Category Archives: Transhuman News

CARLSBAD, Calif. (PRWEB) May 05, 2022

NAD3 is a multi-patents-pending nutraceutical containing a unique Wasabi Japonica extract, Theacrine and Copper(I)-Niacin complex. Preliminary pre-clinical and human studies suggest that NAD3 upregulates enzymes that boost the conversion of NAD+ precursors, such as niacin, niacinamide, nicotinamide riboside (NR) and/or NMN to NAD+, while also suppressing the activity of proteins that deplete and consume NAD+. Collectively, these data support the use of NAD3 in combination with any NAD+ precursor or booster (as an ideal companion) for amplifying net cellular NAD+ status.

Recently published in the prestigious journal Physiologia, human data from the ENHANCE Trial revealed that 12 weeks of oral supplementation with NAD3 decreased various independent cardiovascular risk factors (e.g., VLDL, TAGs, LDL-C and Total Cholesterol) by 16% to 19%. In the same study, beneficial changes in the NAD+/NADH ratio were noted despite the fact that NAD3 does NOT contain an appreciable dose of an NAD vitamin precursor. Taken together, the data provide a strong basis for including NAD3 as part of a comprehensive plan to optimize cardiometabolic health and longevity.

While its still the "early days" for NAD3, and much about how NAD+ influences human health and the biology of aging remains to be studied, JUVN3 Holdings continues to invest heavily in NAD3 research. JUVN3 is an ingredient incubator specializing in human longevity. Its NAD3 pipeline of mechanistic, pre-clinical science and human clinical research is well underway. They are committed to providing a solid body of clinical evidence that pushes the forefront of science, advances the field of longevity, and makes a positive impact on human healthspan for society.

While previous studies have demonstrated increases in NAD+ levels using supplement precursors (e.g. niacin, niacinamide, nicotinamide riboside (NR), NMN), NAD3 is the first nutraceutical to demonstrate an improvement in NAD+ status without utilizing a precursor. Its also the first NAD ingredient to show clinical benefits in humans.

NAD3 is distributed exclusively by Compound Solutions, Inc. (CSI) on behalf of JUVN3. Compound Solutions is the go-to company representing and distributing unique, patented nutraceutical ingredients that improve the health and performance of individuals. CSI supplies effective, science-based ingredients to wellness brands, sports nutrition, functional food and nutraceutical manufacturers. CSI is committed to building and maintaining long-term relationships with our global customers and suppliers.

*ENHANCE Trial: Effects of NAD3 on Hallmarks of Aging and Clinical Endpoints of Health in Middle Aged Adults: a subset analysis focused on blood cell NAD+ concentrations and lipid metabolism.

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Landmark NAD3 human study shows improvements in cellular NAD+ status and biomarkers of cardiovascular health - PR Web

Washington [US], May 11 (ANI): As the global elderly population grows, it is socioeconomically and medically critical to have diverse and effective means of mitigating the impact of aging on human health.

A recent study has demonstrated the effectiveness of using cytomegalovirus in mice as a gene therapy vector for two age-protecting factors to prolong life up to 41.4% of ones age. It extended the median lifespan of treated mice without increasing cancer risk, while improving ageing-related biomarkers, including glucose tolerance, exercise performance, body mass loss, hair loss, telomere shortening, and deterioration of the mitochondrial structure.

The two age-protecting factors, namely, are enzyme telomerase reverse transcriptase and the protein follistatin.

The goal of achieving a healthy lifespan remains a difficult topic in biomedical science. It has been well established that ageing is associated with a decrease in the number of telomere repeats at the ends of chromosomes, partly as a result of insufficient telomerase activity. Importantly, the biological functions of the telomerase complex rely on telomerase reverse transcriptase (TERT).

TERT plays a major role in telomerase activation, which in turn, lengthens the telomere DNA. Because telomerase supports cell proliferation and division by reducing the erosion of chromosomal ends in mitotic cells, animals deficient in TERT have shorter telomeres and shorter lifespans. Recent studies on animal models have supported the therapeutic efficacy of TERT in increasing healthy longevity and reversing the ageing process.

Telomere shortening also increases the risk of heart disease. The follistatin (FST) gene encodes a monomeric secretory protein that is expressed in nearly all mammalian tissues. In muscle cells, FST functions as a negative regulator of myostatin, a myogenesis inhibitory signal protein. FST overexpression is known to increase skeletal muscle mass in transgenic mice by 194 to 327% by neutralizing the effects of various TGF-b ligands involved in muscle fiber breakdown, including myostatin and activin inhibition complex. FST knockout mice have smaller and fewer muscle fibers, show retarded growth, skeletal defects, and reduced body mass, and they die within a few hours after birth. The acceleration of these degenerative trends post FST knockout underscore an important role of FST in skeletal muscle development.

Aged mice have exhibited loss of motor unit function with impaired neuromuscular junction transmission. It has been shown that follistatin expression in aged mice not only increased muscle mass but also improved the neuromuscular function. These findings strongly implicate the therapeutic potential of FST in the treatment of muscular dystrophy, muscle loss, and impaired neuromuscular function caused by ageing or microgravity. Based on this evidence and supporting assumptions, TERT and FST are among prime candidates for gene therapy protocols directed to improve healthy lifespans.

As more longevity-supporting factors are discovered, it is natural to explore potential large capacity vectors for delivering multiple genes simultaneously. Unlike adeno-associated virus (AAV), lentiviruses or other viral vectors now commonly used for gene delivery, cytomegaloviruses (CMVs) have a large genome size and unique ability to incorporate multiple genes. Further, cytomegaloviruses do not integrate their DNA into the host genome during the infection cycle, thereby mitigating the risk of insertional mutagenesis. CMV infections are usually asymptomatic in most healthy adults, but can become problematic in neonates or transplant patients. Human CMV (HCMV) has been proven to be a safe delivery vector for expressing therapeutic proteins in human clinical trials (20). Mouse CMV (MCMV) and HCMV are similar in many aspects, including viral pathogenesis, homology, viral protein function, viral gene expression, and viral replication.

Cytomegalovirus vector has been proven to be a potent delivery vector for delivering foreign genes and is utilized in different immunotherapies, including cancer, tuberculosis (TB), acquired immunodeficiency syndrome (AIDS), malaria, and many others. Using MCMV as a viral vector, the researchers examined the therapeutic potential of TERT and FST gene therapy to offset biological ageing in a mouse model, and demonstrated significant lifespan increase, as well as positive metabolic and physical performance effects. The researchers believe further studies may elucidate the full CMV cargo capacity and effectiveness. Translational studies are required to determine whether the findings can be replicated in human subjects. (ANI)

This report is auto-generated from ANI news service. ThePrint holds no responsibility for its content.

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New intranasal and injectable gene therapy could prolong healthy life - ThePrint

Experiencing the myriad of natural and entirely normal effects of aging is what one could describe as a bit of a contradiction. On the one hand, the very fact that you are aging and maturing means that you are lucky enough to be in fine proverbial fettle and that you are likely to be around for many years to come.

On the other hand, however, aging can understandably be somewhat frustrating, upsetting, and in some peoples cases, downright devastating, to start to experience the effects of aging as it makes one confront reality and indeed, their own mortality.

With this in mind, here for your information and to hopefully provide at least some positive consolation to getting older, are some top tips, techniques, and pieces of advice for handling the effects of aging.

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One of the most noticeable signs of aging, especially to yourself when you look in the mirror of a morning, is that your skin may have started to display signs of wrinkles, frown lines, crows feet, and/or furrows on your forehead.

There is a wide plethora of both more affordable and incredibly expensive lotions, potions, and creams whose taglines claim to, quite literally, reverse the signs of aging and at the risk of catastrophic revelation, these claims are really not worth the paper they are written on.

However, having said that, it is true to say that making a thick, non-sticky, and water-based moisturizer part of your daily and ideally evening as well, skincare routine is well worth it, especially as most moisturizer brands contain a certain SPF along with their other ingredients.

For men and especially those men whose father, brother, and/or uncle began to lose their hair in their early forties, it is most likely that they will also follow the same trend. Some men who are experiencing hair thinning, balding, or a general receding of their hairline are more than happy, quite rightly, to embrace their natural baldness and own it.

However, if you are not one of those men and instead feel as if losing your hair also signifies losing part of your identity, character, and overall personal style, there are several options you may want to consider.

There are two principal prescription drugs, both of which are designed for treatment, prevention, and combat hair loss, called Minoxidil and Finasteride, the latter of which must never be prescribed to women as it can be dangerous to females.

Alternatively, a more permanent, pricey yet ultimately far more effective option to combat baldness is to research hair transplants, as not only does such a procedure result in an incredibly natural looking hairline but it also encourages new hair growth in and around the treated area.

You will no doubt remember your grandma or grandad complaining of aching joints or holding their back after standing up for too long. You probably and quite understandably laughed at their protestations that this happens when you get old.

Muscle, joint aches and pain can happen at any age and is sometimes only the result of an injury or sprain, in which case such symptoms will dissipate over time, but if you have recently started to feel particularly achy and uncomfortable, there are a number of things you can do in an effort to combat this:

Additionally, ensure you are eating enough fresh fruit and vegetables and drinking enough water, not just for the health of your joints and muscles, but also for the physical health and wellbeing of your entire body.

As with every single other organ of the human body, everyone is entirely unique and individual and therefore it is entirely likely that if you stood one hundred thirty-five-year-old people in a line and rated their eyesight, you would receive widely conflicting data and results.

There is a multitude of factors that can affect the strength of your vision and act as a catalyst for the decline of your eyesight.

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If your job involves staring at a computer screen for hours upon hours on end, or if you are one of those people who are glued to their smartphone or tablet at every given opportunity, then over time this may result in dry, itchy, tired and strained eyes.

Start taking regular, five-minute breaks away from the screen whenever possible approximately every hour, move your screen further away from your face and improve the level of the lighting on your desk to try and reduce the glare from the screen.

Everyone in the world knows and understands by now that smoking cigarettes and cigars is not only bad for your lungs and heart, but also bad for your eyes as well.

Smoking drastically increases the risk of such eye issues as diabetic retinopathy cataracts ad glaucoma and if you are a smoker, this is yet another reason to give up immediately.

Another, perhaps slightly less widely known, factor that can influence the quality and longevity of your vision is when you are not consuming the right kinds of foods.

Try and improve your general daily diet by eating more of the following:

Warning signs that you may have a problem with one or both of your eyes include, but are not limited to, the following issues:

If you are experiencing any of the above signs and symptoms, it is best to make an appointment with your medical doctor as soon as possible, just in case there could be a more serious underlying problem.

As a person gets older, the levels of strength and stamina naturally decline, and there is no better explanation than obviously, the older you are, the more use your legs, arms, and back have had and therefore the more worn out they may become.

Whereas the strength of your arms and legs is both measurable and easy to see, the concept of stamina is far harder to measure and therefore less practical to build, however, both strength and stamina are equally as important in your quest to stave off the natural signs of aging.

Consistent exercise is one way to steadily build your stamina levels, although if, prior to reading this article, you rarely, if ever, engage in physical exercise, then it is crucial to both stretches before you start your exercise session and to work your way up slowly. Along with physical exercise, another way to ensure your body has the strength and stamina it needs is to ensure that you are always sufficiently hydrated, so put down the soda and instead invest in a funky and aesthetically pleasing water bottle that you can carry around with you both at work and around the house.

There are a wide plethora of benefits to drinking more water, not just for your physical health, but for your emotional wellbeing as well, which include, amongst others:

Another key way in which your body starts to show signs of aging and more importantly, an element of your physical health that you need to start keeping your proverbial eye on, is your blood pressure reading.

If you currently believe your blood pressure to be slightly too high, the best thing to do is to book an appointment with your medical doctor, or at the very least with a quality blood pressure monitor so you can take your blood pressure at regular intervals at home.

Luckily, if you do find your blood pressure to be high, or else you are concerned that if you dont change some of your bad habits and adapt your lifestyle then this could be the result, there is a myriad of ways in which you can reduce the level of your blood pressure to a normal and acceptable level.

Such ways to keep your blood pressure in check include:

General awareness and the acceptance of diabetes as a serious and potentially even fatal disease of the body has only, in recent years, started to enter the mainstream media and publics conscience and it is absolutely imperative that you avoid contracting diabetes as much as feasibly possible. The main way to avoid diabetes entirely is to reduce your sugar intake.

Diabetes is essentially when the glucose, or sugar, levels in your blood are too high. As blood glucose is the primary source of energy to fuel your entire body, the food you eat directly affects the amount of sugar in your body. If your pancreas is unable to make enough insulin to transport the sugar into your cells, it stays in the blood and causes a whole host of problems.

The most prolific and noticeable signs and symptoms of diabetes include the following:

Contracting diabetes is by no means a life sentence for constant pills and drugs. However, if diabetes is not handled correctly, it could lead to more serious health issues:

You will no doubt struggle to find a single person who can honestly claim that they have never entered a room and immediately forgotten why they went in there in the first place. These tiny lapses in memory are as laughable as they are insignificant.

However, it is true to say that both men and women of any age and of any particular situation and lifestyle should always look after their minds. They need to protect the quality and durability of their cognitive brain functions.

There is often talk, both casually amongst friends and in more serious news articles in the newspaper, online, or on the television, about the importance of keeping your brain young, and frankly, this should be adhered to.

Proven-to-be effective ways of training your brain and ensuring it is in as good a condition as it possibly can include:

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Handle The Effects of Aging With These Top Tips - Longevity LIVE - Longevity LIVE

Mara Martinn-Torres says that her book Homo imperfectus reflects the chaotic way that her mind works. The volume explores what makes humans imperfect by weaving scientific details with literary references. The 48-year-old paleoanthropologist, originally from Ourense in northwestern Spain, heads the National Center for Research on Human Evolution in Burgos. Her background in medicine allows her to see the diseases we suffer as chapters in a story that explains what Homo sapiens is like today.

Question. The book is like a culinary deconstruction of the human being, a journey through the ingredients of our evolution to the dish we are now.

Answer. I try to identify what ingredients were made of and how they are mixed. It is very difficult to separate the ingredients. In some places, we find a taste, like an evolutionary advantage, but in other places, we find other textures, like other stages of life or a disease. I like to describe it from the point of view of imperfection, which has always been reviled. We want to be perfect creatures, but the reality is that we are full of imperfections, and that gives our species its richness.

Q. Our diversity made us indestructible.

A. Exactly. The law of nature does not prioritize the individual, but the collective. Individually, we have to deal with many problems and vulnerabilities, but that personal suffering does not interfere with our success. And therein lies the key. Natural selection is not concerned with happiness, health or well-being. Those are human issues. Natural selection is concerned with survival, and humans are concerned with living well. The history of our species is collective and social, and therefore we end up dealing with individual suffering.

Q. Will the pursuit of happiness ever be an evolutionary advantage?

A. Natural selection is an unstoppable filter. When there is a crisis or an important change in the environment, the varieties that are better adapted will prosper or have more children, period. Where does it make the cut? In the traits that can harm our reproductive success. Everything that happens after reproduction is our business. Cancer, which usually appears in old age, is a real issue, but it has no impact on reproduction. Happiness and wellness are the same. If we are capable of generating environments of greater happiness, that contributes to prosocial behavior, and that matters to us. Although happiness is not really a characteristic that is going to be favored by natural selection, it is reached when we put into action the prosocial characteristics that have been positively selected throughout evolution. Our strength is not individual. It is always as a group. This allows us to welcome and compensate and protect individual weaknesses or frailties. The weakest individual is not the one who is physically frail or sick, but the one who is alone. Natural selection favors many characteristics that allow for connection, including longevity: we live longer not to have children, but to take care of others. Natural selection favors us being a long-lived species to take care of highly dependent individuals, who need others from very early and until very late. Rather than being a disadvantage or a weakness, dependence is the reason why we live so many years.

Q. Are we programmed to protect the vulnerable?

A. This is our hallmark as a hypersocial species, the consequence of one of our most useful weapons, which is empathy. Our brain allows us the incredible experience of living our life and imagining that of others, which gives us great advantages in our survival, because we can recognize friends and anticipate enemies. This is reflected, for example, in the care for the vulnerable. Most of our characteristics, even the negative ones, lead us to seek acceptance by the group. We feel most protected and fulfilled when were part of a family, a group, a club or a tribe. I believe that the portrait of the human being as ruthless, opportunistic and selfish is not really our true nature. Natural selection favors altruistic and prosocial behaviors for our success. We have to get rid of the clich that human beings are bad and selfish. There is very little margin for individualism in this species.

Q. Did other extinct species, like Neanderthals or Denisovans, fail due to lack of empathy?

A. In the case of the Neanderthals, I dont think it was that, because they were a compassionate social group. They buried their dead, they had symbolic thought, they also had a sophisticated behavioral capacity, they controlled hunting, they knew their environment. In the case of the Neanderthals, it has been a demographic issue. There were very few of them and ice-age Europe was a harsh and arid environment. They had great abilities, they were well adapted, but they were very isolated and their population was decreasing. We, on the other hand, were at a peak moment, fully developing our capabilities, and we entered Europe when they were already disappearing, because of something that is fundamental to the human species: diversity. Neanderthals, being an isolated group, were probably also a very homogeneous group genetically. They had less to work with when new threats such as infections appeared. Sapiens, however, were more diverse. The diversity and flexibility of behavior is the key to the strength of a species, because you have a greater repertoire with which to face a greater number of dangers.

Q. In the book you mention that 90% of the people who have lived have had a hunter-gatherer lifestyle. Is that a determinant?

A. When we look back at the evolutionary history of Homo sapiens, since it appeared on Earth 200,000, almost 300,000 years ago, we see that we have been living as a hunter-gatherer species much longer than in cities and towns. This is new. Our biology has been shaped over hundreds of thousands of years to adapt to a lifestyle that suddenly, in this last tweak of the last 10,000 years, has changed radically. But biology has other rates of change, and a mismatch occurs, because our adaptation is much slower than the speed at which we are capable of transforming the world. We have created a completely new world, of routines, of diet, of interactions, of sexual relationships, of exposure to new toxins that have nothing to do with what has happened in 90% of our history as a species.

Q. Is our understanding of our past biased?

A. There has always been a lot of bias. For example, I always say that we do not give the Neanderthal version of events. When we study the brain of Sapiens and Neanderthals, we immediately think about what we can do that Neanderthals did not. These poor Neanderthals went extinct because they had less working memory than Homo sapiens, we say. And I say, if they had the same brain size, there will be something that they did have more developed than us and we dont know what it is. Maybe they were much sharper visually, maybe they were more empathetic, more expressive. Perhaps they communicated with greater nuance and with greater expression. We have a hard time imagining what they could have that we didnt have. One of the great biases is to see ourselves as a prototype of the perfect species that has things that others do not have. We always tell our story in terms of success.

Q. We read evolution as if our destiny is to become the kings of creation.

A. Natural selection is humbling: the same rules of evolution apply to us, to cauliflower, to pine trees and to viruses. I dont think we are better adapted than tulips in Holland or an eagle flying in the sky. They are different types of adaptations to different worlds. Were not doing badly, but there are still many adjustments to be done. Illnesses are a reflection that there are still many nuts to tighten throughout evolution.

Q. Have we learned many new things about sapiens?

A. In recent years, the image we had of ourselves as a uniform category, a perfect lineage that triumphantly advanced and colonized the world, has changed. Now we see that the key to the success of our species is to have room for exceptions, for crooked lines, for asterisks. This has allowed us to adapt to such different environments. We have not come forward as a uniform species, quite the contrary. And that includes our mixing with other species.

Q. So going back to the sapiens recipe, we are more like croquettes that have been made with food from different places.

A. Well, yes, and thats very good on an evolutionary level, discovering that we are a mixture and that this mixture has given us advantages. Most of the genes that have been positively selected from our mix with Neanderthals have to do with the immune system. We are a croquette with a lot of ancestors, but also with a lot of flavor and a lot of history.

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Mara Martinn-Torres: The weakest creature is not the frail or the sick, but the one who is alone - EL PAS in English

One of the more fascinating parts about kart racing games is their malleability with franchises. Mario Kart sits atop the genre but other takes have included video game characters such as Sonic and Diddy Kong. Beyond that, kart racing games have featured Nickelodeon characters such as SpongeBob SquarePants, the Ninja Turtles and Rugrats and Looney Tunes mainstays such as Bugs Bunny characters.

What makes these games successful is that theres a basic formula and developers can plug in whatever characters are necessary. Its a fun genre thats accessible to most players. Thats why Warped Kart Racers looks to be a promising game headed to Apple Arcade.

Developed by Electric Square, this kart racer stars characters from 20th Century Animation. The roster includes 20 heroes from shows such as Family Guy, American Dad!, King of the Hill and Solar Opposites. Theyll compete across 16 maps that also happen have their own themed traits and shortcuts. The karts themselves are customizable with the gliders and antennas showing off a players personality.

Our design pillar was frenetic karting shenanigans and I think we delivered, said Nicholas Lovell, director at Electric Square.

Players can select from five Family Guy characters in Warped Kart Racers. (Apple)He said Warped Kart Racers is infused with irreverent humor that some of the franchises are known for, but thats up to a limit. The humor still has to be within Apple Arcades 12+ rating. Dont expect Family Guy humor like this.TWO MODES WITH THE ACCOUTREMENTSWhen they start, players will find a race mode and a battle mode. In the race mode, players compete against 11 other karts using items such as shields, dumb missiles and drop weapons. Battle mode has the same array of items except players are in an enclosed arena.

Electric Square took pains in creating a visual style that works with a number of different franchises. They wanted to create a game, in which seeing Hank Hill racing against Peter Griffin looked natural. It appears that they pulled it off fairly well. The team also said that though Warped Kart Racers features 20 characters at the start, they have plans to expand the roster. Im hoping for some Bobs Burger integration.

Players can choose any racers and not worry about their stats because every character is equal. Keeping a level playing field was a conscious decision, Lovell said. They wanted fans to pick their favorite TV show character and have fun. It also means that Warped Kart Racers doesnt have as much depth and the decision eliminates the need for balancing characters.

Players will need to go through a 10-plus hour campaign to unlock all the characters in Warped Kart Racers. (Apple)UNLOCKING NEW CHARACTERSInitially, players will have access to eight characters but through a 10-hour campaign they can unlock everything. The tracks are available to all from the start. The longevity of Warped Kart Racers will come from its online multiplayer and its progression system that unlocks new karts and parts.

When it comes to multiplayer races, players can expect competition of 8 human players and 4 AI-controller racers for a total of 12 on the track. Lovell said it creates the right amount of chaos. Whats notable here is that there is a bit of rubberbanding with the competition. Players who are behind will have a higher chance of getting better items.

AI characters will also use shortcuts scattered throughout the tracks about 90% of the time. To find them all, players will have to be perceptive of their surroundings or follow some characters who are seemingly always ahead. As in other kart racers, those paths always carry some risk.

Lastly, Warped Kart Racers will be playable on iPhone, iPad and Apple TV. The game can be played with touch controls but it also supports controllers. Whatever scheme players choose, Lovell said, We dont think theres a huge advantage for one or another.

Warped Kart Racers is scheduled for launch on May 20.

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Preview: Warped Kart Racers adds Family Guy and King of the Hill to familiar formula - The Mercury News

SINGAPORE, May 11, 2022 /PRNewswire/ --Interplex, a leading design and manufacturer of customized connector and mechanical products, has committed to set company-wide emissions reduction target in line with the Science Based Targets initiative (SBTi).

SBTi aims to drive ambitious climate action in the private sector by enabling organizations to set science-based emissions reduction targets. As part of the initiative, Interplex has committed to set science-based emissions reduction target that aligns its efforts to tackle climate change with the Paris Agreement's goal to limit global warming to well below 2 degrees Celsius.

"Sustainable business practices lead to increased innovation, cost savings, improved investor confidence and reduced regulatory uncertainty. As such, this is becoming the new 'normal' in the business world, demonstrating that a low-carbon economy is not only vital for consumers and the planet, but also for future-proofing growth. By setting science-based targets, Interplex seeks to reduce emissions in our own operations and our value chains, which can move entire industries toward more efficient and greener supply chains," said the CEO at Interplex.

Interplex's commitment to developing science-based emissions reduction targets reflects its ongoing responsible growth strategy and demonstrates the measurable actions it is taking to reduce its environmental impact. These commitments come on top of the company's existing risk-based environmental management framework, which earned the organization a Platinum Medal from EcoVadis in 2021. Interplex conducts routine audits to ensure it remains vigilant to its EHS goals and continuously improves its sustainability efforts.

Beyond emissions reduction, Interplex places a strong emphasis on maintaining a fair, healthy and safe workplace for employees, both now and in the future. In addition to its existing Diversity and Inclusion, Philanthropy and Labor Relations policies, Interplex officially became a WASH Pledge signatory in November 2021. This pledge reflects the company's commitment to implementing access to safe water, sanitation and hygiene for all employees in all of Interplex's offices and manufacturing facilities.

Interplex is committed to forming partnerships with customers to deliver best-fit customized solutions and enable them to tackle their toughest engineering challenges. By continuously implementing industry-leading sustainability, health and safety initiatives, Interplex upholds the highest standards for environmental, human rights, and corporate social responsibility whilst empowering clients and partners do the same.

About Interplex

Interplex is the world's leading designer and manufacturer of customized interconnect and mechanical product solutions focused on key megatrends around Decarbonization of Transportation, Future Mobility, Increased Longevity and Digitalization. Interplex has established a leading position in key fast-growing markets: eMobility, Medical & Life Sciences and ICT. Our unique product offering, speed and agility is unmatched in the industry thanks to a unique combination of electromechanical (interconnect) and mechanical (high-precision) design skills.

Technology and innovation define us; customization sets us apart. With over 100 years of expertise, key OEMs and Tier 1s trust us to design, develop and manufacture best-fit solutions to reduce their Total Cost of Ownership (TCO). Our global footprint spans 33 locations across 13 countries and 12 R&D centers enabling us to work closely with customers to truly make tomorrow's possibilities a reality today.

Be a part of the next revolution; visit us at http://www.interplex.com.

SOURCE Interplex

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New technologies may have rapid, dramatic effects on society, but they may also spread slowly and subtly. Blockchain-powered decentralized science (DeSci) is taking off after some years of gestation. Its impact is being felt not only in the rarified confines of high-tech labs but more broadly in the business world as well.

Paul Kohlhaas, co-founder and CEO of Molecule a platform for biotech decentralized autonomous organizations (DAOs) founded in 2019 spoke about pharmaceutical research and its funding on the Zima Red podcast in April. We believe it could be way cheaper, if it was coordinated in a better way, Kohlhaas said of pharmaceuticals research. I think theres this cultural and bureaucratic problem.

Kohlhaas compared blockchain in pharma to fintech in banking. The banking industry has only started evolving in the past 10 years in the wake of fintech, because fintech is starting to really hurt their bottom line and take away customers, he said.

Molecule allows researchers, biotech companies and universities to combine data and intellectual property (IP) rights into IP-nonfungible tokens (IP-NFTs), thus creating a new market. The holder of an IP-NFT could solicit funding to continue research activities, or an organization can reach an agreement with the IP-NTF holder to use the data and IP for its own purposes.

Funding may also find new outlets. Kohlhaas mentioned psychedelics research in psychiatry as a priority that he embraces personally, as well as longevity. Longevity startups are currently funded by billionaires, he said. But I think there's a risk there. Because if like the richest people in the world live longer and longer and get richer and richer, that will fundamentally, in the long run, create an unjust society, because wealth isn't distributed.

Related: The crypto world should know about longevity

Research Hub is a platform for open-access research that chief operating officer Patrick Joyce compared to GitHub for scientific research. Joyce told Cointelegraph that the platform, which has the backing of Coinbase CEO Brian Armstrong, may eventually provide a serious incentive for open access publishing and to fund research in subjects that the National Science Foundation does not fund, such as quantum biology.

DeSci can provide an advantage in a number of commercial contexts. The crowded field of consumer genomics is an example. London-based Genomes.io offers the public 30x whole genome sequencing. This is in contrast to many more familiar brands that sequence only the genetic exome, passing over the junk genes that make up the vast majority of the genome and whose importance is rapidly being uncovered. Not a week goes by without a discovery, Genomes.io CEO and cofounder Aldo de Pape told Cointelegraph.

Genomes.io has 14 employees and is the second company de Pape and co-founder Mark Hahnel have been in together. The entrepreneurs met when they worked at MacMillan Publishers, and de Pape followed Hahnel to Figshare, a company that provides research data infrastructure to big government customers, which Hahnel launched in 2011.

In 2018, in anticipation of the gene mapping developments that have reduced the price of genetic sequencing from billions to hundreds of dollars, de Pape, Hahnel and three others founded Genomes.io. The following year, the company was accepted into the ConsenSys Ventures Tachyon 2.0 accelerator. It held an initial coin offering (ICO) in 2021.

Genomes.io sequences customers genomes, encrypts them and keeps them in an electronic vault. Customers can opt into receiving reports based on their genetic information, such as ancestry and rare disease carrier status, with a range of new topics planned to come.

Customers can also allow their data to be used in research queries. Query matching occurs within the data vault so that genomic data never leaves the vault. Blockchain technology provides security by recording all queries made to holders data in a single version of the ledger.

Holders who decide to share genomic information are rewarded with GENE, as are those who contribute to the development or design of the project through the DAO. GNOME is used for governance and is available on the Sushi exchange. The Geneticats NFT, available on OpenSea, offers genomic sequencing and hybrid GENE/GNOME benefits.

The barrier is low for participation in the DAO. There is really lovely interest from people who wanted a closer relationship with the company, de Pape said. Participants are rewarded bounties for contributing development and design ideas. The DAO has no say on the Ltd. side, which includes large-scale projects with partners in Australia, Bermuda and the United States.

Madrid-based DNAVerse has found another quite practical use for genomics. The company will use genetic information to confirm holders identities as human as opposed to AI or chatbots across metaverses. In conjunction with its sister organization, 3DforScience, DNAVerse creates DNArt NFTs that can be used comparably to avatars.

DNAVerse, according to marketing director Juan Castillo, is at the presale stage. It has eight employees and shares several more with 3DforScience. It recently partnered with Polygon Studios and has opened an embassy in the Matrix World metaverse. The company will mint 200 cryptoprotein NFTs and 3,200 highly customizable DNArt NFTs based on customers genetic data but not containing their data.

After the minting of all the DNArt NFTs, new customers will be required to select a cryptoprotein and DNArt staked on a decentralized market, with the holders receiving a percentage of the price for their participation in the replication process. Their genetic data will be delivered to customers, who remain in control of their data and have the option to remain anonymous. They will be gathered under the governance of a DAO that has yet to be formed.

There are a lot of clubby aspects to the business model. A line of clothing featuring customers DNArt, wellbeing channels and virtual events based on genetic affinities are planned. Customers can obtain DNAat for their pets as well.

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Decentralization is helping to shape the course of scientific research and business - Cointelegraph

As far as local roadside art and attractions go, one recent installation wont have the longevity of Lucy the Elephant or even that guy on the Black Horse Pike with a giant pyramid of hubcaps in his yard to promote his resale business.

No, this is strictly a limited-time event, like those that the late artist Christo presented, notably wrapping the Arc de Triumph and other landmarks in fabric. And, as Christo so often did, Don Swensons design in Hammonton makes an environmental statement.

In Hammonton Lake Park sits Leviathan, a 50% octopus, 50% dragon covered almost 100 percent in one thing: single-use plastic bags, the kind that retail stores in New Jersey have been barred from using since last week.

The sculpture is actually a multi-party project hatched almost three years ago. Although local artist Swenson is responsible for the design, the idea came from a group of elementary students in Hammonton. The town environmental commission liked the idea so much for boosting awareness of the then-coming bag ban that it applied for, and received, a $500 grant from the Atlantic County Utilities Authority (the one with the wind turbines) to establish Leviathan. Local Mormon church missionaries, the Hammonton Green Committee and other volunteers brought him/her we dont know the preferred pronouns to life.

Standing 10 feet tall and 15 feet wide, and in place since October, Leviathans last days are nearing, says Dan Bachalis, who heads the environmental commission. Its exact extinction date hasnt been announced, but Bachalis expects it will be within the next month. Itll be dismantled, with the bags reused for plastic benches or lumber. He pointedly notes that 90% of plastic bags in America are never recycled.

So, you still have some limited time to see a walk-through attraction that dispenses recycling information from its belly.

Its had an impact, Bachalis said about the awareness it has brought to the town.

One wonders if people in Hammonton, or who have visited the sculpture, do better than other New Jerseyans remembering to take reusable bags with for shopping. Even the availability of thousands of plastic bags to cover the beast is a stark reminder of the sheer wastefulness of these bags.

Despite pre-ban protests that people need thin bags for trash or storage, there were more than enough orphans around so that Leviathans creators did not to have to stress over supply chain issues. Wonder how many of these bags would have ended up as traps for marine life, litter in tree branches or would have spent several human lifetimes in a landfill before decomposing?

First-week statewide observations of bagless supermarkets and Styrofoam-free restaurants were all over the lot. One call well make here is that it shouldnt be long for shoppers seen heading to their cars cradling cartfuls of items in their arms to learn to bring their reusable bags with them.

The wisdom of the paper-bag ban, also in effect for large grocery stores, has been the most questioned aspect of the new law from letter-to-the-editor writers. The state Department of Environmental Protection notes these have a carbon footprint, too, and they require the sacrifice of trees. But paper bags are degradable, made partly from recycled pulp, and are more easily re-recycled than plastic. Before you slam the most strident earth mothers for that aspect of the law, let it be said that the great ShopRite-Wegmans-Acme-Stop&Shop power axis apparently had a role in this.

It seems that free paper bags are lots more expensive for retailers than free plastic ones. Supermarkets didnt like the added cost for paper, if only plastic bags had been banned. That doesnt fully explain why you cant BUY paper sacks at the checkstand, though.

After Leviathan is fully retired, perhaps some town will decide to make another beast out of paper(bag) mache. Thanks to the folks in Hammonton for an awareness campaign that brought a smile, a chuckle, and a possible nomination for the next Roadside America edition if only the critters stay had not been so brief.

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N.J. town reinforces bag ban with timely public art | Editorial - NJ.com