian authorities have unleashed an unprecedented, nationwide crackdown on independent journalism and dissenting voices following Russias military operation in Ukraine. Roskomnadzor, Russias media regulator, blocked access to Facebook and Twitter, and so also the most popular critical media outlets, closing independent radio stations and forcing dozens of journalists to halt their work or leave the country, the authorities have almost completely deprived people in Russia of access to objective, unbiased and trustworthy information.

For two decades, the Russian authorities have waged a covert war against dissenting voices by arresting journalists, cracking down on independent newsrooms and forcing media owners to impose self-censorship. Yet, after Russian tanks entered Ukraine, the authorities switched to a scorched-earth strategy that has turned Russias media landscape into a wasteland, said Marie Struthers, Amnesty Internationals Director for Eastern Europe and Central Asia.

On 28 February, Roskomnadzor blocked Nastoyashchee Vremya(Current Times), a subsidiary of Radio Free Europe/Radio Liberty, for spreading unreliable information about the invasion. On 1 March, almost all Ukrainian news outlets were inaccessible to internet users in Russia.

That was followed by the Kremlin ruthlessly censored a swathe of independent media, including broadcaster TV Rain, the Echo of Moscow radio station, Latvia-based Meduza, critical Russian news outlets Mediazona, Republic and Sobesednik, grassroots activism portal Activatica and the Russian-language services of the BBC, Voice of America and Deutsche Welle.

The blocking of news sites and the threat of criminal prosecutions has also led to an exodus of journalists from Russia. According to Agentstvo, an investigative journalism site now inaccessible in Russia, at least 150 journalists have fled the country since the beginning of the war.

TV Rain chose to suspend broadcasting amidst fears of reprisals. Znak.com, a significant regional news channel, halted its operations citing censorship fears. The Echo of Moscow radio station was taken off the air; shortly after, its state-aligned owners decided to liquidate the company. Even Novaya Gazeta, a beacon of independent journalism led by Nobel Peace Prize laureate Dmitry Muratov, announced on 4 March that it would remove articles on Russias invasion of Ukraine.

Russia has closed the British Council, the American Educational Council with its Future Leaders Exchange (FLEX) programme, and Alliance Franaise and Geothe Institute. These are the largest cultural networks of Britain, the United States, France and Germany. While Russia struggles with it non-profit NGO Russkiy Mir primarily tasked to popularize Russian language, literature and Russian culture around the world, it found it necessary to halt non-political and non-profit educational branches of western ones that operated under their diplomatic missions in the Russian Federation.

The FLEX programme, created as the best way to ensure long-lasting peace and mutual understanding between the U.S. and the countries of Eurasia, enables young people, over 35,000 students who compete annually, to learn about the United States, and to teach Americans about their countries, mostly from the former Soviet republics.

These educational and cultural centers have practically helped thousands of Russian students, with government-sponsored grants, to acquire comparative knowledge in various academic fields abroad. While some, after the training programmes, still remain abroad, others returned to contribute their quota in sustainable development in Russia.

Early March 2022 perception survey conducted by the Russian Public Opinion Research Center, the results of an opinion poll, the majority of Russians reported that they feel negatively about the United States (71%). On the other hand, Russians are generally obsessed by American and European dreams, wealthy Russians have bought the most expensive mansions along the coast of Miami et cetera, placed their thousands of kids in western educational institutions.

In addition, Russian academics throughout the year run forth and back under the umbrella of conducting research. Alexey Khokhlov, the vice-president of the Russian Academy of Sciences, told Telegram channel early April that the decision made by the worlds largest publishers of science magazines to suspend access for Russian organizations would make 97% of scientific information unavailable to Russian researchers.

Khokhlov said that legal access to the full-text collections of articles published by Elsevier, Springer/Nature, IOP Publishers and others, and in addition, the Web of Science and Scopus reference data bases in Russias territory would soon be terminated.

The publishers who signed this statement believe that in this way they punish not scientists but research organizations. This sounds very strange, because the above-mentioned services are used by scientists and not administrators. This statement is a serious challenge because Russia accounts for a tiny 2.5% of the worlds science products. This means that 97.5% of information is blocked, Khokhlov said.

Russia is experiencing a massive outflow of scientists from the country amid the foreign sanctions, which can only be stopped only by adopting a system of special measures, including an increase in financing, Russian Academy of Sciences (RAS) President Alexander Sergeyev suggested, speaking at the media conference late March.

In general, what can be done here is to provide better conditions for the development of science than exist abroad. Then, the scientists wont leave. What else can you do? Certainly, theres a need for a system of measures for our researchers and to stop this outflow. Its hard to estimate the scope of the losses, but I think they are high. Its necessary to offer benefits and increase the financing so that, apart from prestige, there should also be a proper material basis for it, he said.

The RAS has a major package of proposals submitted to the government as to how to organize the work of institutes and offer them more freedom. It is difficult to compete for science with the whole world. It is necessary to unshackle initiative and the creativity of scientists and give them a chance to work conveniently in the country, according to Sergeyev.

On April 8, the Russian Ministry of Justice delisted Amnesty Internationals Moscow Office from the register of the representative offices of the international organizations and foreign NGOs, effectively closing it down alongside with offices of Human Rights Watch, Carnegie Endowment for International Peace, Friedrich Naumann Foundation for Freedom, Friedrich Ebert Foundation and other organizations. This decision was taken in connection with the discovered violations of the Russian legislation.

Reacting to the news, Agns Callamard, Secretary General of Amnesty International, said: The authorities are deeply mistaken if they believe that by closing down our office in Moscow they will stop our work documenting and exposing human rights violations. We continue undeterred to work to ensure that people in Russia are able to enjoy their human rights without discrimination. We will redouble our efforts to expose Russias egregious human rights violations both at home and abroad.

Callamard added: We will never stop fighting for the release of prisoners of conscience unjustly detained for standing up for human rights. We will continue to defend independent journalisms ability to report facts, free of the Russian governments intervention. We will continue to work relentlessly to ensure that all those who are responsible for committing grave human rights violations, whether in Russia, Ukraine or Syria, face justice. Put simply, we will never give up.

Since February 24, Amnesty International, Human Rights Watch, Rights Without Borders and many independent Research Organizations and Think Tanks have monitored and documented step-by-step developments, chronicled the global effects of the Russia-Ukraine crisis. Monographs and books have already published around the world. For instance, Amnesty International has released well-written reports that Russian military forces have extra-judicially executed civilians in Ukraine in apparent war crimes published in new testimony following on-the-ground research.

In recent weeks, we have gathered evidence that Russian forces have committed extrajudicial executions and other unlawful killings, which must be investigated as likely war crimes. Testimonies shows that unarmed civilians in Ukraine are being killed in their homes and streets in acts of unspeakable cruelty and shocking brutality. The intentional killing of civilians is a human rights violation and a war crime. These deaths must be thoroughly investigated, and those responsible must be prosecuted, including up the chain of command, said Agns Callamard, Secretary General of Amnesty International.

To date, Amnesty International has obtained evidence that civilians were killed in indiscriminate attacks in Kharkiv and Sumy Oblast, documented an airstrike that killed civilians queueing for food in Chernihiv, and gathered evidence from civilians living under siege in Kharkiv, Izium and Mariupol. Russian militarys siege warfare tactics in Ukraine, marked by relentless indiscriminate attacks on densely-populated areas, are unlawfully killing civilians in several cities.

The Kremlins ruthless crackdown stifles independent journalism, anti-war movements, human rights and other non-profit organizations. The Justice Ministry has created a unified register of individuals designated as foreign agents, and for NGOs. It choosesto persecute all kinds of foreign NGOs, considered as undesirable and providing any kind of financial support for civil society organizations and activists.

Earlier for instance, NGOs such as the Future of Russia Foundation (UK), European Choice (France), Khodorkovsky Foundation (UK), and Oxford Russia Fund (UK), the Civic Assistance Committee and the Memorial Human Rights Centers Migration Rights Network, the Anti-Corruption Foundation and the Citizens Rights Protection Foundation (FBK and FZPG, and many others were listed as foreign-agent NGOs in the Russian Federation.

As matter of facts, contemporary political history shows the level of degradation of the civil society in Russia. These have practically raised much public concern especially for academics, experts and the civil society.

The U.S. based Freedom House says that democracy is under assault and that the effects are evident not just in authoritarian states like Russia and China, but also in countries with a long track record of upholding basic rights and freedoms around the world. According to the report by the Freedom House, Freedom in the World 2020, assesses the political rights and civil liberties of 210 countries and territories worldwide.

Russian President Vladimir Putin announced a special military operation, after both the Federation Council and the State Duma (legislative chambers) approved the implementation of the presidential decision that has since sparked debates, analysis and criticisms throughout the world. It has resultantly pushed the United States and Canada, European Union members, Australia, New Zealand and many other external countries to impose stringent sanctions against the Russian Federation.

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The libertarian phenomenon towards 2023: strengths and challenges – Zyri

Posted: at 10:09 am

In our column last Monday we presented a public opinion poll conducted by DAlessio IROL Berensztein on the libertarian phenomenon and, in particular, on Javier Mileis emergence on the political scene. Due to the scale that this phenomenon is acquiring, it is worth returning to some of the conclusions that we arrived at based on these data, to deepen them, and introduce some new concepts that allow us to build a more exhaustive analysis and begin to think what can happen with Javier Milei in 2023.

Pushed by the visible hand of a State that systematically fails to provide public goods and that generates inflation, restlessness and uncertainty in the citizenry, Liberal and libertarian ideas gain ground in Argentine society. The leaders of related spaces had a timid electoral representation with Jos Luis Espert in 2019 (he obtained a meager 1.5%) and a much more relevant performance in 2021, when they added four national deputies, including Espert himself and Javier Milei.

The latter gains more and more prominence on the scene of the national economic debate while increase in voting intention: From the aforementioned survey it emerged that a third of the electorate would consider it as an option in the 2023 presidential elections.

I also read: In search of more collection, the Government advances with the regulation of investments in cryptocurrencies

A good part of the voters of Together for Change and independents feel attracted by a counter discourse of innovative characteristics and with footprint antiestablishment. This process shakes the ideological foundations of a country in which the consecrated ideas turned to the left after the 2001 crisis and deepened in that same terrain during the last two decades, even during the Macri interregnum.

Why Javier Mileis counter-discourse caught on in young people

The wave hits harder among the young. In the ideological spectrum, the rebellion seems to have remained on the right margin, if that scale is still valid. For this reason, a set of simplistic ideas, bordering on the Manichaean, seduces this segment of the electorate that is not characterized by seeking great explanations or subtle nuances. On the contrary, it demands answers to concrete questions and a new story that is not necessarily applicable to public policies. Feasibility takes a backseat, the what matters more than the how.

This narrative fills a void of thought in terms of political economy in relation to the great problems facing Argentine society: inflation, lack of growth, informality, lack of competitiveness, lack of prospects. The traditional leaders (the Political caste in terms of Javier Milei) not only does not find answers, but often seeks to avoid discussion regarding these issues.

In some sense, Milei and Espert do not compete with another space: on the other side there is hardly a government that insists on old ideas, imaginary wars and sarasas (despite the disastrous results it has obtained) and an opposition that fails to complete mourning for the failure of the Macri administration. What is the overall response of Together for Change to end inflation? So far nothing concrete only some timid, incomplete and uncoordinated proposals, that do not achieve a minimum of internal consensus.

In fact, the repudiation of ideas from the space itself sometimes goes much further: Gerardo Morales, president of the UCR, said that it was clowny and one stupidity the project of dollarization of the economy presented by a deputy Alejandro Cacace, who is also radical. For this reason, the presence of libertarian leaders grows exponentially in public spaces (the media, social networks, conferences) and their voice is amplified.

I also read: Francisco was already born, and when was Albertism?

To what extent are we facing a new alternative, capable of revolutionizing the foundations of the Argentine political system? Or will Milei be a new one-hit wonder (one hit singer)? In Argentina we had experiences of this type, such as the UCD, Cavallismo or even Recreate for Growth by the also liberal Ricardo Lpez Murphy, who obtained 17% of the votes at the national level in the 2003 presidential elections, but less than 1 .5% four later.

To gain permanence, he does not reach his leadership capacity or the strength of his speech: success will depend largely on the political and territorial construction that he manages to deploy in the year and a half that remains until the population goes to the polls again. Argentina is very unique: it presents enormous entry barriers for political competition, which prevent the construction of electoral alternatives.

Milei can get financing, structure an unforgettable campaign, bet on the best possible running mate and even turn slightly towards the center to expand its voter base, but without a presence in all the provinces and in all the cities and without a network of prosecutors, can hardly establish himself as a political leader that lives up to the noise it generated.

In addition, there is a factor that remains outside its orbit: what are the other forces going to do to prevent its growth? Until now, no one seriously attacked him. Together for Change, which concentrates the largest number of voters who identify with the libertarian phenomenon, continues to be entropically involved in its internal problems and has not defined any strategy to contain or reverse this advance, something that it could solve more or less simple: it would suffice to point out that Mileis proposals were never applied in any country.

I also read: Patricia Bullrich winks at Javier Milei and shakes the intern of Together for Change

Anarcholiberalism has a great discursive arrival, it is true, but when it competes, it loses: in the United States, to reach a seat, libertarians usually join the Republican Party. Otherwise, an unfailing defeat would await them. Perhaps it is enough for the current opposition to point out how impractical and utopian Mileis ideas are to generate a decline.

In this way, they would reduce him to the testimonial candidate model, as they were at the time Chacho lvarez or Lilita Carri: characters that people vote to express their anger, but that they would not choose if they had concrete chances of winning.

The other big question is whether, even going through all the previous challenges and setting himself up as president, he will be able to govern. For something Argentina did not have a Bolsonaro until now. Perhaps, it is destined not to have it.

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Will Washington County shift back to its conservative roots? – Portland Tribune

Posted: at 10:09 am

Despite redistricting favoring Democrats, some feel that this area's history of Republican leadership could win out.

Washington County has shifted a lot politically over the past two decades.

Its conservative rural roots, built on the backs of farmworkers and loggers, have given way to a highly urbanized, technological hotspot of innovation. Current and former politicians say it's this change that has led to a shift toward Democrats over Republicans despite a long history of Republicans being elected from Washington County to state and local elected offices.

It wasn't that long ago that Washington County seats in the Oregon House of Representatives and Oregon Senate could be considered reliably Republican. But today, Democrats dominate Washington County's legislative delegation.

Some say the days of competitive legislative races in Washington County are gone altogether, which they attribute to changing demographics, economic factors, and redistricting.

But Republican control over this area is by no means ancient history, and some say a return to the red is not as big of a long shot as some may think.

In the 2010 wave election, Republicans picked up six seats in the Oregon House, including two in Washington County. Republicans also picked up two Senate seats, one of which was SD 20, including northern Clackamas County.

This result was an evenly divided House and a narrow 16-14 Democratic Senate majority.

House District 29, which had been represented by Hillsboro Democrat Chuck Riley, was won by Republican Katie Eyre Brewer. She defeated Katie Riley, wife of the retiring incumbent, who instead tried for an unsuccessful bid for Senate District 15.

Neighboring House District 30 saw Hillsboro Republican Shawn Lindsay defeat Democrat Doug Ainge.

In both of those cases, the Democrats lost by more than 1,000 votes.

Lindsay says he lost re-election in 2012 only because of Libertarian Kyle Markley running in race. Markley got 1,441 votes, while Lindsay lost by about 1,200, and he thinks that since Libertarian votes tend to tilt conservative, he would have eked out a win if they'd gone his way instead.

"But for a conservative running and taking votes away, I think I would have held my seat," Lindsay said.

He also said Sen. Bruce Starr, R-Hillsboro, lost his re-election for the same reason in 2014, when Libertarian Caitlin Mitchel-Marley pulled 9% of the votes and Starr lost by less than a percentage point.

The person Starr lost to? Democrat Chuck Riley, successful in his second attempt to win election to Senate District 15.

Republicans like Lindsay point to these cyclical factors for why this area is still competitive for his party.

"I believe it's still winnable for a Republican in this area," he concluded. "I believe that Republicans could still be holding these seats but for some base consolidation."

Looking back a bit further, local seats were more firmly Republican. The party held a majority in both chambers of the Oregon Legislature heading into the 2002 general election. But that year, Democrats took control of the Senate, and they haven't relinquished it since.

Aloha Democrat Jeff Barker, who represented District 28 in the Oregon House of Representatives from 2003 to 2021, said that he was among the first legislators to benefit from Washington County's leftward shift.

"I ran in 2002 and then (this area) was all Republican men," he said. "That was kind of the first year that Washington County started to shift toward Democrats. But that was very competitive."

Barker won by just 40 votes in fact, the tightest election in the state at that time. He defeated Keith Parker to represent District 28. A Democrat has held that seat ever since. Before Barker won election, the seat was held by a Republican.

Politicians who ran for office and who saw the changing landscape at that time all point to similar factors: urbanization, diversification of the voting base and economic changes.

"I've lived in Hillsboro for over 30 years," said Joe Gallegos, a Democrat who represented HD 30 from 2013 to 2017. "When I first got here, it was about 40,000 people. Now it's over 100,000."

"I used to come out here as a kid to do migrant work," he recalled. "It was the place you'd come out to pick berries. But with that shift away from agriculture you're seeing more service industry-type jobs. That goes in with the suburban shift."

Gallegos and others point to the influx of highly educated workers drawn particularly to the growing semiconductor industry built up by major corporations like Intel as a predominant reason for Washington County's blue shift.

Urbanization also leads to more connectivity between the suburbs and the city, so people can work in Portland and live in Hillsboro, or vice versa meaning the previously isolated and rural population that surrounded Hillsboro in decades past is now more blended with the urban spillover from Portland.

As for diversification, the results of the latest U.S. Census have made clear that Washington County is the most racially diverse in the state. About 40% of the county's population is non-white, with the largest share of that being Hispanic.

The Hispanic population grew by more than 20% compared to the previous census. The Asian population grew by slightly less than that.

However, don't make the mistake of thinking that people of color always vote blue, politicians say. Some Republicans feel the party hasn't done enough to attract minority voters, particularly Hispanic ones, who could be persuaded to vote red.

"I personally think the Republicans have missed the boat, particularly on securing Hispanic votes," said Paul Phillips, a Tigard Republican who served for 14 years in the Legislature. "The Hispanic community is not necessarily uniform and leaning Democrat. People assume that, but it's a false assumption. The older generation of Hispanic voters is very Catholic, very conservative religious-wise."

If Washington County shifted to the left, what's to stop it from shifting back to the right? Some say there's nothing stopping that from happening. Some others mention one word: redistricting.

During the past two redistricting efforts, which follow every decennial census based on population growth, district lines have been redrawn largely to favor Democrats. In both 2011 and 2021, districts surrounding Portland were redrawn in many cases to draw more of the population of Portland proper into districts that represent the suburbs.

House District 28, for instance, which currently comprises central Washington County and predominantly covers West Beaverton, will shift much further to the east come Jan. 9, 2023. The new district includes more of Portland, and a district that once rested squarely in Washington County will now span the urban parts of three counties, Washington, Multnomah and Clackamas.

Even some Democrats have called out the redistricting process as unfair. Democrats had full control of the process last fall, 10 years after a bipartisan redistricting effort nonetheless produced maps many Republicans have criticized as unfair.

"I would like to see somebody that's not involved be able to draw those lines in the future," said Barker. "Democrats won't always be in charge, and when someone else is, they will use it as a way of getting even. It just makes a mess of the whole thing."

Barker said he volunteered to be the sole Democrat on a commission set up in 2017 by then-Secretary of State Dennis Richardson, a Republican, to come up with a new process for redistricting.

"I caught some flak for that," Barker said, "But I said, 'Well, it's just a matter of fairness.'"

Lindsay, a co-chair of the bipartisan redistricting committee back in 2011, also talked about the uneven playing field of that process.

"We were fighting with our hands tied behind our backs," Lindsay said. "Yes, we were tied 30-30 in the Legislature, but if we failed, then it automatically gets kicked to the Democratic secretary of state. The Dems had that leverage."

Even being out of the Legislature for a decade, Lindsay remains involved in Republicans' redistricting battles. He was the chief counsel for the lawsuit brought to the Oregon Supreme Court last year that alleged partisan gerrymandering by Oregon Democrats.

Republican lawsuits over redistricting last year were thrown out of court, but Lindsay says the legal battle demonstrates how contentious and important the redistricting process is every time.

Lindsay pointed out, too, that the Oregon Supreme Court associate justice who wrote the opinion dismissing the lawsuits out, Christopher Garrett, was the Democratic co-chair of that same 2011 redistricting committee that Lindsay sat on.

"It's interesting that 10 years later, the same players are still at it," Lindsay said.

Despite these factors, the Washington County Republican Party thinks that the area is due for a shift, and that a tilt back to the middle is likely. Some are predicting a red wave this year, a reaction to the dissatisfaction with President Joe Biden's handling of the pandemic, school closures and the economy. National polling consistently shows Biden's approval rating in the 30s to high 40s.

"With Democrats holding complete power in Washington and Oregon, and with the lockdowns I think there are a lot of voters that are not too happy with Democrats' choices," Lindsay said. "I think some of those seats that Democrats thought were out of reach for Republicans, based on the redistricting they did in 2021, I think some of those will even be recaptured, surprising a lot of people."

Gallegos counters that voters have reason to be fed up with Republican leadership, too, particularly in Oregon, where the minority party has walked out in the middle of a legislative session three times in the last four years, grinding the business of government to a halt.

"I think the average citizen just gets so disheartened by the fact that even as a minority, the Republicans are able to walk out and all of this kind of stuff," he said. "All of that antagonism in Salem is more and more disheartening to the average citizen."

Gallegos noted that with Oregon's largest share of voters registered as non-affiliated, both parties have to appeal to independent voters, rather than just their own base.

As for Washington County specifically, he feels like the urbanization of this area ultimately has a larger impact on its political representation than whatever gerrymandering may have accomplished.

"It's those sorts of factors that all kind of add together to make the change," Gallegos said. "It was gradual, but clearly, it was a steady march."

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The risk in a Biden reversal of medical conscience protections – The Week

Posted: at 10:09 am

"The Biden administration is preparing to scrap aTrump-era rulethat allows medical workers to refuse to provide services that conflict with their religious or moral beliefs," Politico reported Tuesday, citing "three people familiar with the deliberations." The exact scope of the prospective update isn't clear, but the Department of Health and Human Services confirmed it's coming.

In one sense, the change is irrelevant. Introduced in 2019, the rulein question would have denied federal funding to health-care organizations that don't allow staff to opt out of participation in abortions, procedures related to gender transition, assisted suicide, and the like. But it was blocked in federal court before it took effect and so has never been implemented. The Biden administration's "change" would merely confirm the status quo. Moreover, cases where health-care workers are forced to perform services they believe to be immoral (or fired for refusing to do so) seem to be relatively rare. They do happen, but most states already have laws on the books providing at least some conscience protections for medical professionals.

Still, the federal reversal is a step in the wrong direction on two counts. One is a matter of principle: The government technically isn't forcing doctors who believe abortion is murder to perform abortions. This isn't a straightforward mandate, because the doctors can, of course, quit their jobs instead. But federal endorsement of organizational policies that require employees to choose between conscience and livelihood does not exactly evince a civil libertarian spirit. It isn't a clear-cut state violation of freedom of conscience or religious liberty, yet it does give the government's blessing (and dollars) to private rejection of very serious claims of conscience.

Then there's the practical side of things. Politico quotes Jacqueline Ayers of Planned Parenthood, who says the change would "help ensure people can access the health care and information they need when they need it." If this revocation of a rule, again, that never took effect and is already broadly echoed at the state level changes anything, I suspect the opposite would be true.

Were medical professionals widely required to work in violation of their consciences, many would leave their fields, change their specialties, or outright refuse to take on certain patients something doctors, in particular, will always be able to do by citing facially neutral concerns like workload. In the worst case, I can imagine situations where a medical worker forced to act against conscience would deliberately misdiagnose or mistreat a patient, rationalizing that this is the lesser sin.

Compelling any violation of conscience is a very grave proposal. Compelling it of medical staff is uniquely risky, too.

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What Peter Thiel, J.D. Vance, and Others Are Learning From Curtis Yarvin and the New Right – Vanity Fair

Posted: at 10:09 am

Despair, he signed off, serves the regime.

Part of why people have trouble describing this New Right is because its a bunch of people who believe that the system that organizes our society and government, which most of us think of as normal, is actually bizarre and insane. Which naturally makes them look bizarre and insane to people who think this system is normal. Youll hear these people talk about our globalized consumerist society as clown world. Youll often hear the worldview expressed by our media and intellectual class described as the matrix or the Ministry of Truth, as Thiel described it in his opening keynote speech to NatCon. It can be confusing to turn on something like the influential underground podcast Good Ol Boyz and hear a figure like Anton talk to two autodidact Southern gamers about the makeup of the regime, if only because most people reading this probably dont think of America as the kind of place that has a regime at all. But thats because, as many people in this world would argue, weve been so effectively propagandized that we cant see how the system of power around us really works.

This is not a conspiracy theory like QAnon, which presupposes that there are systems of power at work that normal people dont see. This is an idea that the people who work in our systems of power are so obtuse that they cant even see that theyre part of a conspiracy.

The fundamental premise of liberalism, Yarvin told me, is that there is this inexorable march toward progress. I disagree with that premise. He believes that this premise underpins a massive framework of power. My job, as he puts it, is to wake people up from the Truman Show.

We spoke sharing a bench outside in the dark one evening, a few days into the conference. Yarvin is friendly and solicitous in person, despite the fact that he tends to think and talk so fast that he can start unspooling, reworking baroque metaphors to explain ideas to listeners who have heard them many times before.

Strange things can happen when you meet him. Id gotten in touch with him through a mutual friend, a journalist I knew from New York who once had a big magazine assignment to write about him. The piece never came out. They wanted him to say I was really evil and all that, Yarvin told me. He wouldnt do it and pulled the piece. And I thought, Okay, thats a cool guy. This friend has now made a bunch of money in crypto, works on a project Yarvin helped launch to build a decentralized internet, and lives hours out into the desert in Utah, where hell occasionally call in to New Rightish podcasts. He recently had dinner with Thiel and Mastersboth Masters and Vance have raised money by offering donors a chance to dine with Thiel and the candidate.

Yarvin has a pretty condescending view of the mainstream media: Theyre just predators, he has said, who have to make a living attacking people like him. They just need to eat. He doesnt usually deal with mainstream magazines and wrote that hed been ambushed at the last NatCon, in 2019, by a reporter for Harperswhere I also writewho made him out to be a bit of a loon and predicted that the NatCons populist program would soon be stripped of its parts by the corporate-minded Republican establishment.

But the winds are shifting. He told me about how hed gone to read poetry in New York recently, at the Thiel-funded NPC fest. A bunch of lit kids showed up, he said, grinning. I had grown into adulthood in the New York lit-kid world; even a few years ago, there was no question that anything like this could have happened. But now Yarvin is a cult hero to many in the ultrahip crowd that youll often hear referred to as the downtown scene. I dont even think antifa bothered showing up, Yarvin said. What would they do? It was an art party.

Yarvin had asked his new girlfriend, Lydia Laurenson, a 37-year-old founder of a progressive magazine, to vet me. The radical right turn her life had taken created complications.

One of my housemates was likeI dont know if I want Curtis in our house, she told me. And Im like, Okay, that makes sense. I understand why youre saying that.

Laurenson had been a well-known blogger and activist in the BDSM scene back when Yarvin was the central early figure in a world of neo-reactionary writers, publishing his poetry and political theory on the Blogger site under the name Mencius Moldbug.

As Moldbug, Yarvin wrote about race-based IQ differences, and in an early post, titled Why I Am Not a White Nationalist, he defended reading and linking to white nationalist writing. He told me hed pursued those early writings in a spirit of open inquiry, though Yarvin also openly acknowledged in the post that some of his readers seemed to be white nationalists. Some of Yarvins writing from then is so radically right wing that it almost has to be read to be believed, like the time he critiqued the attacks by the Norwegian far-right terrorist Anders Behring Breivikwho killed 77 people, including dozens of children at a youth campnot on the grounds that terrorism is wrong but because the killings wouldnt do anything effective to overthrow what Yarvin called Norways communist government. He argued that Nelson Mandela, once head of the military wing of the African National Congress, had endorsed terror tactics and political murder against opponents, and said anyone who claimed St. Mandela was more innocent than Breivik might have a mother youd like to fuck.

Hes tempered himself in middle agehe now says he has a rule never to say anything unnecessarily controversial, or go out of my way to be provocative for no reason. Many liberals who hear him talk would probably question how strictly he follows this rule, but even in his Moldbug days, most of his controversial writings were couched in thickets of irony and metaphor, a mode of speech that younger podcasters and Twitter personalities on the highly online right have adopteda way to avoid getting kicked off tech platforms or having their words quoted by liberal journalists.

He considers himself a reactionary, not just a conservativehe thinks it is impossible for an Ivy Leagueeducated person to really be a conservative. He has consistently argued that conservatives waste their time and political energy on fights over issues like gay marriage or critical race theory, because liberal ideology holds sway in the important institutions of prestige media and academiaan intertwined nexus he calls the Cathedral. He developed a theory to explain the fact that America has lost its so-called state capacity, his explanation for why it so often seems that it is not actually capable of governing anymore: The power of the executive branch has slowly devolved to an oligarchy of the educated who care more about competing for status within the system than they do about Americas national interest.

One man raised his hand to ask how Masters planned to DRAIN THE SWAMP. He gave me a sly look. Well, one of my friends has this acronym he calls RAGE, he said. Retire All Government Employees.

No one directs this system, and hardly anyone who participates in it believes that its a system at all. Someone like me who has made a career of writing about militias and extremist groups might go about my work thinking that all I do is try to tell important stories and honestly describe political upheaval. But within the Cathedral, the best way for me to get big assignments and win attention is to identify and attack what seem like threats against the established order, which includes nationalists, antigovernment types, or people who refuse to obey the opinions of the Cathedrals experts on issues like vaccine mandates, in as alarming a way as I possibly can. This cycle becomes self-reinforcing and has been sent into hyperdrive by Twitter and Facebook, because the stuff that compels people to click on articles or share clips of a professor tends to affirm their worldview, or frighten them, or both at the same time. The more attention you gain in the Cathedral system, the more you can influence opinion and government policy. Journalists and academics and thinkers of any kind now live in a desperate race for attentionand in Yarvins view, this is all really a never-ending bid for influence, serving the interests of our oligarchical regime. So I may think I write for a living. But to Yarvin, what I actually do is more like a weird combination of intelligence-gathering and propagandizing. Which is why no one I was talking to at NatCon really thought it would be possible for me to write a fair piece about them.

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