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Pronounce Medical Words Genome - Video

What are the benefits to society of the Human Genome Project?
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What are the benefits to society of the Human Genome Project? - Video

April 25, 2014

Image Caption: This is a golden eagle. Credit: Todd Katzner

Purdue University

Purdue and West Virginia University researchers are the first to sequence the genome of the golden eagle, providing a birds-eye view of eagle features that could lead to more effective conservation strategies.

Their study calls into question long-held assumptions about golden eagle vision, indicating that the raptors may not be as sensitive to ultraviolet light as previously thought. The genome also suggests that golden eagles could have a sharper sense of smell than researchers realized.

Additionally, the genome provides thousands of genetic markers that will help researchers track populations and monitor eagle mortality.

Having the golden eagle genome in hand could directly affect the way we make conservation and management decisions, said Jacqueline Doyle, postdoctoral research associate and first author of the paper.

Though it is one of the most widespread avian species, the golden eagle is threatened throughout much of its range by poaching, shrinking habitats and fatal collisions with wind turbines. An estimated 67 golden eagles are killed annually at a single wind farm the Altamont Pass Wind Resource Area in central California a heavy toll on a species that reproduces slowly and can live up to 30 years, said J. Andrew DeWoody, professor of genetics and senior author of the study.

One recently proposed method of reducing turbine-related eagle deaths was to coat wind turbines with ultraviolet-reflective paint, thereby heightening their visibility to eagles, which were thought to be sensitive to ultraviolet light. But the golden eagle genome suggests that eagle vision is rooted in the violet spectrum like human sight rather than the ultraviolet.

We find little genomic evidence that golden eagles are sensitive to ultraviolet light, Doyle said. Painting wind turbines with ultraviolet-reflective paint is probably not going to prevent eagles from colliding with turbines.

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Genome Of Golden Eagle Could Lead To More Effective Conservation Strategies

Mining the genome of the disease-transmitting tsetse fly, researchers have revealed the genetic adaptions that allow it to have such unique biology and transmit disease to both humans and animals.

The tsetse fly spreads the parasitic diseases human African trypanosomiasis, known as sleeping sickness, and Nagana that infect humans and animals respectively. Throughout sub-Saharan Africa, 70 million people are currently at risk of deadly infection. Human African trypanosomiasis is on the World Health Organization's (WHO) list of neglected tropical diseases and since 2013 has become a target for eradication. Understanding the tsetse fly and interfering with its ability to transmit the disease is an essential arm of the campaign.

This disease-spreading fly has developed unique and unusual biological methods to source and infect its prey. Its advanced sensory system allows different tsetse fly species to track down potential hosts either through smell or by sight. This study lays out a list of parts responsible for the key processes and opens new doors to design prevention strategies to reduce the number of deaths and illness associated with human African trypanosomiasis and other diseases spread by the tsetse fly.

"Tsetse flies carry a potentially deadly disease and impose an enormous economic burden on countries that can least afford it by forcing farmers to rear less productive but more trypanosome-resistant cattle." says Dr Matthew Berriman, co-senior author from the Wellcome Trust Sanger Institute. "Our study will accelerate research aimed at exploiting the unusual biology of the tsetse fly. The more we understand, the better able we are to identify weaknesses, and use them to control the tsetse fly in regions where human African trypanosomiasis is endemic."

The team, composed of 146 scientists from 78 research institutes across 18 countries, analysed the genome of the tsetse fly and its 12,000 genes that control protein activity. The project, which has taken 10 years to complete, will provide the tsetse research community with a free-to-access resource that will accelerate the development of improved tsetse-control strategies in this neglected area of research.

The tsetse fly is related to the fruit fly -- a favoured subject of biologists for more than 100 years -- but its genome is twice as large. Within the genome are genes responsible for its unusual biology. The reproductive biology of the tsetse fly is particularly unconventional: unlike most insects that lay eggs, it gives birth to live young that have developed to a large size by feeding on specialised glands in the mother.

Researchers found a set of visual and odour proteins that seem to drive the fly's key behavioural responses such as searching for hosts or for mates. They also uncovered the photoreceptor gene rh5, the missing link that explains the tsetse fly's attraction to blue/black colours. This behaviour has already been widely exploited for the development of traps to reduce the spread of disease.

"Though human African trypanosomiasis affects thousands of people in sub-Saharan Africa, the absence of a genome-wide map of tsetse biology was a major hindrance for identifying vulnerabilities, says Dr Serap Aksoy, co-senior author from the University of Yale. "This community of researchers across Africa, Europe, North America and Asia has created a valuable research tool for tackling the devastating spread of sleeping sickness."

Tsetse flies have an armament of salivary molecules that are essential for feeding on blood. The team found one family of genes, the tsal genes, that are particularly active in the salivary glands of the tsetse fly. This allows the tsetse fly to counteract the responses from the host to stop bloodfeeding. This finding and several others are explored in more detail in eight research papers that accompany the publication of the tsetse fly genome in Science.

"This information will be very useful to help develop new tools that could reduce or even eradicate tsetse flies," says Dr John Reeder, Director of the Special Programme for Research Training in Tropical Diseases, at WHO. "African sleeping sickness is understudied, and we were very pleased to help bring together so many research groups to work collaboratively with the one shared goal in sight -- the elimination of this deadly disease."

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Tsetse fly genome reveals weaknesses: International 10-year project unravels biology of disease-causing fly