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Category Archives: Transhuman News

Forum Highlights International Space Station Future Research

Posted: May 23, 2014 at 8:45 am

Image Caption: An image of Crystal of Trypsin grown in microgravity during Expedition 4 on the International Space Station. Credit: NASA

Laura Niles, NASA

To highlight the direction for life and physical sciences aboard the International Space Station, a panel of experts gathered today for the Destination Station: International Space Station Science Forum. This forum, the first in a new series of public discussions dedicated to research aboard the station, emphasized current and future microgravity research that will prepare astronauts for long-duration missions farther into the solar system than ever before and provide lasting benefits to life on Earth.

Not only does the space station provide a one-of-a-kind orbiting laboratory for researching many science disciplines in microgravity, but it also serves as a technology development testbed for deep space exploration and is a destination to grow a robust commercial market in low-Earth orbit. While the use of the space station continues to grow, science studied aboard is underway at an unprecedented pace. In addition to continued scientific opportunity, there also are key areas in which to focus on the most crucial research needs in space.

In 2011, the National Research Council published a report on how best to use the space station. This report, entitled Recapturing a Future for Space Exploration: Life and Physical Sciences Research for a New Era, established priorities and provided recommendations for life and physical sciences research in microgravity for the 2010-2020 decade.

We took a broad look at what research needed to be done in the physical sciences and the life sciences to underpin the future of space exploration, said Elizabeth Cantwell, director for mission development in the engineering directorate at Lawrence Livermore National Laboratory in Livermore, California, and co-chair of the National Research Councils decadal study. We recommended that because animal studies underpin so much of our knowledge and understanding of human health terrestrially, that animal studies be supported more strongly in the space station science program and that microbial studies be beefed up in the form of long-term ability to study microbes in space on the space station.

Among other recommendations for the space station, the report endorsed a clearly defined and prioritized integrated life and physical sciences research portfolio and associated objectives. This report detailed seven major disciplines for focus by station research, including plant and microbial biology and animal and human biology.

Life science research already conducted aboard the space station includes studies of protein crystals, pharmaceutical treatments and model organisms like plants and fish. Model organisms have characteristics that allow them to easily be maintained, reproduced and studied in a laboratory and have a genetic makeup that is relatively well-documented and well-understood by scientists. Upcoming research in the area of omics, the study of the entire complement of biomolecules like proteins or genes, and in rodent research will further enable humans to carry out long-term space exploration and support a greater understanding of how gravity shapes fundamental biological processes.

In response to the report, we identified new facilities that we needed, like new rodent and plant habitats, and starting this year, those facilities are going to keep coming online one-by-one, and each will be used on every flight over and over on the space station for the next 10 years, said Julie Robinson, Ph.D., chief program scientist for the International Space Station.

Protein crystals have been studied in microgravity throughout the space stations assembly, and investigations using protein crystals continue today. High quality crystals grown on the space station are used to determine protein structure. This helps researchers understand better protein the three-dimensional structure of proteins and may lead to designing new therapeutics for diseases. In fact, a previous study of protein crystals on the space station led to the discovery of a water molecule in a protein-inhibitor complex that now is being used to develop a treatment for Duchenne muscular dystrophy.

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As defense budgets shrink, drive for international space cooperation grows

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Stars and Stripes

Published: May 22, 2014

COLORADO SPRINGS, Colo. Civilian space projects, including the International Space Station, have driven cooperation between the U.S. and its allies for more than 20 years.

With defense belt-tightening squeezing military space endeavors across Europe, North America and the Pacific, the people in uniform are hatching plans for similar cooperation in defense satellite work.

Some cooperative projects are already flying, including a military communications satellite used by American, Canadian and Australian forces. Air Force Lt. Gen. Ellen Pawlikowski told an audience at the Space Symposium in Colorado Springs on Wednesday that working with allies makes financial sense as the Pentagon plans to cuts billions from its space budget over the next decade.

"We needed to reach out and share the costs of access to space," said Pawlikowski who commands the Space and Missile Systems Center at Los Angeles Air Force Base, which develops the Air Force's new satellites and rockets.

Allies were reaching out to the U.S. at the Space Symposium, which drew a large international contingent among its 9,000 attendees.

"Let's be clear: It is very difficult for a single European nation to afford a full-spectrum capability," said Col. Dominique Arbiol, a French air force officer who oversees military space efforts there.

"My minister is very, very keen on international cooperation," said Cdmr. Volker Brasen, a German navy officer who serves as a top space officer in his country's defense ministry.

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Solestia – Genetic Engineering – Video

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Solestia - Genetic Engineering

By: BeyondTheBeyond

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Solestia - Genetic Engineering - Video

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Gene therapy extends survival in an animal model of spinal muscular atrophy

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PUBLIC RELEASE DATE:

22-May-2014

Contact: Kathryn Ruehle kruehle@liebertpub.com 914-740-2100 Mary Ann Liebert, Inc./Genetic Engineering News

New Rochelle, NY, May 22, 2014To make up for insufficient amounts of SMN protein, the cause of the inherited neuromuscular disease spinal muscular atrophy (SMA), researchers have successfully delivered a replacement SMN1 gene directly to the spinal cords of animal models of SMA. A new study demonstrating that enough copies of the SMN1 gene can be delivered to the spinal cord motor neurons to extend the survival of the treated animals is published in Human Gene Therapy, a peer-reviewed journal from Mary Ann Liebert, Inc., publishers. The article is available free on the Human Gene Therapy website.

Marco Passini and coauthors from Genzyme (Framingham, MA), University of California San Francisco, Emory University School of Medicine (Atlanta, GA), and Georgetown University Medical Center (Washington, DC) used an adeno-associated viral vector as the delivery vehicle to transport copies of the SMN1 gene into motor neurons in the spinal cord via intrathecal delivery. They report on the effectiveness of restoring the levels of functional SMN protein in normal pig and non-human primate SMA models that would predict efficacy based on gene transfer with the same vector in an authentic mouse model of SMA in the article "Translational Fidelity of Intrathecal Delivery of Self-Complementary AAV9Survival Motor Neuron 1 for Spinal Muscular Atrophy."

"This is a very promising and thorough set of preclinical studies that supports rapid translation to the clinic," says James M. Wilson, MD, PhD, Editor-in-Chief of Human Gene Therapy, and Director of the Gene Therapy Program, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia.

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About the Journal

Human Gene Therapy, the official journal of the European Society of Gene and Cell Therapy, British Society for Gene and Cell Therapy, French Society of Cell and Gene Therapy, German Society of Gene Therapy, and five other gene therapy societies, is an authoritative peer-reviewed journal published monthly in print and online. Human Gene Therapy presents reports on the transfer and expression of genes in mammals, including humans. Related topics include improvements in vector development, delivery systems, and animal models, particularly in the areas of cancer, heart disease, viral disease, genetic disease, and neurological disease, as well as ethical, legal, and regulatory issues related to the gene transfer in humans. Its sister journals, Human Gene Therapy Methods, published bimonthly, focuses on the application of gene therapy to product testing and development, and Human Gene Therapy Clinical Development, published quarterly, features data relevant to the regulatory review and commercial development of cell and gene therapy products. Tables of content for all three publications and a free sample issue may be viewed on the Human Gene Therapy website.

About the Publisher

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Court decision keeps NZ GE-free

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Court decision keeps NZ GE-free

A recent High Court decision is a victory for New Zealand consumers, farmers and foresters, says the Soil & Health Association. The High Court ruled against a decision by the Environmental Protection Authority (EPA) that two new plant breeding techniques were not genetic engineering techniques.

Soil & Health welcomes the court ruling. Without it New Zealand would have lost its status and international reputation as a producer of GE-free food and fibre.

If the EPAs decision had not been challenged and found wanting, plants bred using these GE techniques could have been planted in New Zealand without any public consultation or monitoring of their effects, said Marion Thomson, co-chair of Soil & Health.

There are other new techniques like this, and they must all be thoroughly and independently scrutinised and the precautionary principle applied. Otherwise, its an uncontrolled experiment that could have adverse effects for people, animals and the environment.

The High Court ruled that the EPA had misinterpreted the law and that it had failed to apply the precautionary principle.

Soil & Health is concerned about the ability of the EPA to protect our environment, says Thomson. We commend the Sustainability Council for challenging the EPAs decision, but we should not have to rely on not-for-profit watchdog organisations to protect our environment. That is the job of the EPA, and we urge them to apply the precautionary principle in any similar decisions in future.

Soil & Health has been informing its members and the public about genetic engineering for over 25 years. It has played a key role in advocating for a GE-free New Zealand for health, environmental, economic and other reasons. The New Zealand public, and our key markets, have consistently opposed genetic engineering in food and the environment.

ENDS

Scoop Media

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Fish study could advance medicine

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A small fish that East Carolina University biologist Jeff McKinnon collected as a boy growing up in British Columbia will be the centerpiece of a study that could give insight to human genetics.

McKinnon, professor and chair of biology at ECU, is studying the threespine stickleback to find out why the bright colors of the male, which help it attract mates, sometimes show up in females. The findings could give scientists insight into the genes behind sex differences and help tailor medicine to better suit patients sex and race.

McKinnon and co-investigators Chris Balakrishnan of ECU and Catherine Peichel of the Fred Hutchinson Cancer Research Center in Seattle, have received a $316,241 grant from the National Institute of General Medical Sciences to fund the three-year study.

The fish lives on the northern Pacific and Atlantic coasts of Europe and Asia as well as North America. Fish from many populations spend most of their lives in the ocean but breed in brackish and fresh water. Purely freshwater forms also have evolved, independently on different continents and islands.

We are trying in general to understand how the sexes diverge despite sharing many genes, McKinnon said. This is a critical issue for medicine as well as evolution. We are looking at the genes involved and at patterns of gene expression.

McKinnon has studied the threespine stickleback for much of his career. His early work helped develop the stickleback as a model organism for genetic and evolutionary studies since it shows great morphological variation.

We hope to ... better understand the genetic mechanisms responsible for causing seemingly male traits to appear in female animals in some populations, McKinnon said. We also want to know if females who possess one male-like trait are only masculinized for that trait or more generally.

The research will shed light on whether some male-like traits are present in females because they benefit females or as a by-product of the benefits they provide to males and vice-versa, McKinnon said. Given the interest in better tailoring medicine by gender and ethnicity, we may provide useful insights on matters important to health.

ECU doctoral student Lenny Yong is playing a key role in this research program and helped write the grant application. The grant also will support the research of two masters students and a number of undergraduates who will be trained in behavioral studies, genetics and genomics.

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Fish study could advance medicine

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LPS: DNA SHORT MV – Video

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LPS: DNA SHORT MV
well this sucked and took forever.

By: elleisrandom

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LPS: DNA SHORT MV - Video

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Coco Martin Speaks Up About Undergoing DNA Test – Video

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Coco Martin Speaks Up About Undergoing DNA Test
Coco Martin speaks up for the first time about undergoing a DNA test after choosing to stay silent about reports that he has a child out of wedlock. For More...

By: Pinoy Scoop

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Coco Martin Speaks Up About Undergoing DNA Test - Video

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DNA VS PREZ MAFIA: SMACK/ URL – Video

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DNA VS PREZ MAFIA: SMACK/ URL
THE LEADERS OF MC BATTLE CULTURE RELEASE A DOPE MATCH UP BETWEEN VETERAN MC DNA AND NEW COMER PREZ MAFIA. THE MATCH UP TOOK PLACE ON MAY 17TH TO CELEBRATE SMACK/ URL #39;S UPCOMING NOME 4 EVENT...

By: Ultimate Rap League

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DNA VS PREZ MAFIA: SMACK/ URL - Video

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dna 2131 – Video

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dna 2131

By: Mind Intruder

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dna 2131 - Video

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